#macrophages — Public Fediverse posts

Toll-like Receptor 🇺🇸

#Immunity #PPR #Patternrecognition #TRL #dendriticcells #immunecellresponses #macrophages #patternrecognitionreceptor

▶️ 1 new picture from NIH BioArt https://commons.wikimedia.org/wiki/File:Toll-like_Receptor_%28NIH_BioArt_700_-_784261%29.png

Toll-like Receptor 🇺🇸

#Immunity #PPR #Patternrecognition #TRL #dendriticcells #immunecellresponses #macrophages #patternrecognitionreceptor

▶️ 1 new picture from NIH BioArt https://commons.wikimedia.org/wiki/File:Toll-like_Receptor_%28NIH_BioArt_700_-_784261%29.png

Toll-like Receptor 🇺🇸

#Immunity #PPR #Patternrecognition #TRL #dendriticcells #immunecellresponses #macrophages #patternrecognitionreceptor

▶️ 1 new picture from NIH BioArt https://commons.wikimedia.org/wiki/File:Toll-like_Receptor_%28NIH_BioArt_700_-_784261%29.png

Toll-like Receptor 🇺🇸

#Immunity #PPR #Patternrecognition #TRL #dendriticcells #immunecellresponses #macrophages #patternrecognitionreceptor

▶️ 1 new picture from NIH BioArt https://commons.wikimedia.org/wiki/File:Toll-like_Receptor_%28NIH_BioArt_700_-_784261%29.png

🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.

When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.

👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/

#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research

🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.

When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.

👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/

#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research

🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.

When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.

👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/

#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research

🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.

When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.

👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/

#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research

🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.

When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.

👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/

#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research

#Pigeons navigate using magnetic sensors in their livers https://www.mpg.de/26511515/pigeons-navigate-using-magnetic-sensors-in-their-livers

Homing #pigeon navigation relies on superparamagnetic #macrophages under overcast conditions: Clivia Lisowski, et al. https://www.science.org/doi/10.1126/science.ady2486

"pigeons may sense magnetic field using iron-rich immune cells in their livers, a quantum effect... Findings suggest a new link between immunity and sensory perception in #birds... Many questions remain, particularly how signals from these cells are processed in the brain"

#Pigeons navigate using magnetic sensors in their livers https://www.mpg.de/26511515/pigeons-navigate-using-magnetic-sensors-in-their-livers

Homing #pigeon navigation relies on superparamagnetic #macrophages under overcast conditions: Clivia Lisowski, et al. https://www.science.org/doi/10.1126/science.ady2486

"pigeons may sense magnetic field using iron-rich immune cells in their livers, a quantum effect... Findings suggest a new link between immunity and sensory perception in #birds... Many questions remain, particularly how signals from these cells are processed in the brain"

#Pigeons navigate using magnetic sensors in their livers https://www.mpg.de/26511515/pigeons-navigate-using-magnetic-sensors-in-their-livers

Homing #pigeon navigation relies on superparamagnetic #macrophages under overcast conditions: Clivia Lisowski, et al. https://www.science.org/doi/10.1126/science.ady2486

"pigeons may sense magnetic field using iron-rich immune cells in their livers, a quantum effect... Findings suggest a new link between immunity and sensory perception in #birds... Many questions remain, particularly how signals from these cells are processed in the brain"

#Pigeons navigate using magnetic sensors in their livers https://www.mpg.de/26511515/pigeons-navigate-using-magnetic-sensors-in-their-livers

Homing #pigeon navigation relies on superparamagnetic #macrophages under overcast conditions: Clivia Lisowski, et al. https://www.science.org/doi/10.1126/science.ady2486

"pigeons may sense magnetic field using iron-rich immune cells in their livers, a quantum effect... Findings suggest a new link between immunity and sensory perception in #birds... Many questions remain, particularly how signals from these cells are processed in the brain"

https://www.europesays.com/ie/502058/ Study reveals the evolution of the most ancient human blood cell #700MillionYears #biology #BloodCell #Éire #Health #IE #Ireland #macrophages #Science #SingleCelledAncestors

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization.
🍞 Endothelial lactate losses hinder muscle regrowth and vessel restoration
🦠 Lactate enhances M2-like macrophage function
⚕️ Restored lactate levels recuperate ischemic muscles
🧠 Loss of pfkfb3 in endothelial cells decreases muscle lactate levels

#ECs #Ischemia #MuscleRegeneration #Lactate #Macrophages
https://tnyp.me/fsSnex0v/m

🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...

🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...

🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...

🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...

🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice

📰 Original title: Scientists remove “zombie” cells and reverse liver damage in mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/ucla-researchers-identify-and-clear-senescent-macrophages-to-reverse-fatty-liver-disease-in-mice/?redirpost=be87fc0c-de2a-4d1b-a6de-0cc7857a6426

#health #senescentcells #fattyliverdisease #macrophages

UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice

📰 Original title: Scientists remove “zombie” cells and reverse liver damage in mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/ucla-researchers-identify-and-clear-senescent-macrophages-to-reverse-fatty-liver-disease-in-mice/?redirpost=be87fc0c-de2a-4d1b-a6de-0cc7857a6426

#health #senescentcells #fattyliverdisease #macrophages

UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice

📰 Original title: Scientists remove “zombie” cells and reverse liver damage in mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/ucla-researchers-identify-and-clear-senescent-macrophages-to-reverse-fatty-liver-disease-in-mice/?redirpost=be87fc0c-de2a-4d1b-a6de-0cc7857a6426

#health #senescentcells #fattyliverdisease #macrophages

UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice

📰 Original title: Scientists remove “zombie” cells and reverse liver damage in mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/ucla-researchers-identify-and-clear-senescent-macrophages-to-reverse-fatty-liver-disease-in-mice/?redirpost=be87fc0c-de2a-4d1b-a6de-0cc7857a6426

#health #senescentcells #fattyliverdisease #macrophages

#Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. @robinsall &co show that macrophages extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @PLOSBiology https://plos.io/4txkZez

#Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. @robinsall &co show that macrophages extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @PLOSBiology https://plos.io/4txkZez

#Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. @robinsall &co show that macrophages extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @PLOSBiology https://plos.io/4txkZez

#Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. @robinsall &co show that macrophages extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @PLOSBiology https://plos.io/4txkZez

#Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. @robinsall &co show that macrophages extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @PLOSBiology https://plos.io/4txkZez

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

https://www.europesays.com/ie/183575/ A Crucial Genetic Mutation Behind Crohn’s Disease Has Finally Been Revealed #Crohn'sDisease #Éire #IE #ImmuneCells #InflammatoryBowelDisease #Ireland #macrophages #Science

#Immune systems of female and male mice age differently, study on #macrophages shows. Explains a mechanism of "inflammaging": survival of #inflammatory cells. https://www.nature.com/articles/d41586-025-02788-0

#Immune systems of female and male mice age differently, study on #macrophages shows. Explains a mechanism of "inflammaging": survival of #inflammatory cells. https://www.nature.com/articles/d41586-025-02788-0

#Immune systems of female and male mice age differently, study on #macrophages shows. Explains a mechanism of "inflammaging": survival of #inflammatory cells. https://www.nature.com/articles/d41586-025-02788-0

#Immune systems of female and male mice age differently, study on #macrophages shows. Explains a mechanism of "inflammaging": survival of #inflammatory cells. https://www.nature.com/articles/d41586-025-02788-0

Research uncovers gene variant role in disease biology

Immune New research has filled in missing links between gene variants that have been implicated in disease through…
#NewsBeep #News #Genetics #alternativeRNAsplicing #AU #Australia #BioWorld #BioWorldMedTech #BioWorldScience #Europe #Genome-wideassociationstudies #immune #immunediseases #Macromap #macrophages #Science
https://www.newsbeep.com/au/103494/

Research uncovers gene variant role in disease biology

Immune New research has filled in missing links between gene variants that have been implicated in disease through…
#NewsBeep #News #Genetics #alternativeRNAsplicing #AU #Australia #BioWorld #BioWorldMedTech #BioWorldScience #Europe #Genome-wideassociationstudies #immune #immunediseases #Macromap #macrophages #Science
https://www.newsbeep.com/au/103494/

Research uncovers gene variant role in disease biology

Immune New research has filled in missing links between gene variants that have been implicated in disease through…
#NewsBeep #News #Genetics #alternativeRNAsplicing #BioWorld #BioWorldMedTech #BioWorldScience #Europe #Genome-wideassociationstudies #Immune #immunediseases #Macromap #macrophages #Science #UK #UnitedKingdom
https://www.newsbeep.com/uk/100004/

Research uncovers gene variant role in disease biology

New research has filled in missing links between gene variants that have been implicated in disease through genome-wide…
#NewsBeep #News #Genetics #alternativeRNAsplicing #BioWorld #Europe #Genome-wideassociationstudies #Immune #immunediseases #Macromap #macrophages #Science #UK #UnitedKingdom
https://www.newsbeep.com/uk/98026/

https://www.europesays.com/uk/379046/ Research uncovers gene variant role in disease biology #AlternativeRNASplicing #BioWorld #Europe #Genetics #GenomeWideAssociationStudies #immune #ImmuneDiseases #Macromap #macrophages #Science #UK #UnitedKingdom

Research uncovers gene variant role in disease biology

New research has filled in missing links between gene variants that have been implicated in disease through genome-wide…
#NewsBeep #News #Genetics #alternativeRNAsplicing #AU #Australia #BioWorld #Europe #Genome-wideassociationstudies #immune #immunediseases #Macromap #macrophages #Science
https://www.newsbeep.com/au/100877/