#macrophages — Public Fediverse posts

Toll-like Receptor 🇺🇸

#Immunity #PPR #Patternrecognition #TRL #dendriticcells #immunecellresponses #macrophages #patternrecognitionreceptor

▶️ 1 new picture from NIH BioArt https://commons.wikimedia.org/wiki/File:Toll-like_Receptor_%28NIH_BioArt_700_-_784261%29.png

🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.

When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.

👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/

#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

🧠New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury. #Neuroscience

Intravital calcium imaging of ...

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

UCLA Researchers Identify and Clear Senescent Macrophages to Reverse Fatty Liver Disease in Mice

📰 Original title: Scientists remove “zombie” cells and reverse liver damage in mice

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/ucla-researchers-identify-and-clear-senescent-macrophages-to-reverse-fatty-liver-disease-in-mice/?redirpost=be87fc0c-de2a-4d1b-a6de-0cc7857a6426

#health #senescentcells #fattyliverdisease #macrophages

#Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. @robinsall &co show that macrophages extract directional information from their environment from a constant concentration of C5a #chemoattractant, self-generate a gradient & enhance guidance @PLOSBiology https://plos.io/4txkZez

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

#Immune systems of female and male mice age differently, study on #macrophages shows. Explains a mechanism of "inflammaging": survival of #inflammatory cells. https://www.nature.com/articles/d41586-025-02788-0

@roylelab Nice work! This reminds me of a paper published while I was in my PhD lab addressing ER membrane contribution to the Phagocytic cup.

It still stands as a fantastic example of structured hypothesis testing.

https://doi.org/10.1016/j.cell.2005.08.018

#EndoplasmicReticulum #Phagocytosis #macrophages #ScienceMastodon

Another experimental anti-tumor therapy based on weaponized immune cells: #macrophages loaded with drugs attack #glioblastoma cells and activate #immune system.
https://www.science.org/doi/10.1126/scitranslmed.adr4058

#Macrophages are #immune cells good at hoovering up pathogens. Turns out that they are real predators that use gobbled bacteria as fuel. Depending on whether this food is dead or alive they become more tame or go berserk. Massive work. https://www.nature.com/articles/s41586-025-08629-4

Human aging is assoc. with inflammation and intestinal barrier dysfunction. One might assume that barrier permeability would spark increased inflammation. This (and prev.) work suggests the opposite—that #inflammaging, driven by #monocytes and #macrophages appear to *cause* the barrier dysfunction!

How do #apoptotic cells signal to their neighbors to stimulate proliferation? This study shows that apoptotic #ExtracellularVesicles (#EVs) carrying MIF stimulate epithelial #StemCell repopulation, guiding #macrophages to induce proliferation #PLOSBiology https://plos.io/48SeCd3

#Tuberculosis bacteria release tuberculosinyladenosine to help them survive in human #macrophages. This study identifies >100 such #terpene #nucleoside metabolites, revealing how #TB's ancestors acquired the genes to make these lipids #PLOSBiology https://plos.io/4gIfmol

Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics

#RefereedPreprint c/o @ReviewCommons by Véronique Le Cabec, Sébastien Carréno, Renaud Poincloux and colleagues shows that #macrophages do not require the ERM family proteins for phagocytosis and cell migration, suggesting divergence of macrophage cortical properties

https://www.embopress.org/doi/full/10.1038/s44318-024-00173-7

Superbug that now kills 300,000 people a year evolved rapidly from common bacteria | The Independent
https://www.independent.co.uk/news/science/superbug-antibiotic-resistance-origin-spread-b2575769.html

#Superbug
#CommmonBacteria
#Bacteria
#Evolution
#CysticFibrosis
#PseudomonasAeruginosa
#LungDamage
#Smoking
#Macrophages
#DenselyPopulatedAreas

PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap. https://doi.org/10.1186/s12931-024-02790-6 #Aco #Asthma #Copd #Macrophages #Senescence

New drug against #Tuberculosis: @alexe_mre @TailleuxLudovic &co identify an #oxadiazole-based compound that induces #zinc redistribution in host cells, synergizing with other anti-#TB drugs to control infection in human #macrophages & mice #PLOSBiology https://plos.io/3w60MVs