#biochemistry — Public Fediverse posts

Lab Manager / Research Associate -- Joiner Lab, Univ. of Cincinnati
University of Cincinnati

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-cincinnati-27778-lab-manager-research-associate-joiner-lab-univ-of-cincinnati/

#biochemistry #cellbiology #structuralbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-cincinnati-27778-lab-manager-research-associate-joiner-lab-univ-of-cincinnati/?fsp_sid=13944

Lab Manager / Research Associate -- Joiner Lab, Univ. of Cincinnati
University of Cincinnati

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-cincinnati-27778-lab-manager-research-associate-joiner-lab-univ-of-cincinnati/

#biochemistry #cellbiology #structuralbiology #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-cincinnati-27778-lab-manager-research-associate-joiner-lab-univ-of-cincinnati/?fsp_sid=13944

#mwgic #2026 #Aging #Rejuvenation #Longevity #Biochemistry

https://www.seattletimes.com/nation-world/can-this-new-enzyme-turn-back-the-clock-in-the-human-body/

"The most important single statistic about the drug industry is the clinical failure rate" (percent of drugs that fail human clinical trials): 91% over the past two decades.

About 77% of failures are attributed to biological factors like inadequate clinical safety and efficacy, which are parameters typically aquired in preclinical animal studies.

The suggested solution comes from New Approach Methodologies (NAMs), like:

- in vitro models (cell and tissue-based) including
2D cell cultures, 3D spheroids and organoids, organ-on-chip systems
- In silico models (computational toxicology)
- Omics: transcriptomics, proteomics, metabolomics
- In chemico methods: cell-free, chemical- or biochemistry-based laboratory assays
- High-Throughput Screening: automatic robotic laboratories.
- Framework Integration: integrating all above and using conceptual causal-chains from molecular integration to adverse effects.

Clinical Failure Rates Over the Decades: Yikes
https://www.science.org/content/blog-post/clinical-failure-rates-over-decades-yikes

Need for NAMs: A systematic evidence synthesis revealing over half a century of drug development failure
https://www.sciencedirect.com/science/article/pii/S3050620426000448

#biochemistry #drugs #medicine

"The most important single statistic about the drug industry is the clinical failure rate" (percent of drugs that fail human clinical trials): 91% over the past two decades.

About 77% of failures are attributed to biological factors like inadequate clinical safety and efficacy, which are parameters typically aquired in preclinical animal studies.

The suggested solution comes from New Approach Methodologies (NAMs), like:

- in vitro models (cell and tissue-based) including
2D cell cultures, 3D spheroids and organoids, organ-on-chip systems
- In silico models (computational toxicology)
- Omics: transcriptomics, proteomics, metabolomics
- In chemico methods: cell-free, chemical- or biochemistry-based laboratory assays
- High-Throughput Screening: automatic robotic laboratories.
- Framework Integration: integrating all above and using conceptual causal-chains from molecular integration to adverse effects.

Clinical Failure Rates Over the Decades: Yikes
https://www.science.org/content/blog-post/clinical-failure-rates-over-decades-yikes

Need for NAMs: A systematic evidence synthesis revealing over half a century of drug development failure
https://www.sciencedirect.com/science/article/pii/S3050620426000448

#biochemistry #drugs #medicine

Staff Associate I
Columbia University Irving Medical Center: Department of Microbiology and Immunology

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-irving-medical-center-department-of-microbiology-and-immunology-27778-staff-associate-i/

#biochemistry #cellbiology #molecularbiology #ScienceJobs #hiring #res...
https://jobrxiv.org/job/columbia-university-irving-medical-center-department-of-microbiology-and-immunology-27778-staff-associate-i/?fsp_sid=13846

Staff Associate I
Columbia University Irving Medical Center: Department of Microbiology and Immunology

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-irving-medical-center-department-of-microbiology-and-immunology-27778-staff-associate-i/

#biochemistry #cellbiology #molecularbiology #ScienceJobs #hiring #res...
https://jobrxiv.org/job/columbia-university-irving-medical-center-department-of-microbiology-and-immunology-27778-staff-associate-i/?fsp_sid=13846

🔋How Cells Secure Their Energy

Researchers at the University of Cologne have uncovered a surprising link between two fundamental processes in our cells: oxidative protein folding and the production of heme, a vital molecule. Heme isn’t just a key component of hemoglobin – it’s essential for energy production in mitochondria, the cell’s “power plants.”

Read more ➡️https://uni.koeln/RA3JK

#uniköln #unicologne #biochemistry

🔋Wie Zellen ihre Energieversorgung sichern

Forschende der Uni Köln haben einen Zusammenhang zwischen zwei zentralen Prozessen in unseren Zellen entschlüsselt: der oxidativen Proteinfaltung und der Bildung des lebenswichtigen Häm-Moleküls. Häm ist nicht nur der Baustein unseres Blutfarbstoffs – es ist essenziell für die Energiegewinnung in den Mitochondrien, den „Kraftwerken der Zelle“.

Mehr dazu ➡️ https://uni.koeln/V4JH2

#uniköln #unicologne #biochemistry

🔋How Cells Secure Their Energy

Researchers at the University of Cologne have uncovered a surprising link between two fundamental processes in our cells: oxidative protein folding and the production of heme, a vital molecule. Heme isn’t just a key component of hemoglobin – it’s essential for energy production in mitochondria, the cell’s “power plants.”

Read more ➡️https://uni.koeln/RA3JK

#uniköln #unicologne #biochemistry

🔋Wie Zellen ihre Energieversorgung sichern

Forschende der Uni Köln haben einen Zusammenhang zwischen zwei zentralen Prozessen in unseren Zellen entschlüsselt: der oxidativen Proteinfaltung und der Bildung des lebenswichtigen Häm-Moleküls. Häm ist nicht nur der Baustein unseres Blutfarbstoffs – es ist essenziell für die Energiegewinnung in den Mitochondrien, den „Kraftwerken der Zelle“.

Mehr dazu ➡️ https://uni.koeln/V4JH2

#uniköln #unicologne #biochemistry

The human skin microbiome constitutes a vast, diverse community of bacteria, fungi, and viruses that acts as a protective barrier against external pathogens. Recent research indicates that these endogenous microbial populations naturally produce novel antimicrobial compounds to defend their host.
#Microbiology #Biochemistry #BiomedicalSciences #InfectiousDiseasePharmacology #sflorg
https://www.sflorg.com/2026/07/mcb07212601.html

The human skin microbiome constitutes a vast, diverse community of bacteria, fungi, and viruses that acts as a protective barrier against external pathogens. Recent research indicates that these endogenous microbial populations naturally produce novel antimicrobial compounds to defend their host.
#Microbiology #Biochemistry #BiomedicalSciences #InfectiousDiseasePharmacology #sflorg
https://www.sflorg.com/2026/07/mcb07212601.html

Hereditary ATTR amyloidosis is a progressive, genetic condition characterized by the misfolding of the transthyretin (TTR) protein into tissue-damaging amyloid deposits. Recent research demonstrates that a disrupted antioxidant balance and the resulting oxidative stress act as critical triggers for the clinical onset of the disease.
#MolecularBiology #Biochemistry #Genetics #ClinicalPathology #sflorg
https://www.sflorg.com/2026/07/mbio07192601.html

Hereditary ATTR amyloidosis is a progressive, genetic condition characterized by the misfolding of the transthyretin (TTR) protein into tissue-damaging amyloid deposits. Recent research demonstrates that a disrupted antioxidant balance and the resulting oxidative stress act as critical triggers for the clinical onset of the disease.
#MolecularBiology #Biochemistry #Genetics #ClinicalPathology #sflorg
https://www.sflorg.com/2026/07/mbio07192601.html

What is the main function of vitamin D in the body?
A. Aid in digestion
B. Promote red blood cell production
C. Help absorb calcium and phosphorus
D. Lower cholesterol levels
#vitaminD #biochemistry # ... Continue to: https://www.facebook.com/1130092409221646/posts/1384459137118304

Researchers have developed a gentle, water-based method for assembling massive collections of potential drug candidates without damaging their molecular DNA "barcodes." This technique utilizes engineered enzymes instead of harsh synthetic chemicals to construct small-molecule libraries.
#Biochemistry #PharmaceuticalSciences #Biocatalysis #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/bchm07172601.html

Researchers have developed a gentle, water-based method for assembling massive collections of potential drug candidates without damaging their molecular DNA "barcodes." This technique utilizes engineered enzymes instead of harsh synthetic chemicals to construct small-molecule libraries.
#Biochemistry #PharmaceuticalSciences #Biocatalysis #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/bchm07172601.html

Hiroshima University researchers successfully used CRISPR-Cas9 genome editing to disrupt the flavanone 3-hydroxylase (F3H) gene in red perilla (Perilla frutescens), creating a green-leafed variant with a significantly altered metabolic profile.
#Genetics #PlantBiology #Biochemistry #FoodScience #sflorg
https://www.sflorg.com/2026/07/gen07162601.html

Hiroshima University researchers successfully used CRISPR-Cas9 genome editing to disrupt the flavanone 3-hydroxylase (F3H) gene in red perilla (Perilla frutescens), creating a green-leafed variant with a significantly altered metabolic profile.
#Genetics #PlantBiology #Biochemistry #FoodScience #sflorg
https://www.sflorg.com/2026/07/gen07162601.html

💁🏻‍♀️ TIL: 🐻🚀 Scientists are studying how hibernating #animals survive months without food, hoping to replicate the process in #humans for #space travel.

Researchers funded by #NASA and #ESA are testing #brain stimulation techniques like #ultrasound to trigger torpor. The work could make #Mars missions feasible and help treat Parkinson’s and stroke on #Earth.

👉 https://www.theguardian.com/science/ng-interactive/2026/jul/14/human-hibernation-space-mars

#hibernation #science #medicine #astronauts #biochemistry #neuroscience #biology #squirrel #humanbody

💁🏻‍♀️ TIL: 🐻🚀 Scientists are studying how hibernating #animals survive months without food, hoping to replicate the process in #humans for #space travel.

Researchers funded by #NASA and #ESA are testing #brain stimulation techniques like #ultrasound to trigger torpor. The work could make #Mars missions feasible and help treat Parkinson’s and stroke on #Earth.

👉 https://www.theguardian.com/science/ng-interactive/2026/jul/14/human-hibernation-space-mars

#hibernation #science #medicine #astronauts #biochemistry #neuroscience #biology #squirrel #humanbody

A recently engineered RNA-based enzyme, or ribozyme, demonstrates the ability to selectively recognize and mend broken RNA strands without the need for proteins. This finding suggests that primordial life forms could have successfully maintained and repaired their genetic codes using only RNA.
#Biochemistry #Biotechnology #EvolutionaryBiology #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/bchm07132601.html

A recently engineered RNA-based enzyme, or ribozyme, demonstrates the ability to selectively recognize and mend broken RNA strands without the need for proteins. This finding suggests that primordial life forms could have successfully maintained and repaired their genetic codes using only RNA.
#Biochemistry #Biotechnology #EvolutionaryBiology #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/bchm07132601.html

Biomolecular engineering is the application of engineering principles and practices to the purposeful manipulation of molecules of biological origin. Its primary goal is the intentional design, synthesis, and analysis of biomolecules—such as proteins, nucleic acids, and carbohydrates—to solve complex problems in human health, agriculture, energy production, materials science
#BiomolecularEngineering #ChemicalEngineering #Biochemistry #Biophysics #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/cat07122603.html

Biomolecular engineering is the application of engineering principles and practices to the purposeful manipulation of molecules of biological origin. Its primary goal is the intentional design, synthesis, and analysis of biomolecules—such as proteins, nucleic acids, and carbohydrates—to solve complex problems in human health, agriculture, energy production, materials science
#BiomolecularEngineering #ChemicalEngineering #Biochemistry #Biophysics #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/cat07122603.html

#Servicetweet #News #Biologie #Biology #Biochemie #Biochemistry
➡️ Immunzellen verständigen sich anscheinend auf dieselbe Art wie Nervenzellen, über Katecholamine
https://www.forschung-und-wissen.de/nachrichten/medizin/immunzellen-sprechen-dieselbe-sprache-wie-unsere-nervenzellen-133711509 1/x

#Servicetweet #News #Biologie #Biology #Biochemie #Biochemistry
➡️ Immunzellen verständigen sich anscheinend auf dieselbe Art wie Nervenzellen, über Katecholamine
https://www.forschung-und-wissen.de/nachrichten/medizin/immunzellen-sprechen-dieselbe-sprache-wie-unsere-nervenzellen-133711509 1/x

Researchers do know that “women tend to oxidize fat at higher rates and run at a lower respiratory exchange ratio during submaximal endurance exercise,” he says. In other words, women tend to burn more fat for energy than men during steady, moderate-intensity endurance exercise, such as a marathon.
#exercise #physiology #biology #women #marathons #biochemistry
https://www.scientificamerican.com/article/male-marathoners-might-be-twice-as-likely-to-hit-the-wall-as-women-the-reason-why-might-surprise-you/

Researchers do know that “women tend to oxidize fat at higher rates and run at a lower respiratory exchange ratio during submaximal endurance exercise,” he says. In other words, women tend to burn more fat for energy than men during steady, moderate-intensity endurance exercise, such as a marathon.
#exercise #physiology #biology #women #marathons #biochemistry
https://www.scientificamerican.com/article/male-marathoners-might-be-twice-as-likely-to-hit-the-wall-as-women-the-reason-why-might-surprise-you/

An international research team has engineered "Tumbleweed," an artificial protein motor capable of taking externally controlled, directed steps along a DNA track to mimic the biological engines found inside living cells.
#SyntheticBiology #Nanophysics #MolecularBiology #Biochemistry #sflorg
https://www.sflorg.com/2026/07/sybi07072601.html

An international research team has engineered "Tumbleweed," an artificial protein motor capable of taking externally controlled, directed steps along a DNA track to mimic the biological engines found inside living cells.
#SyntheticBiology #Nanophysics #MolecularBiology #Biochemistry #sflorg
https://www.sflorg.com/2026/07/sybi07072601.html

Researchers at McMaster University have identified the specific immune and metabolic pathway responsible for the muscle pain and weakness frequently caused by statin medications, offering a route to mitigate these side effects without compromising the drugs' cardiovascular benefits.
#Biochemistry #Biomedical #Immunology #Pharmacology #sflorg
https://www.sflorg.com/2026/07/bchm07062601.html

Researchers at McMaster University have identified the specific immune and metabolic pathway responsible for the muscle pain and weakness frequently caused by statin medications, offering a route to mitigate these side effects without compromising the drugs' cardiovascular benefits.
#Biochemistry #Biomedical #Immunology #Pharmacology #sflorg
https://www.sflorg.com/2026/07/bchm07062601.html

Discover Pinealon: The tripeptide research exploring genomic stability, circadian rhythm, and longevity. https://english.mathrubhumi.com/marketing-feature/pinealon-glu-asp-arg-regulatory-function-jkf1w7tl?utm_source=dlvr.it&utm_medium=mastodon #Pinealon #PeptideResearch #Biochemistry #Genomics #MolecularBiology

Congrats to five of our researchers, including Matthias Feige, Professor of Cellular #Protein #Biochemistry, who receive prestigious ERC #ProofOfConcept Grants by the European Research Council: http://go.tum.de/774526 👏

#ERCGrants

📷A. Heddergott

Congrats to five of our researchers, including Matthias Feige, Professor of Cellular #Protein #Biochemistry, who receive prestigious ERC #ProofOfConcept Grants by the European Research Council: http://go.tum.de/774526 👏

#ERCGrants

📷A. Heddergott

Bacterial membrane protein insertion is the complex biochemical process by which newly synthesized hydrophobic proteins are transported from ribosomes and correctly folded into the cell membrane.
#Biochemistry #MolecularBiology #StructuralBiology #Microbiology #sflorg
https://www.sflorg.com/2026/06/bchem06292601.html

Bacterial membrane protein insertion is the complex biochemical process by which newly synthesized hydrophobic proteins are transported from ribosomes and correctly folded into the cell membrane.
#Biochemistry #MolecularBiology #StructuralBiology #Microbiology #sflorg
https://www.sflorg.com/2026/06/bchem06292601.html

What metal is included in hemoglobin?
A. Aluminum
B. Iron
C. Cobalt
D. Gold

#metals #hemoglobin #biochemistry #survey ... Continue to: https://www.facebook.com/1130092409221646/posts/1367151652182386

Spirostomum ambiguum is a giant aquatic ciliate capable of contracting to a quarter of its body length in less than five milliseconds, moving hundreds of times faster than a human blink.
#Biophysics #Biochemistry #CellBiology #sflorg
https://www.sflorg.com/2026/06/biph06262601.html

Spirostomum ambiguum is a giant aquatic ciliate capable of contracting to a quarter of its body length in less than five milliseconds, moving hundreds of times faster than a human blink.
#Biophysics #Biochemistry #CellBiology #sflorg
https://www.sflorg.com/2026/06/biph06262601.html

A microbial "copper economy" is a mutualistic interaction in which human pathogens, specifically fungi and bacteria, coordinate the uptake and export of copper to form resilient, mixed-species biofilms.
#Microbiology #MedicalMycology #InfectiousDiseases #Biochemistry #sflorg
https://www.sflorg.com/2026/06/mcb06262601.html

A microbial "copper economy" is a mutualistic interaction in which human pathogens, specifically fungi and bacteria, coordinate the uptake and export of copper to form resilient, mixed-species biofilms.
#Microbiology #MedicalMycology #InfectiousDiseases #Biochemistry #sflorg
https://www.sflorg.com/2026/06/mcb06262601.html

Postdoctoral researcher
Memorial Sloan Kettering Cancer Center

Postdoc position at Memorial Sloan Kettering in New York to study biochemical and structural mechanisms of DNA replication.

See the full job description on jobRxiv: https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-researcher/

#biochemistry #cryoEM #DNAReplication #genomebiology #ScienceJo...
https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-researcher/?fsp_sid=13200

Postdoctoral researcher
Memorial Sloan Kettering Cancer Center

Postdoc position at Memorial Sloan Kettering in New York to study biochemical and structural mechanisms of DNA replication.

See the full job description on jobRxiv: https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-researcher/

#biochemistry #cryoEM #DNAReplication #genomebiology #ScienceJo...
https://jobrxiv.org/job/memorial-sloan-kettering-cancer-center-27778-postdoctoral-researcher/?fsp_sid=13200

Mitochondria construct their own protein-producing machinery, known as mitoribosomes, through a dynamic and modular maturation process.
#MolecularBiology #Biochemistry #CellBiology #sflorg
https://www.sflorg.com/2026/06/mbio06242602.html

Mitochondria construct their own protein-producing machinery, known as mitoribosomes, through a dynamic and modular maturation process.
#MolecularBiology #Biochemistry #CellBiology #sflorg
https://www.sflorg.com/2026/06/mbio06242602.html

A newly identified biological pathway explains how high-cholesterol diets degrade the liver's ability to clear low-density lipoprotein (LDL) cholesterol from the bloodstream, a process that can be reversed using an existing investigational drug.
#MolecularBiology #Biochemistry #Pharmacology #Cardiology #sflorg
https://www.sflorg.com/2026/06/mbio06242601.html

A newly identified biological pathway explains how high-cholesterol diets degrade the liver's ability to clear low-density lipoprotein (LDL) cholesterol from the bloodstream, a process that can be reversed using an existing investigational drug.
#MolecularBiology #Biochemistry #Pharmacology #Cardiology #sflorg
https://www.sflorg.com/2026/06/mbio06242601.html

Researchers have developed precisely modified sugar building blocks that can be automatically assembled into defined structures, creating powerful new tools to study how complex carbohydrates function in biology and disease.
#ChemicalBiology #Biochemistry #Biotechnology #MaterialsScience #sflorg
https://www.sflorg.com/2026/06/bchm06242601.html

Researchers have developed precisely modified sugar building blocks that can be automatically assembled into defined structures, creating powerful new tools to study how complex carbohydrates function in biology and disease.
#ChemicalBiology #Biochemistry #Biotechnology #MaterialsScience #sflorg
https://www.sflorg.com/2026/06/bchm06242601.html

How many essential amino acids are there?
A. 5
B. 9
C. 11
D. 20
#aminoacids #biochemistry #proteins #nutrition ... Continue to: https://www.facebook.com/1130092409221646/posts/1364542072443344

The video 🎥 of the #BeilsteinTalk “Tungsten aldehyde #oxidoreductase – a new type #hydrogenase” with Maciej Szaleniec from the Polish Academy of Sciences is NOW available 🔓 in the video portal @TIB_AVPortal of the @tibhannover:
🔗 https://av.tib.eu/media/73257

#biochemistry #biotechnology #EnzymeKinetics #EnzymeAssays #biocatalysis #enzymes #BeilsteinTalks

Researchers have developed novel, preventive therapeutics designed to intercept and destroy metastasizing cancer cells before they can form secondary tumors in the brain. This approach targets specific enzymatic mechanisms to block the neurological spread of primary lung, breast, skin, and other cancers.
#Oncology #Biochemistry #MedicinalChemistry #Pharmacology #sflorg
https://www.sflorg.com/2026/06/ongy06192601.html

Possiamo riprogrammare i batteri in modo che si nutrano di plastica, ma finora il processo era troppo lento e inefficiente o troppo veloce e poco controllabile.

Un team di scienziati guidato da Julius Fredens, Assistant Professor all'Università di Singapore, ha risolto entrambi i problemi.

https://www.asianscientist.com/2026/05/in-the-lab/plastic-eating-bacteria-just-got-a-powerful-upgrade/

#biochemistry #biology #biologia #biochimica #batteri #bacteria #plastic #plastica