#medicinalchemistry — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #medicinalchemistry, aggregated by home.social.
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⚛️ Can we design drugs that stabilize biomolecular interactions instead of blocking them?
🔗 In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0016
📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
#StructuralBiology #DrugDiscovery #ComputationalBiology #RNA #MolecularBiology #Bioinformatics #DrugDesign #SystemsBiology #MedicinalChemistry
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https://www.europesays.com/ie/394319/ Check for black particles: Children’s ibuprofen recalled | Local News #ChemicalsInMedicine #ClinicalMedicine #Drugs #Éire #Health #HealthCare #HealthCareIndustry #HealthSciences #ibuprofen #IE #Ireland #MedicalTreatments #Medication #MedicinalChemistry #medicine #PharmaceuticalSciences #Pharmacology #pharmacy #ProductsOfChemicalIndustry
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New preprint from our LED3 hub, now on ChemRxiv!
The labs of Sebastian Pomplun, Gerard van Westen and Laura Heitman at the Leiden Academic Centre for Drug Research with first author Sean M. McKenna present COMBINAUT: an automated parallel synthesis platform enabling rapid access to a 22.9M-member synthetically accessible chemical space for fast validation of virtual screening hits.
https://chemrxiv.org/doi/full/10.26434/chemrxiv.15000200/v1
#DrugDiscovery #Automation #VirtualScreening #MedicinalChemistry #HitDiscovery
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Good news! 🏆 I’ve been awarded my second consecutive research grant from Wroclaw Medical University for the project: "New heterocyclic Pt(II) derivatives in cancer therapy."
I’m using ab initio methods (DFT/MD) to model DNA intercalation and hydration, followed by synthesis of lead complexes. My goal is to develop a predictive tool to simplify drug design based on structural descriptors. 🧪💻
#MedicinalChemistry #DrugDiscovery #CompChem #ResearchGrant #Oncology
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8#drugdesign #chemistry #MedicinalChemistry #research #science
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🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
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🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
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🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
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🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
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🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
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🔁📄 'Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.' - a #DrugRepurposing Research article on #ScienceOpen:
➡️ https://www.scienceopen.com/document?vid=86a9a26d-fa33-4c20-8ef2-41c90ddc56fa
#REPO4EU #COVID19Research #Antivirals #MedicinalChemistry #SyntheticChemistry
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🔁📄 'Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.' - a #DrugRepurposing Research article on #ScienceOpen:
➡️ https://www.scienceopen.com/document?vid=86a9a26d-fa33-4c20-8ef2-41c90ddc56fa
#REPO4EU #COVID19Research #Antivirals #MedicinalChemistry #SyntheticChemistry
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🔁📄 'Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.' - a #DrugRepurposing Research article on #ScienceOpen:
➡️ https://www.scienceopen.com/document?vid=86a9a26d-fa33-4c20-8ef2-41c90ddc56fa
#REPO4EU #COVID19Research #Antivirals #MedicinalChemistry #SyntheticChemistry
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Professor Tony James is speaking at the Chemical Science Symposium which is being held on the 18th and 19th of November!
Discover his recent research on the detection of peroxynitrite in drug-induced liver injury and FRET nano probes in our themed collection, rsc.li/ChemSciSymColl25!
Read the papers for free at https://doi.org/10.1039/D5SC01433F and https://doi.org/10.1039/D3SC05010F.
Submissions are now also open for poster abstracts to be presented in London, with a closing date of the 8th September.
Interested in presenting a poster or attending the talks? Register here: https://invt.io/1lxbmhrv5io
#Chemistry #Conference #Symposium #ChemSciSymposium #Imaging #Diagnostics #MedicinalChemistry
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Passionate about #MedicinalChemistry, #Photochemistry, and #CancerResearch?
Join the Sylvestre Bonnet group at the LED3 hub of Leiden University for a #PhD in #Photoactivated #Chemotherapy!
This is your chance to contribute to the future of targeted #CancerTherapy.
Find all the details and apply here:
https://www.universiteitleiden.nl/vacatures/2025-nl/q3/15882-phd-candidate-in-photoactivated-chemotherapy#PhDposition #PhD #Vacancy #ScienceJobs #Chemistry #ChemBio #BioinorganicChemistry #DrugDiscovery #Academia #Hiring #Leiden #Netherlands
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Starting TOMORROW 📅 February 13, 2025, at 🕒 5:00 PM CET: Online #BeilsteinTalk “From drugs to #catalysts: Application of #boron #heterocycles" with Dennis G. Hall, University of Alberta.
Participation is FREE! Just register 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-application-of-boron-heterocycles/?M=y
#BoronHeterocycles #HeterocyclicChemistry #MedicinalChemistry #DrugDiscovery #BeilsteinTalks
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Coming up next week: Online #BeilsteinTalk “From drugs to #catalysts: Application of #boron #heterocycles" with Dennis G. Hall, University of Alberta.
Register for FREE! 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-application-of-boron-heterocycles/?M=y
#BoronHeterocycles #HeterocyclicChemistry #MedicinalChemistry #DrugDiscovery #BeilsteinTalks
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Save the date: 📅 Feb. 13, 2025 🕒 5–6 pm CET:
Online #BeilsteinTalk “From drugs to #catalysts: Application of #boron #heterocycles" with Dennis G. Hall, University of Alberta.Register for FREE! 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-application-of-boron-heterocycles/?M=y
#BoronHeterocycles #HeterocyclicChemistry #MedicinalChemistry #DrugDiscovery #BeilsteinTalks
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Innatura Scientific is #hiring for and a Research Intern in our Medicinal Chemistry Division! Gain hands-on experience in synthesizing novel drug candidates, collaborating with a passionate team of scientists, and contributing to life-saving therapies. Plus, high-performing interns have the chance to transition to an Industrial Ph.D. program!
#ResearchIntern #PhD #MedicinalChemistry #DrugDiscovery #PharmaCareers #ScienceJobs #Innaturascientific
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The first articles of the thematic issue “Modern #RadicalChemistry” edited by Huan-MingHuang, ShanghaiTech Uni 🇨🇳 in the 💎🔓 #BJOC are ONLINE:
➡️ https://www.beilstein-journals.org/bjoc/series/123?M=y
More to come soon!
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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The first articles of the thematic issue “Modern #RadicalChemistry” edited by Huan-MingHuang, ShanghaiTech Uni 🇨🇳 in the 💎🔓 #BJOC are ONLINE:
➡️ https://www.beilstein-journals.org/bjoc/series/123?M=y
More to come soon!
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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The first articles of the thematic issue “Modern #RadicalChemistry” edited by Huan-MingHuang, ShanghaiTech Uni 🇨🇳 in the 💎🔓 #BJOC are ONLINE:
➡️ https://www.beilstein-journals.org/bjoc/series/123?M=y
More to come soon!
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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The first articles of the thematic issue “Modern #RadicalChemistry” edited by Huan-MingHuang, ShanghaiTech Uni 🇨🇳 in the 💎🔓 #BJOC are ONLINE:
➡️ https://www.beilstein-journals.org/bjoc/series/123?M=y
More to come soon!
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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The first articles of the thematic issue “Modern #RadicalChemistry” edited by Huan-MingHuang, ShanghaiTech Uni 🇨🇳 in the 💎🔓 #BJOC are ONLINE:
➡️ https://www.beilstein-journals.org/bjoc/series/123?M=y
More to come soon!
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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How to print a LiC book:
The #autobiography of HORST KESSLER @tu_muenchen “#NMR was my Compass in Organic and Medicinal #Chemistry” will be shipped on December 16, orders will arrive in Germany and EU before Xmas. The short video shows some impressions of the production process of the printed sheets and the screen-printed hardcovers.
https://l-i-c.org/1132#organicchemistry #medicinalchemistry #spectroskopy #NMRspectroscopy
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New ChemRxiv preprint! “Pitfalls and considerations in determining the potency and mutant selectivity of covalent #EGFR inhibitors.” Collaboration between our group and AssayQuant Technologies, Inc. #MedicinalChemistry #oncology https://chemrxiv.org/engage/chemrxiv/article-details/64e50861dd1a73847f5020a1
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC
🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y
#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC
🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y
#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC
🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y
#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC
🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y
#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC
🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y
#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 #BJOC.
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 #BJOC.
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 #BJOC.
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 #BJOC.
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
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Celebrating the successful synopsis defense by graduate student Blessing Ogboo! Congratulations on all the hard work, commitment, and looking forward to seeing your thesis take shape! #ProudPI #MedicinalChemistry
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Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
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Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
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Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
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Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease
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NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#
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NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#
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NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#
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NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#
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-Time for a short #Introduction-
I am a group leader in #MedicinalChemistry at the University of Parma. My lab combines #chemical & #computational techniques to develop novel pharmacological tools to study different Chronic Diseases (#CysticFibrosis, #IBD, #Hypercholesterolemia, #Alzheimer, #Cancer) and Infective Agents (#SARSCoV2, #Enterovirus, #Flavivirus, #Monkeypox, #HIV).
We are particularly interested in the development of #MultiTarget inhibitors and open to new #collaborations in #DrugDiscovery.
#Tooting (sooner or later) about the #chemistry and #science -
It’s a Three Viva Fortnight in our team!
One down …
Viva 1: Charlie (PhD) today ✅And two to go …
Viva 2: Katie (transfer to PhD) on Thursday
Viva 3: Will (PhD) next ThursdayCongratulations to the new Dr. Charlie!
Great to see talented scientists ticking off another milestone, and a relief to see that the first project proposal I was responsible for writing didn’t end in disaster…!Thanks to the examiners for giving up their time and effort!