Live and recent posts from across the Fediverse tagged #medicinalchemistry, aggregated by home.social.
Inductive Bio launches AI tools for day-to-day medicinal chemistry
Artificial intelligence is moving into the work that can eat up a medicinal chemist’s day. The pharmaceutical…
#NewsBeep #News #Science #adme #AI #CA #Canada #infomatics #MedicinalChemistry #structure-activity
https://www.newsbeep.com/ca/922770/
Probing the many benefits of GLP-1 receptor agonists
RESEARCH HIGHLIGHT 05 October 2026 Glucagon-like peptide 1 (GLP-1) receptor agonists are approved for the treatment of type…
#NewsBeep #News #Medication #Biomedicine #Biotechnology #CA #Canada #CancerResearch #general #Health #MedicinalChemistry #MolecularMedicine #Pharmacology/Toxicology
https://www.newsbeep.com/ca/922092/
https://www.europesays.com/ie/721523/ Probing the many benefits of GLP-1 receptor agonists #Biomedicine #Biotechnology #CancerResearch #Éire #general #Health #IE #Ireland #Medication #MedicinalChemistry #MolecularMedicine #Pharmacology/Toxicology
https://www.europesays.com/uk/1238640/ Probing the many benefits of GLP-1 receptor agonists #Biomedicine #biotechnology #CancerResearch #general #Health #Medication #MedicinalChemistry #MolecularMedicine #Pharmacology/Toxicology #UK #UnitedKingdom
Student explores new treatments for depression, addiction
A pharmacist and PhD candidate in medicinal chemistry at the University of Toledo, United States, Trust Nwaka, is…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Mentalhealth #addiction #Afro-depression #AmericanChemicalSociety #Health #MedicinalChemistry #MentalHealth #Neuropsychiatricconditions #psychedelicdrugs #TrustNwaka #UniversityofToledo
https://www.newsbeep.com/us/869447/
Student explores new treatments for depression, addiction
A pharmacist and PhD candidate in medicinal chemistry at the University of Toledo, United States, Trust Nwaka, is…
#NewsBeep #News #Mentalhealth #Addiction #Afro-depression #AmericanChemicalSociety #Health #MedicinalChemistry #MentalHealth #Neuropsychiatricconditions #psychedelicdrugs #TrustNwaka #UK #UnitedKingdom #UniversityofToledo
https://www.newsbeep.com/uk/790718/
https://www.europesays.com/uk/1234213/ Student explores new treatments for depression, addiction #addiction #AfroDepression #AmericanChemicalSociety #Health #MedicinalChemistry #MentalHealth #NeuropsychiatricConditions #PsychedelicDrugs #TrustNwaka #UK #UnitedKingdom #UniversityOfToledo
https://www.europesays.com/ie/718081/ Student explores new treatments for depression, addiction #Addiction #AfroDepression #AmericanChemicalSociety #Éire #Health #IE #Ireland #MedicinalChemistry #MentalHealth #MentalHealth #NeuropsychiatricConditions #PsychedelicDrugs #TrustNwaka #UniversityOfToledo
https://www.europesays.com/ie/714139/ UPDATE: FDA expands recall of blood pressure medication to include 13K+ bottles | Local News #antihypertensive #BloodPressure #ChemicalsInMedicine #chlortalidone #ClinicalMedicine #Drug #DrugBrandNames #Drugs #Éire #FoodAndDrugAdministration #Health #HealthCare #HealthCareBrands #HealthCareIndustry #IE #Ireland #MedicalTreatments #Medication #MedicinalChemistry #medicine #PharmaceuticalSciences #Pharmacology #pharmacy #Tablet(pharmacy)
DATE: September 25, 2026 at 10:00AM
SOURCE: PSYPOST.ORG
** Research quality varies widely from fantastic to small exploratory studies. Please check research methods when conclusions are very important to you. **
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TITLE: Scientists strip down the LSD molecule to find the exact parts that trigger hallucinations
A recent study has successfully stripped down the complex chemical structure of LSD to pinpoint exactly which parts of the molecule cause hallucinations and which parts might be harnessed for therapy. By testing these simplified molecules, scientists identified a specific structural combination that produces antipsychotic effects in mice without triggering a hallucinogenic trip. The research was published in PNAS.
Lysergic acid diethylamide, commonly known as LSD, is a powerful psychedelic drug that alters perception, mood, and cognitive processes. It exerts its effects primarily by interacting with specific proteins on the surface of brain cells called serotonin receptors. One of these, the serotonin 5-HT2A receptor, is widely recognized as the main trigger for hallucinogenic experiences. It is also responsible for promoting neuroplasticity, which is the brain’s ability to grow and rewire itself.
Classic psychedelics tend to activate a broad array of targets in the brain and body. This wide-ranging activity was detailed in a study covered by PsyPost in 2025, which demonstrated that these compounds engage many different signaling pathways. Activating some of these pathways can lead to unwanted physical side effects. For instance, a 2011 review noted that when drugs stimulate a receptor known as 5-HT2B, it can lead to a dangerous thickening of the heart valves.
To develop safe psychiatric treatments from psychedelics, scientists aim to modify these molecules so they no longer activate the 5-HT2B receptor or cause hallucinations. To measure hallucinogenic potential in the lab, researchers observe mouse behavior. Specifically, a 2020 study demonstrated that the intensity of a rapid side-to-side head movement in mice, known as a head-twitch response, closely matches the potency of hallucinogenic effects in humans.
LSD has a highly complex, four-ring chemical skeleton known as an ergoline core. Because of this complexity, modifying its structure to isolate its therapeutic benefits has been historically challenging. A research team that included lead author Andrian G. Basargin and senior author David E. Olson sought to systematically deconstruct LSD.
“The synthesis of ergolines like LSD is quite challenging,” Olson, director of the Institute for Psychedelics and Neurotherapeutics at the University of California, Davis, told PsyPost. “By creating simpler analogues, we were able to determine which structural features of LSD were responsible for which pharmacological properties.”
By removing different rings from LSD’s four-ring core, the researchers aimed to identify the absolute minimum structural requirements needed to trigger hallucinogenic effects, and to discover simpler, safer variations of the molecule that might treat mental health conditions. “This information is critical for medicinal chemists to develop optimized medicines,” added Olson, a professor of chemistry and biochemistry who leads the Olson Lab.
The researchers used a process called function-oriented synthesis to create nine simplified versions of LSD. These new compounds were stripped down to possess only three, two, or one of the original four chemical rings found in LSD. To evaluate how these structural changes altered the drugs’ effects, the team first tested the compounds on lab-grown cells engineered to express different human serotonin receptors. They measured how tightly each compound bound to the receptors and how strongly it activated them.
Next, they tested the compounds in mice. They administered varying doses of each compound to groups of three to four female mice and used an automated magnetic system to track their head-twitch responses. In separate tests, they also placed the mice in an open-field arena and administered a dose of amphetamine, a stimulant that increases dopamine release and causes hyperactivity, to see if the new compounds could calm the animals.
The team found that the complete four-ring structure of LSD is necessary for the drug to maximally activate the 5-HT2A receptor. Every simplified molecule they tested had a weaker ability to bind to and activate this receptor compared to the original LSD molecule. By stripping the molecule down, the scientists pinpointed the exact structural components responsible for a psychedelic trip. They found that a two-ring combination corresponding to the “A” and “D” rings of the original LSD molecule was the bare minimum required to induce the characteristic head-twitch response in mice.
“If you delete certain structural elements of LSD, you can still produce psychedelic effects,” Olson explained. “This is analogous to determining that you can remove the roof of a car, windshield, doors, etc. and it can still drive.”
Removing a specific part of the molecule called the “D” ring resulted in a three-ring compound named UCD0094. This modified version showed a drastically reduced ability to activate both the hallucinogenic 5-HT2A receptor and the heart-risk 5-HT2B receptor. However, it maintained a strong ability to activate the 5-HT2C receptor, a target that is associated with antipsychotic and anti-addictive properties. The authors suggest UCD0094 could be a strong candidate for developing drugs that promote brain plasticity without causing hallucinations.
An even simpler, two-ring compound called UCD0076 demonstrated unique promise. UCD0076 showed almost no ability to activate the hallucinogenic 5-HT2A receptor, but it strongly activated the 5-HT2C receptor. When tested in mice, UCD0076 did not induce head twitches. Instead, it behaved like an antipsychotic medication. At high doses of 31 milligrams per kilogram, pretreating the mice with UCD0076 prevented them from having head twitches when they were subsequently given a known hallucinogen.
In the open-field tests, UCD0076 successfully reduced amphetamine-induced hyperactivity in a dose-dependent manner. The findings indicate that by selectively targeting the 5-HT2C receptor, this simplified molecule can suppress behaviors linked to psychosis. These findings align with research covered by PsyPost in 2025, which found that slightly modifying LSD’s structure can eliminate its hallucinogenic effects while producing a therapeutic, antipsychotic-like compound capable of healing damaged brain circuits.
However, not all of the new molecules behaved in live animals exactly as they did in isolated cells. For instance, a synthesized compound named UCD0179 appeared to be a potent activator of the 5-HT2A receptor in cell cultures, but it failed to trigger head twitches in mice.
“We were surprised that UCD0179 did not produce hallucinogenic effects in vivo given its in vitro profile,” Olson said. “This really speaks to the importance of a drug reaching its target in sufficiently high concentrations.”
As with all research, there are a few things to keep in mind regarding this study. First, the majority of the new compounds were tested as racemic mixtures, meaning they contained a blend of two mirror-image versions of the molecule. Because receptors in the brain often respond differently to exact structural shapes, testing isolated, pure versions of these molecules might yield slightly different results regarding their potency.
Additionally, the head-twitch response is a reliable indicator of hallucinogenic effects in rodents, but mice are not humans. It is always possible that a compound might affect human perception in ways that animal behavior cannot fully capture. The researchers also noted that LSD interacts with a wide variety of other targets, including dopamine and adrenergic receptors. Future studies will need to explore how these newly synthesized molecules interact with this broader array of brain targets to fully understand their safety and potential side effects.
“Our long-term goals are to use this information to develop better medicines for treating neuropsychiatric and neurodegenerative conditions,” Olson concluded.
The study, “Deconstruction of lysergic acid diethylamide,” was authored by Andrian G. Basargin, Andras Domokos, Joseph J. Hennessey, Isak K. Aarrestad, Rohini Sambyal, Yara A. Khatib, Johanna Krüger, Lee E. Dunlap, Samuel J. Carter, Isabella A. Rebek, John L. McKee, Serena S. Schalk, Min Liu, James C. Fettinger, Monica A. Gonzalez, Abhay Potluri, Dean J. Tantillo, Oliver Fiehn, John D. McCorvy, and David E. Olson.
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Private, vetted email list for mental health professionals: https://www.clinicians-exchange.org
Unofficial Psychology Today Xitter to toot feed at Psych Today Unofficial Bot @PTUnofficialBot
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#psychology #counseling #socialwork #psychotherapy @psychotherapist @psychotherapists @psychology @socialpsych @socialwork @psychiatry #mentalhealth #psychiatry #healthcare #depression #psychotherapist #LSDDeconstruction #PsychedelicsResearch #5HT2A #5HT2C #AntipsychoticPotential #HeadTwitchResponse #SerotoninReceptors #MedicinalChemistry #OpenFieldTest #Neuropsychiatry
https://www.europesays.com/ch/134007/ American Chemical Society honors Novartis researchers #BCRABL1 #BiomedicalResearch #cancer #Chemistry #ChronicMyeloidLeukemia #CML #DrugDesign #DrugDiscovery #MedicinalChemistry #Novartis #Oncology #R&D #research #ResearchAndDevelopment #Science
Computational Biologist - Fully Remote
micro1
Computational Biologists (MSc or PhD) needed for fully remote contract work (up to $120/hour!). Ideally looking for experience in medicinal chemistry
See the full job description on jobRxiv: https://jobrxiv.org/job/micro1-27778-computational-biologist-fully-remote/
#bioinformatics #cheminformatics #computationalbiology #drugdiscovery #medicinalchemistry #S...
https://jobrxiv.org/job/micro1-27778-computational-biologist-fully-remote/?fsp_sid=15130
Scientist Says Human DNA Contains Clues of an Intelligent Creator
His credentials are solid. He holds a PhD in organic medicinal chemistry, is based in New Zealand, and…
#NewsBeep #News #Headlines #Functionalproteins #GeraldJoyce #MedicinalChemistry #NewZealand #SalkInstitute #virtuallyimpossible #Wedgwood #World
https://www.newsbeep.com/724082/
A novel halogen-guided “cut-to-fuse” strategy enables the mild, transition-metal-free transformation of accessible hydroxycoumarins into valuable coumaranone scaffolds via carbonyl deletion.
#SyntheticOrganicChemistry #MedicinalChemistry #PharmaceuticalSciences #sflorg
https://www.sflorg.com/2026/08/chm08272601.html
Computational Biologist - Fully Remote
micro1
Computational Biologists (MSc or PhD) needed for fully remote contract work (up to $120/hour!). Ideally looking for experience in medicinal chemistry
See the full job description on jobRxiv: https://jobrxiv.org/job/micro1-27778-computational-biologist-fully-remote/
#bioinformatics #cheminformatics #computationalbiology #drugdiscovery #medicinalchemistry #S...
https://jobrxiv.org/job/micro1-27778-computational-biologist-fully-remote/?fsp_sid=14384
https://www.europesays.com/ie/633743/ Researchers find unexpected protein regulator of leukemia drug sensitivity #cancer #Catalyst #Cell #Drugs #Éire #Enzyme #Health #IE #Ireland #Leukemia #MedicinalChemistry #medicine #Metabolism #Protein #Research #Technology
Bioinformatics Scientist - Fully Remote
micro1
Bioinformatics scientists (MSc or PhD) needed for fully remote contract work (up to $120/hour!). Ideally looking for experience in medicinal chemistry
See the full job description on jobRxiv: https://jobrxiv.org/job/micro1-27778-bioinformatics-scientist/
#bioinformatics #computationalbiology #drugdesign #medicinalchemistry #structureactivityrelationships #ScienceJobs...
https://jobrxiv.org/job/micro1-27778-bioinformatics-scientist/?fsp_sid=14248
https://www.europesays.com/ie/623560/ Study identifies a novel direct drug target for head and neck squamous cell carcinoma #Bone #Brain #cancer #carcinoma #Cell #chemotherapy #Cisplatin #DrugDiscovery #Éire #Gene #Genetic #HeadAndNeckCancer #Health #IE #Ireland #Liver #MedicinalChemistry #medicine #Metastasis #Molecule #Neck #pH #pharmacy #Prostate #ProstateCancer #Protein #Research #SquamousCellCarcinoma #StemCells #Therapeutics #therapy #Tumor
🎉 We're excited to share that our latest paper, “Syn–Anti Conformational Equilibrium of Indomethacin: A Combined NOESY and Quantum Chemical Study,” has been published in Pharmaceutical Research.
This work was carried out as part of Alexey Kovalev’s PhD research in collaboration with our colleagues Prof. Savaş Kaya (Sivas Cumhuriyet University, Türkiye) and Dr. Yoshio Barrera (UNAM, Mexico).
🔗 https://doi.org/10.1007/s11095-026-04162-9
#PharmaceuticalResearch #MedicinalChemistry #NMR #QuantumChemistry
💬 Behind the Science Interview with Aniello Palma (University College Dublin, Ireland)
Discover the story behind the first cyclo-polyproline macrocycle capable of induced-fit host–guest recognition
https://doi.org/10.1002/chemv.202600034
#Chemistry #ChemistryViews #SupramolecularChemistry #Peptides #Macrocycles #HostGuestChemistry #MolecularDesign #DrugDelivery #MedicinalChemistry #ScienceCommunication #ResearchHighlights
Researchers have developed novel, preventive therapeutics designed to intercept and destroy metastasizing cancer cells before they can form secondary tumors in the brain. This approach targets specific enzymatic mechanisms to block the neurological spread of primary lung, breast, skin, and other cancers.
#Oncology #Biochemistry #MedicinalChemistry #Pharmacology #sflorg
https://www.sflorg.com/2026/06/ongy06192601.html
https://www.europesays.com/dk/103961/ ‘Cheaper’ Wegovy pill set for approval | Lifestyle #ChemicalsInMedicine #ClinicalMedicine #CombinedOralContraceptivePill #drugs #Glp1ReceptorAgonist #Health #HealthCare #HealthCareIndustry #HumanBodyWeight #MedicalSpecialties #MedicalTreatments #MedicinalChemistry #medicine #NovoNordisk #Nutrition #PharmaceuticalSciences #pharmacology #pharmacy #semaglutide #WeightLoss
https://www.europesays.com/dk/103771/ ‘Cheaper’ Wegovy pill set for approval | Nation #ChemicalsInMedicine #ClinicalMedicine #CombinedOralContraceptivePill #drugs #Glp1ReceptorAgonist #Health #HealthCare #HealthCareIndustry #HumanBodyWeight #MedicalSpecialties #MedicalTreatments #MedicinalChemistry #medicine #NovoNordisk #Nutrition #PharmaceuticalSciences #pharmacology #pharmacy #semaglutide #WeightLoss
https://www.europesays.com/uk/1003370/ Towards mRNA therapeutics 2.0 | Nature Reviews Drug Discovery #Biomedicine #biotechnology #CancerResearch #general #MedicinalChemistry #MolecularEngineering #MolecularMedicine #NucleicAcidTherapeutics #Pharmacology/Toxicology #Science #UK #UnitedKingdom
TriPcides are a newly developed class of synthetic compounds designed to eliminate harmful bacteria and neutralize their ability to cause infections, specifically targeting antibiotic-resistant strains.
#Microbiology #MedicinalChemistry #Pharmacology #InfectiousDiseases #sflorg
https://www.sflorg.com/2026/05/mcb05192601.html
https://www.europesays.com/2964801/ MAMMAL – Molecular Aligned Multi-Modal Architecture and Language for biomedical discovery #AI #ArtificialIntelligence #Biomedicine #ComputationalBiologyAndBioinformatics #DrugDiscovery #general #MedicinalChemistry #PharmaceuticalSciences/Technology
https://www.europesays.com/ie/439982/ Anxiety drug Xanax under nationwide recall, FDA says | Local News #alprazolam #ChemicalsInMedicine #ClinicalMedicine #DrugBrandNames #Drugs #Éire #Health #HealthCare #HealthSciences #IE #Ireland #MedicalSpecialties #MedicalTreatments #MedicinalChemistry #medicine #MentalHealth #MentalHealth #PharmaceuticalSciences #Pharmacology #pharmacy #ProductsOfChemicalIndustry #Tablet(pharmacy)
⚛️ Can we design drugs that stabilize biomolecular interactions instead of blocking them?
🔗 In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0016
📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj
#StructuralBiology #DrugDiscovery #ComputationalBiology #RNA #MolecularBiology #Bioinformatics #DrugDesign #SystemsBiology #MedicinalChemistry
https://www.europesays.com/ie/394319/ Check for black particles: Children’s ibuprofen recalled | Local News #ChemicalsInMedicine #ClinicalMedicine #Drugs #Éire #Health #HealthCare #HealthCareIndustry #HealthSciences #ibuprofen #IE #Ireland #MedicalTreatments #Medication #MedicinalChemistry #medicine #PharmaceuticalSciences #Pharmacology #pharmacy #ProductsOfChemicalIndustry
https://www.europesays.com/ch/31361/ Hunting for biopharma’s innovation sweet spot #Biomedicine #biotechnology #CancerResearch #General #MedicinalChemistry #MolecularMedicine #Pharmacology/Toxicology #Roche
https://www.europesays.com/ch/28210/ Biopharma dealmaking in 2025 #Biomedicine #biotechnology #CancerResearch #General #MedicinalChemistry #MolecularMedicine #Pharmacology/Toxicology #Roche
New preprint from our LED3 hub, now on ChemRxiv!
The labs of Sebastian Pomplun, Gerard van Westen and Laura Heitman at the Leiden Academic Centre for Drug Research with first author Sean M. McKenna present COMBINAUT: an automated parallel synthesis platform enabling rapid access to a 22.9M-member synthetically accessible chemical space for fast validation of virtual screening hits.
https://chemrxiv.org/doi/full/10.26434/chemrxiv.15000200/v1
#DrugDiscovery #Automation #VirtualScreening #MedicinalChemistry #HitDiscovery
Researchers at Ural Federal University (UrFU) have synthesized a new family of chemical compounds that selectively target and suppress the growth of specific #tumor cells by halting their division rather than immediately destroying them.
#Pharmaceutical #Oncology #MedicinalChemistry #Pharmacology #sflorg
https://www.sflorg.com/2026/02/pham02042601.html
Good news! 🏆 I’ve been awarded my second consecutive research grant from Wroclaw Medical University for the project: "New heterocyclic Pt(II) derivatives in cancer therapy."
I’m using ab initio methods (DFT/MD) to model DNA intercalation and hydration, followed by synthesis of lead complexes. My goal is to develop a predictive tool to simplify drug design based on structural descriptors. 🧪💻
#MedicinalChemistry #DrugDiscovery #CompChem #ResearchGrant #Oncology
PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8
#drugdesign #chemistry #MedicinalChemistry #research #science
🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.
🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling
#ActaMateriaMedica: 'Biologically active guanidine alkaloids' - an article on #ScienceOpen 🔓📄🔗 https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0088
#GuanidineAlkaloids #NaturalProducts #DrugDiscovery #MarineNaturalProducts #MedicinalChemistry
🔁📄 'Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.' - a #DrugRepurposing Research article on #ScienceOpen:
➡️ https://www.scienceopen.com/document?vid=86a9a26d-fa33-4c20-8ef2-41c90ddc56fa
#REPO4EU #COVID19Research #Antivirals #MedicinalChemistry #SyntheticChemistry
Professor Tony James is speaking at the Chemical Science Symposium which is being held on the 18th and 19th of November!
Discover his recent research on the detection of peroxynitrite in drug-induced liver injury and FRET nano probes in our themed collection, rsc.li/ChemSciSymColl25!
Read the papers for free at https://doi.org/10.1039/D5SC01433F and https://doi.org/10.1039/D3SC05010F.
Submissions are now also open for poster abstracts to be presented in London, with a closing date of the 8th September.
Interested in presenting a poster or attending the talks? Register here: https://invt.io/1lxbmhrv5io
#Chemistry #Conference #Symposium #ChemSciSymposium #Imaging #Diagnostics #MedicinalChemistry
Passionate about #MedicinalChemistry, #Photochemistry, and #CancerResearch?
Join the Sylvestre Bonnet group at the LED3 hub of Leiden University for a #PhD in #Photoactivated #Chemotherapy!
This is your chance to contribute to the future of targeted #CancerTherapy.
Find all the details and apply here:
https://www.universiteitleiden.nl/vacatures/2025-nl/q3/15882-phd-candidate-in-photoactivated-chemotherapy
#PhDposition #PhD #Vacancy #ScienceJobs #Chemistry #ChemBio #BioinorganicChemistry #DrugDiscovery #Academia #Hiring #Leiden #Netherlands
Classification of sulfonamides
The classification of sulfa drugs takes into account their period of action in the body (short-acting, long-acting, ultra-long-acting).
#Sulfonamides #sulfonamidespharmacology #medicinalchemistry #pharmacology
Starting TOMORROW 📅 February 13, 2025, at 🕒 5:00 PM CET: Online #BeilsteinTalk “From drugs to #catalysts: Application of #boron #heterocycles" with Dennis G. Hall, University of Alberta.
Participation is FREE! Just register 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-application-of-boron-heterocycles/?M=y
#BoronHeterocycles #HeterocyclicChemistry #MedicinalChemistry #DrugDiscovery #BeilsteinTalks
Coming up next week: Online #BeilsteinTalk “From drugs to #catalysts: Application of #boron #heterocycles" with Dennis G. Hall, University of Alberta.
Register for FREE! 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-application-of-boron-heterocycles/?M=y
#BoronHeterocycles #HeterocyclicChemistry #MedicinalChemistry #DrugDiscovery #BeilsteinTalks
Save the date: 📅 Feb. 13, 2025 🕒 5–6 pm CET:
Online #BeilsteinTalk “From drugs to #catalysts: Application of #boron #heterocycles" with Dennis G. Hall, University of Alberta.
Register for FREE! 🔗 https://www.beilstein-institut.de/en/talks/organic-chemistry-application-of-boron-heterocycles/?M=y
#BoronHeterocycles #HeterocyclicChemistry #MedicinalChemistry #DrugDiscovery #BeilsteinTalks
Unlock the Hidden Challenge in Drug Design: Conformational Strain
This critical factor affects efficacy, stability, and timelines. I’ve broken it down step-by-step in a carousel.
👉 View it here: https://buff.ly/4a2FJT2
📢 Our Transfer Group Anti-infectives team found that modifying the C-6 position of BTZ compounds, active against #tuberculosis, reduces the production of unfavorable metabolites.
🦠🔬 Read more in #CommunChem: https://www.nature.com/articles/s42004-024-01235-x#citeas
#TB #DrugDiscovery #ChemInformatics #MedicinalChemistry
@unijena @bmbf_bund @tmwwdg
Remdesivir, a successful #antiviral for #COVID19 inspired a new nucleoside analogue with a CN group at the 4' position, exhibiting broad-spectrum activity against RSV, pneumo- and picornaviruses. This analogue demonstrates promising cellular uptake, triphosphate formation, and efficacy in respiratory tissues, with a possibility of an inhaled treatment. Published by #Gilead #Science in #biorxiv
#chemistry #drug #MedicinalChemistry
https://www.biorxiv.org/content/10.1101/2024.04.17.589937v1.full
Structural Modifications Enhance Antibacterial Potency of Bacitracin
The team of N. Martin from Leiden University optimized the antibiotic bacitracin, leading to a 256-fold increase in activity and also showed activity against vancomycin-resistant strains.
The team made the compound's non-polar side chains more lipophilic, enhancing bacterial membrane anchoring and hydrophobic interactions.
#MedicinalChemistry #Chemistry #Science #Research
Read more in #PNAS: https://www.pnas.org/doi/10.1073/pnas.2315310121
The first articles of the thematic issue “Modern #RadicalChemistry” edited by Huan-MingHuang, ShanghaiTech Uni 🇨🇳 in the 💎🔓 #BJOC are ONLINE:
➡️ https://www.beilstein-journals.org/bjoc/series/123?M=y
More to come soon!
#electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
You are cordially invited to submit your latest research to the thematic issue “Modern #RadicalChemistry” edited by Huan-Ming Huang from ShanghaiTech University 🇨🇳 in the 💎🔓 Beilstein Journal of Organic Chemistry. #BJOC
🔗 https://www.beilstein-journals.org/bjoc/series/123/?M=y
#Electrosynthesis #PhotoredoxChemistry #MedicinalChemistry #MaterialScience
‘Almost magical’: chemists can now move single atoms in and out of a molecule’s core
https://www.nature.com/articles/d41586-023-01735-1
#SkeletalEditing #Chemistry #MedicinalChemistry #ChemToots #ChemiVerse
Postdoctoral Fellow - Ferguson Lab - Medicinal Chemistry, Chemical Biology @FleurMFerguson
The Ferguson Lab at UCSD is hiring a #MedicinalChemistry #postdoc to work on #TPD #TargetedProteinDegradation in #NeurodegenerativeDisease