#neuroblastoma — Public Fediverse posts

https://www.europesays.com/ie/445690/ Scientists disrupt key cancer proteins to target neuroblastoma #cancer #children #Éire #IE #Ireland #Molecule #Neuroblastoma #Protein #Research #Science #StructuralBiology

Discovery Overturns Longstanding Biology of Human Development

Summary: Scientists have long believed that embryonic cells “decide” what to become only after migrating to their final…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #embryonicdevelopment #neuralcrestcells #neuraltube #Neuroblastoma #Neuroscience #peripheralnervoussystem #SensoryGanglia #UniversityofUtah
https://www.newsbeep.com/us/586016/

Discovery Overturns Longstanding Biology of Human Development

Summary: Scientists have long believed that embryonic cells “decide” what to become only after migrating to their final…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #embryonicdevelopment #neuralcrestcells #neuraltube #Neuroblastoma #Neuroscience #peripheralnervoussystem #SensoryGanglia #UniversityofUtah
https://www.newsbeep.com/us/586016/

https://www.europesays.com/ie/424450/ Blocking nitric oxide suppresses tumor growth in aggressive pediatric neuroblastoma #Apoptosis #blood #BloodVessels #Brain #cancer #Cell #DNA #Éire #Enzyme #Genetic #Genomic #Glioblastoma #Health #IE #Ireland #medicine #Neuroblastoma #Neurons #Neuroscience #NitricOxide #Phosphorylation #Protein #Research #siRNA #Stress #Tumor #website #Xenograft

https://www.europesays.com/es/395695/ Dinutuximab beta potencia la quimioterapia y mejora la respuesta en neuroblastoma #agresivo #beacon #beta #cáncer #combinación #demuestra #dinutuximab #Ensayo #ES #España #este #estrategia #frente #Health #incrementa #inmunoterapia #Internacional #libre #mejora #neuroblastoma #pediátrico #perfila #potencia #progresión #prolonga #prometedora #quimioterapia #reducción #respuesta #Salud #Spain #supervivencia #tumoral

Using machine learning and a large volume of data on #genes and existing drugs, researchers at Lund University in Sweden have identified a combination of #statins and #phenothiazines that is particularly promising in the treatment of the aggressive form of #neuroblastoma
#MolecularScience #Oncology #MachineLearning #sflorg
https://www.sflorg.com/2025/12/ms12292501.html

Circle Pharma's CID-078 shows potent preclinical anti-tumor activity in neuroblastoma, a tough pediatric cancer. This first-in-class oral macrocycle inhibitor targets cell cycle dysregulation. Exciting progress for hard-to-treat targets.
#Neuroblastoma #PediatricCancer #Biotech

"By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"

https://link.springer.com/article/10.1007/s11684-024-1081-7

Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.

#scRNAseq #tumour #Neuroblastoma #pseudotime

While looking for #GeneExpression in tissues, specifically for #pediatric samples, I came across the #developmental #GTEx page, "a new effort to study development-specific genetic effects on gene expression from donors at each of 4 developmental windows".

https://gtexportal.org/home/aboutdGTEx

Exciting and important: for example the first age group, i.e. 0-2 years, in which our #Neuroblastoma patients often are, is mostly hard to compare to adult references and healthy controls.

#OpenScience

MYCN drives #neuroblastoma by activating ribo biogenesis & protein synth genes, but repressing neuronal differentiation genes. @theNCI study shows that #MYCN cooperates with the HMT G9a & WDR5 adaptor to orchestrate global gene transcription #PLOSBiology https://plos.io/4amRZ03

"Using two separate disease models previously known to be responsive to HDAC inhibitors, we evaluated the physiological effects of volatile exposure. Diacetyl exposure halted proliferation of a #neuroblastoma cell line in culture. Exposure to #diacetyl vapors slowed progression of neurodegeneration in a #Drosophila model for Huntington’s disease. These changes strongly suggest that certain volatiles in the surroundings can have profound effects on #histone acetylation"

https://elifesciences.org/articles/86823

Yesterday, me and my colleague took the #NightTrain to #Vienna, to join the #SIOPEN #translational research meeting.

Little under 10 hours from Utrecht.

I had to present our latest work on
#neuroblastoma. Beers to celebrate this event. 🍻

#train #NightJet
#PedriaticCancer
#NoFlying

Yesterday, me and my colleague took the #NightTrain to #Vienna, to join the #SIOPEN #translational research meeting.

Little under 10 hours from Utrecht.

I had to present our latest work on
#neuroblastoma. Beers to celebrate this event. 🍻

#train #NightJet
#PedriaticCancer
#NoFlying

Yesterday, me and my colleague took the #NightTrain to #Vienna, to join the #SIOPEN #translational research meeting.

Little under 10 hours from Utrecht.

I had to present our latest work on
#neuroblastoma. Beers to celebrate this event. 🍻

#train #NightJet
#PedriaticCancer
#NoFlying

Yesterday, me and my colleague took the #NightTrain to #Vienna, to join the #SIOPEN #translational research meeting.

Little under 10 hours from Utrecht.

I had to present our latest work on
#neuroblastoma. Beers to celebrate this event. 🍻

#train #NightJet
#PedriaticCancer
#NoFlying

Yesterday, me and my colleague took the #NightTrain to #Vienna, to join the #SIOPEN #translational research meeting.

Little under 10 hours from Utrecht.

I had to present our latest work on
#neuroblastoma. Beers to celebrate this event. 🍻

#train #NightJet
#PedriaticCancer
#NoFlying

Important work, the #ITCC #SIOPEN #BEACON #neuroblastoma #trial

https://ascopubs.org/doi/10.1200/JCO.23.00458

In this trial Moreno et al. assessed possible added effects of #antiangiogenic agent #bevacizumab to #temozolomide treatment plus or minus #irinotecan or #topotecan for children with relapsed and refractory neuroblastoma.

Perhaps some early effects, but after 5-6 years rather depressing survival graphs, if I'm very honest.

#CancerResearch

"Integrative analysis of #neuroblastoma by single-cell RNA sequencing identifies the #NECTIN2-#TIGIT axis as a target for #immunotherapy"
https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00436-1

Great new work from Judith Wienke et al. from the Molenaar lab in the #PrincessMaximaCenter in #Utrecht.

Great to see this out after seeing it in our group meetings several times. In vivo results sometimes are impressive, but very much in a subgroup it seems. Intriguiging, and curious what underlies this.

#scRNAseq #CancerResearch

@kestral

Lay person here - you may want to inquire whether immunotherapy is a possible treatment option for neuroblastoma, and if so, whether there any immunotherapy trials that can be considered for enrolment.

@CassandraZeroCovid @artisanrox

#cancer #neuroblastoma #immunotherapy

Neuroblastoma is a #cancer in children that is sometimes benign, but can also be very aggressive. Researchers from #CharitéBerlin & @MDC_Berlin now show: Specific patterns of DNA alterations in #neuroblastoma cells reflect the different aggressiveness of this pediatric #tumor. The results could provide a starting point for a more targeted approach to treatment.
👉 https://www.charite.de/en/research/paper_spotlight/2023/new_findings_on_the_biological_processes_behind_neuroblastoma_risk_differences/

#Medicine #Research #CharitéPaper #CharitéOncology #ScienceMastodon #MedMastodon

Neuroblastoma is a #cancer in children that is sometimes benign, but can also be very aggressive. Researchers from #CharitéBerlin & @MDC_Berlin now show: Specific patterns of DNA alterations in #neuroblastoma cells reflect the different aggressiveness of this pediatric #tumor. The results could provide a starting point for a more targeted approach to treatment.
👉 https://www.charite.de/en/research/paper_spotlight/2023/new_findings_on_the_biological_processes_behind_neuroblastoma_risk_differences/

#Medicine #Research #CharitéPaper #CharitéOncology #ScienceMastodon #MedMastodon

Come and work with us - job opening at the Molenaar research group in the Princess Máxima Center for pediatric oncology, looking for a #bioinformatician / #DataScientist.

Together with my colleagues and me you will research #neuroblastoma, with a focus on #tumour #microenvironment and the #immune compartment using a range of #sequencing data and other high-throughput data.

#CancerResearch #scRNAseq
#FediJobs #JobOffer

For further information, see the vacancy below:
https://werkenbijprinsesmaximacentrum.nl/en/vacancy/bioinformatics-research-scientist/

#Postdoctoral position offered by the #KidsCaN group of Céline Delloye-Bourgeois, titled "Exploring the spatio-temporal dynamics of #Neuroblastoma phenotypes
during #metastasis to the bone marrow"
#JobOpening (pdf): https://www.crcl.fr/app/uploads/2023/07/KidsCaN_postdoc_Modymime.pdf
Group website: https://www.crcl.fr/en/tumor-escape-resistance-immunity-department/kidscan-cancer-neuroscience-and-metastasis-in-pediatric-malignancies/

Me and the groups I'm in have an ongoing collaboration with this group in #Lyon, France. Great people to work with, excellent data analyses, #DevelopmentalBiology

#CellularBiology #scRNAseq #cancer #FediJobs #JobOffer

"NB cells signal to the BM microenvironment, rewiring via macrophage migration inhibitory factor and #midkine signaling specifically #monocytes ..."

#Neuroblastoma paper by Fetahu et al., the latest publication from the Taschner-Mandl lab in Vienna.

Going through this right now - very alike our own work - and talking to a few team members on Wednesday while they visit our center.

#macrophages #scATACseq #scRNAseq #OpenAccess #cancer #immunology

Data available on EGA, behind a DAC.

A new piece of the puzzle on how #neuroblastoma – a #cancer affecting children – develops: A #CharitéBerlin study shows that the #tumor forms RNA rings that contribute to the growth of cancer cells. In the future, RNA therapeutics could target these rings.

👉 https://www.charite.de/en/research/engl_neues_aus_der_forschung/2023/new_findings_on_the_role_of_rna_rings_in_neuroblastoma/

#Medicine #ScienceMastodon #Science #RNA #CharitéPaper #CharitéOncology

A new piece of the puzzle on how #neuroblastoma – a #cancer affecting children – develops: A #CharitéBerlin study shows that the #tumor forms RNA rings that contribute to the growth of cancer cells. In the future, RNA therapeutics could target these rings.

👉 https://www.charite.de/en/research/engl_neues_aus_der_forschung/2023/new_findings_on_the_role_of_rna_rings_in_neuroblastoma/

#Medicine #ScienceMastodon #Science #RNA #CharitéPaper #CharitéOncology

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".

An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.

https://www.nature.com/articles/s43018-022-00405-x

Sadly, not open access.

Yesterday, in the afternoon plenty of #scRNAseq work, a.o. Céline Delloye-Bourgeois showing her group's latest work on #neuroblastoma development and #metastatic progression. Including some of our own scRNA-seq data. Very cool.

Furthermore, more #SingleCell, also spatial, sequencing on #tumour heterogeneity and early stages. And work on cells that persist during/after #therapy, dubbed persister cells.

#anr2023

Further presentations on #MYCN binding not just DNA but also RNA, #MKK7 mutations in high risk #neuroblastoma, #BARD1 mutations,
DNA damage repair deficiency incl. enhanced #metastasis.

Plus 1 minute pitches for posters, including a #poem. 👌

#anr2023

The Advances Neuroblastoma Research meeting #anr2023 has kicked off, Lisa Werr showing the role of #telomerase / #TERT in #neuroblastoma in mice and humans in the first talk.

The Advances Neuroblastoma Research meeting #anr2023 has kicked off, Lisa Werr showing the role of #telomerase / #TERT in #neuroblastoma in mice and humans in the first talk.

The Advances Neuroblastoma Research meeting #anr2023 has kicked off, Lisa Werr showing the role of #telomerase / #TERT in #neuroblastoma in mice and humans in the first talk.

The Advances Neuroblastoma Research meeting #anr2023 has kicked off, Lisa Werr showing the role of #telomerase / #TERT in #neuroblastoma in mice and humans in the first talk.

My family has held plenty of Lemonade Stands to support Alex's Lemonade Stand Foundation. So many in fact that we built our own stand with their plans: https://www.alexslemonade.org/files/downloads/resource_stand_construction.pdf
And as a side note, my son had the same cancer as Alex called #Neuroblastoma and he even does speaking engagements for #ALSF

I think it's time for an #introduction Hi, I am a #postdoc in the field of cancer biology! My #research 🔬 is focused on #TreatmentResistance 💉 and #CellDeath ☠️ in #Neuroblastoma. I also work to promote #GenderBalance ⚖️ in academia and to improve the scientific system and community overall. Expect toots about #science 🧬 both in english and spanish. Looking forward to interact with all of you! 😄

#Neuroblastoma is an aggressive #cancer of the sympathetic #nervous system, especially of the #adrenal gland. Despite intense treatment with #chemotherapy, the disease can be difficult to cure and the prognosis is poor for children who have the aggressive variant
#Medical #Biology #sflorg
https://www.sflorg.com/2022/11/med11112202.html

#introduction Long overdue, but here goes:

I'm Arjan, during working hours researching a specific children's #cancer, #neuroblastoma, mostly by means of #bioinformatics analyses of #sequencing data; right now lots of #scRNAseq . I might occasionally toot about this, or related stuff like #immunology , #rstats , #atherosclerosis and other scientific interests and/or fields that I've worked in.