#treatment — Public Fediverse posts

It feels like my campaign is moving on the back of a turtle. 🐢💔

We’re still $16 short of a fish meal my little girl is longing for. 🐟
My mother’s surgery is still waiting for support — $2,495 remains.

And to keep our story heard, I urgently need $40 for internet.

If you can help with even $1, or simply share this, you could make a real difference to us. ❤️
https://chuffed.org/project/sereengaza?pdm=url_copy
#helpgaza
#Gazachildren
#foodsafety
#foodsecurity
#surgeryneeded
#treatment

RE: https://ieji.de/@DiaaMahmoud097/117104182149194241

💔😭 We urgently need to raise $900
Kind-hearted people, I urgently need surgery on my foot to replace the internal metal plate and screws, because I am in severe pain that I can no longer bear. 🦶💔
The surgery costs $900, and so far, only $40 has been raised. 😭
Is this really fair? Why doesn’t everyone want to help me? I am not asking for the impossible. Every small contribution can bring me closer to getting treatment and saving me from this pain. 🙏💔
Please, don’t leave me alone. Donate whatever you can and share my post with others. 🇵🇸❤️
https://chuffed.org/project/193219-support-diyaa-after-devastating-injury

#HelpGaza #HelpPalestine #Donate #Donation #Fundraiser #Fundraising #MutualAid #Crowdfunding #Support #HelpNeeded #EmergencyHelp #HumanitarianAid #HumanitarianCrisis #Emergency #PleaseHelp #Share #Boost #SignalBoost #Humanity #Humanitarian #HumanRights #HumanRightsMatter #Compassion #Solidarity #Hope #Survival #Crisis #War #Conflict #Refugees #Displaced #Displacement #Children #Families #SaveLives #ProtectCivilians #Health #Healthcare #Medical #MedicalHelp #MedicalAid #MedicalEmergency #EmergencyCare #Surgery #Hospital #Doctors #Nurses #Patients #Medicine #Treatment #HealthcareCrisis #MedicalCrisis #Food #FoodCrisis #FoodShortage #Hunger #Famine #Starvation #FoodAid #FoodSecurity #Water #WaterCrisis #CleanWater #WaterAid #BasicNeeds #EssentialNeeds #PleaseShare #PleaseBoost #Boost #BoostThisPost #SignalBoost #ShareThis #SpreadTheWord #RaiseAwareness #Awareness #Amplify #DontLookAway #KeepSharing #MakeItVisible #Peace #PeaceNow #PeaceForAll #NoWar #StopWar #CeasefireNow #EndTheWar #PeaceAndJustice #HumanityFirst #LoveAndPeace #Solidarity #GlobalSolidarity #StandTogether #Together #Community #CommunitySupport #PeopleHelpingPeople #OneHumanity #NeverGiveUp #HopeForHumanity #Mastodon #Fediverse #Fedi #FediverseCommunity #SocialMedia #SocialJustice #Activism #Activist #DigitalActivism #OnlineActivism #Community #Awareness #Love #Hope #Help #Support #Kindness #Compassion #Courage #Strength #PrayForGaza #PrayForPalestine #NeverForget #DontForgetGaza #VoicesOfGaza #GazaVoices

RE: https://ieji.de/@DiaaMahmoud097/117104182149194241

💔😭 We urgently need to raise $900
Kind-hearted people, I urgently need surgery on my foot to replace the internal metal plate and screws, because I am in severe pain that I can no longer bear. 🦶💔
The surgery costs $900, and so far, only $40 has been raised. 😭
Is this really fair? Why doesn’t everyone want to help me? I am not asking for the impossible. Every small contribution can bring me closer to getting treatment and saving me from this pain. 🙏💔
Please, don’t leave me alone. Donate whatever you can and share my post with others. 🇵🇸❤️
https://chuffed.org/project/193219-support-diyaa-after-devastating-injury

#HelpGaza #HelpPalestine #Donate #Donation #Fundraiser #Fundraising #MutualAid #Crowdfunding #Support #HelpNeeded #EmergencyHelp #HumanitarianAid #HumanitarianCrisis #Emergency #PleaseHelp #Share #Boost #SignalBoost #Humanity #Humanitarian #HumanRights #HumanRightsMatter #Compassion #Solidarity #Hope #Survival #Crisis #War #Conflict #Refugees #Displaced #Displacement #Children #Families #SaveLives #ProtectCivilians #Health #Healthcare #Medical #MedicalHelp #MedicalAid #MedicalEmergency #EmergencyCare #Surgery #Hospital #Doctors #Nurses #Patients #Medicine #Treatment #HealthcareCrisis #MedicalCrisis #Food #FoodCrisis #FoodShortage #Hunger #Famine #Starvation #FoodAid #FoodSecurity #Water #WaterCrisis #CleanWater #WaterAid #BasicNeeds #EssentialNeeds #PleaseShare #PleaseBoost #Boost #BoostThisPost #SignalBoost #ShareThis #SpreadTheWord #RaiseAwareness #Awareness #Amplify #DontLookAway #KeepSharing #MakeItVisible #Peace #PeaceNow #PeaceForAll #NoWar #StopWar #CeasefireNow #EndTheWar #PeaceAndJustice #HumanityFirst #LoveAndPeace #Solidarity #GlobalSolidarity #StandTogether #Together #Community #CommunitySupport #PeopleHelpingPeople #OneHumanity #NeverGiveUp #HopeForHumanity #Mastodon #Fediverse #Fedi #FediverseCommunity #SocialMedia #SocialJustice #Activism #Activist #DigitalActivism #OnlineActivism #Community #Awareness #Love #Hope #Help #Support #Kindness #Compassion #Courage #Strength #PrayForGaza #PrayForPalestine #NeverForget #DontForgetGaza #VoicesOfGaza #GazaVoices

RE: https://ieji.de/@DiaaMahmoud097/117104182149194241

I am dying from the unbearable pain. 💔😭
Kind-hearted people, the pain in my foot has become unbearable. I feel like I am dying from the intensity of it, moment after moment. 💔😭
Please don’t leave me alone. I urgently need your help now. Any donation, no matter how small, and any share of my post could help me get the treatment I desperately need and relieve this pain. 🙏🇵🇸
https://chuffed.org/project/193219-support-diyaa-after-devastating-injury
#HelpGaza #HelpPalestine #Donate #Donation #Fundraiser #Fundraising #MutualAid #Crowdfunding #Support #HelpNeeded #EmergencyHelp #HumanitarianAid #HumanitarianCrisis #Emergency #PleaseHelp #Share #Boost #SignalBoost #Humanity #Humanitarian #HumanRights #HumanRightsMatter #Compassion #Solidarity #Hope #Survival #Crisis #War #Conflict #Refugees #Displaced #Displacement #Children #Families #SaveLives #ProtectCivilians #Health #Healthcare #Medical #MedicalHelp #MedicalAid #MedicalEmergency #EmergencyCare #Surgery #Hospital #Doctors #Nurses #Patients #Medicine #Treatment #HealthcareCrisis #MedicalCrisis #Food #FoodCrisis #FoodShortage #Hunger #Famine #Starvation #FoodAid #FoodSecurity #Water #WaterCrisis #CleanWater #WaterAid #BasicNeeds #EssentialNeeds #PleaseShare #PleaseBoost #Boost #BoostThisPost #SignalBoost #ShareThis #SpreadTheWord #RaiseAwareness #Awareness #Amplify #DontLookAway #KeepSharing #MakeItVisible #Peace #PeaceNow #PeaceForAll #NoWar #StopWar #CeasefireNow #EndTheWar #PeaceAndJustice #HumanityFirst #LoveAndPeace #Solidarity #GlobalSolidarity #StandTogether #Together #Community #CommunitySupport #PeopleHelpingPeople #OneHumanity #NeverGiveUp #HopeForHumanity #Mastodon #Fediverse #Fedi #FediverseCommunity #SocialMedia #SocialJustice #Activism #Activist #DigitalActivism #OnlineActivism #Community #Awareness #Love #Hope #Help #Support #Kindness #Compassion #Courage #Strength #PrayForGaza #PrayForPalestine #NeverForget #DontForgetGaza #VoicesOfGaza #GazaVoices

RE: https://ieji.de/@DiaaMahmoud097/117104182149194241

I am dying from the unbearable pain. 💔😭
Kind-hearted people, the pain in my foot has become unbearable. I feel like I am dying from the intensity of it, moment after moment. 💔😭
Please don’t leave me alone. I urgently need your help now. Any donation, no matter how small, and any share of my post could help me get the treatment I desperately need and relieve this pain. 🙏🇵🇸
https://chuffed.org/project/193219-support-diyaa-after-devastating-injury
#HelpGaza #HelpPalestine #Donate #Donation #Fundraiser #Fundraising #MutualAid #Crowdfunding #Support #HelpNeeded #EmergencyHelp #HumanitarianAid #HumanitarianCrisis #Emergency #PleaseHelp #Share #Boost #SignalBoost #Humanity #Humanitarian #HumanRights #HumanRightsMatter #Compassion #Solidarity #Hope #Survival #Crisis #War #Conflict #Refugees #Displaced #Displacement #Children #Families #SaveLives #ProtectCivilians #Health #Healthcare #Medical #MedicalHelp #MedicalAid #MedicalEmergency #EmergencyCare #Surgery #Hospital #Doctors #Nurses #Patients #Medicine #Treatment #HealthcareCrisis #MedicalCrisis #Food #FoodCrisis #FoodShortage #Hunger #Famine #Starvation #FoodAid #FoodSecurity #Water #WaterCrisis #CleanWater #WaterAid #BasicNeeds #EssentialNeeds #PleaseShare #PleaseBoost #Boost #BoostThisPost #SignalBoost #ShareThis #SpreadTheWord #RaiseAwareness #Awareness #Amplify #DontLookAway #KeepSharing #MakeItVisible #Peace #PeaceNow #PeaceForAll #NoWar #StopWar #CeasefireNow #EndTheWar #PeaceAndJustice #HumanityFirst #LoveAndPeace #Solidarity #GlobalSolidarity #StandTogether #Together #Community #CommunitySupport #PeopleHelpingPeople #OneHumanity #NeverGiveUp #HopeForHumanity #Mastodon #Fediverse #Fedi #FediverseCommunity #SocialMedia #SocialJustice #Activism #Activist #DigitalActivism #OnlineActivism #Community #Awareness #Love #Hope #Help #Support #Kindness #Compassion #Courage #Strength #PrayForGaza #PrayForPalestine #NeverForget #DontForgetGaza #VoicesOfGaza #GazaVoices

The Spinal Cord Could Provide a Radical New Way To Treat Depression

https://onlinemarketingscoops.com/2026/08/12/the-spinal-cord-could-provide-a-radical-new-way-to-treat-depression/

Neurosurgical #Biopsy and #Resection for #Diagnosis and #Treatment of #Balamuthia mandrillaris Amebic #Encephalitis, #USA, https://etidiohnew.blogspot.com/2026/06/neurosurgical-biopsy-and-resection-for.html

https://www.theguardian.com/science/2026/may/18/magic-mushrooms-treatment-cocaine-addiction-study. A somewhat inaccurate #headline, @guardian! "Results from a new #clinical #trial show that a single #dose of #psilocybin could be an effective #treatment for #cocaine #addiction." Psilocybin is the active hallucinogenic substance found in #mushrooms such as Psilocybe cubensis, & is metabolised into #psilocin in the human body, but the chemical, & ingesting that, isn't the same thing as eating a "magic mushroom"!

💊 #PlaceboEffect – Every #medication has this secret #ingredient!✨

What if the effect of a medication is never just “chemical”?

Every #treatment is always a combination of #active ingredient and #expectation, #relationship, and #trust.

📺 https://youtu.be/TPCADLkSBWM

📎 https://philosophies.de/index.php/2024/03/12/grenzen_physik_psychologie/

#Medicine #Psychology #Consciousness #Healing #Therapy #DoctorPatientRelationship #Science #InterdisciplinaryFields #SystemsTheory #QuantumPhysics #Entanglement #Parapsychology #Zoomposium #WalterVonLucadou

Intravenous #immunoglobulin #treatment for #longCOVID: a case report of clinical and immunological findings, https://etidiohnew.blogspot.com/2026/04/intravenous-immunoglobulin-treatment.html

Ultrasound Cancer Treatment: Sound Waves Fight Tumors

https://spectrum.ieee.org/ultrasound-cancer-treatment

#HackerNews #Ultrasound #Cancer #Treatment #Sound #Waves #Fight #Tumors #Healthcare #Innovation #Cancer #Research #Medical #Technology

Breakthrough chemotherapy treatment eliminates side effects and is 20,000 times stronger

https://web.brid.gy/r/https://www.upworthy.com/chemotherapy-treatment-eliminates-side-effects

FDA Takes Action to Make a Treatment Available for Autism Symptoms

https://www.fda.gov/news-events/press-announcements/fda-takes-action-make-treatment-available-autism-symptoms

#HackerNews #FDA #Autism #Treatment #Action #AutismResearch #HealthNews #MedicalBreakthroughs

A treatment is a drug AND a dosage | @destiny

#Medication #Treatment #Healthcare #PubertyBlockers #Destiny

A #Fascinating #Illustration of Why We Need #Imaginary #Numbers : Medium

#Woman in #Cancer #Remission for record 19 years after #CAR-T #Immune #Treatment : Nature

A whole new #World of tiny beings challenges fundamental ideas of #Life : New Sci

Check our latest #KnowledgeLinks

https://knowledgezone.co.in/resources/bookmarks

''Several #workers experienced #influenza-like #symptoms and missed work during March 4–6. A maternity worker visited a local #clinic and received
#treatment for influenza-like symptoms; 2 #milkers also experienced influenza-like symptoms and stayed home. No cases of conjunctivitis, severe illness, or hospitalizations were reported among workers.''

[#TRADESHOW] 2024 The 24th China (Guangzhou) Int’l #Platemetal, #Bar, #Wire, Metal Processing & #Setting Equipment #exhibition presents #steel #smelting #technology, #aluminium, #steel #meshes, #screw #wires #rods, #board #cutting #equipment, #metallurgic #automation #apparatus, #cooling #fluid and #oil for #metal #processing, #CNC equipment, #sheet #metal #processing, and #surface #treatment. 11.-13. May 2024. China #Import and #Export Fair Pazhou Complex (CFC), #China.
https://cnbusinessforum.com/event/the-24th-chinaguangzhouintl-plate-metalbar-wirelaser-equipment-and-sheet-metal-industry-exhibition/

[#TRADESHOW] The 24th #China (Guangzhou) Int’l #Platemetal, #Bar, #Wire, Metal Processing & #Setting Equipment #exhibition presents #steel #smelting #technology, #aluminium, #steel #meshes, #screw #wires #rods, #board #cutting #equipment, #metallurgic #automation #apparatus, #cooling #fluid and #oil for #metal #processing, #CNC equipment, #sheet #metal #processing, and #surface #treatment. 11.-13. May 2024. China #Import and #Export Fair Pazhou Complex (CFC), #Guangzhou. https://cnbusinessforum.com/event/the-24th-chinaguangzhouintl-plate-metalbar-wirelaser-equipment-and-sheet-metal-industry-exhibition/

#CARTcell #therapy is a promising #immunebased #treatment approach. Explore how #scientists at #StJude are working to optimize #CARTCellTherapy to better meet all #cancer patients' needs. http://bit.ly/3Lnw8Md #StJudeOn

@explainpaper

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk Jaeger

Targeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases

#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.

the microenvironment of #liver metastases of #colorectal cancer (#CRC).

the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.

the effects of CCR5 blockade on the #tissue level.

Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.

The microenvironment of the invasive margin of #liver metastases.

There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.

#CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).

The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.

A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.

CCR5 blockade, is a type of #therapy used to treat #cancer.

The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.

Les opérateurs LockBit revendiquent des attaques informatiques à l'encontre de :

• 🇮🇹 Gruppo Waste Italia S.p.A. (gruppowasteitalia.it)

• 🇮🇩 PT Medco Energi Internasional Tbk (medcoenergi.com)

• 🇲🇱 La Direction Générale des Impôts du Mali (dgi.gouv.ml)

• 🇬🇧 Genus plc (genusplc.com)

#italy #indonesia #mali #uk #lockbit #government #ransomware #animal #industrial #chemicals #food #genetics #biotechnology #pharma #treatment #governance #smart #production #innovative #gas #pigs #accounting #services #shareholders #treatments #research #investment #development #meat #energies #partnership #future #strategic #farmers #technologies #rental #taxes #agricultural #databreach #corporate #organic #financial #power #impots #advisers #economic #customers #milk #waste #management #modern #investors #slavery #oil #fiscal #teleservices #business #informatique