home.social

#treatment — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #treatment, aggregated by home.social.

  1. It feels like my campaign is moving on the back of a turtle. 🐢💔

    We’re still $16 short of a fish meal my little girl is longing for. 🐟
    My mother’s surgery is still waiting for support — $2,495 remains.

    And to keep our story heard, I urgently need $40 for internet.

    If you can help with even $1, or simply share this, you could make a real difference to us. ❤️
    chuffed.org/project/sereengaza
    #helpgaza
    #Gazachildren
    #foodsafety
    #foodsecurity
    #surgeryneeded
    #treatment

  2. chuffed.org/project/174651-hel
    Dear friends and followers on Mastodon, I am in dire need of funds to cover medical expenses. Any contribution, no matter how small, would make a real difference to my current health situation.

    The amount needed is $25 (or whatever suits you). I am extremely grateful to anyone who can help or share this post to reach as many people as possible.
    #donate #gaza #palestine @[email protected] @[email protected] #helpgaza
    #trending #helpMe #Treatment #Donate

  3. ​A Testimony of Truth and Humanity: ough the Eyes of Prof. Nick Maynard
    ​When a world-renowned British surgeon like Professor Nick Maynard visits the Gaza Strip and witnesses the suffering firsthand, his testimony is not merely a passing impression; it is a badge of honor bestowed by a medical savior upon a people who teach the entire world the true meaning of resilience.
    ​Professor Maynard described the people of Gaza with words overflowing with humanity and depth, stating:
    ​"They are the kindest, most beautiful, and most generous people I have ever met in the world. They have an astonishing capacity for resilience, are brilliantly resourceful, possess remarkable scientific knowledge, and practice medicine at an exceptionally high level despite severely limited resources."
    ​This heartfelt praise embodies the genuine character of the patient people of this land, who face the harshest circumstances with hearts full of dignity and giving, and minds ablaze with creativity and determination.
    ​An Urgent Humanitarian Appeal to Support My Family
    ​Building upon this profound testimony, and under the extremely harsh and inhumane conditions my family is enduring in the Gaza Strip, I turn to you today with a heart heavy with hope and a plea for help. My family is part of this giving community praised by the world, yet today they lack the most basic necessities of life—food, clean water, and safety.
    ​War has taken its toll on them, and their means of endurance are nearly exhausted. Your support and solidarity with us in this critical moment, no matter how small, means a true lifeline and a step toward preserving a dignified life for them and my children.
    ​How can you help?
    ​Providing direct financial support to help secure basic necessities.
    ​Sharing this message and spreading it as widely as possible so it may reach compassionate hearts.
    ​To connect or extend a helping hand to my family:

    chuffed.org/project/178629-noo

    🤖👆👆👆👆

    #Mastodon #gazaverified #gazagenocide #GazaWar

    #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza
    @DailyGaza @apenkop
    @DailyGaza @kathimmel @DrALJONES @simon_brooke @wrzky @Majden888 @DrALJONES @raphaellakay @eldadoinquieto @sallytheflame @franciswashere @DailyGaza

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @[email protected]
    @delsaulnier @[email protected] @[email protected] @majorlinux @mutualaid @1kmadleenfr @mutualaid @GazaFFlotilla @freepalestine @GazaFFlotilla @Christo_459 @Lazarou @foufoutos @noiseician @MajDen @Mau_or_ @Mau_or_ @Pine_Affinity
    @Mau_or_ @Pine_Affinity @epso @Literbook @[email protected] @Strandjunker @AliceMarshall @Sine_Nomine @rpardee
    @amans
    @BKoepka #gaza @gergelyorosz @MarieClaire
    @gergelyorosz
    @gergelyorosz
    @simon_brooke
    @shad
    @Pine_Affinity
    @Testoceratops
    @Pine_Affinity
    @DrSprockets
    @GreyElm @lisagetspolitik
    @danatommasino
    @mutualaid
    #MutualAidRequest #Gaza #Palestine #FediForGaza
    @gvenema @simon_brooke @chielk @apenkop @kathimmel @aral @kathimmel

    #Fedivers #FediForGaza #Gaza #Palestine #GazaChildren #HumanitarianCrisis #MutualAid #HelpGaza #EducationForAll #KeepGazaLearning
    #fedihelp #fediverse #fediforgaza
    #fediart #fedi #gaza
    #Mastodon #fediforgaza #helpgaza #Donate #share #FreePalestine #Palestine #Treatment
    #medicine
    #MutualAid #MutualAidRequest #Gaza #Palestine #FediForGaza
    #Mastodon @BKoepka
    #Gaza #MutualAid #Palestine
    @apenkop @kathimmel @DrALJONES @simon_brooke @wrzky @sallytheflame @karelbrits @marion_v @fedipourgaza #Fedivers @franciswashere

    @sandradejong
    @BrianJopek @imigueldiaz @imigueldiaz
    @bifouba @lateinhemd @evan @franciswashere @kgaiji
    @irix @heyrochelle
    #Gaza #GazaVerified #helpgaza
    #Help @aral @irfan
    @Pine_Affinity
    @[email protected]
    @[email protected]
    @ciaranmak
    @gvenema
    @akn

    #cornelluniversity #usa #Palestine

    @sandradejong @BrianJopek @imigueldiaz @velvetmolotov @bifouba @lateinhemd

    @TheCentralScrutinizer
    #Mastodon #gazaverified #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    #Mastodon #gaza #gazaverified #gazagenocide #Palestine #FreePalestine #Palestine #GazaWar @aral @marion_v @Apoorva__Lal @ProPublica

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @sally
    @lkn
    @CryptoLek

    chuffed.org/project/178629-noo

  4. ​A Testimony of Truth and Humanity: ough the Eyes of Prof. Nick Maynard
    ​When a world-renowned British surgeon like Professor Nick Maynard visits the Gaza Strip and witnesses the suffering firsthand, his testimony is not merely a passing impression; it is a badge of honor bestowed by a medical savior upon a people who teach the entire world the true meaning of resilience.
    ​Professor Maynard described the people of Gaza with words overflowing with humanity and depth, stating:
    ​"They are the kindest, most beautiful, and most generous people I have ever met in the world. They have an astonishing capacity for resilience, are brilliantly resourceful, possess remarkable scientific knowledge, and practice medicine at an exceptionally high level despite severely limited resources."
    ​This heartfelt praise embodies the genuine character of the patient people of this land, who face the harshest circumstances with hearts full of dignity and giving, and minds ablaze with creativity and determination.
    ​An Urgent Humanitarian Appeal to Support My Family
    ​Building upon this profound testimony, and under the extremely harsh and inhumane conditions my family is enduring in the Gaza Strip, I turn to you today with a heart heavy with hope and a plea for help. My family is part of this giving community praised by the world, yet today they lack the most basic necessities of life—food, clean water, and safety.
    ​War has taken its toll on them, and their means of endurance are nearly exhausted. Your support and solidarity with us in this critical moment, no matter how small, means a true lifeline and a step toward preserving a dignified life for them and my children.
    ​How can you help?
    ​Providing direct financial support to help secure basic necessities.
    ​Sharing this message and spreading it as widely as possible so it may reach compassionate hearts.
    ​To connect or extend a helping hand to my family:

    chuffed.org/project/178629-noo

    🤖👆👆👆👆

    #Mastodon #gazaverified #gazagenocide #GazaWar

    #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza
    @DailyGaza @apenkop
    @DailyGaza @kathimmel @DrALJONES @simon_brooke @wrzky @Majden888 @DrALJONES @raphaellakay @eldadoinquieto @sallytheflame @franciswashere @DailyGaza

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @[email protected]
    @delsaulnier @[email protected] @[email protected] @majorlinux @mutualaid @1kmadleenfr @mutualaid @GazaFFlotilla @freepalestine @GazaFFlotilla @Christo_459 @Lazarou @foufoutos @noiseician @MajDen @Mau_or_ @Mau_or_ @Pine_Affinity
    @Mau_or_ @Pine_Affinity @epso @Literbook @[email protected] @Strandjunker @AliceMarshall @Sine_Nomine @rpardee
    @amans
    @BKoepka #gaza @gergelyorosz @MarieClaire
    @gergelyorosz
    @gergelyorosz
    @simon_brooke
    @shad
    @Pine_Affinity
    @Testoceratops
    @Pine_Affinity
    @DrSprockets
    @GreyElm @lisagetspolitik
    @danatommasino
    @mutualaid
    #MutualAidRequest #Gaza #Palestine #FediForGaza
    @gvenema @simon_brooke @chielk @apenkop @kathimmel @aral @kathimmel

    #Fedivers #FediForGaza #Gaza #Palestine #GazaChildren #HumanitarianCrisis #MutualAid #HelpGaza #EducationForAll #KeepGazaLearning
    #fedihelp #fediverse #fediforgaza
    #fediart #fedi #gaza
    #Mastodon #fediforgaza #helpgaza #Donate #share #FreePalestine #Palestine #Treatment
    #medicine
    #MutualAid #MutualAidRequest #Gaza #Palestine #FediForGaza
    #Mastodon #FediForGaza
    #Gaza #MutualAid #Palestine
    @apenkop @kathimmel @DrALJONES @simon_brooke @wrzky @sallytheflame @karelbrits @DrALJONES @fedipourgaza #Fedivers @franciswashere

    @sandradejong
    @BrianJopek @imigueldiaz @imigueldiaz
    @bifouba @lateinhemd @evan @franciswashere @kgaiji
    @irix @heyrochelle
    #Gaza #GazaVerified #helpgaza
    #Help @aral @irfan
    @Pine_Affinity
    @[email protected]
    @[email protected]
    @ciaranmak
    @gvenema
    @akn

    #cornelluniversity #usa #Palestine

    @sandradejong @BrianJopek @imigueldiaz @velvetmolotov @bifouba @lateinhemd

    @TheCentralScrutinizer
    #Mastodon #gazaverified #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    #Mastodon #gaza #gazaverified #gazagenocide #Palestine #FreePalestine #Palestine #GazaWar @aral @marion_v @Apoorva__Lal @mAstodon

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @sally
    @lkn
    @CryptoLek

    chuffed.org/project/178629-noo

  5. RE: kolektiva.social/@retareta/117

    #Mastodon #gazaverified #gazagenocide #GazaWar

    #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza
    @Geri @apenkop
    @DailyGaza @kathimmel @DrALJONES @simon_brooke @wrzky @Majden888 @DrALJONES @raphaellakay @eldadoinquieto @sallytheflame @franciswashere @DailyGaza

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @burnitdown
    @[email protected] @[email protected] @[email protected] @majorlinux @mutualaid @1kmadleenfr @mutualaid @GazaFFlotilla @freepalestine @GazaFFlotilla @Christo_459 @Lazarou @foufoutos @noiseician @MajDen @Mau_or_ @Mau_or_ @Pine_Affinity
    @Mau_or_ @Pine_Affinity @epso @Literbook @[email protected] @Strandjunker @AliceMarshall @sine_nomine @rpardee
    @amans
    @BKoepka #gaza @ManUtd @marieclaire
    @[email protected]
    @gergelyorosz
    @[email protected]
    @shad
    @harrysentonbury
    @Testoceratops
    @Pine_Affinity
    @DrSprockets
    @GreyElm @lisagetspolitik
    @danatommasino
    @mutualaid
    #MutualAidRequest #Gaza #Palestine #FediForGaza
    @gvenema @simon_brooke @chielk @apenkop @kathimmel @aral @kathimmel

    #Fedivers #FediForGaza #Gaza #Palestine #GazaChildren #HumanitarianCrisis #MutualAid #HelpGaza #EducationForAll #KeepGazaLearning
    #fedihelp #fediverse #fediforgaza
    #fediart #fedi #gaza
    #Mastodon #fediforgaza #helpgaza #Donate #share #FreePalestine #Palestine #Treatment
    #medicine
    #MutualAid #MutualAidRequest #Gaza #Palestine #FediForGaza
    #Mastodon #FediForGaza
    #Gaza #MutualAid #Palestine
    @apenkop @kathimmel @DrALJONES @simon_brooke @wrzky @sallytheflame @karelbrits @DrALJONES @fedipourgaza #Fedivers @franciswashere

    @sandradejong
    @BrianJopek @imigueldiaz @imigueldiaz
    @bifouba @lateinhemd @evan @franciswashere @kgaiji
    @irix @heyrochelle
    #Gaza #GazaVerified #helpgaza
    #Help @aral @irfan
    @Pine_Affinity
    @[email protected]
    @[email protected]
    @ciaranmak
    @gvenema
    @akn

    #cornelluniversity #usa #Palestine

    @sandradejong @BrianJopek @imigueldiaz @velvetmolotov @bifouba @lateinhemd

    @TheCentralScrutinizer
    #Mastodon #gazaverified #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    #Mastodon #gaza #gazaverified #gazagenocide #Palestine #FreePalestine #Palestine #GazaWar @aral @marion_v @Apoorva__Lal @Mastodon

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @sally
    @lkn
    @CryptoLek

  6. When even a kite becomes a crime

    They are reportedly holding an urgent meeting involving the Israeli defense minister, the army chief of staff, and military commanders to discuss kites coming from Gaza.

    Think about that for a moment: a kite. A child’s toy.

    Children in Gaza have already lost their homes, their schools, their safety, and so much of their childhood. Now even the simple act of flying a kite is treated as a threat.

    I am a mother of six, and my family of eight is living through these unbearable conditions. We have been displaced, we live in a tent, and for several days now our donations have completely stopped. We struggle to secure food, clean water, and the basic necessities my children need.

    While powerful people hold meetings about children’s kites, my children are worrying about whether there will be food on the table.

    Please don’t let us disappear from your feed. If you can donate, even a small amount can help my family survive. If you cannot, please share our campaign. Your support could mean food for my children today.

    We don’t need luxury. We need a chance to survive with dignity. 💔🙏
    chuffed.org/project/178629-noo

    🤖👆👆👆👆

    #Mastodon #gazaverified #gazagenocide #GazaWar

    #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza
    @Geri @apenkop
    @DailyGaza @kathimmel @DrALJONES @simon_brooke @wrzky @Majden888 @DrALJONES @raphaellakay @eldadoinquieto @sallytheflame @franciswashere @DailyGaza

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @[email protected]
    @[email protected] @[email protected] @[email protected] @majorlinux @mutualaid @1kmadleenfr @mutualaid @GazaFFlotilla @freepalestine @GazaFFlotilla @Christo_459 @Lazarou @foufoutos @noiseician @MajDen @Mau_or_ @Mau_or_ @Pine_Affinity
    @Mau_or_ @Pine_Affinity @epso @Literbook @[email protected] @Strandjunker @AliceMarshall @Sine_Nomine @rpardee
    @amans
    @BKoepka #gaza @ManUtd @MarieClaire
    @[email protected]
    @gergelyorosz
    @[email protected]
    @shad
    @harrysentonbury
    @Testoceratops
    @Pine_Affinity
    @DrSprockets
    @GreyElm @lisagetspolitik
    @danatommasino
    @mutualaid
    #MutualAidRequest #Gaza #Palestine #FediForGaza
    @gvenema @simon_brooke @chielk @apenkop @kathimmel @aral @kathimmel

    #Fedivers #FediForGaza #Gaza #Palestine #GazaChildren #HumanitarianCrisis #MutualAid #HelpGaza #EducationForAll #KeepGazaLearning
    #fedihelp #fediverse #fediforgaza
    #fediart #fedi #gaza
    #Mastodon #fediforgaza #helpgaza #Donate #share #FreePalestine #Palestine #Treatment
    #medicine
    #MutualAid #MutualAidRequest #Gaza #Palestine #FediForGaza
    #Mastodon #FediForGaza
    #Gaza #MutualAid #Palestine
    @apenkop @kathimmel @DrALJONES @simon_brooke @wrzky @sallytheflame @karelbrits @DrALJONES @fedipourgaza #Fedivers @franciswashere

    @sandradejong
    @BrianJopek @imigueldiaz @imigueldiaz
    @bifouba @lateinhemd @evan @franciswashere @kgaiji
    @irix @heyrochelle
    #Gaza #GazaVerified #helpgaza
    #Help @aral @irfan
    @Pine_Affinity
    @[email protected]
    @[email protected]
    @ciaranmak
    @gvenema
    @akn

    #cornelluniversity #usa #Palestine

    @sandradejong @BrianJopek @imigueldiaz @velvetmolotov @bifouba @lateinhemd

    @TheCentralScrutinizer
    #Mastodon #gazaverified #gazagenocide #GazaWar

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    #Mastodon #gaza #gazaverified #gazagenocide #Palestine #FreePalestine #Palestine #GazaWar @aral @marion_v @Apoorva__Lal @mAstodon

    #Gaza #GazaChildren #Palestine #FreePalestine #GazaGenocide #ChildrenOfGaza #Humanity #CeasefireNow #StandWithGaza #PalestinianLivesMatter #SaveGaza #HelpGaza

    @sally
    @lkn
    @CryptoLek

  7. The Spinal Cord Could Provide a Radical New Way To Treat Depression

    (magicmine/Getty Images) With depression affecting around 1 in 10 of us at some point during our lives, the need for new and improved treatments is a top priority for researchers – and it appears that spinal cord stimulation could be one route for experts to investigate. A team led by researchers at the University of Cincinnati College of Medicine devised a pilot clinical trial in which a little black box was placed on the spinal cord of 20 volunteers with depression, with one […]

    onlinemarketingscoops.com/2026

  8. 🎶 "Befriending #tinnitus makes it vanish"—a groundbreaking technique that involves cozying up to your inner ear screeching until it politely leaves. 🌪️ Next up: hugging your taxes until they stop demanding payment. 😂
    mynoise.net/vlog.php?ep=202608 #treatment #mindfulness #innerpeace #humor #innovation #HackerNews #ngated

  9. Shalini

    Published in 2006 - Edited in 2026 “Come Mohandas, it is time for your interview with the doctor.” “Yes, coming.” Rishi, a young assistant, dressed in a freshly starched uniform walked ahead, as he led a tired old man, with balding head, thinly covered with greying hair, to the consulting rooms. At his soft knock, a deep voice from inside replied, “Come in.” “Sir, patient No. 33.” The square room was sparsely furnished. At the far end, there was a wooden table with two […]

    ishitadeshmukh.com/2026/06/26/

  10. Tiger Woods turns down Ryder Cup captaincy as he seeks treatment outside of United States

    Tiger Woods has turned down the United States’ Ryder Cup captaincy after a Florida judge approved his motion…
    #NewsBeep #News #Golf #arrest #AU #Australia #dui #Europe #notguiltyplea #Pills #RyderCup #sports #TigerWoods #treatment #UnitedStates #us
    newsbeep.com/au/579699/

  11. Fuck it. Depression is chronic pain. There, I said it!

    I have both. I can't speak for yours, but I can say mine are comparable. Mental or emotional or whatever kind of pain are still pain: unpleasant discomfort beyond what an individual considers tolerable.
    And if it lasts a while: chronic.

    Hence depression is chronic pain.
    Also chronic illness or chronic sickness. Since it doesn't tend to be acute or short-term, after all.
    (I mean maybe, for transient stressors sure. Not if you have no "premorbid personality" since it started so young, probably.)

    #Spoonie #MedMastodon #Depression #WorldMentalHealthDay #ChronicallyIll #ChronicIllnesses #ChronicPain #Sick #ill #diagnosis #medical #medicine #treatment #MentalIllness

  12. Homeless and Addiction Outreach Officer (HAOO) Android
    As machines took human jobs, and drugs and synth-alcohol became cheaper and more prevalent, people found themselves on the streets. Strangely, it was machines who also came to tend to the victims of addiction and homelessness.
    Hand drawn ink art from page 35, from The Mutant Epoch RPG Expansion Rules book
    Check it out here: outlandarts.com/expansionrules

    #homeless #outreach #streetpeople #skidrow #drugaddict #addiction #treatment #homelessoutreach #android #humanoidrobot #selfaware #ai #noai #noaiart #ink #rpg #ttrpg #scifi #playercharacter #mutantepoch #expansionrules #tme #indiegame #postapocalyptic #fallout #euthanasia #syringe

  13. #LetterOfTheWeek
    🇸🇬🏆How I reduce the chances of my #patients getting #longterm #nervepain from #shingles
    "The cost of #shinglesvaccination, from $720-950, is beyond the reach of many of my patients. I thus adopt a different approach to reduce the chances of patients developing #postherpeticneuralgia.. Besides #vaccination, which does not guarantee lifelong immunity, the key to not developing long-term nerve pain is #early #diagnosis and the start of appropriate #treatment"
    straitstimes.com/opinion/forum

  14. @explainpaper

    Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

    Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
    Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk Jaeger

    Targeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases

    #Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.

    the microenvironment of #liver metastases of #colorectal cancer (#CRC).

    the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.

    the effects of CCR5 blockade on the #tissue level.

    Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.

    The microenvironment of the invasive margin of #liver metastases.

    There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.

    #CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).

    The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.

    A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.

    CCR5 blockade, is a type of #therapy used to treat #cancer.

    The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.