#actin — Public Fediverse posts

A previous @PLOSBiology study presented IntAct, a tool to study isoform-specific #actin localization. Now this Update Article couples IntAct & Ux-EM to enable super-resolution imaging of actin structures in yeast & mammalian cells https://plos.io/4vansgr

@dzne The @MaFu55 Lab (#DZNE) at #BonnBrain26:

#Microglial Ca-dynamics (Eyberg, A44)
NE-modulated #microglia (Antony, A45)
#Stress-driven #synapse remodeling (Crux, A46)
#Actin control of microglia (Hoffmann, A47)
#Odor coding in #SNNs (myself, A11)

Stop by our posters today 👌

💪 Could one molecular “typo” break the balance between strength and flexibility in our muscles?

🔗 Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.010

📚 CSBJ: https://www.csbj.org/

#ComputationalBiology #MolecularDynamics #ProteinScience #Actin #RareDiseases #PrecisionMedicine #Biophysics #CryoEM #Bioinformatics #DrugDiscovery #VisceralMyopathy #AorticAneurysm

@sellathechemist @compoundchem phallotoxins like phalloidin, also fascinating. Used extensively in #CellBiology research to label #Actin #Cytoskeleton, but i don't really know the route of toxicity in animals.

🧠 #Neurons can communicate via a hidden network of #nanotubes, new study finds. Chang et al. (2025) show that dendritic nanotubes (DNTs) are #actin-based #dendrite-to-dendrite conduits transferring Ca²⁺ and molecular cargo (incl. #Aβ), rising before plaque deposition in mouse #cortex. This overlooked pathway may expand our view of neuronal communication beyond #synapses:

🌍 https://www.science.org/doi/10.1126/science.adr7403

#Neuroscience

📰 "Substrate properties and actin polymerization speed dictate universal modes of cell migration: gripping, slipping, and stick-slip"
https://www.biorxiv.org/content/10.1101/2025.06.20.660727v1?rss=1 #CellMigration #Mechanical #Actin #Cell

📰 "Automated Tracking of Learned Actin Structures (ATLAS) in the Motility Assay"
https://doi.org/doi:10.1016/j.bpr.2025.100221
https://pubmed.ncbi.nlm.nih.gov/40550418/
#Mechanical #Myosin #Actin

📰 "Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics"
https://doi.org/doi:10.1038/s41567-025-02847-3
https://pubmed.ncbi.nlm.nih.gov/40546251/
#Mechanical #Mechanics #Actin

📰 "F-Actin Polarization and Microtubule Integrity Direct Regeneration Patterns and Polarity of Cell Outgrowth in Wound-Induced Reprogramming"
https://doi.org/doi:10.1111/pce.70032
https://pubmed.ncbi.nlm.nih.gov/40545731/
#Mechanical #Actin #Cell

📰 "Motor-driven modulation of actin network mechanics across linear and nonlinear regimes"
https://www.biorxiv.org/content/10.1101/2025.06.15.659806v1?rss=1 #Cytoskeletal #Mechanical #Mechanics #Actin

📰 "Stressed Actin Binding by the Prickle2 LIM Domains and its Regulation in the Full-Length Protein"
https://doi.org/doi:10.1101/2025.05.30.657073
https://pubmed.ncbi.nlm.nih.gov/40501967/
#Cytoskeletal #Mechanical #Actin

📰 "A benchtop bioreactor to impart coarctation-induced deformation and assess mechanisms of endothelial dysfunction"
https://doi.org/doi:10.1101/2025.05.23.655865
https://pubmed.ncbi.nlm.nih.gov/40501964/
#Mechanical #Actin

📰 "The divergent intron-containing actin in sponge morphogenetic processes"
https://doi.org/doi:10.1093/nargab/lqaf071
https://pubmed.ncbi.nlm.nih.gov/40491973/
#Cytoskeleton #Mechanical #Actin

📰 "The fastest movements and the most extreme deformations of the cell nucleus are driven by microtrubules in the model fungus Podospora anserina"
https://www.biorxiv.org/content/10.1101/2025.06.08.658251v1?rss=1 #Mechanical #Actin #Cell

📰 "Agent-based computational modeling of the stochastic dynamic behavior of actin filaments recapitulates the homeostatic cortical array in plant epidermal cells"
https://www.biorxiv.org/content/10.1101/2025.06.06.658236v1?rss=1 #Mechanical #Actin

📰 "Reconstitution of actomyosin networks in cell-sized liposomes reveals distinct mechanical roles of cytoskeletal organization in membrane shape remodeling"
https://doi.org/doi:10.1101/2025.05.18.654456
https://pubmed.ncbi.nlm.nih.gov/40475593/
#Actomyosin #Mechanical #Forces #Actin

📰 "Fine-Tuning of Material Properties by Catch Bonds"
https://doi.org/doi:10.1016/j.actbio.2025.06.004
https://pubmed.ncbi.nlm.nih.gov/40472916/
#Mechanical #Actin

📰 "Stressed Actin Binding by the Prickle2 LIM Domains and itsRegulation in the Full-Length Protein"
https://www.biorxiv.org/content/10.1101/2025.05.30.657073v1?rss=1 #Cytoskeletal #Mechanical #Actin

📰 "Actin in mitochondrial regulation and mechanometabolic crosstalk"
https://doi.org/doi:10.1016/j.ceb.2025.102539
https://pubmed.ncbi.nlm.nih.gov/40424939/
#Mechanical #Actin

📰 "Emergence of Anti-chemotactic Flocking in Active Biomimetic Colloids"
https://arxiv.org/abs/2505.17394 #Physics.Bio-Ph #Cond-Mat.Soft #Dynamics #Actin

📰 "Theory of active self-organization of dense nematic structures in the actin cytoskeleton"
https://arxiv.org/abs/2306.15352 #Physics.Bio-Ph #Cond-Mat.Soft #Dynamics #Actin

📰 "Modelling Actin-MT Crosstalk in Migrating Cells"
https://www.biorxiv.org/content/10.1101/2025.04.09.647914v1?rss=1 #Mechanical #Actin

📰 "Piezo1, F-actin Remodeling, and Podocyte Survival and Regeneration"
https://doi.org/doi:10.1681/ASN.0000000697
https://pubmed.ncbi.nlm.nih.gov/40172977/
#Mechanical #Actin