#immune — Public Fediverse posts

https://www.europesays.com/es/514716/ 226ERS lanza IMMUNE WHEY PROTEIN, nueva proteína funcional para ciclistas y deportistas – Esciclismo #ACO #aportar #apoyar #Bienestar #Capaces #Ciclismo #ciclista #completas #Cycling #Deportes #deportiva #diseñada #ers #ES #España #evolucionando #funcional #General #hacía #immune #la #linea #mas #mundo #muscular #nueva #nutrición #presentado #protein #proteína #rendimiento #sigue #soluciones #soporte #Spain #Sports #tanto #vez #whey

This review highlights the way #immune receptors and proteases work together to limit viral spread and reveals new opportunities to engineer #crops with stronger and broader resistance to #viral diseases.

https://doi.org/10.1111/jipb.70259
@WileyLifeSci
#PlantSci #JIPB #CropSci #PlantPath #botany

This review highlights the way #immune receptors and proteases work together to limit viral spread and reveals new opportunities to engineer #crops with stronger and broader resistance to #viral diseases.

https://doi.org/10.1111/jipb.70259
@WileyLifeSci
#PlantSci #JIPB #CropSci #PlantPath #botany

Oh, look! A #groundbreaking #discovery from the land of saunas: getting sweaty in a wooden box makes your #immune cells do a happy dance. 🕺🎉 Too bad the article is locked behind a digital #sauna of 'Enable #JavaScript and cookies'. 🔒🥵
https://www.tandfonline.com/doi/full/10.1080/23328940.2026.2645467#abstract #health #cookies #HackerNews #ngated

Finnish sauna heat exposure induces stronger immune cell than cytokine responses

https://www.tandfonline.com/doi/full/10.1080/23328940.2026.2645467#abstract

#HackerNews #Finnish #sauna #immune #response #heat #exposure #wellness #health

New publication: #Urbanization is associated with innate #immune functions in adult, but not nestling #Turdusmerula (#EurasianBlackbird).
https://doi.org/10.1093/ornithapp/duaf056

#Plant & animal #immune systems share an #evolutionary challenge: Defending against biotic #stress while minimizing self-damage.
Li et al. survey what we know & how understanding cross-kingdom mechanisms might improve #AgTech.
https://doi.org/10.1111/jipb.70109
@WileyLifeSci
#PlantSci #JIPB #botany #FreeAccess

#Plant & animal #immune systems share an #evolutionary challenge: Defending against biotic #stress while minimizing self-damage.
Li et al. survey what we know & how understanding cross-kingdom mechanisms might improve #AgTech.
https://doi.org/10.1111/jipb.70109
@WileyLifeSci
#PlantSci #JIPB #botany #FreeAccess

#Plant & animal #immune systems share an #evolutionary challenge: Defending against biotic #stress while minimizing self-damage.
Li et al. survey what we know & how understanding cross-kingdom mechanisms might improve #AgTech.
https://doi.org/10.1111/jipb.70109
@WileyLifeSci
#PlantSci #JIPB #botany #FreeAccess

#Plant & animal #immune systems share an #evolutionary challenge: Defending against biotic #stress while minimizing self-damage.
Li et al. survey what we know & how understanding cross-kingdom mechanisms might improve #AgTech.
https://doi.org/10.1111/jipb.70109
@WileyLifeSci
#PlantSci #JIPB #botany #FreeAccess

#Plant & animal #immune systems share an #evolutionary challenge: Defending against biotic #stress while minimizing self-damage.
Li et al. survey what we know & how understanding cross-kingdom mechanisms might improve #AgTech.
https://doi.org/10.1111/jipb.70109
@WileyLifeSci
#PlantSci #JIPB #botany #FreeAccess

#Cancer immunotherapy is a type of cancer treatment that harnesses the #immune system to fight cancer cells. The treatment involves #CD8⁺ T cells, also known as killer T cells, which play a crucial role in attacking #tumors
#Immunology #Oncology #Metabolomics #sflorg
https://www.sflorg.com/2026/01/imgy01212601.html

Pura Collagen enters GLP-1 market with ‘pure’ hormone stimulating alternative

The two innovations expand…
#NewsBeep #News #Nutrition #assortment #body #capsules #colorful #consumption #cure #Daily #Diet #dosage #Energy #essentials #Fitness #gummy #healing #Health #healthcare #Immune #kid #Lifestyle #multivitamin #Natural #Nutrients #options #pharmaceutical #Pills #Remedy #Supplements #tablets #Therapy #treatment #UK #UnitedKingdom #variety #Vitamins #wellness
https://www.newsbeep.com/uk/378325/

https://www.europesays.com/ie/292130/ Pura Collagen enters GLP-1 market with ‘pure’ hormone stimulating alternative #assortment #body #capsules #colorful #Consumption #cure #daily #diet #dosage #Éire #Energy #essentials #Fitness #gummy #Healing #Health #Healthcare #IE #Immune #Ireland #kid #lifestyle #multivitamin #natural #Nutrients #Nutrition #options #pharmaceutical #Pills #remedy #supplements #tablets #therapy #treatment #variety #Vitamins #wellness

https://www.europesays.com/uk/706207/ Pura Collagen enters GLP-1 market with ‘pure’ hormone stimulating alternative #assortment #body #capsules #colorful #consumption #cure #Daily #diet #dosage #Energy #essentials #Fitness #gummy #healing #Health #Healthcare #immune #kid #Lifestyle #multivitamin #Natural #Nutrients #Nutrition #options #Pharmaceutical #pills #remedy #supplements #tablets #Therapy #treatment #UK #UnitedKingdom #variety #Vitamins #Wellness

For the first time, researchers at the University of British Columbia have demonstrated how to reliably produce an important type of human #immune cell—known as helper T cells—from stem #cells in a controlled laboratory setting.
#Biomedical #Bioengineering #Tcells #sflorg
https://www.sflorg.com/2026/01/bmed01082601.html

Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

De Strijders van Je Lichaam: Immune Helden!

Hallo daar, nieuwsgierige vrienden! 🐾 Ik ben Mauw de Poes, en vandaag gaan we op avontuur in de spannende wereld van onze immuunsysteem! Wist je dat er kleine, dappere helden in je lichaam rondhup...

🌞 Leer verder: https://leeralles.nl/de-strijders-van-je-lichaam-immune-helden/?feed_id=17871

#HELDEN #IMMUNE #LICHAAM #STRIJDERS #VAN

Don't give your pet mouse 🐁️ a tattoo. A study by Capucetti et al. in PNAS found the ink lingers in lymph nodes for months and kills immune cells. Effect on vaccines varied; Comirnaty (for COVID) injected into a tattoo was weaker while the flu jab was stronger.
https://www.consumeraffairs.com/news/tattoo-ink-races-into-lymph-nodes-kills-immune-cells-and-alters-vaccine-responses-study-finds-120225.html

#MouseStudy #tattoo #vaccine #PNAS #lymph #immune #InMice

A new UCLA study reveals that #breast #milk from women living with #HIV contains significantly lower levels of #tryptophan , an essential #amino acid likely important for #infant #immune function, growth, and #brain development.
#Medical #Biomedical #sflorg
https://www.sflorg.com/2025/10/med10282502.html

A new study, led by experts at the University of Nottingham, has found that combining certain types of #dietary #supplements is more effective than single #prebiotics or #omega-3 in supporting #immune and metabolic health, which could lower the risk of conditions linked to chronic #inflammation.
#Medical #sflorg
https://www.sflorg.com/2025/10/med10162501.html

Three #scientists — Americans Mary E. Brunkow and Fred Ramsdell, and Japan’s Shimon Sakaguchi won the 2025 #NobelPrize in #Medicine for discovering how the body prevents its immune system from attacking itself through peripheral #immune tolerance, pioneering research that has advanced treatments for #cancer, #autoimmune #diseases, and #organ #transplants. #medicine #healthcare #research

Cells migrate as part of their normal function (patrolling #immune cells...), but also when malignant (think of #metastasis). Their velocity is an important parameter but difficult to quantify. Simo Kitanovski et al have developed a new quantitative Bayesian approach for experimental data analysis, #cellmig, that hopefully will set a new standard for reproducibility.
https://www.biorxiv.org/content/10.1101/2025.06.12.659342v2
Free open source software:
https://bioconductor.org/packages/cellmig/

#Immune systems of female and male mice age differently, study on #macrophages shows. Explains a mechanism of "inflammaging": survival of #inflammatory cells. https://www.nature.com/articles/d41586-025-02788-0

2025-8-9 I almost went in to anaphylaxis from drinking water.

https://www.illmarks.com/2025-8-9-i-almost-went-in-to-anaphylaxis-from-drinking-water/

#allergy #art #autoimmune #bodyHorror #bodyMapping #chronicIllness #immune #immunology #longCovid #longcovid #mastCell #mastcell #mcas #medArt #medBlog #medart #medicalArt #MillionsMissing #pwLC #pwme #sciArt #sciBlog #SciArt

2025-8-9 Is this MCAS anaphylaxis, anxiety, or anaphylaxis from anxiety?

I almost didn’t want to share this one, because I’m in a bit of a nervous state, and I was worried about the people who think people with Long Covid are psychological malingerers, etc. When I had to leave work, and filed for US Social Security Disability, I kept my Generalized Anxiety Disorder out of my initial application, afraid of getting the dreaded “just anxiety,” dismissal that many complex chronic illness kin are familiar with. (I was later told this was a bad move, and to definitely include all mental health and neurodivergence things, which I did for the ongoing process.)

Even as I’m having less anaphylaxis risk, it’s taking time to recover psychologically. I told my therapist how I felt like I backslid over a decade in mental health work overnight from the first recent anaphylaxis episode. She kindly said that while I might feel as scared and threatened as I often did back then, that the trigger was different. I was not feeling that anxious about an email, I was feeling that way about a literal life and death situation, one which I still don’t fully understand the triggers of.

A decade ago, de-stigmatizing mental healthcare was really important to me too. Now, I’m especially aware of how much these issues intersect, so heck yeah, publishing the medical art about anxiety.

Lastly, I wanted to include few examples of the ways in which these issues intersect. These are absolutely the tip of the iceberg.

• Mast Cell Activation Snydrome (often MCAS for space, in my art) can trigger so, so many pyschological symptoms. Mast Attack has a great overview of the topic, and while I haven’t been able to read the study fully because of the severe brain fog, Prevalence and treatment response of neuropsychiatric disorders in mast cell activation syndrome caught my eye.

• Anaphylaxis, or near anaphylaxis, has many symptoms in common with anxiety, from chest tightness to clammy skin, and “a feeling of impending doom”. While MCAS is not allergies, All Things Allergies has an easy intro to anxiety & anaphylaxis, and here’s a study The impact of anaphylaxis on the quality of life and mental health of adults.

• Ehlers-Danlos Syndrome co-occurs with many mental health issues, and I really appreciate how this article lists suspected mechanisms, misattributions, and related factors.

• Postural Orthostatic Tachycardia Syndrome, or POTS, is a form of autonomic dysfuntction (when things your body normally does automatically stop behaving normally), and is a part of my Long Covid. It involves a high heart rate, and often symptoms like room spinning or lightheadedness, trembling or shaking, shortness of breath, and poor bloodflow. POTS is often misdiagnosed as anxiety, and The Disabled Ginger wrote about it here.

Theories that diseases are caused by mental states and can be cured by will power are always an index of how much is not understood about the physical terrain of a disease.

Moreover, there is a peculiarly modern predilection for psychological explanations of a disease, as of everything else. Psychologizing seems to provide control over the experiences and events (like grave illnesses) over which people have in fact little or no control. Psychological understanding undermines the ‘reality’ of a disease. That reality has to be explained.

Susan Sontag, illness as metaphor (New York: Farrar, Straus and Giroux, 1977), p. 55.

p.s. mental health is physical health and physical health is mental health. you got a literal brain in your body and all of your body is involved in everything that you do. please take care of yourselves and each other. <3

https://www.illmarks.com/2025-8-9-is-this-mcas-anaphylaxis/

#allergy #anaphylaxis #anxiety #art #autoimmune #bodyHorror #bodyMapping #chronicIllness #gad #generalizedAnxiety #immune #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastCellDisease #mastcell #mcas #medart #medblog #medicalArt #medwriting #mentalHealth #MillionsMissing #pwLC #pwme #SciArt #sciblog #sciwriting #symptom

Off-the-shelf #cancer #vaccine elicits strong #immune response in #patients with #pancreatic and #colorectal cancer. Final trial results show durable #Tcell responses and reduced #relapse in patients with pancreatic and colorectal cancer https://www.uclahealth.org/news/release/shelf-cancer-vaccine-elicits-strong-immune-response-patients #medicine #science #research #KRAS patients https://www.uclahealth.org/news/release/shelf-cancer-vaccine-elicits-strong-immune-response-patients #health #HealthResearch #healthcare

#Neutrophils are very abundant and generally helpful #immune cells. However, in tumors they can misfire and form large clumps that block blood vessels. This blockage causes necrosis & metabolic adaptation of #tumor and #metastasis.
https://www.nature.com/articles/s41586-025-09278-3

Now that it's #disability #pride #month, I want to #remind #people that being #disordered doesn't mean you are #immune to being #ableist.
Yes this includes #personality disorders.
Yes this includes #autism.
Yes this includes #PTSD.
Yes this includes people with high #empathy.
Yes this includes #physically disabled people.
Yes this includes #cripplepunks.
No one is immune to #ableism. Not Me, not you, not anyone. What we can do is recognize our mistakes and try to improve upon them and ourselves.

Exciting #research! "Human #brain #cells engineered to #evade #detection by the #immune #system are a step towards development of a ‘universal’ cell line that can be transplanted into anyone, to cure a raft of diseases without the need for anti-rejection drugs." https://www.nature.com/articles/d41586-025-01080-5

There are a number of panicky Facebook posts, to which I will not link, going around about the "shocking" discovery that #mRNA #vaccines cross the #placental barrier. Which really shouldn't be a surprise to anyone, but #antivaxers gonna #antivax.

Okay, the discovery is real enough. Here's a direct link: https://www.sciencedirect.com/science/article/pii/S2162253125000435 Click the "View PDF" button at the top, just above the journal title, to read the full article. Note that this is a pre-print version, meaning there may be some typos and such, but nothing that's likely to change the results.

The problem is ... well, there's no problem here! #Maternal #immunity, however acquired, is routinely passed on to #fetuses: we're all born with #immune systems primed to deal with whatever #diseases our mothers have encountered, and that's a *good thing*.

Of course antivaxers who freak out about any occurrence of the abbreviation "mRNA," like the same people often freak out about the word "pronoun" or the "cis-" and "trans-" prefixes, think this is somehow evil.

It's not. It means *fewer dead kids*. These people would literally rather kill their children than learn anything that contradicts their ideology.

How #plants remember #stress without a brain

#epigenetics #transposons #immune #response #Immune_priming #soil #allelopathy

https://theconversation.com/how-plants-are-able-to-remember-stress-without-a-brain-246615

GB is a #brain #tumor originating in the brain or #spinal cord. Despite advances in #cancer treatment, it can remain resistant to therapies, including #immune checkpoint (ICP) blockade therapies.
#Medical #Neuroscience #Genetics #sflorg
https://www.sflorg.com/2025/02/med02052502.html

Still reeling from #PFAS spill, #BrunswickMaine residents push back on plans for #sludge treatment plant

by AnnMarie Hilton, Tue, January 28, 2025

"Brunswick resident Sandra Carslick said she and her neighbors have been living in a 'bad dream' for the five months since 1,600 gallons of toxic foam spilled so-called forever chemicals at the already contaminated former Naval Air Station nearby.

"At a Brunswick Town Council meeting on Monday night, Carslick said that bad dream could soon become residents’ 'worst nightmare,' if the town reopens a processing site for chemical-laden [#Biosolids] sludge from sewer treatment plants across Maine, and potentially beyond.

"The residents were responding to plans from Delaware-based #ViridiEnergy to update and expand #BrunswickLanding’s anaerobic digester, which converts sewage sludge — also referred to as #biosolids — into renewable natural gas and byproducts that get sent to landfills.

"During Monday’s presentation to the town council, company representatives explained how the facility would work and what local residents could expect. Several councilors said they would like to see additional data before deciding, but some already expressed concerns that the project isn’t right for Brunswick, particularly at this time. Members of the public also spoke for more than an hour, overwhelmingly concerned about the project and its potential to bring more #HarmfulChemicals into the area.
"The town is still dealing with the accidental discharge last summer of #firefighting foam containing #perfluoroalkyl and #polyfluoroalkyl substances, also known as #PFAS, at a hangar at #BrunswickExecutiveAirport, which is also situated at Brunswick Landing.

"The spill has prompted environmental and public health concerns over the PFAS, which have been linked to serious long-term health problems including #cancer, weakened #immune systems, developmental issues, and more. Since it started surveying and reviewing the material in the late 1980s, the U.S. Environmental Protection Agency [#EPA] has found more than 700 chemicals in sewage sludge, including PFAS.

"Chet Benham, a senior advisor and one of the founders of Viridi, tried to address those concerns during the meeting, telling residents the facility will operate according to all state and local requirements. He said there are protocols to prevent spills of the sludge that will move through the closed-loop facility.

"'We feel really, really good about it,' Benham said. 'We wouldn’t be standing here before you if we didn’t.' [Typical #Greenwashing #Bullshit]

"According to Viridi’s plan, the facility would take in about 85,000 tons of biosolids per year, which would be processed into renewable natural gas that would feed into Maine Natural Gas. About 10,000 tons of solid material byproduct would be sent from the plant to the #JuniperRidgeLandfill in Old Town. Over the course of the discussion, it came to light that Viridi would also likely bring in sludge from outside of Maine in order to run their facility at full capacity."

Read more:
https://news.yahoo.com/news/still-reeling-pfas-spill-brunswick-145952948.html
#WaterIsLife #PenobscotRiver #PenobscotNation #AndroscogginRiver #CascoBay

#Scratching an #itch could help boost your #immune defences

Mice that were free to #scratch their #itchy ears saw the number of #immunecells go up and levels of #infection-causing #bacteria decline

https://www.newscientist.com/article/2466106-scratching-an-itch-could-help-boost-your-immune-defences/

Attention-Worthy Links for December 23rd, 2024

https://bit.ly/awl1223a24

#Parker #1400'C #700000Km/h #Dec.24 #carbohydrate #caffeine #immune #kidney #molecules #microbes #A2RL #intuition #AI #chaos #cold #DMCA #UHC #Mangione takedown #illegal #Lexmark #Xerox #imaging #printing #A4 #APAC

Attention-Worthy Links for December 23rd, 2024

https://bit.ly/awl1223a24

#Parker #1400'C #700000Km/h #Dec.24 #carbohydrate #caffeine #immune #kidney #molecules #microbes #A2RL #intuition #AI #chaos #cold #DMCA #UHC #Mangione takedown #illegal #Lexmark #Xerox #imaging #printing #A4 #APAC

Attention-Worthy Links for December 23rd, 2024

https://bit.ly/awl1223a24

#Parker #1400'C #700000Km/h #Dec.24 #carbohydrate #caffeine #immune #kidney #molecules #microbes #A2RL #intuition #AI #chaos #cold #DMCA #UHC #Mangione takedown #illegal #Lexmark #Xerox #imaging #printing #A4 #APAC

Radboud study links #lockdowns to heightened #immune reactions #postpandemic

https://ground.news/article/the-immune-system-reacts-more-strongly-after-confinement?utm_source=mobile-app&utm_medium=newsroom-share

#SCOTUS #Trump #immunity ruling poses risk for #democracy, experts say

Former #Nixon White House counsel #JohnDean said Monday that had the court’s ruling been in force in the early 1970s, #history could have turned out very differently.

“As I looked at it, I realized Richard Nixon would have had a pass” because the #evidence against him was based on #OfficialActs the #SupremeCourt has deemed #immune from prosecution.

#law #PartisanCourt #ExtremeCourt
https://www.washingtonpost.com/politics/2024/07/01/supreme-court-immunity-trump-democracy/

“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of #immune #response,
and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author.

“We’ve uncovered new rules of the immune system.
This ‘unified healer army’ can do everything
– repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles.

To think that we could use it in such an enormous range of diseases is fantastic:
it’s got the potential to be used for almost everything.”

Lymphoid organs are integral parts of the immune system, responsible for producing #lymphocytes, a type of white blood cell that includes T cells.

T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest,
where they mature into specialized subsets, including #Tregs.

Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes
(some move to the bloodstream).

It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.

To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut.

They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.

“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️
– a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said
https://newatlas.com/medical/regulatory-t-cells-discovery/

#Trump's #SupremeCourt #immunity #arguments make me wish #Americans were #immune to #conartists.

That not one of the #SupremeCourt #justices didn’t just #standup during Thursday’s #oralarguments and say 'OK, this is #absurd. #YallNeedToStopIt!' is #disappointing

https://www.usatoday.com/story/opinion/columnist/2024/04/26/trump-immunity-supreme-court-election-interference/73457803007/

#PaulStamets
More info on benefits of #fungi.
Tell me your thoughts.
https://paulstamets.com/resume
https://www.uclahealth.org/news/turkey-tail-mushrooms-act-as-nonspecific-immune-modulators#:~:text=A%20preparation%20made%20from%20the,at%20work%20here%20remain%20unclear
https://fungi.com/blogs/articles/lions-mane-mushroom-benefits
https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq
#cancer #immune #health #mushroom #cancertreament #knowledge #lionsmane #turkey #turkeytail

(2/2)

#PaulStamets information on benefits of different #fungi (Personally have researched him among others for year.) for health worth viewing at least the YouTube video (Total of 7 minutes.).
https://youtu.be/pXHDoROh2hA?si=kz0ZravBhgkVNOj9
https://www.youtube.com/watch?v=uuL_faveAnw
#cancer #immune #health #mushroom #cancertreament #knowledge #lionsmane #turkey #turkeytail
(1/2)

From our November issue focussed on #CropScience, He et al. explore the potential for rapid alkalinization factor RALF22 to act as an #immune elicitor in #crop protection.
https://doi.org/10.1111/jipb.13566
@wileyplantsci
#JIPB #Plant #pathology #phytopathology #Brassica #fungus #pathogen

#Cannabinoids as novel #AntiInflammatory drugs

by Prakash Nagarkatti, et al.
October, 2009

Abstract:

"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."

Executive summary

- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).

- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.

- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.

- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

#Trump is not #immune from #prosecution in his 2020 #ElectionInterference #case #AppealsCourt rules in #unanimous #decision

“We conclude that the interest in #criminalaccountability, held by both the #public and the #ExecutiveBranch, outweighs the potential #risks of #chilling #Presidential #action and #permitting #vexatious #litigation,” the #judges wrote.

#Women #Transgender #LGBTQ #LGBTQIA #Politics #Progress

https://apnews.com/article/trump-capitol-riot-presidential-immunity-appeal-46c2d7fc7807cd3262764d35e47f390e