#organoids — Public Fediverse posts

https://www.europesays.com/ie/672584/ Crucial brain stem cells rely on metabolic pathways to make decisions #Brain #cancer #Cell #Cortex #Éire #Glucose #Health #IE #Ireland #Language #medicine #Metabolism #Neurons #Organoids #ProgenitorCells #Research #StemCells #Thalamus

Les Organoides (iPSC ou cell. primaires), c'est pas nouveau. En labo, on les utilise en technique alternative toxico pour les fonctions hépatiques, rénales ou le dev de nouveaux traitements.
Comme, par exemple, l'etude montrant le lien entre stress oxydatif (Hypoxie/Hyperoxie) et régulation genétique (1).

La video de TRY explore un pan spécifique, le premier "Organoide-Computeur" de Cortical Labs, nommé CL1, et ses implications éthiques:
youtu.be/yGjy8La0kdU

(1) : pmc.ncbi.nlm.nih.gov/articles/PMC12315710/

Cc: @tournesol @denissalem
#organoidresearch #organoids #organoide #corticallabs

A recent study utilizes 3D human brain #organoids to investigate how the widely used antiepileptic drug valproate disrupts early fetal brain development and contributes to neurodevelopmental disorders.
#Neuroscience #Neuropharmacology #DevelopmentalBiology #sflorg
https://www.sflorg.com/2026/04/ns04302601.html

#Retina #organoids are lab-grown, three-dimensional clusters of retinal tissue derived from fetal cells that replicate the developmental processes of the human eye in a controlled environment.
#Biology #Ophthalmology #RegenerativeMedicine #sflorg
https://www.sflorg.com/2026/02/bio02182601.html

#Oropouche virus infects primary #human #intestinal #organoids and is inhibited by type I and III interferon treatment, https://etidiohnew.blogspot.com/2026/02/oropouche-virus-infects-primary-human.html

A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration.

#Transposons #Retrotransposons #SVA #XLinkedDystoniaParkinsonism #XDP #Neurodegeneration #Organoids #ShortTandemRepeats #Rloops #AntisenseNucleotides

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00583-2

Check out the lab's work: https://liberalilab.org/

They get biopsies from #human patients then can make #organoids from single stem cells, and study development and regeneration of all cell types, with custom culture media they developed (!)

Their #intestinal organoids are very similar to early development, showing fetal gene expression signature