#telomeres — Public Fediverse posts

#cancer #sugar #telomeres

"Babies born under sugar rationing grew into adults with lower cancer risk

Could how much sugar you consumed before your second birthday shape your health decades later – even into your 70s?

A new study that my colleagues and I conducted suggests the answer could be yes. People who had less sugar exposure during the first few years of life were much less likely to develop several different cancers later in life, and they also showed signs of slower biological ageing. We also found that even in adulthood, they continued to consume less sugar and had healthier diets overall.

This is not an easy question to study in real life. Researchers obviously can’t run that experiment on real babies – split them into groups, feed one group sugar, then wait 70 years to see what happens.

Britain’s postwar sugar rationing offered a rare alternative. After the second world war, sugar remained rationed in Britain for several years. But in September 1953, rationing ended and people started eating a lot more sugar. Consumption nearly doubled. This meant that children born just a few months apart had very different levels of sugar exposure both in the womb and during early childhood.

For our study, we used data from over 64,000 people born in Britain between 1951 and 1956. Those born earlier spent a larger share of their first 1,000 days under sugar rationing, while those born later experienced progressively less of it.

(. . .)

We also found that exposure to sugar rationing is related to biological ageing. Biological age is not the same as chronological age. Two people may both be 70 years old, while their cells and immune systems show different levels of ageing.

One way we measure biological ageing is through telomere length. Telomeres are protective structures located at the ends of chromosomes. As cells age, telomeres usually become shorter."

https://theconversation.com/babies-born-under-sugar-rationing-grew-into-adults-with-lower-cancer-risk-289873

Noticed an excessively long label peeling off a flask today. This telomere analogy sprang to mind:

#Chromosomes #Telomeres #Humor #ScienceHumor #Biology

@paninid Yes, #chemistry advances in #PublicHealth of past centuries is the reason for HUGE gains in human #longevity. But research on #telomeres (our ‘biological clock’) is still very promising, if only for potentially universal #cancer therapies.

Basic #science is also fascinating for the curious mind and fun to do! https://theacademic.com/unravelling-the-hydrogen-bonding-patterns-in-telomeric-g-quadruplexes-from-structure-to-function/

Harvard study of 1K people who came to their center in Boston for testing found a 75% reduction in loss of telomere length over 4 years from 2K IU of vit D3 daily. Given Boston, likely these people were mostly vit D deficient to begin with. I'm not finding the free full text of the study, only articles about it like [1], and the study abstract [2].

[1] https://www.ifm.org/articles/vitamin-d-slow-telomere-shortening

[2] https://doi.org/10.1016/j.ajcnut.2025.05.003

#vitaminD #telomeres

@SocraticEthics #Putin will be the first to prove they were just spewing #propaganda to suppress #resistance. Then #Xi. Hopefully, #Trump will win the ‘race to the bottom 🔥’.

#Cancer cells achieve immortality by extending #DNA #telomeres 🧬. They are welcome to it! 🙏 

#8647now #Resist , #DoNotComply and #DoNotCollaborateWithFascists in #USpol or anywhere else!

@benroyce #Putin will be the first to prove they were just spewing #propaganda to suppress #resistance. Then #Xi. Hopefully, #Trump will win the ‘race to the bottom 🔥’.

#Cancer cells achieve immortality by extending #DNA #telomeres 🧬. They are welcome to it! 🙏

#8647now #Resist , #DoNotComply and #DoNotCollaborateWithFascists in #USpol or anywhere else!

@meduza_en #Putin will be the first to prove they were just spewing #propaganda to suppress #resistance. Then #Xi. Hopefully, #Trump will win the ‘race to the bottom 🔥’.

#Cancer cells achieve immortality by extending #DNA #telomeres 🧬. They are welcome to it! 🙏

#8647now #Resist , #DoNotComply and #DoNotCollaborateWithFascists in #USpol or anywhere else!

“Results from a randomized controlled trial reveal that vitamin D supplementation helps maintain telomeres, protective caps at the ends of chromosomes that shorten during aging and are linked to the development of certain diseases.” #isogg #Harvard #geneadons #dna #VITAL #vitaminD #telomeres #epigenetics https://news.harvard.edu/gazette/story/2025/05/vitamin-d-supplements-may-slow-biological-aging/

How Tiny Molecular Machines Keep Our Cells Alive and Thriving

#CellBiology #AgingScience #Telomeres #OxidativeStress #Mitochondria #CircadianRhythms #StemCells #Genetics #CancerResearch #HealthAndWellness

https://youtube.com/shorts/B8zklp2WQsg?feature=share

I just learned that #NationalDNAday in the #UnitedStates was yesterday. I hope it's not too late to celebrate with some eye-candy depicting the hydrogen-bonding of a guanine quadruplex found in #DNA 🧬 #telomeres.

Explanation here: https://theacademic.com/unravelling-the-hydrogen-bonding-patterns-in-telomeric-g-quadruplexes-from-structure-to-function/

#Bacterial ' #jumping_genes' can target and control #chromosome ends.

#transposons #telomeres #Streptomyces #genomes

https://phys.org/news/2025-03-bacterial-genes-chromosome.html

#Data-driven techniques enhance understanding of #cell division.

#mitosis #transposons #Telomeres #chromatin

https://phys.org/news/2025-02-driven-techniques-cell-division.html

Globally, scientists are working to unlock the secrets of extending human #lifespan at the #cellular level, where #aging occurs gradually due to the shortening of #telomeres the protective caps at the ends of #chromosomes that function like shoelace tips to prevent unraveling.
#Bioengineering #Genetics #Pharmaceutical #sflorg
https://www.sflorg.com/2025/02/beng02042501.html

Telomeres by Sleep Token | Personalized Music Box from Donuma

#SleepToken #Telomeres #RockMusic #UniqueGifts

Go Nuts for a longer life.

Greens, Green Tea, and Nuts Put to the Test for Telomeres
https://www.youtube.com/watch?v=SculWYzztSU

#NutritionFacts #DrMichaelGreger #Telomeres

Oh no!! On top of everything else, #Covid19 shortens your #Telomeres… 😱

From: @KeithDJohnson
https://sfba.social/@KeithDJohnson/111631551946521789

"Unexpectedly, approximately 15% of the steady state population of hTR has a CR4/5 conformation lacking features required for hTERT binding. Mutagenesis demonstrates that stabilization of the alternative CR4/5 conformation is detrimental to telomerase assembly and activity. We propose that this misfolded portion of the cellular hTR pool is either slowly refolded or degraded."

#Preprint #Telomeres #Telomerase

https://www.biorxiv.org/content/10.1101/2023.10.04.560962v1

Far from extending life, #long #telomeres appear to cause #cancer and a blood #disorder known as #CHIP, a condition that increases the risk of blood cancers and heart disease.

The longer a person’s telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality.

https://www.nytimes.com/2023/05/04/health/long-telomeres-age-longevity.html?smid=nytcore-ios-share&referringSource=articleShare

'Pot1 is a subunit of telomere capping complex that binds to the G-rich overhang and inhibits the activation of DNA damage checkpoints. In this study, we explore new functions of fission yeast Pot1 by using a pot1-1 temperature sensitive mutant'
@miguelgf et al

#telomeres #telomere

https://www.biorxiv.org/content/10.1101/2023.01.23.525167v1