#dendriticcells — Public Fediverse posts

@gpollara @JExpMed Intriguing. In an earlier postdoc position I had a look at #DendriticCells, and especially the #cDC1 were abundant, but seemed to be just sitting in the inflammatory environment, doing little. One of the very abundant cytokines: #IL6

We also looked at the effect of that and other #cytokines, but mostly on #Tcells, among others due to the low abundance of cDC1 in HC blood to be able to do many in vitro experiments.

The paper focuses on #DendriticCells (DC) and #monocytes from a local inflammatory site, in this case synovial fluid from swollen joints of mainly juvenile #arthritis patients.
Very short: one type of DC were very much enriched but seemed relatively quiescent despite the inflammatory surroundings, while other DC and monocytes behaved clearly pro-inflammatory.

Last week, the paper based on my work in the Wilhelmina Children's Hospital (WKZ) was published, with the title "Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis".
https://doi.org/10.3389/fimmu.2022.1101999

Credits to Anoushka Samat for taking care of this after I left the department. Without her this work would not be out there. And of course thanks to the rest of the team.

#immunology #RNAseq #inflammation #DendriticCells #monocytes

Dear people interested in #organoids #Tcells #Macrophages #Bcells #DendriticCells #MucosalImmunology #microbiome #OrganOnChip #MicroPhysiologicalSystems #IBD #CeliacDisease #iPSCs,

where are you? I want to follow you!

Best regards,
Me