#mucosalimmunology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #mucosalimmunology, aggregated by home.social.
-
'A subset of regulatory T cells expressing the transcription factor RORγ decreased in frequency in the colon and cecum after activation of spinal sensory neurons expressing the pain receptor Trpv1. These neurons communicated with the T cells directly through the calcitonin gene–related peptide.'
#Immunology #MucosalImmunology
https://www.science.org/doi/10.1126/science.adk1679 -
'A subset of regulatory T cells expressing the transcription factor RORγ decreased in frequency in the colon and cecum after activation of spinal sensory neurons expressing the pain receptor Trpv1. These neurons communicated with the T cells directly through the calcitonin gene–related peptide.'
#Immunology #MucosalImmunology
https://www.science.org/doi/10.1126/science.adk1679 -
'A subset of regulatory T cells expressing the transcription factor RORγ decreased in frequency in the colon and cecum after activation of spinal sensory neurons expressing the pain receptor Trpv1. These neurons communicated with the T cells directly through the calcitonin gene–related peptide.'
#Immunology #MucosalImmunology
https://www.science.org/doi/10.1126/science.adk1679 -
'A subset of regulatory T cells expressing the transcription factor RORγ decreased in frequency in the colon and cecum after activation of spinal sensory neurons expressing the pain receptor Trpv1. These neurons communicated with the T cells directly through the calcitonin gene–related peptide.'
#Immunology #MucosalImmunology
https://www.science.org/doi/10.1126/science.adk1679 -
'Here, we established a mouse model of sexual dimorphism during GI colonization by MRSA. Our results show that in contrast to male mice that were susceptible to persistent colonization, female mice rapidly cleared MRSA from the GI tract following oral inoculation in a manner dependent on the gut microbiota.'
#Immunology #Preprint #MucosalImmunology -
'Here, we established a mouse model of sexual dimorphism during GI colonization by MRSA. Our results show that in contrast to male mice that were susceptible to persistent colonization, female mice rapidly cleared MRSA from the GI tract following oral inoculation in a manner dependent on the gut microbiota.'
#Immunology #Preprint #MucosalImmunology -
'Here, we established a mouse model of sexual dimorphism during GI colonization by MRSA. Our results show that in contrast to male mice that were susceptible to persistent colonization, female mice rapidly cleared MRSA from the GI tract following oral inoculation in a manner dependent on the gut microbiota.'
#Immunology #Preprint #MucosalImmunology -
'Here, we established a mouse model of sexual dimorphism during GI colonization by MRSA. Our results show that in contrast to male mice that were susceptible to persistent colonization, female mice rapidly cleared MRSA from the GI tract following oral inoculation in a manner dependent on the gut microbiota.'
#Immunology #Preprint #MucosalImmunology -
"A diverse set of pulmonary inflammatory stimuli, including resolved antecedent respiratory infections with S. aureus or influenza, ongoing pulmonary M. tuberculosis infection, ovalbumin/alum-induced asthma or airway administration of defined TLR ligands and recombinant cytokines, all establish an antiviral state in the lung that restricts SARS-CoV-2 replication upon infection."
#covid19 #Covid #Virology #Immunology #MucosalImmunology #Preprint -
"A diverse set of pulmonary inflammatory stimuli, including resolved antecedent respiratory infections with S. aureus or influenza, ongoing pulmonary M. tuberculosis infection, ovalbumin/alum-induced asthma or airway administration of defined TLR ligands and recombinant cytokines, all establish an antiviral state in the lung that restricts SARS-CoV-2 replication upon infection."
#covid19 #Covid #Virology #Immunology #MucosalImmunology #Preprint -
"A diverse set of pulmonary inflammatory stimuli, including resolved antecedent respiratory infections with S. aureus or influenza, ongoing pulmonary M. tuberculosis infection, ovalbumin/alum-induced asthma or airway administration of defined TLR ligands and recombinant cytokines, all establish an antiviral state in the lung that restricts SARS-CoV-2 replication upon infection."
#covid19 #Covid #Virology #Immunology #MucosalImmunology #Preprint -
"A diverse set of pulmonary inflammatory stimuli, including resolved antecedent respiratory infections with S. aureus or influenza, ongoing pulmonary M. tuberculosis infection, ovalbumin/alum-induced asthma or airway administration of defined TLR ligands and recombinant cytokines, all establish an antiviral state in the lung that restricts SARS-CoV-2 replication upon infection."
#covid19 #Covid #Virology #Immunology #MucosalImmunology #Preprint -
"Here we show that deletion of ST2, the receptor for interleukin (IL)-33, on Treg cells increased granulocyte influx into the lung and increased cytokine production by innate lymphoid and γδ T cells without alteration of adaptive immunity to influenza."
#immunology #MucosalImmunology -
"Here we show that deletion of ST2, the receptor for interleukin (IL)-33, on Treg cells increased granulocyte influx into the lung and increased cytokine production by innate lymphoid and γδ T cells without alteration of adaptive immunity to influenza."
#immunology #MucosalImmunology -
"Here we show that deletion of ST2, the receptor for interleukin (IL)-33, on Treg cells increased granulocyte influx into the lung and increased cytokine production by innate lymphoid and γδ T cells without alteration of adaptive immunity to influenza."
#immunology #MucosalImmunology -
"Here we show that deletion of ST2, the receptor for interleukin (IL)-33, on Treg cells increased granulocyte influx into the lung and increased cytokine production by innate lymphoid and γδ T cells without alteration of adaptive immunity to influenza."
#immunology #MucosalImmunology -
'Although mouse and human MAIT cell transcriptomes showed similarities for immature cells in the thymus, they diverged more strikingly in the periphery. Analysis of pet store mice demonstrated decreased lung MAIT17 cells in these so-called “dirty” mice, indicative of an environmental influence on MAIT cell subsets and function.'
-
'Although mouse and human MAIT cell transcriptomes showed similarities for immature cells in the thymus, they diverged more strikingly in the periphery. Analysis of pet store mice demonstrated decreased lung MAIT17 cells in these so-called “dirty” mice, indicative of an environmental influence on MAIT cell subsets and function.'
-
'Although mouse and human MAIT cell transcriptomes showed similarities for immature cells in the thymus, they diverged more strikingly in the periphery. Analysis of pet store mice demonstrated decreased lung MAIT17 cells in these so-called “dirty” mice, indicative of an environmental influence on MAIT cell subsets and function.'
-
'Although mouse and human MAIT cell transcriptomes showed similarities for immature cells in the thymus, they diverged more strikingly in the periphery. Analysis of pet store mice demonstrated decreased lung MAIT17 cells in these so-called “dirty” mice, indicative of an environmental influence on MAIT cell subsets and function.'
-
"Although type 1 conventional dendritic cells (cDC1s) were not required for initial priming of CD4+ T cells, cDC1s were required for CD4+ T cell expansion and gut homing. cDC1s were also a major source of IL-12 that was not required for priming but promoted full differentiation of CD4+ T cells and local production of IFN-γ. Together, these studies reveal distinct roles for cDC1s in shaping CD4+ T cell responses to enteric infection: first to drive early expansion in the mesLN and second to drive effector responses in the gut."
#InfectionImmunity #Immunology #MucosalImmunology #parasitology #Preprint -
"Although type 1 conventional dendritic cells (cDC1s) were not required for initial priming of CD4+ T cells, cDC1s were required for CD4+ T cell expansion and gut homing. cDC1s were also a major source of IL-12 that was not required for priming but promoted full differentiation of CD4+ T cells and local production of IFN-γ. Together, these studies reveal distinct roles for cDC1s in shaping CD4+ T cell responses to enteric infection: first to drive early expansion in the mesLN and second to drive effector responses in the gut."
#InfectionImmunity #Immunology #MucosalImmunology #parasitology #Preprint -
"Although type 1 conventional dendritic cells (cDC1s) were not required for initial priming of CD4+ T cells, cDC1s were required for CD4+ T cell expansion and gut homing. cDC1s were also a major source of IL-12 that was not required for priming but promoted full differentiation of CD4+ T cells and local production of IFN-γ. Together, these studies reveal distinct roles for cDC1s in shaping CD4+ T cell responses to enteric infection: first to drive early expansion in the mesLN and second to drive effector responses in the gut."
#InfectionImmunity #Immunology #MucosalImmunology #parasitology #Preprint -
"Although type 1 conventional dendritic cells (cDC1s) were not required for initial priming of CD4+ T cells, cDC1s were required for CD4+ T cell expansion and gut homing. cDC1s were also a major source of IL-12 that was not required for priming but promoted full differentiation of CD4+ T cells and local production of IFN-γ. Together, these studies reveal distinct roles for cDC1s in shaping CD4+ T cell responses to enteric infection: first to drive early expansion in the mesLN and second to drive effector responses in the gut."
#InfectionImmunity #Immunology #MucosalImmunology #parasitology #Preprint -
"Despite the high success of the current COVID-19 vaccines, there are several limitations, including their reduced effectiveness against SARS-CoV-2 VoCs, short duration of protection, inability to induce a mucosal immune response to protect the airways, and high cost of production or distribution (11, 12). Therefore, there is an urgent need to develop the next generation of intranasal COVID-19 vaccines which induce durable and broadly protective immunity, both in the airways and systemically."
-
"Despite the high success of the current COVID-19 vaccines, there are several limitations, including their reduced effectiveness against SARS-CoV-2 VoCs, short duration of protection, inability to induce a mucosal immune response to protect the airways, and high cost of production or distribution (11, 12). Therefore, there is an urgent need to develop the next generation of intranasal COVID-19 vaccines which induce durable and broadly protective immunity, both in the airways and systemically."
-
"Despite the high success of the current COVID-19 vaccines, there are several limitations, including their reduced effectiveness against SARS-CoV-2 VoCs, short duration of protection, inability to induce a mucosal immune response to protect the airways, and high cost of production or distribution (11, 12). Therefore, there is an urgent need to develop the next generation of intranasal COVID-19 vaccines which induce durable and broadly protective immunity, both in the airways and systemically."
-
"Despite the high success of the current COVID-19 vaccines, there are several limitations, including their reduced effectiveness against SARS-CoV-2 VoCs, short duration of protection, inability to induce a mucosal immune response to protect the airways, and high cost of production or distribution (11, 12). Therefore, there is an urgent need to develop the next generation of intranasal COVID-19 vaccines which induce durable and broadly protective immunity, both in the airways and systemically."
-
The lung mycobiome & anti-tumor immunity
"Our study revealed that the intratumor mycobiome, albeit at low biomass, plays an important role in stimulating the immunosuppressive TME and thereby promotes lung tumor progression and is associated with poor patient outcome."
#Immunology #MucosalImmunologyhttps://www.sciencedirect.com/science/article/abs/pii/S153561082300288X
-
The lung mycobiome & anti-tumor immunity
"Our study revealed that the intratumor mycobiome, albeit at low biomass, plays an important role in stimulating the immunosuppressive TME and thereby promotes lung tumor progression and is associated with poor patient outcome."
#Immunology #MucosalImmunologyhttps://www.sciencedirect.com/science/article/abs/pii/S153561082300288X
-
The lung mycobiome & anti-tumor immunity
"Our study revealed that the intratumor mycobiome, albeit at low biomass, plays an important role in stimulating the immunosuppressive TME and thereby promotes lung tumor progression and is associated with poor patient outcome."
#Immunology #MucosalImmunologyhttps://www.sciencedirect.com/science/article/abs/pii/S153561082300288X
-
The lung mycobiome & anti-tumor immunity
"Our study revealed that the intratumor mycobiome, albeit at low biomass, plays an important role in stimulating the immunosuppressive TME and thereby promotes lung tumor progression and is associated with poor patient outcome."
#Immunology #MucosalImmunologyhttps://www.sciencedirect.com/science/article/abs/pii/S153561082300288X
-
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
-
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
-
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
-
"Salmonella Typhimurium mutants for spermidine transport and synthesis cannot mount an antioxidative response, resulting in high intracellular ROS levels. These mutants are also compromised in their ability to be phagocytosed by macrophages"
#Microbiology #Preprint #Salmonella #MucosalImmunology #immunology
https://www.biorxiv.org/content/10.1101/2023.09.29.560257v1?med=mas
-
'Here, we have shown that IgA B cell receptor (BCR) is required for B cell fitness during the germinal center (GC) reaction in Peyer’s patches (PPs) and for generation of gut-homing plasma cells (PCs).'
#Immunology #MucosalImmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00374-6
-
'Here, we have shown that IgA B cell receptor (BCR) is required for B cell fitness during the germinal center (GC) reaction in Peyer’s patches (PPs) and for generation of gut-homing plasma cells (PCs).'
#Immunology #MucosalImmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00374-6
-
'Here, we have shown that IgA B cell receptor (BCR) is required for B cell fitness during the germinal center (GC) reaction in Peyer’s patches (PPs) and for generation of gut-homing plasma cells (PCs).'
#Immunology #MucosalImmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00374-6
-
'Here, we have shown that IgA B cell receptor (BCR) is required for B cell fitness during the germinal center (GC) reaction in Peyer’s patches (PPs) and for generation of gut-homing plasma cells (PCs).'
#Immunology #MucosalImmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00374-6
-
"Here we find, in a clinical cohort of at-risk infants, broad spectrum antibiotic treatment, including cephalosporins, increased the risk of late-onset sepsis in neonates in comparison to penicillin base treatments"
#Preprint #Immunology #MucosalImmunologyhttps://www.medrxiv.org/content/10.1101/2023.09.04.23295031v1
-
"Here we find, in a clinical cohort of at-risk infants, broad spectrum antibiotic treatment, including cephalosporins, increased the risk of late-onset sepsis in neonates in comparison to penicillin base treatments"
#Preprint #Immunology #MucosalImmunologyhttps://www.medrxiv.org/content/10.1101/2023.09.04.23295031v1
-
"Here we find, in a clinical cohort of at-risk infants, broad spectrum antibiotic treatment, including cephalosporins, increased the risk of late-onset sepsis in neonates in comparison to penicillin base treatments"
#Preprint #Immunology #MucosalImmunologyhttps://www.medrxiv.org/content/10.1101/2023.09.04.23295031v1
-
"Here we find, in a clinical cohort of at-risk infants, broad spectrum antibiotic treatment, including cephalosporins, increased the risk of late-onset sepsis in neonates in comparison to penicillin base treatments"
#Preprint #Immunology #MucosalImmunologyhttps://www.medrxiv.org/content/10.1101/2023.09.04.23295031v1
-
'Although infection and these translocated effector proteins are restricted to intestinal epithelial cells (IEC), type I dendritic cells (cDC1) were required to generate CD8+ T cell responses to these model antigens.'
-
'Although infection and these translocated effector proteins are restricted to intestinal epithelial cells (IEC), type I dendritic cells (cDC1) were required to generate CD8+ T cell responses to these model antigens.'
-
'Although infection and these translocated effector proteins are restricted to intestinal epithelial cells (IEC), type I dendritic cells (cDC1) were required to generate CD8+ T cell responses to these model antigens.'
-
'Although infection and these translocated effector proteins are restricted to intestinal epithelial cells (IEC), type I dendritic cells (cDC1) were required to generate CD8+ T cell responses to these model antigens.'
-
"Patients with Crohn’s disease have increased levels of anti-S. cerevisiae antibodies (which detect mannan, a common component of the fungal cell wall. Measurement of these antibodies can be used to distinguish between Crohn’s disease & ulcerative colitis"
#Immunology #MucosalImmunologyhttps://www.nature.com/articles/s41575-023-00816-w?utm_source=dlvr.it&utm_medium=twitter
-
"Patients with Crohn’s disease have increased levels of anti-S. cerevisiae antibodies (which detect mannan, a common component of the fungal cell wall. Measurement of these antibodies can be used to distinguish between Crohn’s disease & ulcerative colitis"
#Immunology #MucosalImmunologyhttps://www.nature.com/articles/s41575-023-00816-w?utm_source=dlvr.it&utm_medium=twitter