#autophagy — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #autophagy, aggregated by home.social.
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Reversible suppression of autophagy in a mouse model reveals neuronal resilience.
Japanese researchers created a unique mouse model in which autophagy could be rapidly switched off and restarted using doxycycline. Just four weeks after autophagy was stopped, protein aggregates accumulated in neurons, protein and RNA composition was disrupted, axonal swellings appeared, and the animals developed motor and cognitive impairments.
However, the next stage of the experiment proved most unexpected: after autophagy was restored, most of these changes disappeared. Neurons were cleared of toxic debris, synapse and axon structure was restored, and the mice again successfully passed memory and motor coordination tests.
This study demonstrates that even after significant disruption of cellular homeostasis, nervous tissue retains significant potential for recovery if intracellular degradation mechanisms are reactivated.
If you clutter your house for too long and don't throw out everything that's broken, it will seem like it's no longer fit for habitation. But: clean it, tidy it up, and it'll be as good as new :)#science #cellular_biology #neurology #brain #autophagy #biology
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Reversible suppression of autophagy in a mouse model reveals neuronal resilience.
Japanese researchers created a unique mouse model in which autophagy could be rapidly switched off and restarted using doxycycline. Just four weeks after autophagy was stopped, protein aggregates accumulated in neurons, protein and RNA composition was disrupted, axonal swellings appeared, and the animals developed motor and cognitive impairments.
However, the next stage of the experiment proved most unexpected: after autophagy was restored, most of these changes disappeared. Neurons were cleared of toxic debris, synapse and axon structure was restored, and the mice again successfully passed memory and motor coordination tests.
This study demonstrates that even after significant disruption of cellular homeostasis, nervous tissue retains significant potential for recovery if intracellular degradation mechanisms are reactivated.
If you clutter your house for too long and don't throw out everything that's broken, it will seem like it's no longer fit for habitation. But: clean it, tidy it up, and it'll be as good as new :)#science #cellular_biology #neurology #brain #autophagy #biology
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#ExerciseForHealth #Autophagy #Wellness #HealthyHabits #FitnessMotivation #Biohacking #CellularHealth #WellnessLifestyle #WellbeingJourney #HealthyAging #WellnessCommunity #WellnessGoals #EmotionalWellbeing #WellnessWarrior #PhysicalWellbeing https://mastodon.social/@biohackingpathway/116831006796406543
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TRIM21 induces selective #autophagy of viruses & bacteria.
TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.
#innateimmunity #immunity #microbiology #immunology
https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html
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TRIM21 induces selective #autophagy of viruses & bacteria.
TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.
#innateimmunity #immunity #microbiology #immunology
https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html
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Subject: Fasting, health, and low-calorie feast. Hopefully, this post will be useful to others seeking to lose weight and improve quality of life.
Illustration: The photo shows my first meal after a 3-day water fast [and the only meal for that day]. It took me most of the day to eat it. Note the protein. It's important for reasons explained below.
Surprisingly, the feast in the photo adds up to only 1,700 calories. That's low enough for me to lose weight on, but I'll try to get it down to the 1,200 to 1,650 calories range as frequently as possible. Regardless, as the photo shows, if you'd like to diet, you don't need to starve.
In 2013, I was referred to as "gaunt". Just a year later, I was seriously overweight. I've been up and down since then. I'm approaching age 70 and overweight at that age means deceased. It's time to stabilize to a reasonable weight.
I completed a 3-day [77 hour] water fast today. The fast ran from about 9:00am PT on Sunday [May 24, 2026] to 2:00pm PT on Wednesday [May 27, 2026]. Note: I'd had no food since Saturday, but I did have a bottle of orange Gatorade about an hour before I started the 77 hours.
A water fast is, ideally, a minimum of 72 hours during which you consume only water. It can go to 4 to 5 days, but even just 3 days is risky. This type of fast can have major benefits, but it can also lead to damage or, in some cases, death. It's safer to limit it to 3 to 4 days.
Positive effects can include temporary #autophagy, #ketosis, and improved immune response and #insulin sensitivity. Autophagy is a cellular repair step. Ketosis means, essentially, "burn fat". In short, a water fast can be a thumbs up for weight loss and health in general.
However, negative effects can include a condition called refeeding syndrome, which is potentially fatal; keto flu, which can include headaches, nausea, dizziness, and vomiting; loss of muscle tissue in addition to fat; and strain on the cardiovascular system that can cause damage.
Muscle tissue loss can be reduced, to some extent, by temporarily increasing protein intake immediately after a water fast.
An additional catch is that, after a fast of any type, one can't eat too much in the way of processed foods such as fast food or lost weight will come right back.
In my case, my fast was 100% water during the 77 hours except for a bottle of diet cola. A review shows that, even though diet cola has zero calories, it can interfere with the benefits of fasting. So, I'll try to skip the drink next time.
I took non-gummy multivitamin tablets one day as well. The non-gummy type has zero calories, but I'll probably skip vitamins as well during future fasts as this is advised.
Oddly, I wasn't conscious of hunger at any stage. Towards the end, I did imagine a turkey wing. I think that there were other side effects during the fast, but I'm not certain.
I plan to repeat the fast periodically. I'll do 3 days on the fast and a number of days eating; then repeat the cycle. During eating days, I'll try to minimize processed foods, especially fast food. I figure, perhaps one restaurant meal for every 1 or 2 cycles. We'll see how it goes. In the end, perhaps I'll have a workable long-term Coder Diet.
My first post-fast meal this time, and the only meal for the day [Wednesday, May 27, 2026] is shown in the attached photo.
The meal is a large turkey wing, 275g sliced ham, 1.5 lbs of grape tomatoes, 9 baby potatoes, 4 large carrots, 3 green onions, 5 sweet mini-peppers, 4 small plums, 2 nectarines, and 1 medium honeycrisp apple. The beverage is water with a small amount of rice vinegar added.
I ended up not eating the apple at the time. Estimated calories for the rest: 1,700 calories. Estimated cost for the rest: $24.00. Note: About 70% of the cost came from the meat and the 1.5 lbs of grape tomatoes.
One take-away is that baby potatoes, sweet mini-peppers, carrots, apples, small plums, and especially green onions are all major bargains from both a cost and a calories perspective. Green onions are practically free in both contexts.
#diet #fasting #health -
Subject: Fasting, health, and low-calorie feast. Hopefully, this post will be useful to others seeking to lose weight and improve quality of life.
Illustration: The photo shows my first meal after a 3-day water fast [and the only meal for that day]. It took me most of the day to eat it. Note the protein. It's important for reasons explained below.
Surprisingly, the feast in the photo adds up to only 1,700 calories. That's low enough for me to lose weight on, but I'll try to get it down to the 1,200 to 1,650 calories range as frequently as possible. Regardless, as the photo shows, if you'd like to diet, you don't need to starve.
In 2013, I was referred to as "gaunt". Just a year later, I was seriously overweight. I've been up and down since then. I'm approaching age 70 and overweight at that age means deceased. It's time to stabilize to a reasonable weight.
I completed a 3-day [77 hour] water fast today. The fast ran from about 9:00am PT on Sunday [May 24, 2026] to 2:00pm PT on Wednesday [May 27, 2026]. Note: I'd had no food since Saturday, but I did have a bottle of orange Gatorade about an hour before I started the 77 hours.
A water fast is, ideally, a minimum of 72 hours during which you consume only water. It can go to 4 to 5 days, but even just 3 days is risky. This type of fast can have major benefits, but it can also lead to damage or, in some cases, death. It's safer to limit it to 3 to 4 days.
Positive effects can include temporary #autophagy, #ketosis, and improved immune response and #insulin sensitivity. Autophagy is a cellular repair step. Ketosis means, essentially, "burn fat". In short, a water fast can be a thumbs up for weight loss and health in general.
However, negative effects can include a condition called refeeding syndrome, which is potentially fatal; keto flu, which can include headaches, nausea, dizziness, and vomiting; loss of muscle tissue in addition to fat; and strain on the cardiovascular system that can cause damage.
Muscle tissue loss can be reduced, to some extent, by temporarily increasing protein intake immediately after a water fast.
An additional catch is that, after a fast of any type, one can't eat too much in the way of processed foods such as fast food or lost weight will come right back.
In my case, my fast was 100% water during the 77 hours except for a bottle of diet cola. A review shows that, even though diet cola has zero calories, it can interfere with the benefits of fasting. So, I'll try to skip the drink next time.
I took non-gummy multivitamin tablets one day as well. The non-gummy type has zero calories, but I'll probably skip vitamins as well during future fasts as this is advised.
Oddly, I wasn't conscious of hunger at any stage. Towards the end, I did imagine a turkey wing. I think that there were other side effects during the fast, but I'm not certain.
I plan to repeat the fast periodically. I'll do 3 days on the fast and a number of days eating; then repeat the cycle. During eating days, I'll try to minimize processed foods, especially fast food. I figure, perhaps one restaurant meal for every 1 or 2 cycles. We'll see how it goes. In the end, perhaps I'll have a workable long-term Coder Diet.
My first post-fast meal this time, and the only meal for the day [Wednesday, May 27, 2026] is shown in the attached photo.
The meal is a large turkey wing, 275g sliced ham, 1.5 lbs of grape tomatoes, 9 baby potatoes, 4 large carrots, 3 green onions, 5 sweet mini-peppers, 4 small plums, 2 nectarines, and 1 medium honeycrisp apple. The beverage is water with a small amount of rice vinegar added.
I ended up not eating the apple at the time. Estimated calories for the rest: 1,700 calories. Estimated cost for the rest: $24.00. Note: About 70% of the cost came from the meat and the 1.5 lbs of grape tomatoes.
One take-away is that baby potatoes, sweet mini-peppers, carrots, apples, small plums, and especially green onions are all major bargains from both a cost and a calories perspective. Green onions are practically free in both contexts.
#diet #fasting #health -
Stop late-night snacking! 🚫🍔 The 3-Hour Rule activates Autophagy and lets Sirtuins repair your DNA. Become biologically younger overnight. All the facts from the Northwestern University study in the video. #Autophagy #Longevity #HealthyAging #Biohacking
https://www.youtube.com/watch?v=C81IqIxnaWM&list=PLCFAL8lW1qRc2_ByG_7s4bc6h4hcK19_b&index=1
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Stop late-night snacking! 🚫🍔 The 3-Hour Rule activates Autophagy and lets Sirtuins repair your DNA. Become biologically younger overnight. All the facts from the Northwestern University study in the video. #Autophagy #Longevity #HealthyAging #Biohacking
https://www.youtube.com/watch?v=C81IqIxnaWM&list=PLCFAL8lW1qRc2_ByG_7s4bc6h4hcK19_b&index=1
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#ExerciseForHealth #Autophagy #Wellness #HealthyHabits #FitnessMotivation #Biohacking #CellularHealth #WellnessLifestyle #WellbeingJourney #HealthyAging #WellnessCommunity #WellnessGoals #EmotionalWellbeing #WellnessWarrior #PhysicalWellbeing https://mastodon.social/@biohackingpathway/116128649408606946
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#OnThisDay The #DavisCup competition, premier international team event in men's tennis, was established (1900)
Happy Birthday Australian #Cricketer Glenn McGrath (1970) - considered one of the greatest bowlers in cricketing history.
Happy Birthday Yoshinori Ohsumi (1945). He discovered of mechanisms for #Autophagy - the process that cells use to destroy and recycle cellular components and received the 2016 Nobel Prize in Physiology or Medicine for his discovery.
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#OnThisDay The #DavisCup competition, premier international team event in men's tennis, was established (1900)
Happy Birthday Australian #Cricketer Glenn McGrath (1970) - considered one of the greatest bowlers in cricketing history.
Happy Birthday Yoshinori Ohsumi (1945). He discovered of mechanisms for #Autophagy - the process that cells use to destroy and recycle cellular components and received the 2016 Nobel Prize in Physiology or Medicine for his discovery.
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Open position: Postdoc position (Wellcome Trust funded): Structural Basis of #Autophagy Initiation. #science #career #jobs #sciencejobs #job #jobsearch #postdoc www.lifescience.net/jobs/219507/...
Postdoc position (Wellcome Tru... -
Open position: Postdoc position (Wellcome Trust funded): Structural Basis of #Autophagy Initiation. #science #career #jobs #sciencejobs #job #jobsearch #postdoc www.lifescience.net/jobs/219507/...
Postdoc position (Wellcome Tru... -
#Genetics #Genomics #Academia #AcademicChatter
Technology is bonkers. We've got an #autophagy project that's been going on, oh I don't know, maybe 2.5 years at this point. Or three? Maybe three years. Quite a bit of RNA-Seq involved with three conditions in primary cells.
I just did some quick tallying. 45 samples. About 2.08 billion reads.
2009 me would be flabbergasted at the amount of sequencing. Now it's just how things are.
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#Genetics #Genomics #Academia #AcademicChatter
Technology is bonkers. We've got an #autophagy project that's been going on, oh I don't know, maybe 2.5 years at this point. Or three? Maybe three years. Quite a bit of RNA-Seq involved with three conditions in primary cells.
I just did some quick tallying. 45 samples. About 2.08 billion reads.
2009 me would be flabbergasted at the amount of sequencing. Now it's just how things are.
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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`..phosphorylation of Optineurin by TBK1 induces the formation of filaments that phase separate upon binding to linear polyubiquitin.. the condensation of filamentous Optineurin with ubiquitylated cargo promotes the nucleation of cargo and its subsequent alignment with LC3-positive nascent autophagosomes, suggesting that co-condensation processes ensure directionality in selective autophagy`
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509927
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`Acting as a molecular glue, spermine orchestrates in vivo condensation of α-synuclein, influences condensate mobility, and promotes degradation via autophagy, specifically through autophagosome expansion. This study unveils the interplay between spermine, protein condensation, and functional outcomes, advancing our understanding of neurodegenerative diseases and paving the way for therapeutic development.`
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`Acting as a molecular glue, spermine orchestrates in vivo condensation of α-synuclein, influences condensate mobility, and promotes degradation via autophagy, specifically through autophagosome expansion. This study unveils the interplay between spermine, protein condensation, and functional outcomes, advancing our understanding of neurodegenerative diseases and paving the way for therapeutic development.`
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Fasting benefits WITHOUT starving? 🤯
An innate substance reduces inflammation by 75%. The key: An olive oil ingredient activates the AMPK switch! Goodbye myths, hello science. Your 3-step cell reset plan. 🔑
Watch now: [https://www.youtube.com/watch?v=-JLWPvqnHsQ&list=PLCFAL8lW1qRc2_ByG_7s4bc6h4hcK19_b&index=1]
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Here's one I've been meaning to feature as a #ThursDeath for a while. I'm always down for more gross, grody death metal, so we have to talk about Portland, Oregon's AUTOPHAGY and their debut LP from 2022, 'Bacteriophage'. Over these 9 tracks, there are endless grotesque, churning OSDM style riffs, tons of drum dynamics, and those cavernous, deep, guttural vocals. Hope we get another from these guys soon. A masterful record.
https://autophagypdx.bandcamp.com/album/bacteriophage
#metal #DeathMetal #PortlandMetal #OregonMetal #Autophagy #2022Records #2022Albums #OSDM @HailsandAles @brian @swampgas @rtw @guffo @Kitty @c0m4 @flockofnazguls
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Here's one I've been meaning to feature as a #ThursDeath for a while. I'm always down for more gross, grody death metal, so we have to talk about Portland, Oregon's AUTOPHAGY and their debut LP from 2022, 'Bacteriophage'. Over these 9 tracks, there are endless grotesque, churning OSDM style riffs, tons of drum dynamics, and those cavernous, deep, guttural vocals. Hope we get another from these guys soon. A masterful record.
https://autophagypdx.bandcamp.com/album/bacteriophage
#metal #DeathMetal #PortlandMetal #OregonMetal #Autophagy #2022Records #2022Albums #OSDM @HailsandAles @brian @swampgas @rtw @guffo @Kitty @c0m4 @flockofnazguls
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Autophagy, The Gut's Role and Ivermectin in Parkinson's Disease Parkinson's disease is a neurological disorder in which neurons and dopamine-producing cells in your brain begin to die. ...
#anti-aging #autophagy #brain #health #detoxification #fasting #ivermectin #parkinson's #disease
Origin | Interest | Match -
Autophagy: Gobbles up Viruses and Bacteria, No Pills Required Autophagy literally means "self-eating" and refers to your body's process of eliminating damaged cells by digesting them. I...
#anti-aging #autophagy #fasting #mercola
Origin | Interest | Match -
Cell Reset NO Hunger? 🤯 Study shows: 75% less inflammation via a naturally occurring compound! Your anti-aging leverage might be in your kitchen (Olive Oil!). 🌿 Food = Information. Switch on your Autophagy. 👇 [https://www.youtube.com/watch?v=LpauESlu9Fg&list=PLCFAL8lW1qRcg33UuQIxYHOaTQX12LurR&index=1]
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Fully Funded PhD in Cancer Biology & Therapeutics
Hebrew University of JerusalemSee the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/
#autophagy #BasicdrugDiscovery #cancer #mitochondria #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/?fsp_sid=1579 -
Fully Funded PhD in Cancer Biology & Therapeutics
Hebrew University of JerusalemSee the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/
#autophagy #BasicdrugDiscovery #cancer #mitochondria #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/?fsp_sid=1579 -
Fully Funded PhD in Cancer Biology & Therapeutics
Hebrew University of JerusalemSee the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/
#autophagy #BasicdrugDiscovery #cancer #mitochondria #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/?fsp_sid=333 -
Fully Funded PhD in Cancer Biology & Therapeutics
Hebrew University of JerusalemSee the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/
#autophagy #BasicdrugDiscovery #cancer #mitochondria #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-in-cancer-biology-therapeutics/?fsp_sid=333 -
From Synapses to DNA Repair: The Science of Brain Health and Cellular Survival
#CellBiology #Neuroscience #Mitochondria #OxidativeStress #Autophagy #Neurodegeneration #DNARepair #Epigenetics #BrainHealth #BiologyExplained #Neurons #CalciumSignaling #Neuroplasticity #CellDeath #MolecularMedicine
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Here's an autophagic punctum for you:
Small but mighty: ATG9A-positive vesicles are a branch of the intracellular nanovesicle superfamily
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Are #autophagy-related proteins involved in #GenomeStability? This study shows that Atg11 has an essential non-canonical function in error-free #chromosome segregation via the Kar9-dependent spindle positioning pathway @PLOSBiology https://plos.io/4lfbeP1
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This fundamental study looks at the role of Ezrin, a membrane-actin linker that assembles signalling complexes, unveiling a critical endosome–lysosome network essential for #autophagy and cellular #homeostasis.
https://elifesciences.org/articles/98523?utm_source=mastodon&utm_medium=social&utm_campaign=organic -
Caspases have well known roles in #apoptosis, but roles in other cellular processes are emerging... This study shows that #caspase -3 & -7 promote cytoprotective #autophagy in response to non-lethal stress by modulating PARP1 activity in #BreastCancer cells #plosbiology https://plos.io/41xfLVm
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#Cellular clean-up: Solving the mystery of how cells initiate their recycling process.
https://phys.org/news/2025-02-cellular-mystery-cells-recycling.html
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What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO
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Fully Funded PhD Position in Cancer Research
Hebrew University of Jerusalem
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606
#autophagy #cancer_biology #cell_death #mitophagy #ScienceJobs #hiring #research
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-fully-funded-phd-position-in-cancer-research/?feed_id=91606 -
Postdoctoral Researcher in Plant Molecular Biology and Autophagy
University of Louvain, Louvain-la-Neuve
See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-louvain-louvain-la-neuve-27778-postdoctoral-researcher-in-plant-molecular-biology-and-autophagy/?feed_id=89765
#abiotic_stress #autophagosome #autophagy #bioche...
https://jobrxiv.org/job/university-of-louvain-louvain-la-neuve-27778-postdoctoral-researcher-in-plant-molecular-biology-and-autophagy/?feed_id=89765 -
Open PhD student position
Hebrew University of Jerusalem
Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.
See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240
