#rapamycin — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #rapamycin, aggregated by home.social.
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https://www.europesays.com/ie/462645/ Food timing may shape how T cells respond to infection and therapy #blood #Cell #CellMetabolism #Chromatin #Éire #Fasting #food #Glucose #Health #IE #ImmuneSystem #immunotherapy #Ireland #Lipids #Metabolism #Nutrition #Protein #Rapamycin #Receptor #Research #therapy #Translation
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UT San Antonio study evaluates rapamycin’s potential to promote healthy aging
UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is…
#NewsBeep #News #Health #Aging #anatomy #AU #Australia #Cell #clinicaltrial #geriatrics #Gerontology #medicine #Rapamycin #research
https://www.newsbeep.com/au/564719/ -
UT San Antonio study evaluates rapamycin’s potential to promote healthy aging
UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is…
#NewsBeep #News #Health #Aging #anatomy #AU #Australia #Cell #clinicaltrial #geriatrics #Gerontology #medicine #Rapamycin #research
https://www.newsbeep.com/au/564719/ -
https://www.europesays.com/ie/404182/ UT San Antonio study evaluates rapamycin’s potential to promote healthy aging #Aging #Anatomy #Cell #ClinicalTrial #Éire #geriatrics #Gerontology #Health #IE #Ireland #medicine #Rapamycin #Research
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UT Health to launch large trial testing potential longevity drugs https://www.byteseu.com/1874213/ #AgingAndLongevity #DrElenaVolpi #Glp1Drugs #Health #Rapamycin #SamAndAnnBarshopInstituteForLongevityAndAgingStudies #semaglutide #SouthTexas #TopStory #type:daily #USDepartmentOfHealthAndHumanServices #UTHealthSanAntonio #VITALH #Wc10001500
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https://www.europesays.com/ie/246904/ Engineered extracellular vesicles enable antigen-specific regulatory T cell induction #Antigen #cancer #CD4 #DrugDelivery #education #Éire #IE #ImmuneSystem #immunity #Immunology #Immunosuppression #InVivo #Ireland #LifeScience #medicine #Rapamycin #Research #Technology
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Safety Warning for people on Rapamycin / Sirolimus / Rapamune
Chrysanthemum, Dandelion, Bishop's Weed, and/or Liquoirce, even if blended with other tea ingredients, can interact with the medications, including stopping absorption & be potentially dangerous. Please be careful.
For me personally, chrysanthemum tea blocked the efficacy of my latest dose of rapamycin. I'm really hoping that's all that it did.
https://pubmed.ncbi.nlm.nih.gov/24824478/
#LongCovid #MECFS #rapamycin #sirolimus #transplant #polybio #putrinoLab #rapamune #mTorInhibitor #lymphaticMalformation #TuberousSclerosisComplex
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🗿 A billion-dollar drug was found in Easter Island soil: What companies owe the Indigenous people they studied
#easterisland #drugs #pharmacology #indigenous #globalsouth #rapamycin
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Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19
#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians
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Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19
#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians
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Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19
#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians
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Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19
#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians
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Metformin reduces risk of Long Covid. https://thesicktimes.org/2025/10/28/metformin-has-been-shown-to-reduce-the-risk-of-long-covid-why-isnt-it-more-widely-used/?mc_cid=01de0f1b88&mc_eid=4b751fcf19
#TheSickTimes #LongCovid #ProlongedPandemic #pandemic #disease #illness #sick #chronic #MedMastodon #medicine #medical #Metformin #Rapamycin #diagnose #prognosis #wellness #digestion #diabetes #hba1c #doctor #doctors #clinic #GP #physicians
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#Indigenous #RapaNui #antibiotics #rapamycin
"An antibiotic discovered on Easter Island in 1964 sparked a billion-dollar pharmaceutical success story. Yet the history told about this “miracle drug” has completely left out the people and politics that made its discovery possible.
Named after the island’s Indigenous name, Rapa Nui, the drug rapamycin was initially developed as an immunosuppressant to prevent organ transplant rejection and to improve the efficacy of stents to treat coronary artery disease. Its use has since expanded to treat various types of cancer, and researchers are currently exploring its potential to treat diabetes, neurodegenerative diseases and even aging. Indeed, studies raising rapamycin’s promise to extend lifespan or combat age-related diseases seem to be published almost daily. A PubMed search reveals over 59,000 journal articles that mention rapamycin, making it one of the most talked-about drugs in medicine.
Despite being so ubiquitous in science and medicine, how rapamycin was discovered has remained largely unknown to the public. Many in the field are aware that scientists from the pharmaceutical company Ayerst Research Laboratories isolated the molecule from a soil sample containing the bacterium Streptomyces hydroscopicus in the mid-1970s. What is less well known is that this soil sample was collected as part of a Canadian-led mission to Rapa Nui in 1964, called the Medical Expedition to Easter Island, or METEI.
As a scientist who built my career around the effects of rapamycin on cells, I felt compelled to understand and share the human story underlying its origin. Learning about historian Jacalyn Duffin’s work on METEI completely changed how I and many of my colleagues view our own field.
Unearthing rapamycin’s complex legacy raises important questions about systemic bias in biomedical research and what pharmaceutical companies owe to the Indigenous lands from which they mine their blockbuster discoveries."
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A billion-dollar drug was discovered in soil samples from Easter Island decades ago, but the question remains — what do scientists and pharmaceutical companies owe the Indigenous Rapa Nui people whose land and knowledge were drawn upon?
This case highlights the urgent need for fair benefit sharing, ethical research practices, and genuine respect for Indigenous sovereignty when global industries profit from local resources.#indigenousrights #scienceethics #bioprospecting #rapanui #rapamycin #multinationals #bigpharma
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A billion-dollar drug was discovered in soil samples from Easter Island decades ago, but the question remains — what do scientists and pharmaceutical companies owe the Indigenous Rapa Nui people whose land and knowledge were drawn upon?
This case highlights the urgent need for fair benefit sharing, ethical research practices, and genuine respect for Indigenous sovereignty when global industries profit from local resources.#indigenousrights #scienceethics #bioprospecting #rapanui #rapamycin #multinationals #bigpharma
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A billion-dollar drug was discovered in soil samples from Easter Island decades ago, but the question remains — what do scientists and pharmaceutical companies owe the Indigenous Rapa Nui people whose land and knowledge were drawn upon?
This case highlights the urgent need for fair benefit sharing, ethical research practices, and genuine respect for Indigenous sovereignty when global industries profit from local resources.#indigenousrights #scienceethics #bioprospecting #rapanui #rapamycin #multinationals #bigpharma
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A billion-dollar drug was discovered in soil samples from Easter Island decades ago, but the question remains — what do scientists and pharmaceutical companies owe the Indigenous Rapa Nui people whose land and knowledge were drawn upon?
This case highlights the urgent need for fair benefit sharing, ethical research practices, and genuine respect for Indigenous sovereignty when global industries profit from local resources.#indigenousrights #scienceethics #bioprospecting #rapanui #rapamycin #multinationals #bigpharma
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A billion-dollar drug was discovered in soil samples from Easter Island decades ago, but the question remains — what do scientists and pharmaceutical companies owe the Indigenous Rapa Nui people whose land and knowledge were drawn upon?
This case highlights the urgent need for fair benefit sharing, ethical research practices, and genuine respect for Indigenous sovereignty when global industries profit from local resources.#indigenousrights #scienceethics #bioprospecting #rapanui #rapamycin #multinationals #bigpharma
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https://medicalxpress.com/news/2025-09-rapamycin-linked-dna-resilience-aging.html
(boomer bolstering )
Originally developed for organ transplantation to prevent immune rejection, previous research has found that, at non-#immunosuppressive doses, #rapamycin can mitigate cellular #senescence.
"rapamycin provides direct #genomicprotection in human immune cells and may support healthy aging, offer benefits after clinical #radiationexposure, and could even address risks from #cosmicradiation during extended #spacetravel."
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Anti-ageing drug rapamycin may extend life almost as effectively as restricting calories – our new research
#Health #Rapamycin #AntiAgeing #Longevity #DietMimics #CalorieRestriction #LifeExtension #AgeingResearch #Metformin #HealthSpan #ScientificResearch
https://the-14.com/anti-ageing-drug-rapamycin-may-extend-life-almost-as-effectively-as-restricting-calories-our-new-research/ -
Anti-ageing drug rapamycin may extend life almost as effectively as restricting calories – our new research
#Health #Rapamycin #AntiAgeing #Longevity #DietMimics #CalorieRestriction #LifeExtension #AgeingResearch #Metformin #HealthSpan #ScientificResearch
https://the-14.com/anti-ageing-drug-rapamycin-may-extend-life-almost-as-effectively-as-restricting-calories-our-new-research/ -
New 30% mouse lifespan extension paper just dropped!
Another example of rapamycin + something increasing mouse lifespan more than rapamycin or something alone. In this case, the something is trametinib, an anti-cancer drug.
Read more here: https://andrewsteele.co.uk/blog/2025/05/rapamycin-trametinib-cocktail-lifespan-mice/
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Peeps with long Covid who live in and around NYC
Mount Sinai is taking applications for a long covid clinical trial using low-dose rapamycin.
#LongCovid @longcovid #rapamycin #Sirolimus #NYC #NY #NJ #CT
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4.) Is there currently any evidence of efficacy of any of the proposed "#anti-aging drugs" and interventions in human aging? E.g. #rapamycin, #metformin #resveratrol but also #reprogramming, #rejuvenation, #caloric restriction and others? In other words, is there a shortcut to health and eternal life? Spoiler: you might not like the answer... Moreover, some of these might even have negative effects on other health-beneficial interventions, e.g. the potential dampening of exercise training adaptation by metformin, resveratrol or rapamycin.
5.) We discuss all of the known factors for which solid data and proof for an impact on human health, the aging process, #morbidity (risk for a disease), #mortality (risk of premature death) and life expectancy exist. The good news: only around 20% (or even as low as 10%) of our aging trajectory is determined by our genes – this means that to a large majority, we can influence this ourselves! Some can be done on the individual level, first and foremost by physical activity, but also #sleep, #nutrition, #stress, social interactions and more. Others will have to be addressed on the societal/political level, e.g. #socioeconomic disparities or access to quality (and affordable) health care. Lastly, there are factors such as anthropogenic #climatechange or #pollution (e.g. air pollution or #microplastics) that we have to solve on a global scale.
2/4
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4.) Is there currently any evidence of efficacy of any of the proposed "#anti-aging drugs" and interventions in human aging? E.g. #rapamycin, #metformin #resveratrol but also #reprogramming, #rejuvenation, #caloric restriction and others? In other words, is there a shortcut to health and eternal life? Spoiler: you might not like the answer... Moreover, some of these might even have negative effects on other health-beneficial interventions, e.g. the potential dampening of exercise training adaptation by metformin, resveratrol or rapamycin.
5.) We discuss all of the known factors for which solid data and proof for an impact on human health, the aging process, #morbidity (risk for a disease), #mortality (risk of premature death) and life expectancy exist. The good news: only around 20% (or even as low as 10%) of our aging trajectory is determined by our genes – this means that to a large majority, we can influence this ourselves! Some can be done on the individual level, first and foremost by physical activity, but also #sleep, #nutrition, #stress, social interactions and more. Others will have to be addressed on the societal/political level, e.g. #socioeconomic disparities or access to quality (and affordable) health care. Lastly, there are factors such as anthropogenic #climatechange or #pollution (e.g. air pollution or #microplastics) that we have to solve on a global scale.
2/4
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#FYI #rapamycin #alzheimers #pharmacokinetics
"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."https://biologists.social/@medrxivpreprint/114188319062962075
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#FYI #rapamycin #alzheimers #pharmacokinetics
"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."https://biologists.social/@medrxivpreprint/114188319062962075
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#FYI #rapamycin #alzheimers #pharmacokinetics
"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."https://biologists.social/@medrxivpreprint/114188319062962075
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#FYI #rapamycin #alzheimers #pharmacokinetics
"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."https://biologists.social/@medrxivpreprint/114188319062962075
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#FYI #rapamycin #alzheimers #pharmacokinetics
"Rapamycin, an mTOR inhibitor used clinically for immunosuppression, shows promise for repurposing in age-related disorders including Alzheimer's disease (AD).
This open-label pilot study investigated the pharmacokinetic properties of weekly oral rapamycin in [...] early-stage AD.
Findings [...] support fixed-dose regimens in future trials."https://biologists.social/@medrxivpreprint/114188319062962075
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Intriguing bit in this video about ketamine + rapamycin improving heat tolerance (this is not a recommendation - I don't know enough about it)
https://youtu.be/9Z4Eg1dtyOc?si=EXVnqvV6-vd7rqEj&t=2188
#thermoregulation #physiology #ketamine #rapamycin #HeatTolerance #neuroscience #POTS
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Intriguing bit in this video about ketamine + rapamycin improving heat tolerance (this is not a recommendation - I don't know enough about it)
https://youtu.be/9Z4Eg1dtyOc?si=EXVnqvV6-vd7rqEj&t=2188
#thermoregulation #physiology #ketamine #rapamycin #HeatTolerance #neuroscience #POTS
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today I watched:
Brain Repair: The Ketamine Combo Treatment for Depression and Chronic Pain
https://youtu.be/9Z4Eg1dtyOc?si=MPMcrFYYj2De6u9YVery interesting and pretty technical. I will have to re-watch.
[37:00] - #POTS #MCAS #hypermobility #LongCovid
#2dayIwatched #ChronicPain #psychiatry #neuroscience #rapamycin #ketamine
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How a cheap, generic drug became a darling of longevity enthusiasts
#rapamycin has gained a large following thanks to longevity researchers and celebrity doctors who, citing #animal #studies, contend that rapamycin could be a game changer in the quest to fend off age-related diseases.
The drug is going mainstream as an anti-aging treatment, even though rapamycin’s 🔹regulatory approval is for treating transplant patients. 🔹
♦️There is no evidence that it can extend human life.♦️
Researchers have found that rapamycin can modify a kind of cellular communications system that gives cells certain directions
— to grow when the body has plenty of food and to slow down when nutrients are scarce.The drug can dial down the signal to grow, causing cells to clear out accumulated junk and allowing them to run more efficiently.
Despite the buzz surrounding the drug, it is unlikely that the Food and Drug Administration will ever approve it for longevity.🔸The agency doesn’t consider aging to be a disease, 🔸and rapamycin’s generic status means 👉there’s little financial incentive to run expensive clinical trials to test it on age-related afflictions.
https://www.washingtonpost.com/business/2024/03/15/rapamycin-longevity-drug/
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(Potential) Anti-Aging drug derived from yeast found on Easter Island, how Sci-fi is that?!
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review article from 2015:
mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455918/
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All the #rapamycin trials in the news this month! This is looking at using it in ME/CFS: https://meassociation.org.uk/2023/11/rapamycin-pilot-treatment-trial-for-me-cfs/
The idea is that ME/CFS may be partly driven by dysfunctional autophagy (a process by which cells recycle waste), and rapa could help. Fascinating, I hope it works!
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CW: Dog Aging Project Update
Interview with Matt Kaeberlein
https://youtu.be/MSCrQYC9Alo?si=MbYl9ETXdOj_5aI3
Longitudinal lifestyle / environmental study ongoing.
Now recruiting for low-dose rapamycin study.
Dogs must be living in US & able to travel to 1 of 20 clinical partner sites. Other criteria: at least 7 yrs old & weigh 40 - 110 lbs.Dog Aging Project website
https://dogagingproject.org/Will there ever be a Cat Aging Project?
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#Rapamycin and Muscle Growth: A Review of the Glass Lab's use of Rapamycin to Reverse #Sarcopenia and Anabolic Resistance
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Fascinating study on how #rapamycin extends longevity in dogs. #aging #longevity https://www.the-scientist.com/news-opinion/aging-dogs-provide-insights-for-human-longevity-71223
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On LinkedIn, Alex Zhavoronkov is celebrating (?) publishing nonsense in #Oncoscience in a day using ChatGPT. Citing the EiC likely helped. The AI churned out text on Pascal’s wager in the context of Rapamycin that fails to develop an argument linking religious belief to the merits of life extension.
I hope this is a sting and Alex doesn't stand by the inane content.
#ChatGPT #AIwriting #PredatoryJournals #Stings #LongevityMedicine #PascalsWager #Rapamycin #LinkedIn
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Unravelling effects of anti-aging drugs on C. elegans using liposome-mediated compound delivery
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🚨 Paper alert!
Yu-Xuan Lu and Jennifer Regan show sex specific differences in response to the #antiaging drug #rapamycin.
Press release:
➡https://www.age.mpg.de/communications/news/detail/do-women-age-differently-from-menOriginal publication:
➡ https://www.nature.com/articles/s43587-022-00308-7 -
Yu Xuan Lu (not yet in the fediverse) and I are happy to share the publication of our work on sex differences in intestinal responses to the anti-#ageing drug #rapamycin, in the making for some time (more years than I care to calculate :)
We show that male and female enterocytes have a different baseline state (autophagy, histone expression, growth) and this matters for ageing and responses to TOR-inhibition.
