#neuroimmunology — Public Fediverse posts

KEM 8.2 New version

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is characterized by Post-Exertional Malaise (PEM), a delayed exacerbation of symptoms after physical, cognitive, emotional, or autonomic challenge. Current energy-metabolism models do not by themselves explain its delayed, nonlinear time course.

The Kinetic Elasticity Model (KEM) proposes that different ME/CFS phenotypes can converge on a common regulatory bottleneck in receptor signaling. Candidate upstream mechanisms include functional GPCR autoantibodies affecting adrenergic and muscarinic signaling and chronically elevated endogenous neuronal/autonomic activation. Increased receptor utilization can drive GRK-dependent phosphorylation, β-arrestin recruitment, desensitization/internalization, trafficking, and delayed recovery. When recovery is slow relative to repeated activation, regulatory burden can accumulate ...

https://doi.org/10.5281/zenodo.23137210

#neuroscience #mecfs #MEScience #neuroimmunology

Postdoctoral Position in Neuroimmunology
Medical University of South Carolina

See the full job description on jobRxiv: https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-position-in-neuroimmunology/

#animalbehavior #complementsystem #microglia #neuroimmunology #traumaticbraininjury #ScienceJobs #hiring #research
https://jobrxiv.org/job/medical-university-of-south-carolina-27778-postdoctoral-position-in-neuroimmunology/?fsp_sid=15642

Understanding postpartum depression at a highly precise, molecular level is absolutely essential for eradicating the profound cultural stigma that continues to surround the disorder. For too long, mothers have suffered under the implicit, unscientific accusation that their severe anxiety, anhedonia, and emotional paralysis represent a psychological weakness.
#PostpartumDepression #Neurobiology #Neuroendocrinology #Epigenetics #Neuroimmunology #Neuropharmacology #sflorg
https://www.sflorg.com/2026/08/wi08292601.html

Researchers have discovered lymph node-like hubs within the skull's bone marrow that function as rapid-response immune "security stations" directly defending the brain.
#Neuroimmunology #Pathology #Immunology #sflorg
https://www.sflorg.com/2026/08/imgy08212601.html

https://www.europesays.com/ie/635724/ Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy #Biomedicine #Éire #general #Health #IE #Immunosurveillance #Ireland #MedicalBiochemistry #MolecularMedicine #Neuroimmunology #StemCells

Microglia, the primary immune cells of the brain, play a critical protective role in maintaining the stability of neuronal networks, challenging the traditional view that they act solely as drivers of neuroinflammation in Alzheimer's disease.
#Neuroscience #Neuroimmunology #Neuropharmacology #sflorg
https://www.sflorg.com/2026/07/ns07282601.html

Postdoc Fellows (1-2): Decoding Cancer-Host interactions
Academia Sinica, Genomics Research Center

Join us as a #postdoc decoding #pancreaticcancer metabolism & #neuroimmunology at Academia Sinica's elite, English-speaking research hub in Taipei!

See the full job description on jobRxiv: https://jobrxiv.org/job/academia-sinica-genomics-research-center-2...
https://jobrxiv.org/job/academia-sinica-genomics-research-center-27778-postdoc-fellows-1-2-decoding-cancer-host-interactions/?fsp_sid=13745

The stimulation of the auricular vagus nerve in the external ear can alleviate lung inflammation through a newly identified neuroimmune reflex linking the skin and the respiratory system.
#Neuroimmunology #Neuroscience #Immunology #Pulmonology #sflorg
https://www.sflorg.com/2026/07/ns07162601.html

Postdoc Fellows (1-2): Decoding Cancer-Host interactions
Academia Sinica, Genomics Research Center

Join us as a #postdoc decoding #pancreaticcancer metabolism & #neuroimmunology at Academia Sinica's elite, English-speaking research hub in Taipei!

See the full job description on jobRxiv: https://jobrxiv.org/job/academia-sinica-genomics-research-center-2...
https://jobrxiv.org/job/academia-sinica-genomics-research-center-27778-postdoc-fellows-1-2-decoding-cancer-host-interactions/?fsp_sid=13006

Traumatic brain injuries (TBI) activate the brain's innate immune system—specifically toll-like receptor 4 (TLR4)—which subsequently elevates the enzyme MMP-9 to disrupt neuronal communication, leading to memory loss, seizures, and impaired cognition.
#Neuroscience #Neuroimmunology #MolecularBiology #Pharmacology #sflorg
https://www.sflorg.com/2026/06/ns06142601.html

🧠🚓 New paper on #microglia depletion: #CSF1R inhibition with #PLX5622 is not microglia-specific, it also depletes long-lived peripheral #macrophage populations. Could become important for interpreting #microglial #depletion experiments: Phenotypes after depletion or recovery may reflect broader macrophage niche perturbation, not microglia alone:

📄 https://doi.org/10.1016/j.celrep.2026.117411

#Neuroscience #Neuroimmunology

Irisin is a muscle-derived hormone released during aerobic exercise that directly shields neurons from damage and reduces clinical disability in preclinical models of multiple sclerosis (#MS ).
#Neurology #Neuroimmunology #Neuroendocrinology #MolecularBiology #sflorg
https://www.sflorg.com/2026/06/ns06042603.html

https://www.europesays.com/be-nl/69908/ Nieuwe aanwijzing voor ernstig verloop van MS: ‘overvolle opruimcellen’ in de hersenen #BE #België #Belgium #geneesmiddelenontwikkeling #Gezondheid #Health #MultipleSclerose #neuroimmunology

🧠📐 Kaltenecker et al present #MouseMapper, that combines whole-body tissue clearing, #lightsheet #imaging and foundation-model-based #DeepLearning to quantify nerves, immune cells & 31 organs/tissues across entire #mouse bodies.

Applied to diet-induced #obesity, it revealed reduced nerve density, infraorbital trigeminal nerve defects, impaired whisker sensing, & body-wide inflammatory CD68⁺ immune-cell clustering.

🌍 https://doi.org/10.1038/s41586-026-10535-2

#Neuroscience #Neuroimmunology #BioimageAnalysis #AI

🧠 New paper by Carneiro-Nascimento et al: awake #invivo #2p #CalciumImaging reveals diverse #CalciumDynamics in #meningeal #macrophages during cortical spreading depolarization (CSD), an aberrant #brain #hyperexcitability event linked to #migraine, #stroke, and #traumatic brain injury.

📝 https://doi.org/10.7554/eLife.109888

#Neuroimmunology #Neuroscience #imaging @eLife https://fediscience.org/@eLife/116605475951455191

Severe #narcolepsy with cataplexy is caused by the degeneration of neurons in two distinct regions of the brain: the hypothalamus and the locus coeruleus. This dual-region damage disrupts the production of both hypocretin and norepinephrine, which are critical chemical messengers for regulating wakefulness and muscle tone.
#Neuroscience #Neurology #Neuroimmunology #Psychiatry #sflorg
https://www.sflorg.com/2026/05/ns05012601.html

https://www.europesays.com/uk/799759/ Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia #Ageing #CognitiveAgeing #Fitness #general #Health #LifeSciences #miRNAs #Neurodegeneration #Neuroimmunology #UK #UnitedKingdom

https://www.europesays.com/ie/364438/ Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia #Ageing #CognitiveAgeing #Éire #Fitness #general #Health #IE #Ireland #LifeSciences #miRNAs #Neurodegeneration #Neuroimmunology

https://www.europesays.com/ie/275684/ Neuro-epithelial circuits promote sensory convergence and intestinal immunity #Éire #Health #HumanitiesAndSocialSciences #IE #Immunology #Ireland #multidisciplinary #Neuroimmunology #Science

Too sick to socialize: How the brain and immune system promote staying in bed | MIT News

“I just can’t make it tonight. You have fun without me.” Across much of the animal kingdom, when…
#NewsBeep #News #Headlines #cytokines #dorsalraphenucleus(DRN) #GloriaChoi #IL-1R1 #IL-1β #Latvia #LiuYang #LV #MITBCS #MITPicowerInstitute #neuroimmuneinteractions #Neuroimmunology #sicknessbehavior #socialisolation
https://www.newsbeep.com/299645/

https://www.europesays.com/ie/224410/ Too sick to socialize: How the brain and immune system promote staying in bed | MIT News #Cytokines #DorsalRapheNucleus(DRN) #Éire #GloriaChoi #Health #IE #IL1R1 #IL1β #Ireland #LiuYang #MITBCS #MITPicowerInstitute #NeuroimmuneInteractions #Neuroimmunology #SicknessBehavior #SocialIsolation

ERC-funded 3-year postdoc position with Michael Dolan in Dublin, Ireland, on neuroimunology and genomics. To apply, write an email to Michael.

https://dolanlab-tcd.com/

#PhDJobs #neuroscience #neuroimmunology #immunology #genomics

Alzheimer’s disease: new three-minute test can spot memory issues – here’s how it works and what it can tell you https://theconversation.com/alzheimers-disease-new-three-minute-test-can-spot-memory-issues-heres-how-it-works-and-what-it-can-tell-you-264519 #neuroimmunology #health #science #STEM

--Postdoctoral Fellowship in Structural Neurophysiology at CSHL—
Cold Spring Harbor Laboratory @Lab_FURUKAWA

Join us to conduct cutting-edge science and advance your career. #cryo-EM #electrophysiology #neuroscience #neuroimmunology

See the full job description on jobRxiv: https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-postdoctoral-fellowship-i...
https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-postdoctoral-fellowship-in-structural-neurophysiology-at-cshl/?fsp_sid=1530

--Postdoctoral Fellowship in Structural Neurophysiology at CSHL—
Cold Spring Harbor Laboratory @Lab_FURUKAWA

Join us to conduct cutting-edge science and advance your career. #cryo-EM #electrophysiology #neuroscience #neuroimmunology

See the full job description on jobRxiv: https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-postdoctoral-fellowship-in...
https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-postdoctoral-fellowship-in-structural-neurophysiology-at-cshl/?fsp_sid=802

Stress and Your Immune System: A Lively Metropolis in Action

#StressResponse #ImmuneSystem #BrainBodyConnection #HealthJourney #Neuroimmunology #StressManagement #BodyAsACity #MindBodyBalance #ImmunityMatters #WellnessInsights

https://youtube.com/shorts/H_jEEXn3fNs?feature=share

How Your Immune System and Brain Communicate: The Hidden Connection

#ImmuneSystem #BrainHealth #Microglia #Inflammation #MentalHealth #Cytokines #StressAndMood #Neuroscience #InflammationAndDepression #Neuroimmunology

https://youtube.com/shorts/G-IzmFV38UA?feature=share

When Brain Balance Tips: Understanding Neuroinflammation After Head Injuries

#BrainHealth #Microglia #Neuroinflammation #Neurodegeneration #Alzheimers #Parkinsons #BrainScience #Neuroscience #BrainAging #Neurobiology #ProteinAggregates #BrainRepair #Neuroimmunology #BrainCells #CognitiveHealth

https://youtube.com/shorts/SwQyfeFs4jg?feature=share

Targeting the Kynurenine Pathway: New Frontiers in Treating Mood Disorders

#KynureninePathway #BrainChemistry #Neuroimmunology #MentalHealth #Neurodegeneration #InflammationAndMood #Neuroprotection #Cognition #BrainHealth #Psychoneuroimmunology

https://youtube.com/shorts/3yUrIeR6LI0?feature=share

The Vagus Nerve and the Microbiome: Keys to a Balanced Mind and Body

#GutBrainConnection #VagusNerve #Microbiome #MentalHealth #GutHealth #StressRelief #MindBodyBalance #WellnessJourney #Psychobiotics #YogaForHealth #Mindfulness #HealthAndHappiness #Neuroimmunology #HolisticHealth

https://youtube.com/shorts/ERfWUNn9LtE?feature=share

Did you know your immune system can influence your emotions? Discover how IL-17 toggles between anxiety and sociability. #NeuroImmunology #MentalHealth #IL17

https://geekoo.news/how-immune-molecules-shape-our-emotions-the-dual-role-of-il-17/

#Biomaterials to regenerate the #NervousSystem: @CZ_Stiftung sponsors new InteReg project, a collaboration of @uni_mainz_eng, @mpi_polymer, and @LIRgGmbH, with EUR 6 million // #NeuralRegeneration #neurobiology #neuroimmunology #chemistry #PolymerResearch
https://nachrichten.idw-online.de/2024/12/10/biomaterials-to-regenerate-the-nervous-system-carl-zeiss-foundation-sponsors-intereg-project-at-mainz-university

Evidence is building that the brain is far from sterile and infection underlies many neurodegenerative conditions.

Press report:
https://www.theguardian.com/lifeandstyle/2024/dec/01/the-brain-microbiome-could-understanding-it-help-prevent-dementia

Preprint of a study of rRNA in brains: https://www.biorxiv.org/content/10.1101/2023.02.06.527297v1

#Microbiome #InfectiousDisease #Dementia #NeurodegenerativeDiseases #BrainInfections #NeuroInfectiousAgents #NeuroImmunology

New #podcast episode! Dr. Jony Kipnis talks about his work in #neuroimmunology, interests outside of #science, career path, failures, successes, & exciting research using immunotherapy to reduce damage after central nervous system injury. 🧪 🧠📈 #scicomm www.peoplebehindthescience.com/dr-jonathan-...

New #podcast episode! Dr. Jony Kipnis talks about his work in #neuroimmunology, interests outside of #science, career path, failures, successes, and exciting research using immunotherapy to reduce damage after central nervous system injury.

https://www.peoplebehindthescience.com/dr-jonathan-kipnis/

#neuroscience #immunology #research #scicomm #sciencecommunication #podcasts #STEM

'We used Bacillus Calmette-Guerin (BCG), a live-attenuated vaccine, to train the innate immune system and detected epigenetic reprogramming of brain-resident myeloid cells and functional restoration of myelin debris clearance and lesion recovery.'
#Immunology #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(24)00348-0

'Our findings position STING as a central regulator of the detrimental neuronal inflammatory stress response, integrating inflammation with glutamate signaling to cause neuronal cell death, and present it as a tractable target for treating neurodegeneration in MS.'
#Immunology #Neuroimmunology #Autoimmunity #multiplesclerosis

https://www.cell.com/cell/fulltext/S0092-8674(24)00576-2

'We uncover that tumor cells mimic the anti-inflammatory mechanism of CNS to evade anti-tumor immunity and NAT8L is a potential target to enhance efficacy of anti-cancer agents.'

#Immunology #Neuroimmunology

https://www.cell.com/cancer-cell/abstract/S1535-6108(24)00169-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1535610824001697%3Fshowall%3Dtrue

'However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes of murine Treg and conventional T cells (Tconv), we observe that the proenkephalin gene (Penk), encoding the precursor of analgesic opioid peptides, ranks among the top 25 genes most enriched in Treg cells.'
#Immunology #Preprint #Neuroimmunology #Treg
https://www.biorxiv.org/content/10.1101/2023.09.12.557326v2

'One common emerging principle is that microglial reactivity triggered by even relatively mild Covid occurring in the respiratory system, not directly infecting the brain or other kinds of immune challenges can trigger this reactivity of microglia and consequently dysregulate the normal interactions between cells and the brain'
Michele Monje

#Covid #Covid19 #LongCovid #Immunology #NeuroImmunology

https://erictopol.substack.com/p/michelle-monje-the-brain-in-long

Researchers discovered that #Bcells play an active role in teaching #Tcells not to attack the body itself. If the "training" fails, #autoimmunediseases such as #neuromyelitis optica can develop: http://go.tum.de/562972

#thymus #Neuroimmunology

📷J. Böttcher, T. Korn

#Neuroimmunology #NeuroCovid #LongCovid Monitor #COVID19 patients for Parkinson’s symptoms, scientists say. The Virus infects dopaminergic neurons in brain, study finds, stopping cell division.

https://parkinsonsnewstoday.com/news/covid-19-dopaminergic-neurons-parkinsons-link-possible/

'Drucker and his colleagues noticed a potential clue: receptors for GLP-1 are scarce in immune cells in many tissues in which the hormone and its mimics reduce inflammation, but are abundant in the brain. To test the nervous system’s role, Drucker’s team began by inducing system-wide inflammation in mice.'
#Immunology #Inflammation #Neuroimmunology #Metabolism

https://www.nature.com/articles/d41586-024-00118-4

Research Technician

SUNY Upstate Medical University

Opening for a Research technician at newly established lab at SUNY Upstate. Work in regenerative neuroscience, neuroimmunology, and glial biology.

See the full job description on jobRxiv: https://jobrxiv.org/job/suny-upstate-medical-university-27778-research-technician-2/?feed_id=68225

#mouse_models #neurobiology #neuroimmunology #ScienceJ...
https://jobrxiv.org/job/suny-upstate-medical-university-27778-research-technician-2/?feed_id=68225