#parkinson — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #parkinson, aggregated by home.social.
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https://www.europesays.com/it/665579/ La voce cambia? Potrebbe essere un segnale precoce di declino cognitivo #cervello #demenza #DeterioramentoCognitivo #DisturbiVocali #DrexelUniversityCollegeOfMedicine #Health #ipoacusia #IT #Italia #Italy #JournalOfVoice #parkinson #Salute #TriNetX #voce
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‘É uma doença que não tem cura, mas posso enfrentar e empatar o jogo’, diz autor do livro ‘Xô, Parkinson’
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‘É uma doença que não tem cura, mas posso enfrentar e empatar o jogo’, diz autor do livro ‘Xô, Parkinson’
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‘É uma doença que não tem cura, mas posso enfrentar e empatar o jogo’, diz autor do livro ‘Xô, Parkinson’
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Iowa State Senator Art Staid "used to enjoy long walks, runs and #bicycle rides, but at times now uses a #wheelchair.”
NOTE: Despite headline, Missouri and Illinois aren’t alone in being U.S. states allowing paraquat use.
Also note: "More than 70 countries, including every nation in the #EuropeanUnion, ban #paraquat. That includes #China, which #exports millions of pounds of it to the U.S.
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"Grant Niver, who testified in support of the bill as a senior state government relations manager with the Michael J. Fox Foundation, said up to 78% of #Parkinson’s diagnoses could be attributed to #environmental factors.” -
https://www.europesays.com/es/708228/ HM CINAC interviene en un estudio sobre la enfermedad de Parkinson #beneficios #cinac #consigue #demuestra #enfermedad #ES #España #Estudio #focalizados #guiados #h&m #Health #interviene #Investigación #lancet #magnetica #mantenidos #mejoria #meses #motores #neurology #palidotalámica #parkinson #publicado #resonancia #Salud #Síntomas #Spain #the #tractotomía #ultrasonidos #unilateral
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https://www.europesays.com/at/329069/ Parkinson: Raucher erkranken laut Studien 40% seltener – neue Ansätze mit Kohlenmonoxid #AI #ARTIFICIALINTELLIGENCE #AT #Austria #Dopamin #Gesundheit #Health #KI #KlinischeStudien #Kohlenmonoxid #KünstlicheIntelligenz #Neurodegeneration #Neuroprotektion #nikotin #Österreich #Parkinson #Rauchen #Zellschutz
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Ping-Pong gegen Parkinson — kreuzer online
Klick, klack, klack, klack« – das typische Tischtennisball-trifft-auf-Platte-Geräusch hört man schon de…
#Leipzig #Deutschland #Deutsch #DE #Schlagzeilen #Headlines #Nachrichten #News #Europe #Europa #EU #Ansatz #Behandlung #Beweglichkeit #bewegung #Diagnose #Erfolg #Erkrankung #Forschung #Germany #gesund #Hilfe #Krankheit #leipzig #Parkinson #pingpont #Sachsen #Sport #Studien #Therapie #Tischtennis #Unterstützung
https://www.europesays.com/de/1186073/ -
Norsk biobank for stamceller er på vei:
«… I laboratoriet er hudcellene nå i ferd med å programmeres om til å bli såkalte iPS-celler. Altså stamceller som kan gi opphav til alle typer spesialiserte celler i kroppen, for eksempel muskel-, blod- og nerveceller. …
Neste mål er å kunne reparere skadede organer og ødelagt vev hos de med #ParkinsonsSykdom, alvorlige #hudsykdommer, #hjerteinfarkt og #diabetes. …»
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Ukraine War Veteran and MS Patient Receive First Medical Cannabis Prescriptions
Two years on from the legalisat…
#Ukraine #UA #Europe #Europa #EU #News #chronicpain #ComplantConsulting #Dravetsyndrome #Epilepsy #HennadiiShabas #LennoxGastautsyndrome #LisaFomenko #LyudmilaMonastyrska #MedicalCannabis #OleksandrAlba #Parkinson's #Prescription #UkrainianMedicalCannabisAssociation #Veteran #VinnytsiaRegionalClinicalPsychoneurologicalHospital #YaroslavYurchuk
https://www.europesays.com/ukraine/4667/ -
Katharina Beyer bekommt vor zehn Jahren die Diagnose "Parkinson". Mit gerade einmal 34 Jahren.#WDR #Oerlinghausen #Lippe #Tönsberg #Parkinson #Diagnose #Erkrankung #Tremor #Krankheit #NRW
Parkinson-Diagnose mit 34: Wie eine schwere Erkrankung das Leben einer jungen Mutter veränderte -
The short documentary 'Parkinson tóxico' (in Spanish, but you can add translated subtitles) reveals the connection between pesticides and Parkinson. It is part of a campaign to recognize pesticide-derived Parkinson, one of worlds quickest growing neurodegenerative diseases, as a workplace hazard for farmers and fieldworkers (and of course, to reduce pesticide use).
Directed by Santi Donaire and Alba García Fijo.
Financed by @ecologistas , @Wwf España and Sociedad Española de Agricultura Ecológica (SEAE).@Su_G @climatenewsnow
@IGG_FAU
@ufwupdates
@PAN_NL#Parkinson #Pesticidas #SaludPublica #Agricultura #Documental #SantiDonaire #EcologistasEnAccion #WWF #SEAE #MedioAmbiente #Pesticides #PublicHealth #Agriculture #Documentary #Ecotoxicology #agroecology #agroecologia #Landwirtschafr #Pestizide
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https://www.europesays.com/es/455826/ Pacientes y familias aprenden a identificar cambios clave en la evolución del Parkinson #abbvie #Andalucía #aprenden #cambios #capacita #clave #clínico #desarrollan #detectar #enfermedad #entorno #ES #España #evolución #familiar #Familias #favorecer #fusan #Health #herramientas #identificar #Pacientes #parkinson #prácticas #proporciona #proyecto #Salud #seguimiento #Spain
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Cartoonjournaal 12 december 2025.
Lees het bijbehorende artikel op mijn LinkedIn profiel:
#cartoonjournaal #humor #socialmedia #actualiteit #vogelgriep #geitenhouderij #Qkoorts #pesticiden #Parkinson #longonsteking #gezondheidsrisico #BBB #BigAgro
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Cartoonjournaal 4 december 2025.
Lees het bijbehorende artikel op mijn LinkedIn profiel:
#cartoonjournaal #humor #socialmedia #actualiteit #cartoon #glyfosaat #bestrijdingsmiddel #toxicologie #landbouw #gif #kanker #Parkinson #Monsanto
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Cartoonjournaal 29 september 2025.
Lees het bijbehorende artikel op mijn LinkedIn profiel:
#cartoonjournaal #humor #actualiteit #nieuws #stikstof #woningtekort #bouw #pesticiden #ammoniak #veestapel #CO2 #Parkinson #boeren #NotaRuimte
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Dodgers hero Kirk Gibson now fights for those with Parkinson’s https://www.rawchili.com/mlb/347645/ #Baseball #Dodgers #FreddieFreeman #gibby #Gibson #KirkGibson #La #LADodgers #LADodgers #life #LosAngeles #LosAngelesDodgers #LosAngeles #LosAngelesDodgers #MLB #MovementClass #parkinson #people #SameTeam #SteveAnnear #time #way #WellnessCenter #WorldSeriesOpener #year
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Dodgers hero Kirk Gibson now fights for those with Parkinson’s https://www.rawchili.com/mlb/347645/ #Baseball #Dodgers #FreddieFreeman #gibby #Gibson #KirkGibson #La #LADodgers #LADodgers #life #LosAngeles #LosAngelesDodgers #LosAngeles #LosAngelesDodgers #MLB #MovementClass #parkinson #people #SameTeam #SteveAnnear #time #way #WellnessCenter #WorldSeriesOpener #year
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Hier het verhaal van huisarts Evelien van Soldt naar de Statencommissie. https://www.youtube.com/watch?v=_L8q9jhiWDA #Landbouwgif #Bollenteelt #Parkinson #ALS #Leukemie #Drenthe #Westerveld #Wapserveen
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Hier het verhaal van huisarts Evelien van Soldt naar de Statencommissie. https://www.youtube.com/watch?v=_L8q9jhiWDA #Landbouwgif #Bollenteelt #Parkinson #ALS #Leukemie #Drenthe #Westerveld #Wapserveen
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"Pas op. Landbouwgif" Actie van bezorgde buurtbewoners. 70 meter van de kinderopvang (waar 1 van onze kindjes ook op zit) is er nu ook een bollenveld. De opvang heeft besloten om de kindjes na 15:30 niet meer buiten te laten spelen. Beetje een symbool maatregel maar het signaal is duidelijk. #Landbouwgif #Bollenteelt #Parkinson #ALS #Leukemie #Drenthe #Westerveld #Wapserveen
Edit: De actie was niet van Extincion Rebellion maar van buurtbewoners.
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"Pas op. Landbouwgif" Actie van bezorgde buurtbewoners. 70 meter van de kinderopvang (waar 1 van onze kindjes ook op zit) is er nu ook een bollenveld. De opvang heeft besloten om de kindjes na 15:30 niet meer buiten te laten spelen. Beetje een symbool maatregel maar het signaal is duidelijk. #Landbouwgif #Bollenteelt #Parkinson #ALS #Leukemie #Drenthe #Westerveld #Wapserveen
Edit: De actie was niet van Extincion Rebellion maar van buurtbewoners.
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"Pas op. Landbouwgif" Actie van bezorgde buurtbewoners. 70 meter van de kinderopvang (waar 1 van onze kindjes ook op zit) is er nu ook een bollenveld. De opvang heeft besloten om de kindjes na 15:30 niet meer buiten te laten spelen. Beetje een symbool maatregel maar het signaal is duidelijk. #Landbouwgif #Bollenteelt #Parkinson #ALS #Leukemie #Drenthe #Westerveld #Wapserveen
Edit: De actie was niet van Extincion Rebellion maar van buurtbewoners.
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‘Parkinson’s is a man-made disease’.
Europe’s flawed oversight of pesticides may be fuelling a silent epidemic, warns Dutch neurologist Bas Bloem.
His fight for reform pits him against industry, regulators — and time.
#Parkinson #Health #BasBloem #Neurology #Science #Pesticides #Fungicides #MPTP #Paraquat #Glyphosate #EFSA #Healthcare #Europe #EU #Longread
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‘Parkinson’s is a man-made disease’.
Europe’s flawed oversight of pesticides may be fuelling a silent epidemic, warns Dutch neurologist Bas Bloem.
His fight for reform pits him against industry, regulators — and time.
#Parkinson #Health #BasBloem #Neurology #Science #Pesticides #Fungicides #MPTP #Paraquat #Glyphosate #EFSA #Healthcare #Europe #EU #Longread
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Des #scientifiques ont développé un #implant capable de “ #restaurer le #fonctionnement #normal du #cerveau chez les personnes atteintes de #Parkinson ”. Une #avancée #médicale #historique !
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Des #scientifiques ont développé un #implant capable de “ #restaurer le #fonctionnement #normal du #cerveau chez les personnes atteintes de #Parkinson ”. Une #avancée #médicale #historique ! #medicine #médecine #medicina www.presse-citron.net/cest-histori...
"C'est historique !" : des sci... -
#CarlosAlbertoSolari, conocido en la escena musical argentina como #IndioSolari, cumplió este viernes 76 años.
El artista nació el 17 de enero de 1949, en la ciudad de #Paraná #EntreRíos. Vocalista, compositor y principal miembro fundador de #PatricioReyYSusRedonditosDeRicota junto al guitarrista Eduardo #SkayBeilinson, una de las bandas más aclamadas del país, y de su proyecto solista #LosFundamentalistasDelAireAcondicionado (#LFDAA).
En la actualidad, el cantante vive alejado de los escenarios, una decisión motivada por su diagnóstico de #Parkinson anunciado en 2016, que lo obligó a dejar de realizar presentaciones en vivo. A pesar de la situación que lo aqueja, su banda solista, LFDAA continúa realizando giras en el territorio argentino y en países limítrofes como Uruguay, acompañados en ocasiones con un holograma del músico.
#Argentina #Rock #RockNacional #LosRedondos #Efemérides #EfeméridesRockArgentino #EfeméridesRockNacional
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"Exon skipping only works if the resulting protein is still functional, so it can't treat every disease with a genetic basis. That's the overall limitation of the approach," noted Professor Pablo Perez-Pinera.
"But for diseases like #Alzheimer's, #Parkinson's, #Huntingtons, or Duchenne's muscular dystrophy, this approach holds a lot of potential."
#genetics #health #medicine #biotechnology #research #science #biology -
Neue KI-basierte Verfahren treiben die personalisierte #Therapie voran, indem sie die tiefe #Hirnstimulation (THS) und andere neurologische #Behandlungen präzisieren. Ein #KIModell kann anhand von #MRT-Daten TMS-Responserate für #Tinnitus mit 85 % Genauigkeit vorhersagen und #Demenzrisiken bei #Parkinson-Patienten durch okulomotorische Muster bestimmen. Diese Fortschritte verbessern die Diagnostik und Therapieplanung.
#Neurologie #Medizin #KI #Gesundheitswesen #AI
https://www.aerztezeitung.de/Medizin/KI-treibt-personalisierte-Therapie-voran-450503.html
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La #OMS advierte de la ‘amplia falta de #disponibilidad’ de #fármacos contra la #epilepsia y el #Parkinson en todo el #mundo https://boletinaldia.sld.cu/aldia/2024/07/24/la-oms-advierte-de-la-amplia-falta-de-disponibilidad-de-farmacos-contra-la-epilepsia-y-el-parkinson-en-todo-el-mundo/
La Organización Mundial de la Salud (OMS) advierte de la «amplia falta de disponibilidad» de fármacos neurológicos en todo el mundo, especialmente en epilepsia y Parkinson, con motivo del Día Mundial del #Cerebro, que se conmemora este lunes.
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Zellen wandern auch vom Gehirn in den Darm. Wechselseitiger Austausch zwischen Gehirn und Darm an Parkinson und Co beteiligt. #Gehirn #Darm #Immunzellen #Darmhirn #Parkinson
https://www.scinexx.de/news/medizin/zellen-wandern-auch-vom-gehirn-in-den-darm/ -
Zellen wandern auch vom Gehirn in den Darm. Wechselseitiger Austausch zwischen Gehirn und Darm an Parkinson und Co beteiligt. #Gehirn #Darm #Immunzellen #Darmhirn #Parkinson
https://www.scinexx.de/news/medizin/zellen-wandern-auch-vom-gehirn-in-den-darm/ -
Zellen wandern auch vom Gehirn in den Darm. Wechselseitiger Austausch zwischen Gehirn und Darm an Parkinson und Co beteiligt. #Gehirn #Darm #Immunzellen #Darmhirn #Parkinson
https://www.scinexx.de/news/medizin/zellen-wandern-auch-vom-gehirn-in-den-darm/ -
Zellen wandern auch vom Gehirn in den Darm. Wechselseitiger Austausch zwischen Gehirn und Darm an Parkinson und Co beteiligt. #Gehirn #Darm #Immunzellen #Darmhirn #Parkinson
https://www.scinexx.de/news/medizin/zellen-wandern-auch-vom-gehirn-in-den-darm/ -
Zellen wandern auch vom Gehirn in den Darm. Wechselseitiger Austausch zwischen Gehirn und Darm an Parkinson und Co beteiligt. #Gehirn #Darm #Immunzellen #Darmhirn #Parkinson
https://www.scinexx.de/news/medizin/zellen-wandern-auch-vom-gehirn-in-den-darm/ -
#Farmers allege link between popular #herbicide and #Parkinsons disease
November 29, 2023
"It is against the law to use #paraquat in China, Switzerland, the United Kingdom and dozens of other countries. Many countries have banned the herbicide due to its extreme #toxicity, while others have expressed concerns over the possible risk for Parkinson's disease.
"Yet the herbicide, manufactured by a #Swiss company that is owned by the #Chinese state, is still widely used throughout the #UnitedStates in part because it is a highly effective way to kill weeds.
"The company, Syngenta, says that paraquat, which it produces under the name Gramoxone, 'is safe for its intended and labelled use.'
"Clayton Tucholke, who used Gramoxone for years on his farm in LaBolt, #SouthDakota, and has since been diagnosed with Parkinson's disease, says otherwise.
"'It should have been pulled, I think, you know, so it didn't happen to somebody else,' Tucholke told ABC News.
"A 76-year-old father and grandfather, Tucholke lived on his farm with his wife Denise, but as the symptoms of #Parkinson's have worsened, he says he was forced to give up his career in #agriculture and had to move to the nearby town of Milbank to be closer to medical professionals.
"Daily tasks have become arduous for Tucholke, who now has to travel to physical therapy three times a week to slow the progression of his symptoms.
"'This man was so independent,' Denise Tucholke said. 'And his independence has been taken from him, which is unfair.'
"The Tucholkes are among the more than 4,000 Americans who have filed lawsuits as part of a multi-district litigation against #Syngenta, which currently manufactures #Gramoxone, and #Chevron, which distributed it in the U.S. from 1966 until 1986.
"Although Syngenta and Chevron told ABC News that there is no scientific evidence that supports a causal link between #paraquat and #Parkinsonsdisease, the Tucholkes and other plaintiffs allege that such a link exists, arguing that Syngenta and Chevron knew or should have known that the #herbicide could 'cause severe #neurological injuries.'
"'Our daughter and son-in-law are still #farming. I think any time [a] chemical is applied to the fields that they have to use, they should know what's going to happen,' Denise Tucholke said.
"'All the generations that are coming up afterwards need to know,' she said."
#SyngentaKnew #ChevronKnew #Herbicide #Toxins #WaterIsLife #EnvironmentalPollution
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What you need to know about a common chemical linked to a increased risk of #Parkinson's disease
By Evan Dawson,
Megan Mack, April 25, 2023"Parkinson’s disease is the fastest growing brain condition in the world. A new paper co-authored by Dr. Ray Dorsey at the University of Rochester Medical Center shows that a common chemical may be fueling the rise of the disease. #Trichloroethylene (#TCE) is used to #DryClean clothes, to #decaffeinate coffee, and to #degrease metal. It was one of the main contaminant at the Marine Corps base #CampLejeune and has been found in up to one-third of the #groundwater in the U.S. According to the research, TCE is linked with a 500 percent increased risk of Parkinson’s disease."
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#DryCleaning chemical may be invisible #Parkinson’s cause
March 15th, 2023 Posted by Mark Michaud-Rochester
"For the past 100 years, #trichloroethylene (#TCE) has been used to decaffeinate coffee, degrease metal, and dry clean clothes. It contaminates the Marine Corps base Camp Lejeune, 15 toxic Superfund sites in Silicon Valley, and up to one-third of groundwater in the US.
TCE causes cancer, is linked to miscarriages and congenital heart disease, and is associated with a 500% increased risk of Parkinson’s disease.
In a hypothesis paper in the Journal of Parkinson’s Disease, researchers, including University of Rochester Medical Center neurologists Ray Dorsey, Ruth Schneider, and Karl Kieburtz, postulate that TCE may be an invisible cause of Parkinson’s. They detail the widespread use of the chemical, the evidence linking the toxicant to Parkinson’s, and profile seven individuals, including a former NBA basketball player, a Navy captain, and a late US Senator, who developed Parkinson’s disease either after likely working with the chemical or being exposed to it in the environment.
Massive TCE contamination
TCE was a widely used solvent used in a number of industrial, consumer, military, and medical applications, including to remove paint, correct typewriting mistakes, clean engines, and anesthetize patients.
Its use in the US peaked in the 1970s, when more than 600 million pounds of the chemical—or two pounds per American—were manufactured annually. Some 10 million Americans worked with the chemical or other similar industrial solvents. While domestic use has since fallen, TCE is still used for degreasing metal and spot dry cleaning in the US.
TCE contaminates countless sites across the country. Half of the most toxic Environmental Protection Agency’s (#EPA) #Superfund sites contain TCE. Fifteen sites are in #California’s #SiliconValley where the chemicals were used to clean electronics and computer chips. TCE is found in numerous military bases, including #CampLejeune in North Carolina. From the 1950s to the 1980s a million Marines, their families, and civilians that worked or resided at the base were exposed to drinking water levels of TCE and #perchloroethylene (#PCE), a close chemical cousin, that were up to 280 times above what is considered safe levels.
Soil, water, and air
The connection between TCE and Parkinson’s was first hinted at in case studies more than 50 years ago. In the intervening years, research in mice and rats has shown that TCE readily enters the brain and body tissue and at high doses damages the energy-producing parts of cells known as mitochondria. In animal studies, TCE causes selective loss of dopamine-producing nerve cells, a hallmark of Parkinson’s disease in humans.
Individuals who worked directly with TCE have an elevated risk of developing Parkinson’s. However, the authors warn that 'millions more encounter the chemical unknowingly through outdoor air, contaminated groundwater, and indoor air pollution.'
The chemical can contaminate soil and groundwater leading to underground rivers, or plumes, that can extend over long distances and migrate over time. One such plume associated with an aerospace company on Long Island, New York, is over four miles long and two miles wide, and has contaminated the drinking water of thousands. Others are found everywhere from Shanghai, China to Newport Beach, California.
Beyond their risks to water, the volatile TCE can readily evaporate and enter people’s homes, schools, and workplaces, often undetected. Today, this vapor intrusion is likely exposing millions who live, learn, and work near former dry cleaning, military, and industrial sites to toxic indoor air. Vapor intrusion was first reported in the 1980s when radon was found to evaporate from soil and enter homes and increase the risk of lung cancer. Today millions of homes are tested for radon, but few are for the cancer-causing TCE."
#WaterIsLife #Toxic #Chemicals #Pollution #EPAFail
Read more:
https://www.futurity.org/parkinsons-disease-trichloroethylene-tce-2890562-2/ -
@FTM_nl Zo jammer dat niet vergelijkbare eisen aan PFAS gesteld gaan worden als aan radioactieve stoffen. Dan is lozen van PFAS bij productie alvast verboden. En bij uitzondering toestaan bij pesticiden is een double whammy: deze stoffen blijven in het milieu waardoor ze de oorzaak zijn van massale insectensterfte en toename ziekte van Parkinson.🙈
https://ggz.nl/neuroloog-luidt-noodklok-bestrijdingsmiddelen-gelinkt-aan-parkinson/
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Virus exposure and neurodegenerative disease risk across national biobanks
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #Parkinson #ALS #Neurovirology #Encephalitis #Flu #Virology #Viruses #Vaccines
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Could a Viral Illness Increase Chances of Developing Alzheimer’s or Other Neurodegenerative Disease?
Study reveals a significant association between certain viral illnesses, including viral encephalitis and pneumonia-causing flu with an increased risk of developing a neurodegenerative disorder later in life. Researchers say existing vaccines against the viruses may reduce the chances of developing neurodegeneration.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neurodegeneration #Alzheimer #Parkinson #ALS #Neurovirology #Encephalitis #Flu #Virology #Viruses #Vaccines
https://neurosciencenews.com/neurodegeneration-viral-infection-22356/
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How Mitochondrial Dynamism Orchestrates Mitophagy
Authors Orian S. Shirihai, Moshi Song, Gerald W. Dorn II
Understanding the Significance of Mitochondrial Fission and Fusion
Mitochondrial dynamics refers to the movement of #mitochondria within a cell. This includes #fission, which is when mitochondria divide into two parts, #fusion, which is when two mitochondria join together, and #translocation, which is when mitochondria move from one part of the #cell to another. This movement is important for maintaining the stability of the mitochondrial #DNA, which is the genetic material found in mitochondria, and for controlling the cell's #respiration. It can also be involved in programmed #CellDeath. In the #heart, mitochondrial dynamics #protein s, such as #mitofusin s, optic #atrophy, and dynamin-related protein, are highly expressed and play an important role in maintaining the quality of the #mitochondria. Other roles for mitochondrial dynamics proteins in the #heart include helping to move #calcium into the mitochondria and regulating the structure of the mitochondria.
#Mitochondria are organelles in cells that are responsible for producing #energy. They can change their structure by breaking apart (#fission) and reforming (#fusion). This process is complicated and energy intensive, so it is important to understand why it is necessary. One reason may be that when cells divide, the mitochondria need to be divided equally between the two daughter cells. This requires the #mitochondria to be broken apart and then reformed in each daughter #cell. This process of breaking apart and reforming is more efficient than growing and budding the mitochondria. To help explain this process, the authors use the analogy of an army. Each soldier in the army is like a protein in the mitochondria, and the different units of the army are like the different parts of the #mitochondria. To increase the size of the army, units are added, rather than individual soldiers. This is similar to how mitochondria are modified, by adding or subtracting intact functional units, rather than individual #protein s.
Mitochondria are #organelle s in cells that can change their physical structure by undergoing fission. Fission can be symmetrical, which is when mitochondria replicate and expand the number of #mitochondria in the #cell, or asymmetrical, which is when damaged components of the mitochondria are removed. The major #protein that helps with mitochondrial fission is called Drp1. It is mostly found in the #cytosol, but it needs to be recruited to the outer mitochondrial #membrane to help with fission. Different factors can cause Drp1 to be recruited, such as phosphorylation by mitotic kinase cyclin B–cyclin-dependent-kinase (cdk) 1 complex during #cell division, or interacting with Bcl-2–associated protein x during #apoptosis. Inhibiting Drp1 can protect cells from some, but not all, forms of programmed cell death.
Mitochondria, which are organelles in cells, can be partitioned in #mitosis. The most efficient way to do this is by dismantling and then reconstituting the cellular #mitochondria network through sequential #organelle fission, distribution, and refusion. To explain this concept, the text uses an analogy of how military units are constituted and managed within an army's hierarchical organization structure. In this analogy, each soldier represents an individual respiratory complex #protein, which are grouped together to form a squad (analogous to a respiratory complex). Squads are arranged into platoons, and approximately 6 platoons comprise a functional unit, the company (like 1 complete respiratory chain). The text suggests that it would be easier to add prefabricated supercomplexes to preexisting ones, as by fusing mitochondrial cristae, rather than trying to make a larger or different shaped mitochondrion through the wholesale incorporation of individual proteins. This is because making major structural modifications of respiratory supercomplexes on paracrystalline cristal membranes would first require destabilizing the #membrane, then incorporating additional individual #protein components, and finally reconstructing the original highly organized structure, which is complicated and potentially disruptive.
#Mitochondria are small organelles in cells that can change their physical structure by undergoing fission. Fission can be symmetrical, which means the #mitochondria are split into two equal parts, or asymmetrical, which means the mitochondria are split into two unequal parts. Symmetrical fission is used to replicate and expand the number of mitochondria in the #cell, while asymmetrical fission is used to remove damaged mitochondria from the cell. The major #protein responsible for mitochondrial fission is called Drp1. Drp1 is mostly found in the cytosol, but it needs to be recruited to the outer mitochondrial #membrane to promote fission. Different factors can stimulate Drp1 to move to the outer mitochondrial #membrane, such as phosphorylation by mitotic kinase cyclin B–cyclin-dependent-kinase (cdk) 1 complex. In addition, the endoplasmic reticulum (ER) is often found at the sites of mitochondrial fission. If Drp1 is not present, the mitochondria can still fragment during #mitosis, suggesting that there are other mechanisms that can promote mitochondrial fission.
The text is talking about the process of mitochondrial fission, which is a process that involves connecting and separating parts of a #mitochondria. The author uses the metaphor of making sausage links to explain the process, but then goes on to explain that mitochondria are actually more like a turducken, which is a dish made of a chicken stuffed inside a duck stuffed inside a turkey. This creates layers of poultry, which is similar to the double #membrane /double space structure of #mitochondria. The author then explains that the process of mitochondrial fusion involves connecting the two mitochondria layer by layer, using proteins called mitofusins. Mitofusins have a #GTPase domain, two hydrophobic heptad repeat coiled-coil domains, and a small hydrophobic transmembrane domain. These proteins insert into the outer #membrane of the #mitochondria, and can interact with other proteins in the cytosol. The process of mitochondrial fusion is GTP-independent and reversible, but #GTP #hydrolysis is essential for irreversible outer membrane fusion.
#Mitofusins are proteins that are essential for the first two stages of mitochondrial fusion, which is the process of two mitochondria joining together. This process is important for the exchange of information between the #mitochondria and the #cell. If the mitofusins are deleted or suppressed, the mitochondria become abnormally small and are unable to undergo normal fusion. This can have serious implications for the health of the #cell.
Membrane-by-membrane mitochondrial fusion is a process that helps to keep the structure of the inner and outer membranes of #mitochondria intact. This helps to preserve the process of oxidative phosphorylation, which is important for providing energy to cells. Without this process, molecules that can be toxic to cells can form and interrupt the electron transport chain. This process is also important for maintaining the normal shape of the crista, which is necessary for the proper assembly and functioning of electron transport chain supercomplexes. In addition, it has been shown that interrupting Mfn-mediated OMM fusion can cause a #cardiomyocyte ER stress response, while interrupting Opa1-mediated IMM fusion can compromise mitochondrial function.
Mitochondrial fission and fusion are important processes in #biology, as evidenced by the fact that mutations in genes related to these processes can cause serious diseases in humans. Altering the balance between fission and fusion can have an effect on the shape of #mitochondria, with more fusion leading to longer, more interconnected mitochondria, and more fission leading to shorter, less interconnected mitochondria. It is generally thought that more interconnected #mitochondria are healthier, but this is not always the case. In some cases, mitochondrial #fragmentation can be beneficial, and it is important to understand the interplay between mitochondrial fragmentation and other processes, such as #mitophagy, in order to understand the effects of mitochondrial fission and fusion.
Mitophagy is a process by which cells eat their own #mitochondria. Mitochondria are organelles that produce energy in the form of #ATP, which is used to power most biological processes. Over time, mitochondria can become damaged and produce toxic levels of reactive oxygen species ( #ROS ). To protect the #cell from this damage, it has developed a sophisticated system to identify and remove these dysfunctional #mitochondria. This process is called mitophagy. #Mitophagy is a combination of the words mitochondria and #autophagy, which means "self-eating". It is a way for cells to selectively target and remove damaged mitochondria, while still keeping healthy ones. This helps to maintain the balance between having enough energy-producing #mitochondria and getting rid of the ones that are no longer functioning properly.
Pulse chase experiments are a type of scientific experiment used to study the behavior of molecules over time. In this particular experiment, researchers found that when #mitochondria (the energy-producing organelles in cells) are targeted for #mitophagy (a process of removing damaged mitochondria from the cell), they have a relatively depolarized #membrane potential before being removed. This means that the #mitochondria have a lower electrical charge than normal, and they are less likely to be involved in #fusion events (when two mitochondria join together). The time between the mitochondria becoming depolarized and being removed from the cell can range from less than an hour to about three hours, suggesting that there is a population of preautophagic #mitochondria (mitochondria that are about to be removed). This #preautophagic pool helps to explain the variation in mitochondrial #membrane potential in different cell types. The process that feeds mitochondria into the preautophagic pool is important for determining how quickly #mitochondria are removed from the #cell. Scientists have developed a technology to label individual mitochondria and track their #membrane potential, which has allowed them to identify the event at which depolarized #mitochondria are produced. This event is called asymmetrical fission, and it occurs when the daughter mitochondria produced by the fission event have different #membrane potentials - one daughter has a higher membrane potential than the mother mitochondrion, while the other daughter has a lower membrane potential. This process of asymmetrical fission helps to separate damaged components from healthy components before they are removed from the #cell.
The concept of mitochondrial fission and fusion and how it affects mitochondrial quality. It suggests that when the fusion factors Mfn1 and Mfn2 are both absent, unusually small and degenerated #mitochondria accumulate in adult mouse hearts. This was associated with impaired #cardiomyocyte respiration, but not with measurable alterations in #oxygen consumption. It was later discovered that the isolation procedure used was not capturing the fragmented #mitochondria produced by interrupting mitochondrial fusion. This led to the discovery that Mfn2 is essential to #Parkin-mediated #mitophagy, which is a process that helps to maintain mitochondrial quality. Three recent papers have also implicated the mitochondrial fission protein Drp1 in cardiac #mitophagy, and it is suggested that if asymmetrical mitochondrial fission normally precedes mitophagy, then chronic suppression of fission by ablating Drp1 would have different consequences on #mitophagy depending on when it is assayed.
Mfn2 and PINK1–Parkin Mitophagy Signaling is a mechanism for controlling the quality of #mitochondria in the body. #PINK1 and #Parkin are proteins that are linked to #Parkinson's disease, and mutations in their genes were the first to be identified as causing the disease. Scientists have studied how PINK1 interacts with Parkin, and how this interaction can lead to the destruction of damaged #mitochondria, which is called #mitophagy. #PINK1 is like an ignition switch that senses when mitochondrial damage has occurred, and then activates Parkin-mediated mitophagy. PINK1 is normally not present in healthy #mitochondria, but when mitochondrial damage occurs, PINK1 accumulates and triggers the destruction of the damaged #mitochondria.
PINK1 is a protein that accumulates on damaged mitochondria and helps to promote mitophagy, which is the process of getting rid of damaged mitochondria. PINK1 does this by inducing the cytosolic protein Parkin to move to the mitochondria and ubiquitinate proteins on the outer membrane of the mitochondria. This helps to prevent the spread of damage from the damaged mitochondria to the healthy ones. PINK1 also inhibits the fusion of the damaged mitochondria. There are different theories about the biochemical events that cause Parkin to move to the mitochondria and stop the fusion. It is thought that PINK1 phosphorylates Parkin on certain sites, which helps Parkin bind to the mitochondria. It is also thought that PINK1 phosphorylates ubiquitin, which helps Parkin bind to the mitochondria and ubiquitinate proteins on the outer membrane. Finally, it is thought that PINK1 phosphorylates Mfn2, which helps Parkin bind to the mitochondria and ubiquitinate proteins on the outer membrane. All of these processes help to promote mitophagy and prevent the spread of damage from the damaged mitochondria to the healthy ones.
#PINK1 is a protein that plays an important role in a process called #mitophagy, which is a form of quality control for mitochondria. Mutations in the #PINK1 #gene have been linked to hereditary #Parkinson's disease in humans, but when the PINK1 gene is deleted in mice, it does not cause the same #neurodegenerative pattern seen in humans. Even when the genes for PINK1, Parkin, and DJ-1 are all deleted in mice, it still does not cause the same loss of dopaminergic #neuron s seen in #Parkinson's disease patients. This suggests that there may be other pathways that can compensate for the loss of #PINK1 and #Parkin, such as increased transcription of other E3 #ubiquitin ligases in the hearts of Parkin-knockout mice.
The text is discussing the idea of mitochondrial quality control pathways, which are processes that help keep mitochondria healthy. The text is suggesting that there may be alternate pathways that can be used to maintain mitochondrial health, rather than waiting until the mitochondria are completely depolarized before triggering their removal. It is comparing this idea to the idea of maintaining a car, where it is better to perform regular maintenance and repairs rather than waiting until the car is completely broken down before replacing it.
Like a car, mitochondria can be maintained through preventative maintenance, such as replacing worn parts, and that more serious damage can be repaired by removing and replacing individual components. It also suggests that, like a car, #mitochondria can be repaired by removing and replacing damaged parts, but on a smaller scale. The different types of maintenance and repair may be part of a continuum, rather than distinct categories.
#Mitophagy and mitochondrial dynamism are two processes that are closely connected. Mitophagy is the process of removing damaged #mitochondria from the #cell, while mitochondrial dynamism is the process of mitochondria fusing together and separating. The two processes work together to keep the cell healthy by eliminating damaged mitochondria and preventing healthy mitochondria from being contaminated by the damaged ones. The protein #Mfn2 plays a role in both processes, acting as a factor for mitochondrial fusion when it is not acted on by #PINK1 and as a receptor for #Parkin when it is. This suggests that the two processes are mutually exclusive, meaning that they cannot happen at the same time. This helps to protect healthy #mitochondria from being contaminated by the damaged ones. Finally, the involvement of PINK1 and Parkin in multiple mitochondrial quality control mechanisms shows that there are multiple ways to keep the #mitochondria healthy, which is important for preventing chronic degenerative diseases and providing opportunities for #therapeutic intervention.
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@BVL_Bund
was scheinbar auch so tricky ist, ist das #Parkinson patienten eine zeitlang mit dem #Wirkstoff #Pergolid behandelt wurden in Humanmedizinischen Dosen aber die zulassung scheinbar zurückgenommen wurde...
man sollte die von euch erwähnten fälle auch unter diesem Gesichtspunkt untersuchen...
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Quelle
https://de.wikipedia.org/wiki/Pergolid