#astrocytes — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #astrocytes, aggregated by home.social.
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Glucocorticoid signaling is thought to be important for #circadian rhythms only during development. This study shows that the adult SCN, a key pacemaker for the brain's clock, remains sensitive to these hormones, but through #astrocytes rather than neurons
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Glucocorticoid signaling is thought to be important for #circadian rhythms only during development. This study shows that the adult SCN, a key pacemaker for the brain's clock, remains sensitive to these hormones, but through #astrocytes rather than neurons
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Newly mapped #brain networks link far-flung regions
#Astrocyte networks in #mice link distant brain regions in ways nerve cell wiring does not.
This system, made of star-shaped cells called #astrocytes, is no relic, a new study reports. It’s operational, linking locales near and far in flexible, mysterious ways.
What’s more, astrocyte networks may also have roles in disorders such as #Alzheimer’s disease, traumatic brain injuries and stroke.
https://www.sciencenews.org/article/astrocytes-brain-networks-communicate
https://archive.ph/MKkcZ -
Newly mapped #brain networks link far-flung regions
#Astrocyte networks in #mice link distant brain regions in ways nerve cell wiring does not.
This system, made of star-shaped cells called #astrocytes, is no relic, a new study reports. It’s operational, linking locales near and far in flexible, mysterious ways.
What’s more, astrocyte networks may also have roles in disorders such as #Alzheimer’s disease, traumatic brain injuries and stroke.
https://www.sciencenews.org/article/astrocytes-brain-networks-communicate
https://archive.ph/MKkcZ -
When we look at contactomes instead of connectomes, we also get an obvious bonus: GLIA!! #glia aren't commonly involved in synapses, but they are EVERYWHERE.
Lots of chatter recently about astrocytes:
https://www.thetransmitter.org/astrocytes/the-silent-majority-how-astrocytes-shape-the-brain-across-scales/ -
When we look at contactomes instead of connectomes, we also get an obvious bonus: GLIA!! #glia aren't commonly involved in synapses, but they are EVERYWHERE.
Lots of chatter recently about astrocytes:
https://www.thetransmitter.org/astrocytes/the-silent-majority-how-astrocytes-shape-the-brain-across-scales/ -
To capture this local heterogeneity, the authors developed a #multiphoton #FLIM approach with the Na⁺ indicator ING-2 and #astrocyte labeling, enabling quantitative Na⁺ measurements in individual #astrocytes and their processes. This is important because astrocytic Na⁺ is not just a bulk somatic variable. It varies locally across branches and subdomains, where K⁺ uptake and #glutamate-linked Na⁺ influx are regulated.
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To capture this local heterogeneity, the authors developed a #multiphoton #FLIM approach with the Na⁺ indicator ING-2 and #astrocyte labeling, enabling quantitative Na⁺ measurements in individual #astrocytes and their processes. This is important because astrocytic Na⁺ is not just a bulk somatic variable. It varies locally across branches and subdomains, where K⁺ uptake and #glutamate-linked Na⁺ influx are regulated.
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🧠🎨 New paper by Meyer et al: #astrocytic #sodium #homeostasis is not uniform. Using multiphoton #FLIM in #mouse #brain slices and #invivo, they show strong #cellular and #subcellular heterogeneity in astrocytic Na⁺ levels.
Processes contain more Na⁺ than somata, Na⁺ varies between #astrocyte branches, and distinct Na⁺/K⁺-ATPase subunit patterns help tune local K⁺ uptake and #glutamate-linked Na⁺ influx.
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🧠🎨 New paper by Meyer et al: #astrocytic #sodium #homeostasis is not uniform. Using multiphoton #FLIM in #mouse #brain slices and #invivo, they show strong #cellular and #subcellular heterogeneity in astrocytic Na⁺ levels.
Processes contain more Na⁺ than somata, Na⁺ varies between #astrocyte branches, and distinct Na⁺/K⁺-ATPase subunit patterns help tune local K⁺ uptake and #glutamate-linked Na⁺ influx.
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Interestingly, #Virchow also introduced the concept of #neuroglia as a distinct #cellular component of the #NervousSystem. This was a crucial step in understanding the cellular composition of the nervous system and laid the groundwork for later #neuroscience research on glial cells.
#glia #GliaCells #Astrocytes #Oligodendrocytes #Microglia #NeuroscienceHistory
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Interestingly, #Virchow also introduced the concept of #neuroglia as a distinct #cellular component of the #NervousSystem. This was a crucial step in understanding the cellular composition of the nervous system and laid the groundwork for later #neuroscience research on glial cells.
#glia #GliaCells #Astrocytes #Oligodendrocytes #Microglia #NeuroscienceHistory
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Researchers Identify Astrocyte Pathway That Regulates Appetite and Fullness
📰 Original title: Scientists discover hidden brain switch that tells you to stop eating
🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️View full AI summary: https://killbait.com/en/researchers-identify-astrocyte-pathway-that-regulates-appetite-and-fullness/?redirpost=b88926dc-8771-4ddf-b0ae-c55cf0c57846
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Researchers Identify Astrocyte Pathway That Regulates Appetite and Fullness
📰 Original title: Scientists discover hidden brain switch that tells you to stop eating
🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️View full AI summary: https://killbait.com/en/researchers-identify-astrocyte-pathway-that-regulates-appetite-and-fullness/?redirpost=b88926dc-8771-4ddf-b0ae-c55cf0c57846
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Astrocytes Play a Key Role in Forming and Regulating Fear Memories
📰 Original title: These overlooked brain cells may control fear and PTSD
🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅View full AI summary: https://killbait.com/en/astrocytes-play-a-key-role-in-forming-and-regulating-fear-memories/?redirpost=94e1a4cc-43fa-47d1-bc78-fac7f73d856a
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Astrocytes Play a Key Role in Forming and Regulating Fear Memories
📰 Original title: These overlooked brain cells may control fear and PTSD
🤖 IA: It's not clickbait ✅
👥 Usuarios: It's not clickbait ✅View full AI summary: https://killbait.com/en/astrocytes-play-a-key-role-in-forming-and-regulating-fear-memories/?redirpost=94e1a4cc-43fa-47d1-bc78-fac7f73d856a
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Maladie #Alzheimer :
-> rôle des cellules #astrocytes qui participent à l'impression des souvenirs à long terme dans le #cerveau + peuvent être directement déclenchés par des expériences émotionnelles intenses répétées.https://mastodon.social/@cobrate/114132196272432613
enjeux politiques de la peur/haine + syndrome de stress post-traumatique #SPT.
-> rôle des cellules neurones qui encodent la #memoire selon des traces physiques : les engrammes.
enjeux scolaire.
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Maladie #Alzheimer :
-> rôle des cellules #astrocytes qui participent à l'impression des souvenirs à long terme dans le #cerveau + peuvent être directement déclenchés par des expériences émotionnelles intenses répétées.https://mastodon.social/@cobrate/114132196272432613
enjeux politiques de la peur/haine + syndrome de stress post-traumatique #SPT.
-> rôle des cellules neurones qui encodent la #memoire selon des traces physiques : les engrammes.
enjeux scolaire.
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Scientists discover hidden brain cells that repair spinal cord injuries, offering breakthrough hope for paralysis, stroke, and multiple sclerosis patients.
#SpinalCordInjury #Neuroscience #LesionRemoteAstrocytes #Astrocytes #BrainScience
https://www.scientificworldinfo.com/2026/02/scientists-reveal-secret-repair-system-spinal-cord.html -
Scientists discover hidden brain cells that repair spinal cord injuries, offering breakthrough hope for paralysis, stroke, and multiple sclerosis patients.
#SpinalCordInjury #Neuroscience #LesionRemoteAstrocytes #Astrocytes #BrainScience
https://www.scientificworldinfo.com/2026/02/scientists-reveal-secret-repair-system-spinal-cord.html -
Astrocytes were the background NPCs of neuroscience - they might be calling the shots in our moods. https://www.quantamagazine.org/once-thought-to-support-neurons-astrocytes-turn-out-to-be-in-charge-20260123/ #astrocytes #neuroscience #mentalhealth #scifi #STEM
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Astrocytes were the background NPCs of neuroscience - they might be calling the shots in our moods. https://www.quantamagazine.org/once-thought-to-support-neurons-astrocytes-turn-out-to-be-in-charge-20260123/ #astrocytes #neuroscience #mentalhealth #scifi #STEM
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Magnetic Cell Sorter 🇺🇸
#Astrocytes #CellsandOrganelles #GLAST #GLAST+ #Magnetic #Sorter #astrocyte #brain
⏩ 2 new pictures from NIH BioArt https://commons.wikimedia.org/wiki/Special:ListFiles?limit=22&user=OptimusPrimeBot&ilshowall=1&offset=20251216025720
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Magnetic Cell Sorter 🇺🇸
#Astrocytes #CellsandOrganelles #GLAST #GLAST+ #Magnetic #Sorter #astrocyte #brain
⏩ 2 new pictures from NIH BioArt https://commons.wikimedia.org/wiki/Special:ListFiles?limit=22&user=OptimusPrimeBot&ilshowall=1&offset=20251216025720
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🌟 Astrocytes are superstars in the game of long-term memory
https://medicalxpress.com/news/2025-10-astrocytes-superstars-game-term-memory.html
#memory #brain #biology #astrocytes #physiology #health #psychology
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🌟 Astrocytes are superstars in the game of long-term memory
https://medicalxpress.com/news/2025-10-astrocytes-superstars-game-term-memory.html
#memory #brain #biology #astrocytes #physiology #health #psychology
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From Prof. Tamara Boto (Bristol):
"We have two advertised fully-funded PhD positions to work on memory or disease models in Drosophila! Please check the SWBio DTP website for more information and reach out if you are interested:"
1. https://bpb-eu-w2.wpmucdn.com/blogs.bristol.ac.uk/dist/f/373/files/2025/11/swbio-26-project-2.pdf
2. https://bpb-eu-w2.wpmucdn.com/blogs.bristol.ac.uk/dist/f/373/files/2025/11/swbio-26-project-32.pdf
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From Prof. Tamara Boto (Bristol):
"We have two advertised fully-funded PhD positions to work on memory or disease models in Drosophila! Please check the SWBio DTP website for more information and reach out if you are interested:"
1. https://bpb-eu-w2.wpmucdn.com/blogs.bristol.ac.uk/dist/f/373/files/2025/11/swbio-26-project-2.pdf
2. https://bpb-eu-w2.wpmucdn.com/blogs.bristol.ac.uk/dist/f/373/files/2025/11/swbio-26-project-32.pdf
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#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @PLOSBiology plos.io/3WHTnFb
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#Tumor-associated #astrocytes (TAAs) have unclear functions in supporting the progression of #glioblastoma. This study identifies and characterizes distinct TAA subtypes with specific adaptive responses to #TumorMicroenvironment modifications @PLOSBiology plos.io/3WHTnFb
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"Astrocytes and neurons encode natural stimuli with partially shared but distinct composite receptive fields", Lu et al .2025 with @neuralengine
https://www.biorxiv.org/content/10.1101/2025.10.06.680791v1.abstract"The features within these astrocytic receptive fields are not spectrotemporally distinct from those of neurons, and at the population level, they span overlapping but different subspaces of the full sensory space compared to neurons."
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"Astrocytes and neurons encode natural stimuli with partially shared but distinct composite receptive fields", Lu et al .2025 with @neuralengine
https://www.biorxiv.org/content/10.1101/2025.10.06.680791v1.abstract"The features within these astrocytic receptive fields are not spectrotemporally distinct from those of neurons, and at the population level, they span overlapping but different subspaces of the full sensory space compared to neurons."
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Astrocytes help control #sleep & arousal. @ashleyingiosi explores a @PLOSBiology study showing that wake-promoting #histamine affects how #astrocytes respond to other signals, reducing awake time via astroglial histamine-1-receptors. Paper: plos.io/4gRj9Ap Primer: plos.io/47at1Sj
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Astrocytes help control #sleep & arousal. @ashleyingiosi explores a @PLOSBiology study showing that wake-promoting #histamine affects how #astrocytes respond to other signals, reducing awake time via astroglial histamine-1-receptors. Paper: plos.io/4gRj9Ap Primer: plos.io/47at1Sj
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The team created “AstroCapsules,” small hydrogel capsules that enclose human #astrocytes ⎯ star-shaped #brain cells that support healthy #nervous system function. Inside the capsules, the cells were engineered to release interleukin-1 receptor antagonist, an anti-inflammatory protein.
#Bioengineering #Biotechnology #Neuroscience #sflorg
https://www.sflorg.com/2025/09/btech09262501.html -
The team created “AstroCapsules,” small hydrogel capsules that enclose human #astrocytes ⎯ star-shaped #brain cells that support healthy #nervous system function. Inside the capsules, the cells were engineered to release interleukin-1 receptor antagonist, an anti-inflammatory protein.
#Bioengineering #Biotechnology #Neuroscience #sflorg
https://www.sflorg.com/2025/09/btech09262501.html -
The #brain does not function via #neurons alone. In fact, nearly half of the cells that make up the brain are glial cells, and among them, #astrocytes occupy a special place.
#Neuroscience #sflorg
https://www.sflorg.com/2025/09/ns09242501.html -
The #brain does not function via #neurons alone. In fact, nearly half of the cells that make up the brain are glial cells, and among them, #astrocytes occupy a special place.
#Neuroscience #sflorg
https://www.sflorg.com/2025/09/ns09242501.html -
Brain organoids are tiny, synthetic representations of real human brains. This section of a human brain organoid shows the star-shaped glial cells known as astrocytes, aged 140 days.
Photograph: Bahaa Al-mhanawi/AIBN
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Brain organoids are tiny, synthetic representations of real human brains. This section of a human brain organoid shows the star-shaped glial cells known as astrocytes, aged 140 days.
Photograph: Bahaa Al-mhanawi/AIBN
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Understanding Brain Trauma: Cellular Responses and Molecular Cascades
#BrainInjury #Neuroinflammation #TraumaticBrainInjury #Microglia #Astrocytes #BloodBrainBarrier #Neuroregeneration #BrainHealth #Neuroscience #BrainRecovery
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Tryptophan and the Kynurenine Pathway: Metabolic Routes Impacting Mood and Neurodegeneration
#BrainChemistry #Neuroimmune #KynureninePathway #GutBrainAxis #Neuroinflammation #Microglia #Astrocytes #Neurodegeneration #OxidativeStress #MentalHealth #BrainHealth #Metabolism #NervousSystem #DietAndBrain #Neuroscience
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Cellular Heroes of the Brain: Microglia, Astrocytes, and More
#Neuroscience #BrainHealth #Neuroplasticity #Neurobiology #BrainScience #Neurodegeneration #Microglia #Astrocytes #Memory #BrainTips
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The Brain’s Immune System: Microglia and Inflammation Explained
#BrainScience #Neuroscience #GlialCells #Microglia #Astrocytes #Neuroinflammation #BrainHealth #Neurodegeneration #Demyelination #Cytokines #Neurons #BrainResearch #Neurobiology #BrainInjury #BrainRecovery
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Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:
🌍 https://www.fabriziomusacchio.com/blog/2025-06-29-astrocyte_enhance_plasticity/
📝 https://doi.org/10.1038/s42003-024-06540-8 -
New research supports brain cell transplantation as a treatment for some neurological disorders https://www.psypost.org/new-research-supports-brain-cell-transplantation-as-a-treatment-for-some-neurological-disorders/?utm_source=dlvr.it&utm_medium=mastodon #Neuroscience #Neurology #BrainHealth #Astrocytes #CellTherapy
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Ketamine’s rapid antidepressant effects traced to overlooked brain cells https://www.psypost.org/ketamines-rapid-antidepressant-effects-traced-to-overlooked-brain-cells/?utm_source=dlvr.it&utm_medium=mastodon #Ketamine #MentalHealth #Depression #Astrocytes #Neuroscience
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From 23 Nov: Tweaking non-neural brain cells can cause memories to fade - “In simple terms, we use genetic tools that allow us to inject mice with a drug that artificially ma... https://arstechnica.com/science/2024/11/tweaking-non-neural-brain-cells-can-cause-memories-to-fade/ #astrocytes #biology #memory #neurobiology #neurons #neuroscience #science
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From 23 Nov: Tweaking non-neural brain cells can cause memories to fade - “In simple terms, we use genetic tools that allow us to inject mice with a drug that artificially ma... https://arstechnica.com/science/2024/11/tweaking-non-neural-brain-cells-can-cause-memories-to-fade/ #astrocytes #biology #memory #neurobiology #neurons #neuroscience #science
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Really cool detail on #perineuronalnets: Not only do the holes contain (stabilized) synapses, but those synapses are also tripartite - i.e. they are also contacted by Astrocytes. PNNs constrain the Astrocyte's leaflets, and prevent them from spreading off-synapse. This prevents glutamate spillover and mGluR activation.
Astrocytes require perineuronal nets to maintain synaptic homeostasis in mice
Tewari et al., Nature Neuroscience 2024
https://doi.org/10.1038/s41593-024-01714-3 -
.@KirstenBohmbach & @HennebergerLab explore a #PLOSBiology study showing that prolonged activation of #astrocytes can trigger cognitive impairments and a reactive phenotype, as seen in some brain diseases. Paper: https://plos.io/3LiknWp Primer: https://plos.io/3LmyOZz
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This study shows that repetitive stimulation of hippocampal #astrocytes induces #astrogliosis & release of the inflammatory mediator LCN2, triggering #neuroinflammation, inhibition of #NMDAR-related neuronal activity & cognitive impairment #PLOSBiology https://plos.io/3LiknWpLCN2
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#preprint_alert about #astrocytes, the roadies of the brain!
PhD student Imke Schuurmans and team have come up with a comprehensive one-step #differentiation protocol for turning human #iPSCs directly into functional Astrocytes, and how to co-culture them with induced human neurons on multi-electrode arrays for #electrophysiology.
From my new group (Nadif Kasri lab @radboudumc @DondersInst)
Preprint: https://www.biorxiv.org/content/10.1101/2024.03.27.586938v1
Imke's explainer: https://www.linkedin.com/posts/imke-schuurmans-b713a6105_astrocytes-mea-activity-7180850761176645634-qNVm
#neuroscience #cellculture -
Happy to share that our new paper is now out in GLIA!
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"We discuss preclinical evidence related to both neuronal & nonneuronal mechanisms that may be involved, touching upon the relevance of #interneurons, neuropeptides, & specific synaptic mechanisms in translating gamma stimulation into widespread neuronal activity within the brain. We also explore the roles of #microglia, #astrocytes, & the vasculature in mediating the beneficial effects of gamma stimulation on #brain function. Lastly, we examine upcoming clinical trials"
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This year I finished one of the most fascinating projects I ever worked on.
Together with a team of researchers from the molecular neurodegeneration department at Amsterdam UMC we came up with a visual and interactive way to present their latest paper on tau protein aggregation and its effect on astrocytes.
🧵
#neuroscience #dementia #alzheimers #science #scicomm #design #UI #gamedev #ScienceMastodon #visualStorytelling #astrocytes