#bcells — Public Fediverse posts

https://www.europesays.com/ie/440225/ Engineered Stem Cells Become Lifelong Protein Factories #Antibody #BCells #Éire #Health #IE #Ireland #StemCells

Revolutionary Therapy Cured Three “Incurable” Autoimmune Diseases in a Patient

Car-T cell therapy is “borrowed” from cancer treatment. Image in Creative Commons. A 47-year-old woman in Germany had…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #AIHA #APS #AutoimmuneDisease #Bcells #CAR-Ttherapy #immunotherapy #medicalbreakthrough
https://www.newsbeep.com/us/576715/

Revolutionary Therapy Cured Three “Incurable” Autoimmune Diseases in a Patient

Car-T cell therapy is “borrowed” from cancer treatment. Image in Creative Commons. A 47-year-old woman in Germany had…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #AIHA #APS #AutoimmuneDisease #Bcells #CAR-Ttherapy #immunotherapy #medicalbreakthrough
https://www.newsbeep.com/us/576715/

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS

Post-doctoral fellowship -- B cell & antibody response in tuberculosis
New Jersey Medical School, Rutgers

See the full job description on jobRxiv: https://jobrxiv.org/job/new-jersey-medical-school-rutgers-27778-post-doctoral-fellowship-b-cell-antibody-response-in-tuberculosis/

#Antibody #antigenpresentation #bcells #cytokines #Inflammation #Science...
https://jobrxiv.org/job/new-jersey-medical-school-rutgers-27778-post-doctoral-fellowship-b-cell-antibody-response-in-tuberculosis/?fsp_sid=9993

The virus nearly everyone has and its possible role in MS
#Health #MultipleSclerosis #MS #EpsteinBarrVirus #EBV #Neurology #Immunology #BrainHealth #Autoimmune #Science #PublicHealth #Inflammation #BCells #TCells #Healthcare #DiseasePrevention
https://the-14.com/the-virus-nearly-everyone-has-and-its-possible-role-in-ms/

The virus nearly everyone has and its possible role in MS
#Health #MultipleSclerosis #MS #EpsteinBarrVirus #EBV #Neurology #Immunology #BrainHealth #Autoimmune #Science #PublicHealth #Inflammation #BCells #TCells #Healthcare #DiseasePrevention
https://the-14.com/the-virus-nearly-everyone-has-and-its-possible-role-in-ms/

The virus nearly everyone has and its possible role in MS
#Health #MultipleSclerosis #MS #EpsteinBarrVirus #EBV #Neurology #Immunology #BrainHealth #Autoimmune #Science #PublicHealth #Inflammation #BCells #TCells #Healthcare #DiseasePrevention
https://the-14.com/the-virus-nearly-everyone-has-and-its-possible-role-in-ms/

Post-doctoral fellowship -- B cell & antibody response in tuberculosis
New Jersey Medical School, Rutgers

See the full job description on jobRxiv: https://jobrxiv.org/job/new-jersey-medical-school-rutgers-27778-post-doctoral-fellowship-b-cell-antibody-response-in-tuberculosis/

#Antibody #antigenpresentation #bcells #cytokines #Inflammation #Science...
https://jobrxiv.org/job/new-jersey-medical-school-rutgers-27778-post-doctoral-fellowship-b-cell-antibody-response-in-tuberculosis/?fsp_sid=9489

Lupus may be triggered by a common virus – new research
#Health #Lupus #EBV #EpsteinBarrVirus #BCells #AutoimmuneDisease #HealthNews #MedicalResearch #ImmuneSystem #VirusStudy #ChronicIllness #GlobalHealth #The14 #The14Media
https://the-14.com/lupus-may-be-triggered-by-a-common-virus-new-research/

Lupus may be triggered by a common virus – new research
#Health #Lupus #EBV #EpsteinBarrVirus #BCells #AutoimmuneDisease #HealthNews #MedicalResearch #ImmuneSystem #VirusStudy #ChronicIllness #GlobalHealth #The14 #The14Media
https://the-14.com/lupus-may-be-triggered-by-a-common-virus-new-research/

Lupus may be triggered by a common virus – new research
#Health #Lupus #EBV #EpsteinBarrVirus #BCells #AutoimmuneDisease #HealthNews #MedicalResearch #ImmuneSystem #VirusStudy #ChronicIllness #GlobalHealth #The14 #The14Media
https://the-14.com/lupus-may-be-triggered-by-a-common-virus-new-research/

Lupus may be triggered by a common virus – new research
#Health #Lupus #EBV #EpsteinBarrVirus #BCells #AutoimmuneDisease #HealthNews #MedicalResearch #ImmuneSystem #VirusStudy #ChronicIllness #GlobalHealth #The14 #The14Media
https://the-14.com/lupus-may-be-triggered-by-a-common-virus-new-research/

Lupus may be triggered by a common virus – new research
#Health #Lupus #EBV #EpsteinBarrVirus #BCells #AutoimmuneDisease #HealthNews #MedicalResearch #ImmuneSystem #VirusStudy #ChronicIllness #GlobalHealth #The14 #The14Media
https://the-14.com/lupus-may-be-triggered-by-a-common-virus-new-research/

How the immune system self-instructs to produce #antibodies with increasing affinity to antigens. #affinitymaturation #Bcells https://www.science.org/doi/abs/10.1126/science.adr6896?af=R

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

Researchers discovered that #Bcells play an active role in teaching #Tcells not to attack the body itself. If the "training" fails, #autoimmunediseases such as #neuromyelitis optica can develop: http://go.tum.de/562972

#thymus #Neuroimmunology

📷J. Böttcher, T. Korn

Seung Kim, Frederick Dick et al show that resting #Bcells are uniquely sensitive to #EZH2 #polycomb complex inhibition, which activates expression of repetitive genomic elements and subsequent #innateimmune receptor signaling in a form of viral mimicry

https://www.embopress.org/doi/full/10.15252/embj.2023114462

Electric Pulses Induce Lung Cancer Immune Response

Results of a clinical trial show a lung cancer therapy using highly focused pulses with electrical energy show signs of immune responses that can treat the patients' tumors.

https://sciencebusiness.technewslit.com/?p=45375

#News #Press #Science #Business #Cancer #LungCancer #Therapy #ElectricField #ClinicalTrial #Resection #Surgery #Ablation #MedicalDevice #ImmuneSystem #BCells #TCells

A blood test for long #Covid is possible, new research suggests
The research is among the first to prove that "#LongCovid is, in fact, a biological illness," said David Putrino, principal investigator of the new study and a professor at the Icahn School of Medicine at Mount Sinai in New York. The activity of #immune system cells called #Tcells and #Bcells — which help fight off #germs — was "irregular" in long Covid patients, Putrino said.
https://www.nbcnews.com/health/health-news/long-covid-differences-blood-test-study-finds-rcna116871

Congrats to Louisa Hill from the lab of Meinrad Busslinger
for receiving the Karl Landsteiner Award of the Austrian Society of Allergology and #Immunology! Her research on DNA looping & recombination in developing #bcells revealed the mechanisms behind #antibody diversity.
👉🏾 https://www.imp.ac.at/news/article/karl-landsteiner-award-for-louisa-hill

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

A particular focus is #lymphoid tissues that produce, store and carry #Tcells that fight infection, and #antibody-making #Bcells.

The coronavirus may also be hiding out in long-lived #nerve cells and #heart muscle, where it may drive chest #pain, brain fog, #fatigue and other long-Covid symptoms, said Diane Griffin, a virologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore who has studied the body’s response to viral infections for more than 50 years.

“We have pretty good information from acute #RNA #virus infections that RNA does persist and that it does have consequences,” said Griffin, who is vice president of the US National Academy of Sciences. “Basically, it’s hard to get rid of viruses.”

Proving that persistent viral #infection causes long Covid will be difficult, Griffin said. Viruses in stealth mode suppress replication to avoid harming their host cells.

Despite extensive distribution of coronavirus RNA throughout patients’ bodies, Chertow’s team saw little evidence of inflammation or that the immune system had tried to destroy infected cells outside the respiratory tract.

(4/n)

https://www.bloomberg.com/news/features/2023-03-01/hidden-viruses-in-your-body-could-answer-why-long-covid-lingers?leadSource=uverify%20wall

"Vaccines that resulted in speedy delivery of antigens to follicles preserved intact antigen and generated better antibody responses. These findings may have implications for the design of vaccines against difficult to neutralize or genetically variable pathogens"

#Immunology #ImmunologicalMemory #Antibody #GerminalCenter #Bcells #Vaccine

https://www.science.org/doi/10.1126/science.abn8934

Building on previous research, our lab engineered T cells to express a MuSK-chimeric autoantibody receptor (MuSK-CAAR). Unlike standard CAR-T cells, CAAR-T cells express an autoantigen in place of the Antibody-scFv region, which directs reactivity exclusively against B cells bearing a matching autoreactive BCR. This enables the removal of pathogenic #Bcells while maintaining an otherwise fully diverse patient B cell repertoire and populations.

Seung Kim, Frederick Dick et al show that resting #Bcells are uniquely sensitive to #EZH2 #polycomb complex inhibition, which activates expression of repetitive genomic elements and subsequent #innateimmune receptor signaling in a form of viral mimicry

https://www.embopress.org/doi/full/10.15252/embj.2023114462

Seung Kim, Frederick Dick et al show that resting #Bcells are uniquely sensitive to #EZH2 #polycomb complex inhibition, which activates expression of repetitive genomic elements and subsequent #innateimmune receptor signaling in a form of viral mimicry

https://www.embopress.org/doi/full/10.15252/embj.2023114462

Dear people interested in #organoids #Tcells #Macrophages #Bcells #DendriticCells #MucosalImmunology #microbiome #OrganOnChip #MicroPhysiologicalSystems #IBD #CeliacDisease #iPSCs,

where are you? I want to follow you!

Best regards,
Me

#Innate and #Adaptive #Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms
#COVID19 #Bcells #neutrophils #dendritic_cells #Tcells #NKcells #monocytes #macrophages #SARSCoV2
https://www.mdpi.com/2076-393X/11/2/408

A very common virus may be the trigger for multiple sclerosis - Enlarge / This photomicrograph depicts leukemia cells that contain Epst... - https://arstechnica.com/?p=1825773 #neurologicaldisease #epstein-barrvirus #multiplesclerosis #immunesystem #immunology #infection #science #bcells #myelin #ebv #ms

Gut Immune Cells Found Migrating to Alzheimer’s Brain

Summary: Researchers have uncovered a surprising link between gut immune cells and the brain in Alzheimer’s disease. In…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #Alzheimer'sdisease #Bcells #brainresearch #BuckInstitute #Gut-BrainAxis #immunecells #Microbiome #microbiota #neurobiology #Neurology #Neuroscience
https://www.newsbeep.com/us/120354/

Gut Immune Cells Found Migrating to Alzheimer’s Brain

Summary: Researchers have uncovered a surprising link between gut immune cells and the brain in Alzheimer’s disease. In…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #Alzheimer'sdisease #Bcells #brainresearch #BuckInstitute #Gut-BrainAxis #immunecells #Microbiome #microbiota #neurobiology #Neurology #Neuroscience
https://www.newsbeep.com/us/120354/

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science