#tcells — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tcells, aggregated by home.social.
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"..researchers found that after people had eaten, their T cells could more easily access the nutrition required to go through the energy-demanding activation process than when they had fasted overnight. After feeding, the cells were better able to take up sugars, had more fats and more-efficient mitochondria"
#TCells #ImmuneSystem #Health #Disease #Vaccination
Why you should ‘feed a cold’: eating primes immune cells for action
https://www.nature.com/articles/d41586-026-01362-6 -
Disabling Ant2 Protein Enhances T Cell Function to Combat Cancer
📰 Original title: Blocking a single protein supercharges the immune system against cancer
🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️View full AI summary: https://killbait.com/en/disabling-ant2-protein-enhances-t-cell-function-to-combat-cancer/?redirpost=5c9603a7-c703-4cf5-8a6a-741f8174764b
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Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS
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Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS
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Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS
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Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS
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Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS
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How vaccines give our immune systems a home advantage
#Health #Vaccines #Immunity #ImmuneSystem #TCells #Microbiology #Medicine #InfectiousDiseases #Measles #COVID19 #mRNA #Vaccination #PreventiveCare #DiseasePrevention #GlobalHealth
https://the-14.com/how-vaccines-give-our-immune-systems-a-home-advantage/ -
Kyoto University succeeds in creating thymus cells from iPS cells
The thymus produces cells linked to T cells, the pivot of the immune system, which attacks and destroys foreign substances that enter the body. This achievement may be useful for treating persons born without a thymus and elderly p…
#Japan #JP #Kyoto #iPScell #JijiPress #kyotonews #kyotouniversity #news #Tcells #thymuscell #京都 #京都府
https://www.alojapan.com/1408527/kyoto-university-succeeds-in-creating-thymus-cells-from-ips-cells/ -
Kyoto University succeeds in creating thymus cells from iPS cells
The thymus produces cells linked to T cells, the pivot of the immune system, which attacks and destroys foreign substances that enter the body. This achievement may be useful for treating persons born without a thymus and elderly p…
#Japan #JP #Kyoto #iPScell #JijiPress #kyotonews #kyotouniversity #news #Tcells #thymuscell #京都 #京都府
https://www.alojapan.com/1408527/kyoto-university-succeeds-in-creating-thymus-cells-from-ips-cells/ -
https://www.alojapan.com/1408527/kyoto-university-succeeds-in-creating-thymus-cells-from-ips-cells/ Kyoto University succeeds in creating thymus cells from iPS cells #IPSCell #Japan #JijiPress #Kyoto #KyotoNews #KyotoUniversity #news #TCells #ThymusCell #京都 #京都府 The thymus produces cells linked to T cells, the pivot of the immune system, which attacks and destroys foreign substances that enter the body. This achievement may be useful for treating persons born without a thymus and elderly people with weakened immune systems, according to the
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https://www.alojapan.com/1408527/kyoto-university-succeeds-in-creating-thymus-cells-from-ips-cells/ Kyoto University succeeds in creating thymus cells from iPS cells #IPSCell #Japan #JijiPress #Kyoto #KyotoNews #KyotoUniversity #news #TCells #ThymusCell #京都 #京都府 The thymus produces cells linked to T cells, the pivot of the immune system, which attacks and destroys foreign substances that enter the body. This achievement may be useful for treating persons born without a thymus and elderly people with weakened immune systems, according to the
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Perforin is the substance T and NK cells use to drill into an infected cell and kill it. Selin and Gill’s studies suggest that ME/CFS and long-COVID patients’ T cells produce almost no perforin
https://www.healthrising.org/wp-content/uploads/2025/05/Perforin_Selin_Webinar_25.gif
[alt text: graphs of perforin in two classes of cell. The healthy controls are tall grey bars, compared to 1/10 to 1/3 as tall bars for Long COVID and ME/CFS groups.]
they also found
a huge increase in a distinct type of T-cell called double-positive T-cell (CD4+ CD8+) in people with ME/CFS and/or long COVID. Instead of being differentiated into the two usual major T-cell subsets CD4 (helper/regulatory) and CD8 (killer) T-cells, these hybrid T-cells look like both CD4 and CD8 T-cells at the same time.
Selin found that these cells increased 8-9 fold in ME/CFS and long-COVID patients.
which compensates in part for the lower perforin, but also led to
a “highly dysregulated” cytotoxic T-cell immune response [...] That suggested that the immune system was kind of flailing around, trying to come up with an answer.
from https://www.healthrising.org/blog/2025/05/15/t-cell-exhaustion-chronic-fatigue-long-covid/
#COVID #COVID19 #MECFS #LongCOVID #CovidIsNotOver #TCells #NKCells #CD8 #CD4
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Regulatory #Tcells (Tregs) exist in distinct subsets, but how is this regulated? Saxena & He explore a recent @PLOSBiology study showing that the class III PI3K Vps34 acts as a master orchestrator, driving effector #Treg generation & maintenance. Paper: https://plos.io/42xmddU Primer: https://plos.io/4lz0hYA
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" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"https://insight.jci.org/articles/view/179433
Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.
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Researchers discovered that #Bcells play an active role in teaching #Tcells not to attack the body itself. If the "training" fails, #autoimmunediseases such as #neuromyelitis optica can develop: http://go.tum.de/562972
📷J. Böttcher, T. Korn
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Bystander activated #CD8 #Tcells mediate #neuropathology during #viral infection via antigen-independent #cytotoxicity
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Electric Pulses Induce Lung Cancer Immune Response
Results of a clinical trial show a lung cancer therapy using highly focused pulses with electrical energy show signs of immune responses that can treat the patients' tumors.
https://sciencebusiness.technewslit.com/?p=45375
#News #Press #Science #Business #Cancer #LungCancer #Therapy #ElectricField #ClinicalTrial #Resection #Surgery #Ablation #MedicalDevice #ImmuneSystem #BCells #TCells
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A blood test for long #Covid is possible, new research suggests
The research is among the first to prove that "#LongCovid is, in fact, a biological illness," said David Putrino, principal investigator of the new study and a professor at the Icahn School of Medicine at Mount Sinai in New York. The activity of #immune system cells called #Tcells and #Bcells — which help fight off #germs — was "irregular" in long Covid patients, Putrino said.
https://www.nbcnews.com/health/health-news/long-covid-differences-blood-test-study-finds-rcna116871 -
Natural killer #NKcell #reprogramming into mature T cells is actively inhibited by the #NuRD complex and #BCL11B-mediated regulation of #H3K27 acetylation - which also inhibit #OPA1-dependent #mitochondrial fusion in #Tcells
Peng Li and collaborators
https://www.embopress.org/doi/full/10.15252/embj.2023113448 -
Really cool application of Infinity Flow to #MouseModel #Tcells, which allows readout/prediction of >200 surface epitopes on single cells via #FlowCytometry.
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A property of T #cells that could inspire new anti-tumor therapeutics. Through a previously undescribed form of cell auto-signaling, T cells were shown to activate themselves in peripheral #tissues, fueling their ability to attack #tumors.
#Tcells #Biology #Medical #Cancer #sflorg
https://www.sflorg.com/2023/05/bio05082302.html -
Antitumor T-cell function requires #CPEB4-mediated adaptation to chronic #endoplasmic #reticulum stress
Raúl Méndez and colleagues at IRB Barcelona show that RNA-binding protein CPEB4 mediates transient unfolded protein response #UPR for stress adaptation in #CD8 #Tcells
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@weldeiry Nice succinct overview of CD4+ #Tcells in #cancer #immunology. Also a short paragraph on cancer promotion by (a subset of) these cells, a.o. #Treg.
Thanks for sharing.
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A particular focus is #lymphoid tissues that produce, store and carry #Tcells that fight infection, and #antibody-making #Bcells.
The coronavirus may also be hiding out in long-lived #nerve cells and #heart muscle, where it may drive chest #pain, brain fog, #fatigue and other long-Covid symptoms, said Diane Griffin, a virologist at the Johns Hopkins Bloomberg School of Public Health in Baltimore who has studied the body’s response to viral infections for more than 50 years.
“We have pretty good information from acute #RNA #virus infections that RNA does persist and that it does have consequences,” said Griffin, who is vice president of the US National Academy of Sciences. “Basically, it’s hard to get rid of viruses.”
Proving that persistent viral #infection causes long Covid will be difficult, Griffin said. Viruses in stealth mode suppress replication to avoid harming their host cells.
Despite extensive distribution of coronavirus RNA throughout patients’ bodies, Chertow’s team saw little evidence of inflammation or that the immune system had tried to destroy infected cells outside the respiratory tract.
(4/n)
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Recent work from University of Basel in Nature Communications looking into #Tcell #exhaustion, indicating a role for the SNX9 #gene. Knocking out this gene led to phenotypical and functional changes, e.g. Tmem differentiation, IFNg production, reduced #tumour growth, and improved survival in certain models.
https://www.nature.com/articles/s41467-022-35583-w
#Tcells #Cancer #Immunology #lymphocytes #CancerImmunology #SingleCell #scRNAseq #RNAseq
Found via @sflorg
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Assessment of #Tcell proliferation and other characteristics over a period of ten year. Wow! Fun read.
From the abstract by Soerens et al.: "These observations provide a model to better understand memory cell differentiation, exhaustion, cancer and ageing, and show that functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan."
Found via @biomiha and @billjeffries
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A cool experiment on CD8 T cell proliferative expansion and memory.
Upon adoptive transfer (to a different mouse) "functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan."
(at least 10 years!)#Tcells #CD8Tcells #Tcellmemory #immunology #immuneresponse #celllongevity #cellproliferation
"Functional T cells are capable of supernumerary cell division and longevity"
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A cool experiment on CD8 T cell proliferative expansion and memory.
Upon adoptive transfer (to a different mouse) "functionally competent T cells can retain the potential for extraordinary population expansion and longevity well beyond their organismal lifespan."
(at least 10 years!)#Tcells #CD8Tcells #Tcellmemory #immunology #immuneresponse #celllongevity #cellproliferation
"Functional T cells are capable of supernumerary cell division and longevity"
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New #colitis study from LJI's Kronenberg Lab: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1034648/full
The team investigated whether increased expression of two GPRs (GPR183 and GPR18) in the intestine is related to disease severity in colitis models.
#Immunology #Tcells #ImmuneSystem #CellularBiology #MolecularBiology #GPRs #infammation #BowelDisease #Health #MouseModels
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Hello!
Thank you much for looking in.
I am particularly interested in #ArmChairTravelling and #StreetPhotography due to my #Disability with #MultipleSclerosis and my participation in the drug trial for #ATA188 #EBV #TCells and #Neurology. #ATARABIO.
Please boost the #MultipleSclerosis hashtag so we can come together as PwMS, medical personnel and researchers to share info and expertise.
You are welcome to check my #ATAUpdates on my #SPMS progress and my #StreetPhotography on my profile page.
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Hello!
Thank you much for looking in.
I am particularly interested in #ArmChairTravelling and #StreetPhotography due to my #Disability with #MultipleSclerosis and my participation in the drug trial for #ATA188 #EBV #TCells and #Neurology. #ATARABIO.
Please boost the #MultipleSclerosis hashtag so we can come together as PwMS, medical personnel and researchers to share info and expertise.
You are welcome to check my #ATAUpdates on my #SPMS progress and my #StreetPhotography on my profile page.
