#tcells — Public Fediverse posts

T-cells are a major factor in #tumor control, however their diversity makes them a challenging object for quantitative analysis. This new preprint shows a #quantitative toolbox of free open-source tools in action. #AdaptiveImmunity #TumorImmunology #Tcells #cancer #lymphocytes #lymphNodes #TCR
https://doi.org/10.64898/2026.06.05.730356

Disabling Ant2 Protein Enhances T Cell Function to Combat Cancer

📰 Original title: Blocking a single protein supercharges the immune system against cancer

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/disabling-ant2-protein-enhances-t-cell-function-to-combat-cancer/?redirpost=5c9603a7-c703-4cf5-8a6a-741f8174764b

#science #cancer #immunesystem #tcells

Autoimmune diabetes & #transplant rejection arise when immune checkpoints fail. This study shows that blocking CD22 ligand-binding expands regulatory #Bcells & protective γδ #Tcells, suppressing type 1 #diabetes & prolonging #SkinGraft survival in mice @PLOSBiology https://plos.io/41t4KTS

How vaccines give our immune systems a home advantage
#Health #Vaccines #Immunity #ImmuneSystem #TCells #Microbiology #Medicine #InfectiousDiseases #Measles #COVID19 #mRNA #Vaccination #PreventiveCare #DiseasePrevention #GlobalHealth
https://the-14.com/how-vaccines-give-our-immune-systems-a-home-advantage/

For the first time, researchers at the University of British Columbia have demonstrated how to reliably produce an important type of human #immune cell—known as helper T cells—from stem #cells in a controlled laboratory setting.
#Biomedical #Bioengineering #Tcells #sflorg
https://www.sflorg.com/2026/01/bmed01082601.html

#Psoriasis may be effectively cured by early antibody therapy. Ongoing study. #Immunesystem #Tcells
https://www.nature.com/articles/d41586-025-02649-w

📢 Call for speakers

We are looking for early-career researchers to speak in FocalPlane's mini-symposium run together with the popular membrane trafficking webinar series organised by Francesca Bottanelli, Fèlix Campelo and Ishier Raote.

Application deadline: Sunday 24 August

Find out more:

https://focalplane.biologists.com/2025/07/14/focalplane-features-membrane-trafficking-apply-to-give-a-talk/

#FocalPlaneFeatures #Microscopy #MembraneTrafficking #Cells #TCells #ECR #ImmunologicalSynapse #MembraneDynamics #Microscope #CellBiology

I saw a scientifically and potentially clinically rather interesting presentation from Sniper therapeutics, this morning. But do we really need to militarize our technique and therapy names?

What was wrong with the original name Super Engagers?
Additionally, the mechanism of action here seems to be more 'close combat' than 'sniper'.

#Tcells #CancerTherapy #CellTherapy

Researchers developed a new method to label and track #Tcells in the body using #PETimaging and engineered receptors. This could improve understanding of #celltherapy and support safer use in future treatments: http://go.tum.de/935833

#Immunotherapy

📷V. Morath

Perforin is the substance T and NK cells use to drill into an infected cell and kill it. Selin and Gill’s studies suggest that ME/CFS and long-COVID patients’ T cells produce almost no perforin

https://www.healthrising.org/wp-content/uploads/2025/05/Perforin_Selin_Webinar_25.gif

[alt text: graphs of perforin in two classes of cell. The healthy controls are tall grey bars, compared to 1/10 to 1/3 as tall bars for Long COVID and ME/CFS groups.]

they also found

a huge increase in a distinct type of T-cell called double-positive T-cell (CD4+ CD8+) in people with ME/CFS and/or long COVID. Instead of being differentiated into the two usual major T-cell subsets CD4 (helper/regulatory) and CD8 (killer) T-cells, these hybrid T-cells look like both CD4 and CD8 T-cells at the same time.

Selin found that these cells increased 8-9 fold in ME/CFS and long-COVID patients.

which compensates in part for the lower perforin, but also led to

a “highly dysregulated” cytotoxic T-cell immune response [...] That suggested that the immune system was kind of flailing around, trying to come up with an answer.

from https://www.healthrising.org/blog/2025/05/15/t-cell-exhaustion-chronic-fatigue-long-covid/

#COVID #COVID19 #MECFS #LongCOVID #CovidIsNotOver #TCells #NKCells #CD8 #CD4

Oh look, scientists claim they can sneak #mRNA into T cells to tackle #HIV latency—because if there's anything more efficient than human cells, it's #tech that suggests you upgrade your browser. 🙄🖥️ Maybe next they'll solve world hunger with a new app that only works on Netscape. 🍽️✨
https://www.nature.com/articles/s41467-025-60001-2 #Tcells #latency #science #innovation #humor #HackerNews #ngated

Efficient mRNA delivery to resting T cells to reverse HIV latency

https://www.nature.com/articles/s41467-025-60001-2

#HackerNews #Efficient #mRNA #delivery #to #resting #T #cells #to #reverse #HIV #latency

mRNAdelivery #HIVresearch #Tcells #HIVlatency #medicalinnovation #biotechnology

Regulatory #Tcells (Tregs) exist in distinct subsets, but how is this regulated? Saxena & He explore a recent @PLOSBiology study showing that the class III PI3K Vps34 acts as a master orchestrator, driving effector #Treg generation & maintenance. Paper: https://plos.io/42xmddU Primer: https://plos.io/4lz0hYA

Dietmar Zehn, Professor of Animal Physiology and #Immunology, and his team showed that the body prepares itself for a severe course of illness even in the case of uncomplicated #infections by producing special #Tcells: http://go.tum.de/664167

@HelmholtzMunich

📷A.Eckert

🎉 Groundbreaking news: #aspirin, the hero of headaches, moonlights as a cancer-fighting ninja! 🥋Scientists discover it foils platelet TXA2's evil plot against T cells, while Nature.com battles browser compatibility issues like it's 2005. 🖥️
https://www.nature.com/articles/s41586-025-08626-7 #cancerresearch #Tcells #Naturecom #healthnews #scienceupdates #HackerNews #ngated

today I watched:

How Alzheimer's mutates the immune system | nature video

https://youtu.be/o_dbdhwNbig?si=P53kD4ckA45YXKRL

5 min. interview with David Gate on CXCR3 expressing peripheral T cells and Alzheimer disease.

~

I wonder if thiamine deficiency increases CXCR3 expression?

#2dayIwatched #Alzheimers
#NeurodegenerativeDiseases
#Tcells #BrainHealth #immunology #neuroscience

Quality & longevity of CD4+ #Tcells change with age in mice. @AYatesGroup &co show that these cells have longer lifespans and become more quiescent when the organism ages, but these properties depend on cellular age, not on host age #PLOSBiology https://plos.io/46PBjgX

"Viral persistence and sustained immune activation are linked to Long Covid."

https://www.science.org/doi/10.1126/scitranslmed.adk3295

#LongCOVID #NotInYourHead #SARSCov2 #Virology #ChronicDisease #ViralInfection #ViralRNA #ImmuneCells #TCells #ViralPersistence

“This study represents a significant scientific breakthrough, as it shifts the paradigm in the understanding of MHC Class II peptides and their recognition by CD4+ T cells.”

🥁 One of the #SIBRemarkableOutputs 2023 👏

👉 More: https://tinyurl.com/3ah98n3j

#machinelearning #Tcells #CancerResearch

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

Impressive new work by Moravec et al. in Nature Biotechnology, sadly not open source. "... a #HighThroughput personalized #TCR discovery pipeline ..." with which they "...identified dozens of CD4+ and CD8+ T-cell-derived TCRs with potent tumor reactivity, including TCRs that recognized patient-specific #neoantigens."

https://www.nature.com/articles/s41587-024-02210-6

#cancer #tumour #Tcells
#science

Researchers discovered that #tumors use a messenger substance to influence #immunecells in an early phase of the immune response. This could significantly improve #cancer immunotherapies: http://go.tum.de/368607

#tcells #prostaglandin

📷A.Eckert

New approach detects T cells in "cold" tumors, paves way for broader immunotherapy
https://www.news-medical.net/news/20240229/New-approach-detects-T-cells-in-cold-tumors-paves-way-for-broader-immunotherapy.aspx

#TCells
#Cancer
#ColdTumors
#Tumors
#Immunotherapy
#LaJollaInstituteForImmunology
#Neoantigens

Newborn T cells found to excel in immune defense
https://www.msn.com/en-gb/health/other/newborn-t-cells-found-to-excel-in-immune-defense/ar-BB1iPdkC?cvid=ccf7362250394fd3d915a83e6744c18d&ocid=winp2fptaskbarhover&ei=8

#TCells
#Newborns