#innateimmunity — Public Fediverse posts

The clockwork macrophage: Timing in #innateimmunity

(free review article)

#OpenAccess #circadian #immunity

https://davidojcius.blogspot.com/2026/05/the-clockwork-macrophage-timing-in.html

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNλ-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNλ.'
#Preprint #Immunology #InnateImmunity #Interferon

https://www.biorxiv.org/content/10.1101/2024.05.21.595218v1

Now I cant stop singing "more than a spike gene" to the tune of the BeeGees (protein didnt fit the meter).

'We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors.'
#Covid #Covid19 #SarsCov2 #Interferon #Virology #Immunology #InnateImmunity

https://www.sciencedirect.com/science/article/pii/S1931312823003281

'Together, these results demonstrate that host cGAS–STING senses T. cruzi infection, enhancing parasite growth at the site of entry, and contributes to acute-phase parasite restriction in the heart, a major site of tissue damage in chronic T. cruzi infection.'
#immunology #InnateImmunity #HostPathogen

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300373/265860/cGAS-STING-Pathway-Activation-during-Trypanosoma?redirectedFrom=fulltext

"They have investigated the brains of ageing mice, elucidating the source of the cGAS–STING trigger and the particular cells in which this pathway is activated (Fig. 1). Specifically, the authors find that cytosolic DNA derived from perturbed mitochondria activates the pathway in ageing microglia, the main immune cells in the brain — an observation that agrees with earlier findings that cGAS–STING is involved in activating microglia and in neuroinflammation"
#Immunology #Neuroimmunology #NeurodegenerativeDisease #InnateImmunity

https://www.nature.com/articles/d41586-023-02240-1

'Therefore, to understand the influence of Wolbachia on within-host ZIKV evolution, we characterized the genetic diversity of molecularly barcoded ZIKV virus populations replicating in Wolbachia-infected mosquitoes and found that within-host ZIKV evolution was subject to weak purifying selection and, unexpectedly, loose anatomical bottlenecks in the presence and absence of Wolbachia'

#Preprint #Wolbachia #HostPathogen #Virology #InnateImmunity

https://www.biorxiv.org/content/10.1101/2023.06.26.546271v1

'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al

#WoundHealing #Immunology #Cytokine #InnateImmunity

https://www.cell.com/cell/fulltext/S0092-8674(23)00328-8

'Flagella-driven motility is essential for the entry of H. pylori into the mucus layer and for maintaining a swimming reservoir in the mucus (Fig. 3). H. pylori has a unipolar bundle of rotating sheathed flagella, with filaments composed of two flagellin proteins that evade activating the innate immune system via TLR5 due to specific adaptation of their amino acid sequences'

#Helicobacter #InnateImmunity #HostPathogen

https://www.nature.com/articles/s41572-023-00431-8

'Using fluorescence microscopy, we show that B. burgdorferi associates with mouse and human cells in culture, and we document that internalized spirochetes colocalize with the pattern recognition receptor cyclic GMP-AMP synthase (cGAS).'

#Immunology #InnateImmunity #Borrelia #HostPathogen

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200354/263621/Borrelia-burgdorferi-Engages-Mammalian-Type-I-IFN?redirectedFrom=fulltext

'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al

#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

https://www.nature.com/articles/s41564-023-01338-6

"Our findings underscore the importance of cell death in defense against intracellular bacterial pathogens and provide an example of how layered and hierarchical immune pathways can provide robust defense against pathogens that have evolved a broad arsenal of virulence factors."

#Shigella #HostPathogen #CellDeath #Apoptosis #InnateImmunity #Pathogen #Microbiology #Immunology

https://elifesciences.org/articles/83639

More science about Covid’s strategies for evading immune detection.

Preprint here: https://www.biorxiv.org/content/10.1101/2022.05.04.490614v3

#Covid #COVID19 #MHC #CD8TCells #InnateImmunity #Immune system

My #science #introduction

I am a #pediatrics #infectiousdisease #physicianscientist at #UCSanDiego #MedSchool #PharmacySchool who studies #bacterial #pathogens, #innateimmunity, #antibioticresistance, #vaccines, and #DrugDiscovery

I’m involved extensively in interdisciplinary research program development, #PhD, #MD, #PharmD and dual degree training, and EID initiatives at UC San Diego and beyond

On twitter I do a lot of memes