#innateimmunity — Public Fediverse posts

Postdoc at UConn health on innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/

#autoimmunediseases #bacterialhostinteraction #innateimmunity #proteomics #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/?fsp_sid=13787

Postdoc at UConn health on innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/

#autoimmunediseases #bacterialhostinteraction #innateimmunity #proteomics #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/?fsp_sid=13787

Postdoc at UConn health on innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/

#autoimmunediseases #bacterialhostinteraction #innateimmunity #proteomics #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/?fsp_sid=13787

Postdoc at UConn health on innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/

#autoimmunediseases #bacterialhostinteraction #innateimmunity #proteomics #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/?fsp_sid=13787

Postdoc at UConn health on innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/

#autoimmunediseases #bacterialhostinteraction #innateimmunity #proteomics #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-innate-immunity/?fsp_sid=13787

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

#SARSCoV2 suppresses #InnateImmunity via multiple proteins, but what are their relative roles during infection? This study of a panel of 12 viral proteins shows that they (and especially NSP1 & NSP15) act via distinct yet redundant mechanisms @PLOSBiology https://plos.io/3Rptk6r

#SARSCoV2 suppresses #InnateImmunity via multiple proteins, but what are their relative roles during infection? This study of a panel of 12 viral proteins shows that they (and especially NSP1 & NSP15) act via distinct yet redundant mechanisms @PLOSBiology https://plos.io/3Rptk6r

#SARSCoV2 suppresses #InnateImmunity via multiple proteins, but what are their relative roles during infection? This study of a panel of 12 viral proteins shows that they (and especially NSP1 & NSP15) act via distinct yet redundant mechanisms @PLOSBiology https://plos.io/3Rptk6r

#SARSCoV2 suppresses #InnateImmunity via multiple proteins, but what are their relative roles during infection? This study of a panel of 12 viral proteins shows that they (and especially NSP1 & NSP15) act via distinct yet redundant mechanisms @PLOSBiology https://plos.io/3Rptk6r

#SARSCoV2 suppresses #InnateImmunity via multiple proteins, but what are their relative roles during infection? This study of a panel of 12 viral proteins shows that they (and especially NSP1 & NSP15) act via distinct yet redundant mechanisms @PLOSBiology https://plos.io/3Rptk6r

The clockwork macrophage: Timing in #innateimmunity

(free review article)

#OpenAccess #circadian #immunity

https://davidojcius.blogspot.com/2026/05/the-clockwork-macrophage-timing-in.html

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

https://www.europesays.com/uk/323500/ RNA N-glycosylation enables immune evasion and homeostatic efferocytosis #Health #HumanitiesAndSocialSciences #InnateImmunity #multidisciplinary #rna #Science #UK #UnitedKingdom

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

Cytosolic viral RNA is detected by #antiviral #PatternRecognition receptors like RIG-I. This study shows that #Mediator subunit MED23 limits RIG-I expression via FOXO3, dampening #InnateImmunity & highlighting MED23 as a potential therapeutic target @PLOSBiology https://plos.io/457VwOe

#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0

#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0

#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0

#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0

#InnateImmunity is a crucial surveillance framework. However, @Colombani explores 2 @PLOSBiology studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth. Papers: https://plos.io/4jqpmUh https://plos.io/3RGWESS Primer: https://plos.io/3GyUeU0

New study! Learning about inflammation by studying the differences between mammals – a toot-orial.

https://doi.org/10.1186/s10020-024-01052-x

When the body meets an infectious microbe or similar challenge it activates an inflammatory cascade. Inflammation helps eliminate the microbe, but, if it gets of control, it can be dangerous or even fatal.

We like to assume that inflammation is basically the same for all animals. And this is usually true in cell culture, but in vivo …

#Inflammation #InnateImmunity

1/

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Here we studied the endogenous TLR pathways in human and mouse macrophages. We provide evidence that myddosomes are dynamic and long-lived entities, numbering in the dozens within individual cells. We demonstrate that the complex cellular responses of the entire TLR pathway are coordinated and executed from within these structures.'
#Immunology #InnateImmunity
https://www.nature.com/articles/s41586-024-07614-7

'Here we studied the endogenous TLR pathways in human and mouse macrophages. We provide evidence that myddosomes are dynamic and long-lived entities, numbering in the dozens within individual cells. We demonstrate that the complex cellular responses of the entire TLR pathway are coordinated and executed from within these structures.'
#Immunology #InnateImmunity
https://www.nature.com/articles/s41586-024-07614-7

'Here we studied the endogenous TLR pathways in human and mouse macrophages. We provide evidence that myddosomes are dynamic and long-lived entities, numbering in the dozens within individual cells. We demonstrate that the complex cellular responses of the entire TLR pathway are coordinated and executed from within these structures.'
#Immunology #InnateImmunity
https://www.nature.com/articles/s41586-024-07614-7

'Here we studied the endogenous TLR pathways in human and mouse macrophages. We provide evidence that myddosomes are dynamic and long-lived entities, numbering in the dozens within individual cells. We demonstrate that the complex cellular responses of the entire TLR pathway are coordinated and executed from within these structures.'
#Immunology #InnateImmunity
https://www.nature.com/articles/s41586-024-07614-7

'Distinct patterns emerge when comparing sustained and transient infections. Transiently infected participants have a robust type of antiviral defence response termed a type I interferon (IFN-I) response in the nasal mucosal tissue shortly after viral exposure (day 1 after infection), potentially contributing to viral removal. By contrast, participants who had sustained infection showed delayed (only starting on day 5 after infection) mucosal IFN-I responses, as well as delays in immune-cell infiltration into the nasopharynx, indicating an impaired innate antiviral response at the site of initial viral inoculation and replication.'
#Covid #Covid19 #Immunology #Virology #InnateImmunity

https://www.nature.com/articles/d41586-024-01644-x