#alzheimers — Public Fediverse posts

#Alzheimers #Dementia #Fitness 🏋️‍♂️💟

Practice makes progress! Week 4 of Resiliency in Motion (RIM) 🌟

💜 Our RIM program is specially designed for caregivers and their loved ones living with dementia to stay active, build trust, and move together.

💪🏾 This week, our rockstar participants tackled new adaptive partner movement drills, including guided backward walking and lateral side-steps to high-fives.✋🏽✨

🧠 Did you know? Walking backward doesn't just strengthen knees and improve dynamic balance—it actively challenges the brain, boosting focus and dynamic coordination.

📣 Special thanks to Mystic Valley Aging Services, the I’m Still Here Foundation, and the Wakefield Council on Aging.

🗓️ Next 6-Week Session Starts November 5!
To enroll or learn more about this free adaptive fitness class, contact Paula Buccilli at Mystic Valley #Aging Services: 📞 781-388-2319 | ✉️ [email protected]

🎉 Please like, comment, or share this video to help us spread public awareness!

#brainhealth #fun

What alzheimer does to a really good artist. Man, it really fucking sucks...

Think about it. Instead of spending tons and tons of money to help with dementia research and other related fields, rich people instead spend a really fucking absurd amount of that on things that destroy the environment, steal from actual artists, and make people actually dumb, lazier, maybe even more lonelier.

Insanity ensues when internet outage happens... *sigh*

#art #alzheimer #dementia #alzheimers #mastodon #ai #llm

Mapping Lymphatic Drainage from the Human Brain to the Head and Neck: Potential Surgical Implications for Dementia.

Arch Plast Surg. 2026 Sep;53(5):427-438. Epub 2026 Aug 21Authors: Nguyen DH, Higueras C, Suami H, Carrera Burgaya A, Hong JPPubMed: 42835887Submit Comment

Read more: https://www.alzforum.org/papers/mapping-lymphatic-drainage-human-brain-head-and-neck-potential-surgical-implications-dementia
#Dementia #Alzheimers #Autism #Caregiving

Monospecific antibodies reveal reduction of granulins in frontotemporal dementia caused by GRN mutations.

Mol Neurodegener Adv. 2026;2(1):47. Epub 2026 Oct 6Authors: Merino P, Araujo LT, Mendsaikhan A, Taylor G, Heath C, Chung M, McEachin ZT, Kukar TPubMed: 42846257Submit Comment

Read more: https://www.alzforum.org/papers/monospecific-antibodies-reveal-reduction-granulins-frontotemporal-dementia-caused-grn
#Dementia #Alzheimers #Autism #Caregiving

Aqueous extracts of Phyllanthus amarus leaf mitigate cognitive impairments by enhancing neurotransmitter regulation and antioxidant defense mechanisms.

Neurodegener Dis Manag. 2026 Oct 8;:1-12. Epub 2026 Oct 8Authors: Adedayo BC, Oyeleye IS, Oyelami OS, Aro OP, Ojo OR, Oboh GPubMed: 42847130Submit Comment

Read more: https://www.alzforum.org/papers/aqueous-extracts-phyllanthus-amarus-leaf-mitigate-cognitive-impairments-enhancing
#Dementia #Alzheimers #Autism #Caregiving

Does genetic testing remain relevant in advanced Parkinson's disease?

J Neural Transm (Vienna). 2026 Oct 6; Epub 2026 Oct 6Authors: Westenberger A, Endaya NJ, Brüggemann NPubMed: 42836964Submit Comment

Read more: https://www.alzforum.org/papers/does-genetic-testing-remain-relevant-advanced-parkinsons-disease
#Dementia #Alzheimers #Autism #Caregiving

AA and Parkinson's Disease.

Rev Physiol Biochem Pharmacol. 2027;188:187-202. Authors: Das UNPubMed: 42834215Submit Comment

Read more: https://www.alzforum.org/papers/aa-and-parkinsons-disease
#Dementia #Alzheimers #Autism #Caregiving

An integrated resource for systems-level analysis of aging hallmarks and associated genes.

Biogerontology. 2026 Oct 7;27(5)Authors: Tiwari R, Balaji M, Chivukula N, Sil P, Samal APubMed: 42842105Submit Comment

Read more: https://www.alzforum.org/papers/integrated-resource-systems-level-analysis-aging-hallmarks-and-associated-genes
#Dementia #Alzheimers #Autism #Caregiving

The Therapeutic Potential of MicroRNAs Delivered By Mesenchymal Stem Cells in Parkinson's Disease, Alzheimer's Disease, and Stroke: A Systematic Review of Preclinical Studies.

Mol Neurobiol. 2026 Oct 3;63(1)Authors: Przywara D, Petniak A, Gil-Kulik PPubMed: 42828605Submit Comment

Read more: https://www.alzforum.org/papers/therapeutic-potential-micrornas-delivered-mesenchymal-stem-cells-parkinsons-disease
#Dementia #Alzheimers #Autism #Caregiving

Computational gait analysis in the 3xTg-AD mouse model: evidence of progressive alterations in locomotor coordination.

Front Aging Neurosci. 2026;18:1879487. Epub 2026 Sep 23Authors: Castillo Mariqueo L, Valdivia Gallardo M, Giménez Llort L, Taramasco Toro C, Chahuan Moyano L, Robles Cruz DPubMed: 42846493Submit Comment

Read more: https://www.alzforum.org/papers/computational-gait-analysis-3xtg-ad-mouse-model-evidence-progressive-alterations-locomotor
#Dementia #Alzheimers #Autism

[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model.

Int J Mol Med. 2026 Nov;58(5) Epub 2026 Oct 2Authors: Chen J, Long Z, Li Y, Luo M, Luo S, He GPubMed: 42825350Submit Comment

Read more: https://www.alzforum.org/papers/corrigendum-alteration-wntgsk3vv-catenin-signalling-pathway-rapamycin-ameliorates-pathology
#Dementia #Alzheimers #Autism #Caregiving

Comment on: Association Between Calcium Supplement Use and Cognitive Impairment in Ageing Women: A Longitudinal Analysis.

Australas J Ageing. 2026 Dec;45(4):e70238. Authors: Kucur Yonet C, Yilmaz Kars M, Cicek O, Turgut ZI, Akkar I, Uyar D, Kizilarslanoglu MCPubMed: 42836637Submit Comment

Read more: https://www.alzforum.org/papers/comment-association-between-calcium-supplement-use-and-cognitive-impairment-ageing-women
#Dementia #Alzheimers #Autism #Caregiving

Cognitive reserve and adaptive resilience: a conceptual analysis of a cross-species framework for neuropsychology and cognitive aging.

Front Psychol. 2026;17:1948103. Epub 2026 Sep 22Authors: Broche-Pérez Y, Díaz-Guerra DD, Hernández-Lugo MC, Ramos-Galarza CPubMed: 42840685Submit Comment

Read more: https://www.alzforum.org/papers/cognitive-reserve-and-adaptive-resilience-conceptual-analysis-cross-species-framework
#Dementia #Alzheimers #Autism #Caregiving

Long-term exposure to ultrafine particles and mortality from neurodegenerative diseases: a population-based cohort study.

Epidemiology. 2026 Oct 5; Epub 2026 Oct 5Authors: Batisse E, Lloyd M, Renoux C, Ganji A, Xu J, Hatzopoulou M, Weichenthal S, Baumgartner JPubMed: 42832702Submit Comment

Read more: https://www.alzforum.org/papers/long-term-exposure-ultrafine-particles-and-mortality-neurodegenerative-diseases-population
#Dementia #Alzheimers #Autism #Caregiving

Still kinda haunts me this is what Alzheimer's does to a person.

I know all of what happens. I've listened to Everywhere At The End of Time...

#alzheimer #dementia #alzheimers #mastodon

Limitations of current neuroprotective therapies in dementia with Lewy bodies.

Expert Rev Clin Pharmacol. 2026 Oct 8; Epub 2026 Oct 8Authors: O'shea DM, Disla S, Gosling AE, Valdelamar GA, Ioana Tolea M, Galvin JEPubMed: 42847732Submit Comment

Read more: https://www.alzforum.org/papers/limitations-current-neuroprotective-therapies-dementia-lewy-bodies
#Dementia #Alzheimers #Autism #Caregiving

Erratum to "The PINK1-VCP-p47 pathway protects against tau-induced dendritic shrinkage in cortical neurons through interaction with STIP1" [Neurobiol. Dis. 229 (2026) 107592].

Neurobiol Dis. 2026 Oct 6;:107616. Epub 2026 Oct 6Authors: Banerjee S, Wang KZ, DeChellis-Marks MR, Ross MR, Oury NH, Chu CTPubMed: 42838796Submit Comment

Read more: https://www.alzforum.org/papers/erratum-pink1-vcp-p47-pathway-protects-against-tau-induced-dendritic-shrinkage-cortical
#Dementia #Alzheimers #Autism

Synucleins deficiency alter dopamine- and glutamate-induced calcium signal in neurons and astrocytes.

Neurochem Int. 2026 Oct 3;200:106269. Epub 2026 Oct 3Authors: Fedulina AA, Baev AY, Emelyanov AV, Khizeva AA, Chaprov KD, Vinokurov AY, Abramov AYPubMed: 42828908Submit Comment

Read more: https://www.alzforum.org/papers/synucleins-deficiency-alter-dopamine-and-glutamate-induced-calcium-signal-neurons-and
#Dementia #Alzheimers #Autism #Caregiving

‘I want to do everything I can to head off dementia’: why demand for the shingles vaccine is soaring.

Could a drug intended to prevent painful rashes also protect our brains as we get older? The signs are promising – but not conclusive.

Yet that’s enough to be driving a boom in shingles jabs.

https://mediafaro.org/article/20261011-i-want-to-do-everything-i-can-to-head-off-dementia-why-demand-for-the-shingles-vaccine-is-soaring?mf_channel=mastodon&action=forward

#Dementia #Health #Shingles #Alzheimers #Research #Science #Vaccines #Immunisation

Correction to 'Beyond Bulk: Cell-Type-Resolved Epigenomics as the Path Forward in Alzheimer's Disease Research'.

Eur J Neurosci. 2026 Oct;64(7):e70696. Authors: PubMed: 42834006Submit Comment

Read more: https://www.alzforum.org/papers/correction-beyond-bulk-cell-type-resolved-epigenomics-path-forward-alzheimers-disease
#Dementia #Alzheimers #Autism #Caregiving

From pathogenesis to non-medical therapy: A review of exploring sensory and multi-sensory stimulation as a non-invasive treatment approach for Alzheimer's disease.

Neurosci Biobehav Rev. 2026 Oct 7;191:107004. Epub 2026 Oct 7Authors: Zhu Y, Jafari Z, Kolb BE, Mohajerani MHPubMed: 42843100Submit Comment

Read more: https://www.alzforum.org/papers/pathogenesis-non-medical-therapy-review-exploring-sensory-and-multi-sensory-stimulation-non
#Dementia #Alzheimers #Autism #Caregiving

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact.

Ann Clin Transl Neurol. 2026 Oct 8; Epub 2026 Oct 8Authors: Lopez FV, Erani F, Bangen KJ, Coughlin DG, Galasko D, Thomas KRPubMed: 42847555Submit Comment

Read more: https://www.alzforum.org/papers/subjective-cognitive-concerns-and-cognitive-trajectories-parkinsons-disease-biomarker-impact
#Dementia #Alzheimers #Autism #Caregiving

Forced treadmill running and ladder climbing physical activity attenuates cognitive decline and protein aggregates in aged 3xTg-AD mice.

Mol Brain. 2026 Jul 23;19(1)Authors: Yang M, Ouyang X, Gautam S, Singleton M, Davydzenka V, Zhang J, Li YPubMed: 42844635Submit Comment

Read more: https://www.alzforum.org/papers/forced-treadmill-running-and-ladder-climbing-physical-activity-attenuates-cognitive-decline
#Dementia #Alzheimers #Autism #Caregiving

External validation of an integrative model of functional impairment in early-stage behavioral variant frontotemporal dementia (bvFTD).

J Neurol. 2026 Oct 5;273(10)Authors: Chatzidimitriou E, Moraitou D, Ioannidis P, Aretouli E, Chen Y, Rosen HJ, Gorno-Tempini ML, Seeley WW, Miller BL, Rankin KPPubMed: 42834227Submit Comment

Read more: https://www.alzforum.org/papers/external-validation-integrative-model-functional-impairment-early-stage-behavioral-variant
#Dementia #Alzheimers #Autism

Increased Expression of α-Synuclein Impairs Trafficking of the Essential SNARE Protein Synaptobrevin-2.

J Neurochem. 2026 Oct;170(10):e70568. Authors: Arvell EH, Carroll JP, Saito J, Melland H, Unnithan RR, French C, Hatters DM, Gordon SLPubMed: 42847534Submit Comment

Read more: https://www.alzforum.org/papers/increased-expression-synuclein-impairs-trafficking-essential-snare-protein-synaptobrevin-2
#Dementia #Alzheimers #Autism #Caregiving

Profiling Gut Microbiome and Metabolites Aids Diagnosis and Prediction of Progression in Mild Cognitive Impairment.

MedComm (2020). 2026 Oct;7(10):e71045. Epub 2026 Oct 6Authors: Zhang B, Brown R, Bayer A, Waring J, Morgan BP, Marchesi JR, Zhou YPubMed: 42840456Submit Comment

Read more: https://www.alzforum.org/papers/profiling-gut-microbiome-and-metabolites-aids-diagnosis-and-prediction-progression-mild
#Dementia #Alzheimers #Autism #Caregiving

AI-driven transcriptomics for neurodegenerative disease research: A systematic review.

Comput Biol Chem. 2026 Sep 29;126(Pt 1):109448. Epub 2026 Sep 29Authors: Tripathi A, Yadav AK, Kumar NPubMed: 42826575Submit Comment

Read more: https://www.alzforum.org/papers/ai-driven-transcriptomics-neurodegenerative-disease-research-systematic-review
#Dementia #Alzheimers #Autism #Caregiving

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation.

ACS Omega. 2026 Sep 29;11(38):58100-58111. Epub 2026 Sep 16Authors: Bai Y, Zhao J, Zhang S, Yan C, Chen Y, Du G, Liu APubMed: 42824999Submit Comment

Read more: https://www.alzforum.org/papers/machine-learning-guided-discovery-natural-bace1-inhibitors-enzymatic-and-cellular-validation
#Dementia #Alzheimers #Autism #Caregiving

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome-bile acids-serum metabolites networks.

Br J Pharmacol. 2026 Oct 7; Epub 2026 Oct 7Authors: Wu D, Nie MT, Lin J, Liu Y, Wang Y, Chu M, Zheng L, Zhao JPubMed: 42841516Submit Comment

Read more: https://www.alzforum.org/papers/rifaximin-ameliorates-memory-impairment-and-alzheimers-pathological-changes-appps1-mice
#Dementia #Alzheimers #Autism #Caregiving

Novel Therapeutic Strategies in Targeting Alpha Synuclein Dysfunction Pathways for Parkinson's Disease Treatment.

Drug Metab Bioanal. 2026;19(2):95-106. Authors: Guduru KK, Gundawar R, Eranti B, Turaga K, S SA, Tadimarri P, Pujari HP, Mahasool WT, Arigela PPPubMed: 42841465Submit Comment

Read more: https://www.alzforum.org/papers/novel-therapeutic-strategies-targeting-alpha-synuclein-dysfunction-pathways-parkinsons
#Dementia #Alzheimers #Autism #Caregiving

Microglial GPR56 in synaptic pruning: mechanisms, comparative receptor biology, and context-dependent roles in brain disorders.

Biochim Biophys Acta Mol Cell Res. 2026 Oct 2;:120231. Epub 2026 Oct 2Authors: Chaudhari A, Goyal SPubMed: 42826818Submit Comment

Read more: https://www.alzforum.org/papers/microglial-gpr56-synaptic-pruning-mechanisms-comparative-receptor-biology-and-context
#Dementia #Alzheimers #Autism #Caregiving

Scientists created a tiny device that can control your nerves to treat chronic pain

Scientists have developed a tiny, injectable device that can control nerve activity without surgery, batteries, or wires, potentially transforming treatment for chronic pain and movement disorders. Powered wirelessly from outside the body, the seed-sized technology has shown promising results in early testing.

Read more: https://www.sciencedaily.com/releases/2026/10/261008005253.htm
#Dementia #Alzheimers

Cerebrospinal fluid inflammatory proteomic profiling identifies biomarkers linked to disease progression in amyotrophic lateral sclerosis.

J Neurol. 2026 Oct 4;273(10)Authors: Lv C, Zhu W, Wen X, Wang Y, Xie N, Liu H, Jiang Y, Zou W, Liu Q, Gou J, Yu X, Di L, Lu Y, Wang M, Xu M, Chen H, Duo J, Huang Y, Da YPubMed: 42829893Submit Comment

Read more: https://www.alzforum.org/papers/cerebrospinal-fluid-inflammatory-proteomic-profiling-identifies-biomarkers-linked-disease
#Dementia #Alzheimers

Reply: Is the entorhinal signal a tau origin or a treatment-relevant vulnerability map?

Brain. 2026 Oct 5; Epub 2026 Oct 5Authors: Chaggar P, Alexandersen CG, Bassett DS, Goriely APubMed: 42831531Submit Comment

Read more: https://www.alzforum.org/papers/reply-entorhinal-signal-tau-origin-or-treatment-relevant-vulnerability-map
#Dementia #Alzheimers #Autism #Caregiving

‘I want to do everything I can to head off dementia’: why demand for the shingles vaccine is soaring
By Ian Sample Science editor

Could a drug intended to prevent painful rashes also protect our brains as we get older? The signs are promising – but not conclusive. Yet that’s enough to be driving a boom in shingles jabs

https://www.theguardian.com/society/2026/oct/11/dementia-demand-for-shingles-vaccine-is-soaring

#Dementia #Science #Health #Vaccinesandimmunisation #Society #Healthwellbeing #Lifeandstyle #Alzheimers #Medicalresearch #TheGuardian #IanSampleScienceeditor

Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Parkinson's disease patients with subjective cognitive decline.

Front Aging Neurosci. 2026;18:1935631. Epub 2026 Sep 18Authors: Wei S, Qiu M, Gong M, Zou W, Ren J, Qiu WPubMed: 42827547Submit Comment

Read more: https://www.alzforum.org/papers/diffusion-tensor-image-analysis-along-perivascular-space-dti-alps-parkinsons-disease-patients
#Dementia #Alzheimers #Autism #Caregiving

Salivary Extracellular Vesicle Proteome as a Molecular Bridge Between Periodontitis and Neurodegeneration: Mechanisms, Biomarkers, and Therapeutic Opportunities.

ASN Neuro. 2026;18(1):2736964. Epub 2026 Oct 6Authors: Azhar M, Malviya R, Vandana, Chandra P, Sridhar SB, Shareef J, Wadhwa T, Arockiam DPubMed: 42836857Submit Comment

Read more: https://www.alzforum.org/papers/salivary-extracellular-vesicle-proteome-molecular-bridge-between-periodontitis-and
#Dementia #Alzheimers #Autism

Alzheimer's disease and olfactory dysfunction: A 20-year systematic bibliometric and genomic analysis.

J Alzheimers Dis. 2026 Oct 7;:13872877261486344. Epub 2026 Oct 7Authors: Yang G, Meng C, Zhu DPubMed: 42844735Submit Comment

Read more: https://www.alzforum.org/papers/alzheimers-disease-and-olfactory-dysfunction-20-year-systematic-bibliometric-and-genomic
#Dementia #Alzheimers #Autism #Caregiving

Bisphenol A Exposure Perturbs the Immune Microenvironment in Alzheimer's Disease: Insights from Network Toxicology and Single-Cell Transcriptomics.

J Mol Neurosci. 2026 Oct 2;76(4)Authors: Wu J, Wang Y, Zhao M, Liu J, Zhao WPubMed: 42825974Submit Comment

Read more: https://www.alzforum.org/papers/bisphenol-exposure-perturbs-immune-microenvironment-alzheimers-disease-insights-network
#Dementia #Alzheimers #Autism #Caregiving

Exploring the role of glymphatic system in Alzheimer's disease with insights from MRI-based studies: a systematic review.

Neuroradiology. 2026 Oct 3; Epub 2026 Oct 3Authors: Bernetti C, Calandrelli R, Pilato F, Di Lazzaro V, Zobel BB, D'Amelio M, Mallio CAPubMed: 42828568Submit Comment

Read more: https://www.alzforum.org/papers/exploring-role-glymphatic-system-alzheimers-disease-insights-mri-based-studies-systematic
#Dementia #Alzheimers #Autism #Caregiving

Icariside II protects against neuronal injury by modulating PI3K/AKT-dependent mitochondrial dynamics and apoptosis in Alzheimer's disease models.

Front Pharmacol. 2026;17:1911518. Epub 2026 Sep 21Authors: Shan SY, Bai JM, Tian Y, Shen YF, Zhang YX, Cheng YH, Liu Y, Ning HY, Min DY, Ren L, Xiao HHPubMed: 42835365Submit Comment

Read more: https://www.alzforum.org/papers/icariside-ii-protects-against-neuronal-injury-modulating-pi3kakt-dependent-mitochondrial
#Dementia #Alzheimers #Autism

SOD1 co-pathologies in the brain: insights from neuropathological evidence and implications.

Acta Neuropathol. 2026 Oct 6;152(1)Authors: de Azevedo EM, Bernardo VS, Lima MM, Eleutherio EC, Outeiro TFPubMed: 42837018Submit Comment

Read more: https://www.alzforum.org/papers/sod1-co-pathologies-brain-insights-neuropathological-evidence-and-implications
#Dementia #Alzheimers #Autism #Caregiving

Molecular and genetic basis of alzheimer's disease and emerging treatment Modalities.

Neurodegener Dis Manag. 2026 Oct 2;:1-21. Epub 2026 Oct 2Authors: Varshney H, Siddique YHPubMed: 42825454Submit Comment

Read more: https://www.alzforum.org/papers/molecular-and-genetic-basis-alzheimers-disease-and-emerging-treatment-modalities
#Dementia #Alzheimers #Autism #Caregiving

Plasma PINK1/Parkin ratio and ATF5 as potential biomarkers associated with dyskinesia in Parkinson's disease.

Neurobiol Dis. 2026 Oct 5;230:107638. Epub 2026 Oct 5Authors: Qian S, Xiang W, Chen K, Du Y, Xu B, Duan Q, Xiong X, Hou J, Jiang T, Xie D, Qian J, Xie C, Li JPubMed: 42833593Submit Comment

Read more: https://www.alzforum.org/papers/plasma-pink1parkin-ratio-and-atf5-potential-biomarkers-associated-dyskinesia-parkinsons
#Dementia #Alzheimers #Autism #Caregiving

The Cost of Safety: Balancing Biosafety and Histologic Integrity in Prion Research.

J Exp Neurol. 2026;7(3):120-124. Authors: Seerley A, Panter AGPubMed: 42846668Submit Comment

Read more: https://www.alzforum.org/papers/cost-safety-balancing-biosafety-and-histologic-integrity-prion-research
#Dementia #Alzheimers #Autism #Caregiving