#immunology — Public Fediverse posts

🌐 vaccinesresearch2027.pagesconferences.org

VACCINES-2027 | Innovation. Immunity. Impact.

Explore breakthroughs in vaccine research, development & immunology with global experts.

📍 Milan | 📅 April 19–20, 2027
📩 [email protected]

#VACCINES2027 #Immunology #VaccineScience

The 𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝗕𝗶𝗼𝗽𝗵𝗼𝘁𝗼𝗻𝗶𝗰𝘀 section of CSBJ (A Science Partner Journal) is inviting submissions for its upcoming Special Issue:

“𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗜𝗺𝗺𝘂𝗻𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗗𝘆𝗻𝗮𝗺𝗶𝗰 𝗔𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗼𝗳 𝗜𝗺𝗺𝘂𝗻𝗲 𝗦𝘆𝘀𝘁𝗲𝗺𝘀”

⏳ Submission Deadline: 30 November 2026

🔗 For more information and submission guidelines, please visit: https://spj.science.org/journal/csbj/qbio

#CallForPapers #QuantumImmunology #QuantumBiology #Immunology #SystemsBiology #Biophysics #SystemsImmunology #QuantumScience

Rituximab (RTX), an intravenous drug primarily known for depleting B cells, has been found to also trigger positive metabolic changes in T cells, specifically improving energy production and lowering cellular stress in patients with nephrotic syndrome who respond favorably to the treatment.
#Immunology #Nephrology #CellularBiology #sflorg
https://www.sflorg.com/2026/09/imgy09092601.html

https://www.europesays.com/ie/562092/ New structural insights overturn old assumptions about malaria entry #blood #Cell #children #Drugs #Éire #Electron #ElectronMicroscopy #IE #Immunology #Ireland #Malaria #medicine #Membrane #Microbiology #Microscopy #Protein #RedBloodCells #Research #Science

First video of immune cells eating live skin cancer in real time
#Science #Biology #CancerResearch #Immunotherapy #SkinCancer #Melanoma #MedicalScience #Health #Medicine #Immunology #Macrophages #ScienceNews #HealthInnovation #ImmuneCells #NewResearch
https://the-14.com/first-video-of-immune-cells-eating-live-skin-cancer-in-real-time/

🐍💉 Tim Friede spent nearly 20 years gradually immunizing himself against #venom from over a dozen deadly #snakes, including #cobras and black #mambas.

Scientists used #antibodies from his blood to create an experimental #antivenom that protected #mice from 13 types of snake venom. The work could lead to a single broad-spectrum antivenom.

👉 https://www.sciencenews.org/article/antivenom-snakebite-tim-friede#msdynmkt_trackingcontext=8c2b5212-1894-4d71-8f8a-03d5c1aa0300

#science #immunology #biology #wildlife #medicine #research #nature #wisconsin #newyork #biotech

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.

#OpenAccess #virology #immunology #microbiology #phage #bacteriophage

https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html

#Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
#Immunology #Genetics #sflorg
https://www.sflorg.com/2026/02/imgy02182601.html

Symptom: Mast Cell Itching

https://www.illmarks.com/symptom-mast-cell-itching/

#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs

2025 September & October: So tired of this same MCAS nightmare

https://www.illmarks.com/2025-september-october-so-tired-of-this-same-mcas-nightmare/

#Allergies #art #bodyHorror #bodyMapping #bodyhorror #bodymapping #buildingbiology #chemicallysensitive #chronicIllness #chronicIllness #GI #immunology #longCovid #longcovid #mastCell #mastcell #mastcellactivationsyndrome #medicalArt #MillionsMissing #pwLC #pwme

🧬 One amino acid to stabilize them all — myth or molecular reality?

🔗 Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.045

📚 CSBJ: https://www.csbj.org/

#MonoclonalAntibodies #mAbs #Immunology #ComputationalBiology #MolecularDynamics #Bioinformatics #ProteinStability #StructuralBiology

2025-8-9 I almost went in to anaphylaxis from drinking water.

https://www.illmarks.com/2025-8-9-i-almost-went-in-to-anaphylaxis-from-drinking-water/

#allergy #art #autoimmune #bodyHorror #bodyMapping #chronicIllness #immune #immunology #longCovid #longcovid #mastCell #mastcell #mcas #medArt #medBlog #medart #medicalArt #MillionsMissing #pwLC #pwme #sciArt #sciBlog #SciArt

So. How about this careful result demonstrating viral replication inside megakaryocyte immune cells?

transmission electron microscopy pointed to the presence of viral particles inside bone marrow MK. Immunolabeling confirmed the presence of two SARS-CoV-2 proteins, spike and Orf3a, as well as double-stranded RNA suggesting a potential viral replication cycle.

Note this study is from last month, but it's from hospitalized 2020-2021 patient data. It's existence proof, not population statistics.

That said:

bone marrow MK infection is not a strict determinant of mortality. However, all survivors experienced post-acute sequelae SARS-CoV-2 condition (PASC) diagnosed during post-intensive care follow-up

short 🧵

#CovidIsAirborne #SARSCoV2 #COVID #COVID19 #CovidCompetent #AirborneAware #immunology

"a Nature Immunology study from January 2024 "Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2" reveals further harm through T cell dysregulation in long COVID patients. The research identified increased frequencies of exhausted SARS-CoV-2-specific CD8+ T cells, alongside CD4+ T cells primed for inflammation, and a lack of coordination between T and B cell responses."

"a paper in JCI insight showing T cell exhaustion to other infections following a covid infection"

"a Nature Immunology study from January 2022 "Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection" shows that COVID-19 leads to a prolonged reduction in naive T cells (both CD4+ and CD8+) in individuals with long COVID, persisting up to eight months post-infection."

"Such a long-term impact on the naive T cell pool is not a standard feature of recovery from other acute viral infections like influenza, [...] This effect may not completely persist, however, what it represents is sloughing of the T cells."

A study published in Immunity found "Even after vaccination, those with a history of COVID-19 showed weaker and less functional CD8+ T cell responses, a phenomenon likened to the immune damage seen in chronic viral infections like hepatitis C or HIV. This attenuation indicates that SARS-CoV-2 inflicts a lasting impairment on CD8+ T cell effector function"

'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α, -β, and/or -ω can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'

#Immunology #Immunosky #interferon

https://www.pnas.org/doi/10.1073/pnas.2402983121

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Glycoproteins and longevity: an interview with Professor Gordan Lauc

https://doi.org/10.1080/14728222.2024.2375809

#aging #longevity #glycobiology #immunology #biomarkers #inflammation #IgG #glycoproteins #glycans

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNλ-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNλ.'
#Preprint #Immunology #InnateImmunity #Interferon

https://www.biorxiv.org/content/10.1101/2024.05.21.595218v1

"Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota."
Mao, Akiko Iwasaki et al
#Immunology #Interferon

https://www.pnas.org/doi/10.1073/pnas.2319566121

'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
#Immunology #Inflammation #inflammasome #Metabolism

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00028-7

Macrophages are essential immune cells that reside in all tissues. Some macrophages arise from monocytes in the blood, but during fetal development they also come from a unique pathway!

We still have a lot to learn, but here I'll describe how Zhao et al. (2023) used mouse models to uncover hints about which progenitor cells create tissue-macrophages.

https://doi.org/10.1016/j.celrep.2023.113364

#Macrophages #MouseModel #Immunology #Immunity #scRNAseq #FlowCytometry #Research #JournalArticle #JournalClub

1/9🧵

Always been curious how different interferons that signal through same receptor can have different functional effect. Here's a paper that shows how:
#interferon #immunology #receptor #receptors #Signalling https://www.science.org/doi/10.1126/scisignal.adf5494

Now I cant stop singing "more than a spike gene" to the tune of the BeeGees (protein didnt fit the meter).

'We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors.'
#Covid #Covid19 #SarsCov2 #Interferon #Virology #Immunology #InnateImmunity

https://www.sciencedirect.com/science/article/pii/S1931312823003281

Some evidence type I IFN being beneficial in airway infections.

But lots of caveats, context-specific issues, mouse models, etc....
#IFN #Interferon #bacteria #infection #MAIT #immunology #Science @JExpMed
https://rupress.org/jem/article/220/10/e20230037/276132/Type-I-interferons-drive-MAIT-cell-functions?guestAccessKey=9a754261-0c2a-4913-b3b7-d98c2395c025&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2pnqf6-cox1lz-cwe4ixj5

Really cool application of Infinity Flow to #MouseModel #Tcells, which allows readout/prediction of >200 surface epitopes on single cells via #FlowCytometry.

https://doi.org/10.1016/j.immuni.2023.06.005

By @maxevrard
#Immunology #TissueImmunity

'Here, we used CRISPR-based loss-of-function screens to identify a markedly limited set of ISGs that confer interferon-mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectors—ZAP, IFIT3, and IFIT1—together constitute the majority of interferon-mediated restriction of VEEV, while accounting for < 0.5% of the interferon-induced transcriptome.'

#Immunology #Virology #Interferon

https://www.embopress.org/doi/full/10.15252/embr.202356901

"Our investigation reveals that the fetal HSCs respond to T. gondii infection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. Furthermore, maternal IFNγ crosses the fetal–maternal interface, where it is perceived by fetal HSCs."

#Immunology #Interferon #Toxoplasma

https://www.embopress.org/doi/full/10.15252/embj.2022112693

05/2023 Issue ➡️ https://bit.ly/3VPM25i
text mining to assemble molecular mechanisms, modular organisation of human #proteome, transcriptional regulation of #metabolism...
Cover (DrawImpacts): IFN-β activation of inflammatory genes from Alex Hoffmann's lab, UCLA
#immunology #signalling #systemsbiology

"Our understanding of thymic blood vascular hemodynamics is limited due to technical challenges associated with accessing the native thymus in live mice. To overcome this challenge, we developed an intravital two-photon imaging method to visualize the native thymus in vivo and investigated functional changes to the vascular system following sublethal irradiation."
#Preprint

#Immunology #TwoPhoton #Intravital

https://www.biorxiv.org/content/10.1101/2023.04.10.536267v1?med=mas

Interesting study showing balance between bacterial & host factors determining granuloma formation and control of infection. This example being #Yersinia.
#granuloma #immunology #academia #Science #ScienceMastodon

Inflammatory monocytes promote granuloma control of Yersinia infection | Nature Microbiology

https://www.nature.com/articles/s41564-023-01338-6?utm_source=nmicrobiol_etoc&utm_medium=email&utm_campaign=toc_41564_8_4&utm_content=20230404

'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al

#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

https://www.nature.com/articles/s41564-023-01338-6

How the inflammasome is activated. Almost poetic seeing it in step-wise motion here...

Cryo-EM structures of the active NLRP3 inflammasome disc - https://www.nature.com/articles/s41586-022-05570-8?WT.ec_id=NATURE-20230119&utm_source=nature_etoc&utm_medium=email&utm_campaign=20230119&sap-outbound-id=1540E81EA8A2575BEBC0E3AB32A3412AEAC13A1D

#immunology #cells '#academia #Science #IL1 #inflammasome #infection #cellular #EM

Biotech, Academic Lab Partner on Microbiome-Safe Products

A #biotechnology company creating products for #gut #health and a #university #immunology lab are evaluating #cleaning products for potential damage to human protective tissues.

https://sciencebusiness.technewslit.com/?p=44345

#News #Science #Business #Chemistry #Microbiome #GutMicrobes #Detergents #Alcohol #RinseAgents #Microfluidics #Collaboration