#immunology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunology, aggregated by home.social.
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Notable observation:
chow-fed mice showed an increase in T cells specific for corn-derived zein, but surprisingly, the same was not observed when mice were fed purified zein. Then the typical scientific investigation began.
https://www.biorxiv.org/content/10.64898/2026.09.01.748748v2
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Scientists just won't give up searching for the needle in the haystack. That's what cancer neoantigen-specific T-cell discovery feels like. New paper by none other than Ton Schumacher, quite literally the Schumacher of this field.
https://www.biorxiv.org/content/10.64898/2026.09.07.749948v2
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https://www.europesays.com/ie/689745/ Silica and dust mites combine to worsen asthma inflammation #AirwayInflammation #Allergen #allergy #AntiInflammatory #Asthma #Chronic #Corticosteroid #Dexamethasone #DNA #Éire #Glucocorticoid #Health #IE #ImmuneResponse #Immunology #inflammation #Ireland #Laboratory #Lungs #Receptor #Steroid #therapy
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A Window into the Hidden World of Immunity Inside Human Bone Marrow
Newswise — The cells that keep vaccines working for decades have long remained a mystery deep within human…
#NewsBeep #News #Health #AllJournalNews #AU #Australia #Biotech #BoneMarrow;plasmacells;ImmuneMemory;vaccineprotection;humantissuemodel;CellMigration;Microenvironment;Immunology #Cancer #cellbiology #GeorgiaInstituteofTechnology #Healthcare #Immunology #Newswise #publichealth #vaccines
https://www.newsbeep.com/au/891587/ -
A Window into the Hidden World of Immunity Inside Human Bone Marrow
Newswise — The cells that keep vaccines working for decades have long remained a mystery deep within human…
#NewsBeep #News #Health #AllJournalNews #AU #Australia #Biotech #BoneMarrow;plasmacells;ImmuneMemory;vaccineprotection;humantissuemodel;CellMigration;Microenvironment;Immunology #Cancer #cellbiology #GeorgiaInstituteofTechnology #Healthcare #Immunology #Newswise #publichealth #vaccines
https://www.newsbeep.com/au/891587/ -
A huge congratulations to an incredibly motivated and enthusiastic Master Class in T Cell Biology! 🧬🧫
It was inspiring to see such curiosity, energy, and passion especially for Tregs 😉!
#TCellBiology #Immunology #Science #MasterClass #Research #Learning #ScientificCommunity #CRID -
_Этология, етологія, Ethology
#Этология, #етологія, #Ethology
t.me/scilib_yura15cbx/494_Энтомология, Entomology, Ентомологія
#Энтомология, #Entomology, #Ентомологія
t.me/scilib_yura15cbx/493Эмбрио, Ембріо, Embryo
эмбриология биология развития Embryology developmental biology
#Эмбрио, #Ембріо, #Embryo
#эмбриология #биологияразвития #Embryology #developmental biology
t.me/scilib_yura15cbx/492_Экология, Ecology, Екологія
эко окружающая среда энвайронментализм, экосистемы, популяции,
#Экология, #Ecology, #Екологія
t.me/scilib_yura15cbx/491_эволюция, еволюція, evolution
теория эволюции, эволюционная теория
#эволюция, #еволюція, #evolution
t.me/scilib_yura15cbx/490_Флора и фауна Украины
Flora and fauna of Ukraine
Флора і фауна України
t.me/scilib_yura15cbx/489_систематика, taxonomy
#систематика, #taxonomy
t.me/scilib_yura15cbx/488_Палеонтология, Paleontology, Палеонтологія
#Палеонтология, #Paleontology, #Палеонтологія
t.me/scilib_yura15cbx/487_Орнитология, Орнітологія, Ornithology
#Орнитология, #Орнітологія, #Ornithology
t.me/scilib_yura15cbx/486B Biology, Біологія, Биология
#Biology, #Біологія, #Биология
t.me/scilib_yura15cbx/485_нейро, neuro
Нейробиология, нейрология, Нейробіологія, нейрологія, Neurobiology, neurology,
#нейро, #neuro
#Нейробиология, #нейрология, #Нейробіологія, #нейрологія, #Neurobiology, #neurology
t.me/scilib_yura15cbx/483_Нематология, Nematology
#Нематология, #Nematology
t.me/scilib_yura15cbx/482Определители растений, лишайников, грибов
Визначники рослин, лишайників, грибів
#Определители
t.me/scilib_yura15cbx/481_Микробиология и Вирусология
Мікробіологія та вірусологія
Microbiology and Virology
#Микробиология и #Вирусология
#Мікробіологія та #вірусологія
#Microbiology and #Virology
t.me/scilib_yura15cbx/480_Микология, Mycology, Мікологія
#Микология, #Mycology, #Мікологія
t.me/scilib_yura15cbx/479_Макология
#Макология
t.me/scilib_yura15cbx/478_Microscopy, Мікроскопія, Микроскопия
#Microscopy, #Мікроскопія, #Микроскопия
t.me/scilib_yura15cbx/476Cell
Cell biology, Клітина, клітинна біологія, біологія клітини, Клетка, клеточная биология, биология клетки
#Cell
#Cell biology, #Клітина, #клітиннабіологія, #біологіяклітини, #Клетка, #клеточнаябиология, #биология клетки
t.me/scilib_yura15cbx/475Клетка, клеточная биология
#Клетка, #клеточнаябиология
t.me/scilib_yura15cbx/474_Красная книга
Червона книга, the Red Book,
t.me/scilib_yura15cbx/473История биологии
History of biology
Історія біології
t.me/scilib_yura15cbx/472Иммунология, Імунологія, Immunology
#Иммунология, #Імунологія, #Immunology
t.me/scilib_yura15cbx/471Гистология, Histology, Гістологія
#Гистология, #Histology, #Гістологія
t.me/scilib_yura15cbx/469_Грибы
mushrooms, Мікологія, Микология, Mycology
#Грибы
#mushrooms, #Мікологія, #Микология, #Mycology
t.me/scilib_yura15cbx/470Зоология, Зоологія, Zoology
#Зоология, #Зоологія, #Zoology
t.me/scilib_yura15cbx/468Genome, Геном,
геномика, Genomics, геноміка
#Genome, #Геном,
#геномика, #Genomics, #геноміка
t.me/scilib_yura15cbx/466Genetics, генетика
#Genetics, #генетика
t.me/scilib_yura15cbx/465Вода, Water
#Вода, #Water
t.me/scilib_yura15cbx/464Владивосток, Vladivostok, Приморье, Приморский край
природа, наука, в основном биология, ДВГУ, дипломные работы
#Владивосток, #Vladivostok, #Приморье, #Приморскийкрай
#природа, #наука, в основном #биология, #ДВГУ, #дипломныеработы
t.me/scilib_yura15cbx/463Анатомия и морфология растений
Анатомія і морфологія рослин
Anatomy and morphology of plants
t.me/scilib_yura15cbx/462Сосудистые растения,
Судинні рослини
Vascular plants
t.me/scilib_yura15cbx/460Низшие растения
Lower plants
Нижчі рослини
t.me/scilib_yura15cbx/459Геоботаника, Геоботаніка, Geobotany
#Геоботаника, #Геоботаніка, #Geobotany
t.me/scilib_yura15cbx/458Биоэтика, Біоетика, Bioethics
#Биоэтика, #Біоетика, #Bioethics
t.me/scilib_yura15cbx/456Биохимия, молекулярная биология
Biochemistry, molecular biology
Біохімія, молекулярна біологія
#Биохимия, #молекулярнаябиология
#Biochemistry, #molecular biology
#Біохімія, #молекулярнабіологія
t.me/scilib_yura15cbx/455Биология моря, морская биология
Marine biology, Біологія моря, морська Біологія
#Биологияморя, #морскаябиология
#Marine biology, #Біологіяморя, #морськаБіологія
t.me/scilib_yura15cbx/453Альгология, Альгологія, Algology
#Альгология, #Альгологія, #Algology
t.me/scilib_yura15cbx/452Bioinformatics, Биоинформатика, Біоінформатика
#Bioinformatics, #Биоинформатика, #Біоінформатика
t.me/scilib_yura15cbx/450 -
1/ (1-17)
In this thread I give my take on the new @ImmunityCP paper from the Benoist & Mathis lab on the role of TCR specificity in pTreg induction.#science
#immunology
#Treg
#Foxp3https://www.cell.com/immunity/fulltext/S1074-7613(26)00277-3
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Generally speaking, for Tregs to mediate antigen-specific tolerance in the periphery, they must be educated in the thymus by pairing with T cells that share the same antigen specificity.
1/2
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Why do studies claiming #Treg induction by novel designer drugs test them only when given before or with antigen, rather than in established disease that more closely reflects human cases?
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Recent Treg biotech trajectories show that current Treg-based tech do not work. Why? Unlike conventional T cells, Tregs operate within a tripartite system involving the microbiota and naturally IL-2–producing T cells.
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'We found that up-regulation of a primate-specific short isoform of PRDM1-S induces expression of SGK1 independent from the evolutionarily conserved long PRDM1, which led to destabilization of #FOXP3 & #Treg dysfunction. This aberrant PRDM1-S/SGK1 axis is shared among other autoimmune diseases.'
#Immunology
https://www.science.org/doi/10.1126/scitranslmed.adp1720 -
"The Swiss drugmaker also defenestrated three phase 1 programs. Anti-CD25 Treg depleter RG6292 landed on the discard pile. Roche previously stopped a monotherapy clinical trial but continued to study RG6292 in combination with its checkpoint inhibitor Tecentriq."
#Immunology #Treg
https://www.fiercebiotech.com/biotech/roche-pumps-brakes-pompe-axing-gene-therapy-after-assessing-competition -
'Bender et al. report that a phase 2 randomized trial of a single dose of expanded Tregs showed no efficacy in preserving C-peptide, an indicator of β cell function, in early-onset T1D. This negative in vivo result comes despite the suppressive capacity of the expanded Tregs in vitro, and will inform future studies of the role of polyclonal Tregs in T1D.'
#Immunology #Immunotherapy #Treg #Diabetes
https://www.science.org/doi/full/10.1126/scitranslmed.adn2404 -
'However, whether Treg cells hamper pain at steady state and by which mechanism is still unclear. From a meta-analysis of the transcriptomes of murine Treg and conventional T cells (Tconv), we observe that the proenkephalin gene (Penk), encoding the precursor of analgesic opioid peptides, ranks among the top 25 genes most enriched in Treg cells.'
#Immunology #Preprint #Neuroimmunology #Treg
https://www.biorxiv.org/content/10.1101/2023.09.12.557326v2 -
Very cool #Preprint from the lab of Jo Jones at #UniversityOfCambridge I've never used #JuliaLang, but this appears to make a lot of the analyses that our lab has hard-coded into a very nifty interactive web-app!!
Really awesome way to make complex #FlowCytometry analysis accessible when built-in tools to #FlowJo don't quite deliver!
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`Furthermore, we show that 5′-FAD capping protects RNA from RIG-I mediated innate #immune recognition but does not stabilize the HCV #RNA. These results establish #capping with cellular metabolites as a novel #viral RNA-capping strategy, which could be used by other viruses and affect anti-viral treatment outcomes and persistence of #infection.`
https://www.nature.com/articles/s41586-023-06301-3
#interesting #virology #medicine #molecularBiology #molecularBio #biology #ribonucleotide #nucleotide #immunology #pathology
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Lilly walks away from Nektar's PEG conjugate of rhIL-2, rezpeg - aka rezpegaldesleukin, aka NKTR-358 - after disappointing phase II results in lupus.
#Immunology #immunotherapy #RegulatoryTCell #Lupus #Treg #drugdevelopment
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@weldeiry Nice succinct overview of CD4+ #Tcells in #cancer #immunology. Also a short paragraph on cancer promotion by (a subset of) these cells, a.o. #Treg.
Thanks for sharing.
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"Notably, TCR-M cells that were predifferentiated toward a regulatory phenotype in vitro maintained stable in vivo #FOXP3 (Forkhead box P3) expression and anti-inflammatory activity whereas #th17
partially converted toward a regulatory phenotype in the injured myocardium."https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.322183
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Review at EJI
"Dysregulation or overproduction of IL-6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL-6 in altering the balance between Treg and Th17 cells, controlling IL-6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases."
#Immunology #Treg #Th17 #Autoimmunity
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201040391
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"It can be between 10 and 30 years before people develop symptoms so most are unaware they have Chagas, often called a “silent and silenced disease”. Some will never develop symptoms but up to a third suffer heart damage, which can lead to progressive heart failure or sudden death. Others (up to 10%) may experience abnormal enlargement of the colon or oesophagus.
About 12,000 people die from Chagas every year. It kills more people in Latin America than any other parasitic disease, including malaria."
#Parasitology #Immunology #PublicHealth #ChagasDisease
#Trypanosoma #Tcruzi -
"It can be between 10 and 30 years before people develop symptoms so most are unaware they have Chagas, often called a “silent and silenced disease”. Some will never develop symptoms but up to a third suffer heart damage, which can lead to progressive heart failure or sudden death. Others (up to 10%) may experience abnormal enlargement of the colon or oesophagus.
About 12,000 people die from Chagas every year. It kills more people in Latin America than any other parasitic disease, including malaria."
#Parasitology #Immunology #PublicHealth #ChagasDisease
#Trypanosoma #Tcruzi -
"It can be between 10 and 30 years before people develop symptoms so most are unaware they have Chagas, often called a “silent and silenced disease”. Some will never develop symptoms but up to a third suffer heart damage, which can lead to progressive heart failure or sudden death. Others (up to 10%) may experience abnormal enlargement of the colon or oesophagus.
About 12,000 people die from Chagas every year. It kills more people in Latin America than any other parasitic disease, including malaria."
#Parasitology #Immunology #PublicHealth #ChagasDisease
#Trypanosoma #Tcruzi -
"It can be between 10 and 30 years before people develop symptoms so most are unaware they have Chagas, often called a “silent and silenced disease”. Some will never develop symptoms but up to a third suffer heart damage, which can lead to progressive heart failure or sudden death. Others (up to 10%) may experience abnormal enlargement of the colon or oesophagus.
About 12,000 people die from Chagas every year. It kills more people in Latin America than any other parasitic disease, including malaria."
#Parasitology #Immunology #PublicHealth #ChagasDisease
#Trypanosoma #Tcruzi -
I like this intro jump from Mitchison to Sakaguchi (ref 21 to 22)
"Forty years ago, high-zone immune tolerance had been suggested to be mediated by suppressor T cells (21). The existence of suppressor T cells has long remained controversial and was not accepted until regulatory T cells (Tregs) were characterized more than 15 years later (22)."