#immunology — Public Fediverse posts

Notable observation:

chow-fed mice showed an increase in T cells specific for corn-derived zein, but surprisingly, the same was not observed when mice were fed purified zein. Then the typical scientific investigation began.

#science
#immunology

https://www.biorxiv.org/content/10.64898/2026.09.01.748748v2

Scientists just won't give up searching for the needle in the haystack. That's what cancer neoantigen-specific T-cell discovery feels like. New paper by none other than Ton Schumacher, quite literally the Schumacher of this field.

#science
#immunology

https://www.biorxiv.org/content/10.64898/2026.09.07.749948v2

https://www.europesays.com/ie/689745/ Silica and dust mites combine to worsen asthma inflammation #AirwayInflammation #Allergen #allergy #AntiInflammatory #Asthma #Chronic #Corticosteroid #Dexamethasone #DNA #Éire #Glucocorticoid #Health #IE #ImmuneResponse #Immunology #inflammation #Ireland #Laboratory #Lungs #Receptor #Steroid #therapy

A Window into the Hidden World of Immunity Inside Human Bone Marrow

Newswise — The cells that keep vaccines working for decades have long remained a mystery deep within human…
#NewsBeep #News #Health #AllJournalNews #AU #Australia #Biotech #BoneMarrow;plasmacells;ImmuneMemory;vaccineprotection;humantissuemodel;CellMigration;Microenvironment;Immunology #Cancer #cellbiology #GeorgiaInstituteofTechnology #Healthcare #Immunology #Newswise #publichealth #vaccines
https://www.newsbeep.com/au/891587/

A Window into the Hidden World of Immunity Inside Human Bone Marrow

Newswise — The cells that keep vaccines working for decades have long remained a mystery deep within human…
#NewsBeep #News #Health #AllJournalNews #AU #Australia #Biotech #BoneMarrow;plasmacells;ImmuneMemory;vaccineprotection;humantissuemodel;CellMigration;Microenvironment;Immunology #Cancer #cellbiology #GeorgiaInstituteofTechnology #Healthcare #Immunology #Newswise #publichealth #vaccines
https://www.newsbeep.com/au/891587/

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Scientists discover a hidden switch that shuts off inflammation and prevents harmful immune cells from building up

https://www.sciencedaily.com/releases/2026/09/260911214306.htm

#wellness #immunology #research

Postdoctoral Research Scientist in Transplantation Immunology at Columbia U
Columbia University

Come join us as a #transplantation immunology postdoc

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/

#immunology #nextgenerationsequenc...
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/?fsp_sid=14843

Postdoctoral Research Scientist in Transplantation Immunology at Columbia U
Columbia University

Come join us as a #transplantation immunology postdoc

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/

#immunology #nextgenerationsequenc...
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/?fsp_sid=14843

Postdoctoral Research Scientist in Transplantation Immunology at Columbia U
Columbia University

Come join us as a #transplantation immunology postdoc

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/

#immunology #nextgenerationsequenc...
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/?fsp_sid=14843

Postdoctoral Research Scientist in Transplantation Immunology at Columbia U
Columbia University

Come join us as a #transplantation immunology postdoc

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/

#immunology #nextgenerationsequenc...
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/?fsp_sid=14843

Postdoctoral Research Scientist in Transplantation Immunology at Columbia U
Columbia University

Come join us as a #transplantation immunology postdoc

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/

#immunology #nextgenerationsequenc...
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-research-scientist-in-transplantation-immunology-at-columbia-u/?fsp_sid=14843

Researchers have discovered that the internal nucleocapsid protein (NP) of the Crimean-Congo hemorrhagic fever virus (CCHFV) can serve as a viable target for protective antibodies, offering a new pathway for therapeutics against the disease.
#Virology #Immunology #BiomedicalSciences #sflorg
https://www.sflorg.com/2026/08/vi08222601.html

Researchers have discovered that the internal nucleocapsid protein (NP) of the Crimean-Congo hemorrhagic fever virus (CCHFV) can serve as a viable target for protective antibodies, offering a new pathway for therapeutics against the disease.
#Virology #Immunology #BiomedicalSciences #sflorg
https://www.sflorg.com/2026/08/vi08222601.html

Researchers have discovered that the internal nucleocapsid protein (NP) of the Crimean-Congo hemorrhagic fever virus (CCHFV) can serve as a viable target for protective antibodies, offering a new pathway for therapeutics against the disease.
#Virology #Immunology #BiomedicalSciences #sflorg
https://www.sflorg.com/2026/08/vi08222601.html

Researchers have discovered that the internal nucleocapsid protein (NP) of the Crimean-Congo hemorrhagic fever virus (CCHFV) can serve as a viable target for protective antibodies, offering a new pathway for therapeutics against the disease.
#Virology #Immunology #BiomedicalSciences #sflorg
https://www.sflorg.com/2026/08/vi08222601.html

Researchers have discovered that the internal nucleocapsid protein (NP) of the Crimean-Congo hemorrhagic fever virus (CCHFV) can serve as a viable target for protective antibodies, offering a new pathway for therapeutics against the disease.
#Virology #Immunology #BiomedicalSciences #sflorg
https://www.sflorg.com/2026/08/vi08222601.html

A multifunctional nanoplatform using liquid metal nanoparticles coated in whole-blood components to deliver a three-pronged treatment against drug-resistant triple-negative breast cancer (TNBC).
#Oncology #Nanotechnology #Immunology #MaterialsScience #sflorg
https://www.sflorg.com/2026/08/ongy08212601.html

https://www.europesays.com/ie/632381/ Harnessing T Cell Exhaustion in Organ Transplantation: Mechanisms, Metabolism, and Therapeutic Opportunities #AllJournalNews #biotech #cancer #Éire #Genetics #Health #IE #ImmuneResponse;organTransplantation;graftTolerance;epigeneticChanges;metabolicReprogramming;immuneCheckpoint;TranscriptionFactors #Immunology #InfectiousDiseases #Ireland #Newswise #NewswiseReview #RegenerativeMedicine #StemCells #Transplantation

_Этология, етологія, Ethology
#Этология, #етологія, #Ethology
t.me/scilib_yura15cbx/494

_Энтомология, Entomology, Ентомологія
#Энтомология, #Entomology, #Ентомологія
t.me/scilib_yura15cbx/493

Эмбрио, Ембріо, Embryo
эмбриология биология развития Embryology developmental biology
#Эмбрио, #Ембріо, #Embryo
#эмбриология #биологияразвития #Embryology #developmental biology
t.me/scilib_yura15cbx/492

_Экология, Ecology, Екологія
эко окружающая среда энвайронментализм, экосистемы, популяции,
#Экология, #Ecology, #Екологія
t.me/scilib_yura15cbx/491

_эволюция, еволюція, evolution
теория эволюции, эволюционная теория
#эволюция, #еволюція, #evolution
t.me/scilib_yura15cbx/490

_Флора и фауна Украины
Flora and fauna of Ukraine
Флора і фауна України
t.me/scilib_yura15cbx/489

_систематика, taxonomy
#систематика, #taxonomy
t.me/scilib_yura15cbx/488

_Палеонтология, Paleontology, Палеонтологія
#Палеонтология, #Paleontology, #Палеонтологія
t.me/scilib_yura15cbx/487

_Орнитология, Орнітологія, Ornithology
#Орнитология, #Орнітологія, #Ornithology
t.me/scilib_yura15cbx/486

B Biology, Біологія, Биология
#Biology, #Біологія, #Биология
t.me/scilib_yura15cbx/485

_нейро, neuro
Нейробиология, нейрология, Нейробіологія, нейрологія, Neurobiology, neurology,
#нейро, #neuro
#Нейробиология, #нейрология, #Нейробіологія, #нейрологія, #Neurobiology, #neurology
t.me/scilib_yura15cbx/483

_Нематология, Nematology
#Нематология, #Nematology
t.me/scilib_yura15cbx/482

Определители растений, лишайников, грибов
Визначники рослин, лишайників, грибів
#Определители
t.me/scilib_yura15cbx/481

_Микробиология и Вирусология
Мікробіологія та вірусологія
Microbiology and Virology
#Микробиология и #Вирусология
#Мікробіологія та #вірусологія
#Microbiology and #Virology
t.me/scilib_yura15cbx/480

_Микология, Mycology, Мікологія
#Микология, #Mycology, #Мікологія
t.me/scilib_yura15cbx/479

_Макология
#Макология
t.me/scilib_yura15cbx/478

_Microscopy, Мікроскопія, Микроскопия
#Microscopy, #Мікроскопія, #Микроскопия
t.me/scilib_yura15cbx/476

Cell
Cell biology, Клітина, клітинна біологія, біологія клітини, Клетка, клеточная биология, биология клетки
#Cell
#Cell biology, #Клітина, #клітиннабіологія, #біологіяклітини, #Клетка, #клеточнаябиология, #биология клетки
t.me/scilib_yura15cbx/475

Клетка, клеточная биология
#Клетка, #клеточнаябиология
t.me/scilib_yura15cbx/474

_Красная книга
Червона книга, the Red Book,
t.me/scilib_yura15cbx/473

История биологии
History of biology
Історія біології
t.me/scilib_yura15cbx/472

Иммунология, Імунологія, Immunology
#Иммунология, #Імунологія, #Immunology
t.me/scilib_yura15cbx/471

Гистология, Histology, Гістологія
#Гистология, #Histology, #Гістологія
t.me/scilib_yura15cbx/469

_Грибы
mushrooms, Мікологія, Микология, Mycology
#Грибы
#mushrooms, #Мікологія, #Микология, #Mycology
t.me/scilib_yura15cbx/470

Зоология, Зоологія, Zoology
#Зоология, #Зоологія, #Zoology
t.me/scilib_yura15cbx/468

Genome, Геном,
геномика, Genomics, геноміка
#Genome, #Геном,
#геномика, #Genomics, #геноміка
t.me/scilib_yura15cbx/466

Genetics, генетика
#Genetics, #генетика
t.me/scilib_yura15cbx/465

Вода, Water
#Вода, #Water
t.me/scilib_yura15cbx/464

Владивосток, Vladivostok, Приморье, Приморский край
природа, наука, в основном биология, ДВГУ, дипломные работы
#Владивосток, #Vladivostok, #Приморье, #Приморскийкрай
#природа, #наука, в основном #биология, #ДВГУ, #дипломныеработы
t.me/scilib_yura15cbx/463

Анатомия и морфология растений
Анатомія і морфологія рослин
Anatomy and morphology of plants
t.me/scilib_yura15cbx/462

Сосудистые растения,
Судинні рослини
Vascular plants
t.me/scilib_yura15cbx/460

Низшие растения
Lower plants
Нижчі рослини
t.me/scilib_yura15cbx/459

Геоботаника, Геоботаніка, Geobotany
#Геоботаника, #Геоботаніка, #Geobotany
t.me/scilib_yura15cbx/458

Биоэтика, Біоетика, Bioethics
#Биоэтика, #Біоетика, #Bioethics
t.me/scilib_yura15cbx/456

Биохимия, молекулярная биология
Biochemistry, molecular biology
Біохімія, молекулярна біологія
#Биохимия, #молекулярнаябиология
#Biochemistry, #molecular biology
#Біохімія, #молекулярнабіологія
t.me/scilib_yura15cbx/455

Биология моря, морская биология
Marine biology, Біологія моря, морська Біологія
#Биологияморя, #морскаябиология
#Marine biology, #Біологіяморя, #морськаБіологія
t.me/scilib_yura15cbx/453

Альгология, Альгологія, Algology
#Альгология, #Альгологія, #Algology
t.me/scilib_yura15cbx/452

Bioinformatics, Биоинформатика, Біоінформатика
#Bioinformatics, #Биоинформатика, #Біоінформатика
t.me/scilib_yura15cbx/450

Postdoc in Immunology: research where immuno, cell biology and micro meet
Washington University in St. Louis, School of Medicine

#Macrophage mechanotransduction and #metabolism are hot topics in #immunology! Join us as a #postdoc fellow to jumpstart your scientific career!

See the full job description on jobRxiv: https://...
https://jobrxiv.org/job/washington-university-in-st-louis-school-of-medicine-27778-postdoc-in-immunology-research-where-immuno-cell-biology-and-micro-meet/?fsp_sid=13724

The sheer scope and complexity of the vagus nerve serve as a profound testament to the elegant efficiency of human biology. It is endlessly fascinating to consider that a singular neural structure is simultaneously responsible for the biochemical origin of the butterflies in your stomach, the steady, decelerating rhythm of your resting heart rate. . .
#WhatIs #Neurobiology #Immunology #Cardiology #Gastroenterology #Gerontology #sflorg
https://www.sflorg.com/2026/07/wi07172601.html

A disruption in the NOD2 gene, which is critical for immune system activation, causes an unexpected increase in estrogen-related gene activity that drives the gut inflammation and dysfunction characteristic of Crohn's disease.
#Immunology #Endocrinology #Genetics #Gastroenterology #Medical #sflorg
https://www.sflorg.com/2026/06/imgy06242601.html

Scientists Uncover Cause of Inflammatory Bowel Disease Solving Decades-Old Mystery

Researchers have identified a distinct subgroup of inflammatory bowel disease (IBD) patients whose condition appears to be driven…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Health #autoimmune #Gastroenterology #immunesystem #Immunology #inflammation #UniversityofOxford
https://www.newsbeep.com/us/715404/

The Enteric Nervous System is a highly sophisticated, autonomous network of approximately 500 million neurons and supportive glial cells embedded within the human gastrointestinal tract. Often referred to as the body's "second brain".
#Neurogastroenterology #Neuroscience #Gastroenterology #Immunology #DevelopmentalBiology #Microbiology #WhatIs #sflorg
https://www.sflorg.com/2026/06/wi06162601.html

I'm wondering if/how this would affect eosinophilic esophagitis, since sucralose/Splenda is used to make a slurry with topical steroid for treatment. Patients are told to use as much as 20 packets of Splenda, though most only use 2 and some use honey or applesauce instead:

https://www.reddit.com/r/EosinophilicE/comments/1c0pcwa/20_packets_of_splenda/

#EosinophilicEsophagitis #immunology #gastroenterology

Researchers have mapped the precise locations and interactions of immune cells within gut-associated lymphoid tissue (GALT), demonstrating how cellular architecture shifts from preventing inflammation in healthy tissue to driving dysregulation in severe ulcerative colitis.
#Immunology #Gastroenterology #MolecularBiology #sflorg
https://www.sflorg.com/2026/06/imgy06162601.html

Inflammatory bowel disease (IBD) is not a singular condition but a group of biologically distinct disorders, with a specific, severe subset driven by an autoimmune response against interleukin-10 (IL-10), a critical regulator of immune homeostasis.
#Immunology #MolecularGenetics #Gastroenterology #Medical #sflorg
https://www.sflorg.com/2026/06/imgy06152601.html

Postdoc in Immunology: research where immuno, cell biology and micro meet
Washington University in St. Louis, School of Medicine

#Macrophage mechanotransduction and #metabolism are hot topics in #immunology! Join us as a #postdoc fellow to jumpstart your scientific career!

See the full job description on jobRxiv: https://...
https://jobrxiv.org/job/washington-university-in-st-louis-school-of-medicine-27778-postdoc-in-immunology-research-where-immuno-cell-biology-and-micro-meet/?fsp_sid=12410

Celiacase is a molecularly engineered enzyme designed to break down toxic gluten immunogenic peptides (GIPs) in the stomach before they can reach the small intestine and trigger an autoimmune response.
#Biochemistry #MolecularBiology #Immunology #Pharmacology #Gastroenterology #sflorg
https://www.sflorg.com/2026/05/bchm05142601.html

Celiac disease is a chronic autoimmune disorder driven by gluten, and its development is not causally linked to prior antibiotic treatment. A comprehensive nationwide study demonstrates that while celiac patients may have a history of higher antibiotic use, the medication itself does not trigger the disease.
#Gastroenterology #Pediatrics #Epidemiology #Immunology #sflorg
https://www.sflorg.com/2026/04/med04282601.html

Postdoc in Immunology: research where immuno, cell biology and micro meet
Washington University in St. Louis, School of Medicine

#Macrophage mechanotransduction and #metabolism are hot topics in #immunology! Join us as a #postdoc fellow to jumpstart your scientific career!

See the full job description on jobRxiv: https://...
https://jobrxiv.org/job/washington-university-in-st-louis-school-of-medicine-27778-postdoc-in-immunology-research-where-immuno-cell-biology-and-micro-meet/?fsp_sid=11545

Infants diagnosed with food protein-induced enterocolitis syndrome (FPIES) exhibit a distinctly altered and atypical gut bacterial composition compared to healthy individuals, marking a clear biological association with the rare allergic disease.
#Immunology #Microbiology #Pediatrics #Gastroenterology #sflorg
https://www.sflorg.com/2026/04/imgy04022601.html

The Odyssey of macrophages.

This issue spans immune regulation, #macrophage functions, T‑cell tolerance, #AI in infection, #cardiac repair, pelvic care, PDT #inflammation & diverse clinical studies.

https://www.sciencedirect.com/science/article/pii/S2319417026000235 #OpenAccess #microbiology #immunology

clip - Gordan Lauc on a pill to replace IVIG (IV immunoglobin) therapy
https://youtube.com/clip/Ugkx_IwBpHAr8B_75Vt5z9r_BZqcWwhOYB2v

If this existed, there would not be as much need for #PlasmaDonation

#glycobiology #immunology #aging

New journal cover for Immunity by Cell Press!

In this issue, Dolci et al. report a dual role for tumor-associated macrophages (TAMs), which we visualized trough a submarine metaphor 🪸

Learn more: https://www.cell.com/immunity/issue?pii=S1074-7613(25)X0012-1

#immunology #macrophage #sciart #illustration

Researchers developed small-molecule drug candidates that mimic a rare, protective variant of the #CARD9 gene to treat #Crohn's disease and other inflammatory bowel diseases.
#MolecularBiology #MolecularScience #Immunology #Genetics #sflorg
https://www.sflorg.com/2026/01/molb01162601.html

Research Scientist I, Pisu Lab
Tulane University

Research Scientist driving Mtb studies using CRISPR, NGS, flow cytometry, microscopy, BSL2–BSL3 pathogen work, macrophage models, and murine infection

See the full job description on jobRxiv: https://jobrxiv.org/job/tulane-university-27778-research-scientist-i-pisu-lab/

#CRISPRscreen #immunology #macrophage #singlecellanalysis #tuberculosis #ScienceJ...
https://jobrxiv.org/job/tulane-university-27778-research-scientist-i-pisu-lab/?fsp_sid=7144

Research Scientist I, Pisu Lab
Tulane University

Research Scientist driving Mtb studies using CRISPR, NGS, flow cytometry, microscopy, BSL2–BSL3 pathogen work, macrophage models, and murine infection

See the full job description on jobRxiv: https://jobrxiv.org/job/tulane-university-27778-research-scientist-i-pisu-lab/

#CRISPRscreen #immunology #macrophage #singlecellanalysis #tuberculosis #ScienceJ...
https://jobrxiv.org/job/tulane-university-27778-research-scientist-i-pisu-lab/?fsp_sid=6619

Symptom: Mast Cell Itching

https://www.illmarks.com/symptom-mast-cell-itching/

#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs

Research Scientist I, Pisu Lab
Tulane University

Research Scientist driving Mtb studies using CRISPR, NGS, flow cytometry, microscopy, BSL2–BSL3 pathogen work, macrophage models, and murine infection

See the full job description on jobRxiv: https://jobrxiv.org/job/tulane-university-27778-research-scientist-i-pisu-lab/

#CRISPRscreen #immunology #macrophage #singlecellanalysis #tuberculosis #ScienceJ...
https://jobrxiv.org/job/tulane-university-27778-research-scientist-i-pisu-lab/?fsp_sid=5982

So. How about this careful result demonstrating viral replication inside megakaryocyte immune cells?

transmission electron microscopy pointed to the presence of viral particles inside bone marrow MK. Immunolabeling confirmed the presence of two SARS-CoV-2 proteins, spike and Orf3a, as well as double-stranded RNA suggesting a potential viral replication cycle.

Note this study is from last month, but it's from hospitalized 2020-2021 patient data. It's existence proof, not population statistics.

That said:

bone marrow MK infection is not a strict determinant of mortality. However, all survivors experienced post-acute sequelae SARS-CoV-2 condition (PASC) diagnosed during post-intensive care follow-up

short 🧵

#CovidIsAirborne #SARSCoV2 #COVID #COVID19 #CovidCompetent #AirborneAware #immunology

"a Nature Immunology study from January 2024 "Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2" reveals further harm through T cell dysregulation in long COVID patients. The research identified increased frequencies of exhausted SARS-CoV-2-specific CD8+ T cells, alongside CD4+ T cells primed for inflammation, and a lack of coordination between T and B cell responses."

"a paper in JCI insight showing T cell exhaustion to other infections following a covid infection"

"a Nature Immunology study from January 2022 "Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection" shows that COVID-19 leads to a prolonged reduction in naive T cells (both CD4+ and CD8+) in individuals with long COVID, persisting up to eight months post-infection."

"Such a long-term impact on the naive T cell pool is not a standard feature of recovery from other acute viral infections like influenza, [...] This effect may not completely persist, however, what it represents is sloughing of the T cells."

A study published in Immunity found "Even after vaccination, those with a history of COVID-19 showed weaker and less functional CD8+ T cell responses, a phenomenon likened to the immune damage seen in chronic viral infections like hepatitis C or HIV. This attenuation indicates that SARS-CoV-2 inflicts a lasting impairment on CD8+ T cell effector function"

Glycoproteins and longevity: an interview with Professor Gordan Lauc

https://doi.org/10.1080/14728222.2024.2375809

#aging #longevity #glycobiology #immunology #biomarkers #inflammation #IgG #glycoproteins #glycans

Just Published

Intricate Synergy of Mechanical and Biochemical Cues in the Transmigration of Cancer Cells Across the Endothelium

https://link.springer.com/chapter/10.1007/16833_2024_237

#Cancer #CancerResearch #CancerTherapy #Metastasis #Immunology #CellBiology

Someone on YouTube comments asked me what I thought was in cucurbits (squash/melon family veg) that I react to. I had mentioned previously that Corn Allergy Girl (author of now defunct blog of same name) also reacts to most cucurbits (except cucumber). Here's my response, in case anyone has any input:

" I wish I knew. I'm not even sure if the reaction is due to cross-reactivity with corn allergen or if it is due to mast cell activation syndrome. To complicate things further, Corn Allergy Girl has questioned whether corn allergy is due entirely to reaction with the corn protein zein or if people also react to carbohydrate epitopes (bits of the molecule that makes a pattern that is recognized by the immune system) and I think it might be a possibility. So the reaction to cucurbits might be due to cross-reactivity with a similar carbohydrate found in corn. Humans have antibodies to carbohydrate epitopes (called cross-reactive carbohydrate determinants (CCD)), but they are not supposed to cause allergic reactions and allergy tests are designed to ignore these antibodies. I have wondered what would happen if something went wrong in whatever mechanisms the body uses to ignore CCD antibodies. According to one paper*, 'The role of CCDs and their specific IgE antibodies in the pathophysiology of allergic diseases is controversial. ' "

* http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4757059/

#CornAllergy #MCAS #Allergy #Immunology #Glycobiology

in silico talks are our online series of short videos in which SIB’s scientists present the latest in #bioinformatics methods, research and resources to inform all interested in the field including life scientists and clinicians.

You can watch them all here: https://www.sib.swiss/in-silico-talks

Subscribe and be notified of the next one: https://www.sib.swiss/in-silico-talks/variomes-a-search-engine-to-support-the-curation-of-genetic-variants#newsletter #glycobiology #immunology #artificialintelligence #cancer #singlecell #genomics