#immunology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunology, aggregated by home.social.
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Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue
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Scientists discover a hidden switch that shuts off inflammation and prevents harmful immune cells from building up
https://www.sciencedaily.com/releases/2026/09/260911214306.htm
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Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html -
Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html -
Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html -
Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html -
Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html -
🌐 vaccinesresearch2027.pagesconferences.org
VACCINES-2027 | Innovation. Immunity. Impact.
Explore breakthroughs in vaccine research, development & immunology with global experts.
📍 Milan | 📅 April 19–20, 2027
📩 [email protected] -
This #firstreadfriday we have a guest blog from Claire Walker at #univesityoflincoln on why our bodies cannot always tell the difference between parasite and food.
As someone whose body seems to get confused about why I would want to eat and enjoy all kinds of food, understanding more about intolerance and allergy is always so helpful.
Thank you Claire for writing this one.
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This #firstreadfriday we have a guest blog from Claire Walker at #univesityoflincoln on why our bodies cannot always tell the difference between parasite and food.
As someone whose body seems to get confused about why I would want to eat and enjoy all kinds of food, understanding more about intolerance and allergy is always so helpful.
Thank you Claire for writing this one.
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The 𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝗕𝗶𝗼𝗽𝗵𝗼𝘁𝗼𝗻𝗶𝗰𝘀 section of CSBJ (A Science Partner Journal) is inviting submissions for its upcoming Special Issue:
“𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗜𝗺𝗺𝘂𝗻𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗗𝘆𝗻𝗮𝗺𝗶𝗰 𝗔𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗼𝗳 𝗜𝗺𝗺𝘂𝗻𝗲 𝗦𝘆𝘀𝘁𝗲𝗺𝘀”
⏳ Submission Deadline: 30 November 2026
🔗 For more information and submission guidelines, please visit: https://spj.science.org/journal/csbj/qbio
#CallForPapers #QuantumImmunology #QuantumBiology #Immunology #SystemsBiology #Biophysics #SystemsImmunology #QuantumScience
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The 𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝗕𝗶𝗼𝗽𝗵𝗼𝘁𝗼𝗻𝗶𝗰𝘀 section of CSBJ (A Science Partner Journal) is inviting submissions for its upcoming Special Issue:
“𝗤𝘂𝗮𝗻𝘁𝘂𝗺 𝗜𝗺𝗺𝘂𝗻𝗼𝗹𝗼𝗴𝘆 𝗮𝗻𝗱 𝘁𝗵𝗲 𝗗𝘆𝗻𝗮𝗺𝗶𝗰 𝗔𝗿𝗰𝗵𝗶𝘁𝗲𝗰𝘁𝘂𝗿𝗲 𝗼𝗳 𝗜𝗺𝗺𝘂𝗻𝗲 𝗦𝘆𝘀𝘁𝗲𝗺𝘀”
⏳ Submission Deadline: 30 November 2026
🔗 For more information and submission guidelines, please visit: https://spj.science.org/journal/csbj/qbio
#CallForPapers #QuantumImmunology #QuantumBiology #Immunology #SystemsBiology #Biophysics #SystemsImmunology #QuantumScience
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Rituximab (RTX), an intravenous drug primarily known for depleting B cells, has been found to also trigger positive metabolic changes in T cells, specifically improving energy production and lowering cellular stress in patients with nephrotic syndrome who respond favorably to the treatment.
#Immunology #Nephrology #CellularBiology #sflorg
https://www.sflorg.com/2026/09/imgy09092601.html -
Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species | Science
Every tool is neither good nor evil in itself. It's only determined by how we use it.
We're used to thinking of reactive oxygen species (ROS) as dangerous and harmful to cells: they directly damage DNA, causing mutations, and disrupt proteins, supporting signaling pathways that can contribute to cancer development. But even this "absolute evil" has a silver lining: ROS are found to be involved in T cell activation, thereby helping the immune system attack tumors. This paradoxical role of ROS is described in the new issue of Science. ROS oxidize certain phosphatases in T cells, shutting them down, and suppressing phosphatase activity is necessary for T cell activation.
Remarkably, tumors have a mechanism that interferes with this pathway of T cell activation. They release the antioxidant peroxiredoxin 1 into the intercellular space, which prevents ROS from supporting T-cell activation after contact with tumor cells.#cell-biology #biology #science #immunology
https://www.science.org/doi/10.1126/science.adz8203 -
A novel cryopreservation technique utilizing nontoxic antifreeze sugars, such as trehalose and sucrose, to protect CAR-T cells during freezing and thawing without requiring extensive chemical removal prior to patient infusion.
#Bioengineering #Oncology #CellularBiology #Immunology #sflorg
https://www.sflorg.com/2026/08/beng08192601.html -
Scientific Frontline wrote the following post Mon, 10 Aug 2026 13:54:41 -0700 A one-time, three-part therapeutic regimen administered within 72 hours of birth that demonstrates the potential to permanently clear HIV infection in exposed newborns.
#Virology #Immunology #Pathobiology #Neonatology #HIV #sflorg
https://www.sflorg.com/2026/08/vi08102601.html
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A one-time, three-part therapeutic regimen administered within 72 hours of birth that demonstrates the potential to permanently clear HIV infection in exposed newborns.
#Virology #Immunology #Pathobiology #Neonatology #HIV #sflorg
https://www.sflorg.com/2026/08/vi08102601.html -
_Этология, етологія, Ethology
#Этология, #етологія, #Ethology
t.me/scilib_yura15cbx/494_Энтомология, Entomology, Ентомологія
#Энтомология, #Entomology, #Ентомологія
t.me/scilib_yura15cbx/493Эмбрио, Ембріо, Embryo
эмбриология биология развития Embryology developmental biology
#Эмбрио, #Ембріо, #Embryo
#эмбриология #биологияразвития #Embryology #developmental biology
t.me/scilib_yura15cbx/492_Экология, Ecology, Екологія
эко окружающая среда энвайронментализм, экосистемы, популяции,
#Экология, #Ecology, #Екологія
t.me/scilib_yura15cbx/491_эволюция, еволюція, evolution
теория эволюции, эволюционная теория
#эволюция, #еволюція, #evolution
t.me/scilib_yura15cbx/490_Флора и фауна Украины
Flora and fauna of Ukraine
Флора і фауна України
t.me/scilib_yura15cbx/489_систематика, taxonomy
#систематика, #taxonomy
t.me/scilib_yura15cbx/488_Палеонтология, Paleontology, Палеонтологія
#Палеонтология, #Paleontology, #Палеонтологія
t.me/scilib_yura15cbx/487_Орнитология, Орнітологія, Ornithology
#Орнитология, #Орнітологія, #Ornithology
t.me/scilib_yura15cbx/486B Biology, Біологія, Биология
#Biology, #Біологія, #Биология
t.me/scilib_yura15cbx/485_нейро, neuro
Нейробиология, нейрология, Нейробіологія, нейрологія, Neurobiology, neurology,
#нейро, #neuro
#Нейробиология, #нейрология, #Нейробіологія, #нейрологія, #Neurobiology, #neurology
t.me/scilib_yura15cbx/483_Нематология, Nematology
#Нематология, #Nematology
t.me/scilib_yura15cbx/482Определители растений, лишайников, грибов
Визначники рослин, лишайників, грибів
#Определители
t.me/scilib_yura15cbx/481_Микробиология и Вирусология
Мікробіологія та вірусологія
Microbiology and Virology
#Микробиология и #Вирусология
#Мікробіологія та #вірусологія
#Microbiology and #Virology
t.me/scilib_yura15cbx/480_Микология, Mycology, Мікологія
#Микология, #Mycology, #Мікологія
t.me/scilib_yura15cbx/479_Макология
#Макология
t.me/scilib_yura15cbx/478_Microscopy, Мікроскопія, Микроскопия
#Microscopy, #Мікроскопія, #Микроскопия
t.me/scilib_yura15cbx/476Cell
Cell biology, Клітина, клітинна біологія, біологія клітини, Клетка, клеточная биология, биология клетки
#Cell
#Cell biology, #Клітина, #клітиннабіологія, #біологіяклітини, #Клетка, #клеточнаябиология, #биология клетки
t.me/scilib_yura15cbx/475Клетка, клеточная биология
#Клетка, #клеточнаябиология
t.me/scilib_yura15cbx/474_Красная книга
Червона книга, the Red Book,
t.me/scilib_yura15cbx/473История биологии
History of biology
Історія біології
t.me/scilib_yura15cbx/472Иммунология, Імунологія, Immunology
#Иммунология, #Імунологія, #Immunology
t.me/scilib_yura15cbx/471Гистология, Histology, Гістологія
#Гистология, #Histology, #Гістологія
t.me/scilib_yura15cbx/469_Грибы
mushrooms, Мікологія, Микология, Mycology
#Грибы
#mushrooms, #Мікологія, #Микология, #Mycology
t.me/scilib_yura15cbx/470Зоология, Зоологія, Zoology
#Зоология, #Зоологія, #Zoology
t.me/scilib_yura15cbx/468Genome, Геном,
геномика, Genomics, геноміка
#Genome, #Геном,
#геномика, #Genomics, #геноміка
t.me/scilib_yura15cbx/466Genetics, генетика
#Genetics, #генетика
t.me/scilib_yura15cbx/465Вода, Water
#Вода, #Water
t.me/scilib_yura15cbx/464Владивосток, Vladivostok, Приморье, Приморский край
природа, наука, в основном биология, ДВГУ, дипломные работы
#Владивосток, #Vladivostok, #Приморье, #Приморскийкрай
#природа, #наука, в основном #биология, #ДВГУ, #дипломныеработы
t.me/scilib_yura15cbx/463Анатомия и морфология растений
Анатомія і морфологія рослин
Anatomy and morphology of plants
t.me/scilib_yura15cbx/462Сосудистые растения,
Судинні рослини
Vascular plants
t.me/scilib_yura15cbx/460Низшие растения
Lower plants
Нижчі рослини
t.me/scilib_yura15cbx/459Геоботаника, Геоботаніка, Geobotany
#Геоботаника, #Геоботаніка, #Geobotany
t.me/scilib_yura15cbx/458Биоэтика, Біоетика, Bioethics
#Биоэтика, #Біоетика, #Bioethics
t.me/scilib_yura15cbx/456Биохимия, молекулярная биология
Biochemistry, molecular biology
Біохімія, молекулярна біологія
#Биохимия, #молекулярнаябиология
#Biochemistry, #molecular biology
#Біохімія, #молекулярнабіологія
t.me/scilib_yura15cbx/455Биология моря, морская биология
Marine biology, Біологія моря, морська Біологія
#Биологияморя, #морскаябиология
#Marine biology, #Біологіяморя, #морськаБіологія
t.me/scilib_yura15cbx/453Альгология, Альгологія, Algology
#Альгология, #Альгологія, #Algology
t.me/scilib_yura15cbx/452Bioinformatics, Биоинформатика, Біоінформатика
#Bioinformatics, #Биоинформатика, #Біоінформатика
t.me/scilib_yura15cbx/450 -
Quantum computing
Квантовые вычисления, Квантові обчислення
t.me/scilib_yura15cbx/112Programming languages
Мови програмування, Языки программирования
t.me/scilib_yura15cbx/110Computability
Вычислимость, Обчислюваність
t.me/scilib_yura15cbx/109Natural language
Природні мови, Естественные языки
t.me/scilib_yura15cbx/108Image processing
Обработка изображений, Обробка зображень
t.me/scilib_yura15cbx/106Information theory
Теорія інформації, Теория информации
t.me/scilib_yura15cbx/105Formal methods
t.me/scilib_yura15cbx/103Genetic, neural
t.me/scilib_yura15cbx/104Data mining
Сбор данных, Видобуток даних
t.me/scilib_yura15cbx/102Discrete math
Дискретная математика, Дискретна математика
t.me/scilib_yura15cbx/101Databases, базы данных, бази даних
t.me/scilib_yura15cbx/100Cryptography, Криптография, Криптографія
t.me/scilib_yura15cbx/99Computational geometry
Обчислювальна геометрія, Вычислительная геометрия
t.me/scilib_yura15cbx/98Concurrent, distributed
t.me/scilib_yura15cbx/97Computer algebra
Компьютерная алгебра, Комп'ютерна алгебра
t.me/scilib_yura15cbx/96Bioinformatics, Біоінформатика, Биоинформатика
t.me/scilib_yura15cbx/95Algorithms, Алгоритмы, Алгоритми
t.me/scilib_yura15cbx/93AI, artificial intelligence, Искусственный интеллект
штучний інтелект, искусственный интеллект, ИИ, ШІ, artificial intelligence Machine learning Natural language processing Neural networks Data mining Evolutionary computation Fuzzy systems Logic and Functional Programming Robotics Кибернетика Логическое и декларативное программирование ИИ Мозг и моделирование мышления Нейронные сети Нечеткая логика Обработка естественного языка Распознавание образов Робототехника Статьи Эволюционное моделирование Экспертные системы Кібернетика Логічне та декларативне програмування ІІ Мозок та моделювання мислення Нейронні мережі Нечітка логіка Обробка природної мови Розпізнавання образів Робототехніка Статті Еволюційне моделювання Експертні системи
t.me/scilib_yura15cbx/92Органическая химия
Organic chemistry, Органічна хімія
t.me/scilib_yura15cbx/90Химия и химическая технология
Хімія та хімічна технологія, Chemistry and chemical technology
t.me/scilib_yura15cbx/89Chemistry-Environmental-Material
t.me/scilib_yura15cbx/88School-level Chemistry
Химия школьного уровня, Хімія на шкільному рівні
t.me/scilib_yura15cbx/87Physical chemistry
Фізична хімія, Физическая химия
t.me/scilib_yura15cbx/86Encyclopaediae of chemistry
химическая энциклопедия, chemical encyclopedias, Енциклопедія хімії
t.me/scilib_yura15cbx/85Computational chemistry
Комп'ютерна хімія, Вычислительная химия
t.me/scilib_yura15cbx/84Chemistry, Хімія, Химия
history
t.me/scilib_yura15cbx/83Biology, биология, біологія
t.me/scilib_yura15cbx/81Biology - Genetics
генетика
t.me/scilib_yura15cbx/80Biology- Human
Человек, Людина
t.me/scilib_yura15cbx/79mathematical papers
Математичні статті
математические статьи
t.me/scilib_yura15cbx/76The New Yorker [1925 - 2021]
t.me/scilib_yura15cbx/75Grill, barbecue, steak, jerky, curing, smoking, sausage, charcuterie, outdoor kitchen
#кулинария, #готовка, #кухня, #природа, #cooking, #kitchen, #nature, #кулінарія, #готування,
t.me/scilib_yura15cbx/73Азбука кино , Cinema
Периодика, журналы Periodicals, magazines, journals Искусство Кино
t.me/scilib_yura15cbx/71Азбука кино , Cinema
История кино
t.me/scilib_yura15cbx/69_Компьютерная библиотека Ихтика
компьютер, компьютеры, техника, программирование, программы, софт, железо, базы данных computer, computers, programming, programs, software, hardware, databases
t.me/scilib_yura15cbx/64MolBiol Biological library BioLib biolibrary
Библиотека биологической литературы Бібліотека біологічної літератури
#биология #зоология #ботаника #генетика #методы #протоколы #иммунология #рак #протеомика #нейрология #физиология #нейробиология #анатомия и др. #Біологія #зоологія #ботаніка #генетика #методи #протоколи #імунологія #рак #протеоміка #нейрологія #фізіологія #нейробіологія #анатомія та ін. #biology #zoology #botany #genetics #methods #protocols #immunology #cancer #proteomics #neurology #physiology #neurobiology #anatomy, etc.
t.me/scilib_yura15cbx/63 -
💧🧬 Aquagenic urticaria is an extremely rare condition where #skin contact with #water triggers painful hives.
Researchers believe a substance on the skin reacts with water to release histamine. Interestingly, those affected can still drink water safely because their internal digestive systems don't trigger this specific immune response.
👉 https://www.popsci.com/health/water-allergy/
#science #biology #health #medicine #allergies #immunology #research #dermatology
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Harmless skin #bacteria naturally produce small, stable molecules known as #lipopeptides that can suppress the severe allergic inflammation triggered by #eczema causing microbes.
#Immunology #Dermatology #Microbiology #MolecularBiology #sflorg
https://www.sflorg.com/2026/05/imgy05142601.html -
"Aeromonas and Ulcerative Colitis Susceptibility"
🦠 Aeromonas variant linked to ulcerative colitis.
🧪 22 figures and 12 tables detailed.
👩🔬 Data show macrophages, T and B cell analysis.
📊 Studies based on flow cytometry.
📈 Statistical significance: *p<0.05.
🔍 Methods include one-way ANOVA, Mann-Whitney.#Microbiology #UlcerativeColitis #CellBiology #Immunology #Pub2Post
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Newborn babies who develop sepsis from E. coli bacteria suffer from a critical deficiency in specific maternally transferred antibodies that target a major surface protein common to all E. coli strains.
#Immunology #Neonatology #Microbiology #MolecularBiology #sflorg
https://www.sflorg.com/2026/03/imgy03122601.html -
ELISA techniques enable precise antigen detection, supporting disease diagnosis, research accuracy, and clinical testing through sensitive immunological assays.
#ELISA #Immunology #Diagnostics #Biotechnology #ClinicalResearch #LaboratoryScience #MedicalTesting #LifeSciences #BiotechEducation #ResearchTools -
🧪 ELISA techniques enable accurate antigen detection 🔬, supporting diagnostics, research, and clinical testing through sensitive immunoassays 📊.
#ELISA #Immunoassay #ClinicalDiagnostics #Biotechnology #Immunology #LifeScienceStudents #LaboratoryTechniques #MedicalTesting #ResearchLabs #BioResire -
#Neoadjuvant treatment with the #immunotherapy drug pembrolizumab significantly shrinks or eliminates #tumors in patients with desmoplastic #melanoma , a rare and aggressive form of skin #cancer
#Oncology #Immunology #Dermatology #sflorg
https://www.sflorg.com/2026/01/ongy01292601.html -
🇮🇳 INDIA’S TOP HIGH-QUALITY CSIR NET LIFE SCIENCES CRASH COURSE
🚀 LEARN FROM EXPERT MENTORS
#csirnet #biochemistry #biotechnology #zoology #biology #microbiology #science #ugcnet #neet #lifescience #gate #icmr #genetics #iitjam #jrf #csirnetlifesciences #net #phd #iit #research #tifr #icar #instagram #iisc #university #india #education #molecularbiology #immunology #aiims -
Nice study this identifying early immune markers in neonatal sepsis - elevated amphiregulin even when CRP normal... 🤔 #immunology #Sepsis #neonatology #medicine #infectiousdiseases
https://www.nature.com/articles/s41467-023-44387-5 -
@cyrilpedia nice piece, and also informative. Had missed the black box warning on the whole JAK Stat family! Is the increased cardiovascular risk dose / time dependent, or is it idiosyncratic?
#Immunology #drugdiscovery
#drugdevelopment #alopecia -
My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
#Immunology #drugdiscovery #drugdevelopment #alopecia -
My new Clinical Pipeline column is out in Nature Medicine.
It's on JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
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My new Clinical Pipeline column is out today in Nature Medicine, a look at JAK inhibitors for alopecia - and at the black box safety warning the FDA attached to this entire class of drugs.
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'In this Review, we present current knowledge on the role of MDSCs in the immunotherapy of melanoma. We describe the accumulation, infiltration, and immunosuppressive functions of MDSCs in the tumor microenvironment (TME) as well as existing therapeutic strategies to target them in melanoma-bearing hosts. A special focus is placed on preclinical studies and clinical trials applying MDSC inhibition to overcome resistance to ICIs.'
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`Furthermore, we show that 5′-FAD capping protects RNA from RIG-I mediated innate #immune recognition but does not stabilize the HCV #RNA. These results establish #capping with cellular metabolites as a novel #viral RNA-capping strategy, which could be used by other viruses and affect anti-viral treatment outcomes and persistence of #infection.`
https://www.nature.com/articles/s41586-023-06301-3
#interesting #virology #medicine #molecularBiology #molecularBio #biology #ribonucleotide #nucleotide #immunology #pathology
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'Our current study detects chronic low-level type I interferon (IFN) activation in the cancer cells and the reciprocal astrocytes throughout the brain metastatic process. IFN responses in astrocytes promote brain metastasis by enhancing the recruitment of monocytic myeloid cells in both breast cancer and melanoma models'
#Immunology #immunotherapy #immunooncology -
This is not good.
"Changes to the primary end point during or after recruitment were omnipresent in randomized clinical trials with immune checkpoint inhibitors for patients with UC, RCC, and NSCLC. Most common were switching to or adding OS as an outcome measure and subpopulations based on PD-L1 expression. Ultimately, published data often do not allow readers to infer what the results would have been if the primary outcome had not been changed."
#Immunology #Immunotherapy #immunooncology #checkpointinhibitors
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'In patients with resectable stage IIIA or IIIB NSCLC, perioperative treatment with nivolumab plus chemotherapy resulted in a higher percentage of patients with a pathological complete response and longer survival than chemotherapy alone.'
#immunotherapy #Immunology #immunooncology #LungCancer -
'To identify tumor-intrinsic drivers of resistance, we quantified in-vitro response to CD19-directed chimeric antigen receptor T-cells (CD19-CAR) and bispecific antibodies (BsAb) across 46 B-NHL cell lines and measured their proteomic profiles at baseline. Among the proteins associated with poor in-vitro response was Serpin B9, an endogenous granzyme B inhibitor.'
#CART #immunotherapy #Immunology #immunooncology #Preprint
https://www.biorxiv.org/content/10.1101/2023.06.26.546507v1?med=mas
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"In this Review, we will discuss how CD8+ T cell developmental trajectories converge with tissue biology, and how factors such as migration to, localization within and the ability to sense different types of microenvironments shape T cell responses."
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Yet another study showing that tumor mutation burden is a poor predictor of response to checkpoint blockade.
"First we assembled the largest pan-cancer dataset of immunotherapy patients with sequencing and clinical data. Surprisingly, we find little evidence that TMB is predictive of response to ICB.
(...)
Our analysis shows that the use of TMB in clinical practice is not supported by available data and can deprive patients of treatment to which they are likely to respond."
#Immunology #immunooncology #immunotherapy -
CW: Long Hashtag List for the Life Sciences
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• Animal Behaviour
#AnimalBehavior #AnimalBehaviour #AnimalCognition #AnimalPsychology #AnimalResearch #AnimalSocieties #AnimalStudies #BehavioralEcology #BehaviouralEcology #BehavioralScience #BehaviouralScience #CameraTraps #ComparativeCognition #CriticalAnimalStudies #Learning #Memory #PositiveReinforcement #Sociobiology #TrailCam• Astrobiology
#AlienLife #Astrobiology #Biosignatures #Cryosphere DeepIce #EarthScience #Exoplanets #GeoScience #Habitability #Karst #MicroHabitats #OceanWorlds #OriginOfLife #PlanetaryCaves #PlanetaryScience• Behaviour Science
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#Animals #Biology #Zoologist #Zoology(Click to access Scientists in the Formal, Natural & Social Sciences)
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Cholesterol & anti tumor T cell immunity:
"We analyze the cholesterol atlas in the tumor microenvironment and find that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance. Low cholesterol levels inhibit T cell proliferation and cause autophagy-mediated apoptosis, particularly for cytotoxic T cells"
#Immunology #immunotherapy #immunooncology #CancerImmunity
https://www.sciencedirect.com/science/article/abs/pii/S1535610823001423?via%3Dihub
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"To capture the complex interplay between the tumor antigenic landscape and anti-tumor immunity in lung cancer, we integrated genomics, transcriptomics, immunopeptidomics, spatial transcriptomics and multiplexed immunofluorescence (mIF) imaging to investigate the antigenic landscape in tumors with variable degrees of immune infiltration"
#Immunology #immunooncology -
'Our studies demonstrate that in vivo trans PD-L1/CD80 interactions do exist between T and tumor cells, and in vivo blockade of trans PD-L1/CD80 interactions or general PD-L1/CD80 interactions augment tumor immunity via expansion of IFN-γ-producing CD8+T cells and NOS2+macrophages in the tumor tissues.'
#immunology #immunooncology #immunotherapy #checkpointinhibitors
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Hunting submarines.
'Here, we report that CD8+T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression. This capacity proves to be dependent on interactions between T cell NKG2D and tumor NKG2D ligands (NKG2DL).'
#Preprint #immunology #immunooncology #immunotherapy -
This makes sense - PD1/PDL1 are great targets, but the degree of dominance over the last decade was worrisome. Great to see more diversity
"Our current analysis of global IO clinical trials shows that the field took a turn in 2022 with respect to previous years. After more than a decade of an upward trajectory, we notice a decrease in new clinical trials, a shift driven largely by the reduction in phase II studies using anti-PD1/PDL1 mAbs."
#immunology #immunotherapy #immunooncology -
Interesting study showing balance between bacterial & host factors determining granuloma formation and control of infection. This example being #Yersinia.
#granuloma #immunology #academia #Science #ScienceMastodonInflammatory monocytes promote granuloma control of Yersinia infection | Nature Microbiology
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'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity
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Less is more for monoclonal antibody affinity?
(Particularly if deletion is not the goal)"This approach delivered higher immune cell activation, in vivo T cell expansion and antitumour activity in the case of CD40. Moreover, an inert anti-4-1BB monoclonal antibody was transformed into an agonist. Low-affinity variants of the clinically important antagonistic anti-PD-1 monoclonal antibody nivolumab also mediated more potent signalling and affected T cell activation."
#Monoclonal #MonoclonalAntibody #immunology #drugdiscovery #drugdevelopment
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"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."