#immunology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunology, aggregated by home.social.
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Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species | Science
Every tool is neither good nor evil in itself. It's only determined by how we use it.
We're used to thinking of reactive oxygen species (ROS) as dangerous and harmful to cells: they directly damage DNA, causing mutations, and disrupt proteins, supporting signaling pathways that can contribute to cancer development. But even this "absolute evil" has a silver lining: ROS are found to be involved in T cell activation, thereby helping the immune system attack tumors. This paradoxical role of ROS is described in the new issue of Science. ROS oxidize certain phosphatases in T cells, shutting them down, and suppressing phosphatase activity is necessary for T cell activation.
Remarkably, tumors have a mechanism that interferes with this pathway of T cell activation. They release the antioxidant peroxiredoxin 1 into the intercellular space, which prevents ROS from supporting T-cell activation after contact with tumor cells.#cell-biology #biology #science #immunology
https://www.science.org/doi/10.1126/science.adz8203 -
Susumu Tonegawa, born OTD in 1939, was awarded the Nobel Prize in 1987 for his discovery of the genetic mechanism that produces antibody diversity https://toilet-guru.com/blog/49.html?s=mb #immunology #medicine #history
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Susumu Tonegawa, born OTD in 1939, was awarded the Nobel Prize in 1987 for his discovery of the genetic mechanism that produces antibody diversity https://toilet-guru.com/blog/47.html?s=mb #immunology #medicine #history
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Susumu Tonegawa, born OTD in 1939, was awarded the Nobel Prize in 1987 for his discovery of the genetic mechanism that produces antibody diversity https://toilet-guru.com/blog/45.html?s=mb #immunology #medicine #history
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🌐 vaccinesresearch2027.pagesconferences.org
ONE FIELD. MANY PERSPECTIVES. ONE GOAL.
Vaccine science moves forward when research, immunology, development, and global expertise come together.
Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.
📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth
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🌐 vaccinesresearch2027.pagesconferences.org
ONE FIELD. MANY PERSPECTIVES. ONE GOAL.
Vaccine science moves forward when research, immunology, development, and global expertise come together.
Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.
📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth
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🌐 vaccinesresearch2027.pagesconferences.org
ONE FIELD. MANY PERSPECTIVES. ONE GOAL.
Vaccine science moves forward when research, immunology, development, and global expertise come together.
Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.
📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth
-
🌐 vaccinesresearch2027.pagesconferences.org
ONE FIELD. MANY PERSPECTIVES. ONE GOAL.
Vaccine science moves forward when research, immunology, development, and global expertise come together.
Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.
📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth
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Researchers evaluated two experimental Zika virus vaccines to understand the roles of antibodies and T cells, discovering that long-term viral protection requires a coordinated immune response from both components rather than relying on T cells alone.
#Immunology #Virology #Epidemiology #sflorg
https://www.sflorg.com/2026/08/imgy08262601.html -
Receiving the shingles vaccine to prevent the reactivation of the Varicella zoster virus is associated with a significantly reduced risk of developing dementia in older adults. An epidemiological study observed up to a 24% lower risk of dementia over four years among vaccinated nursing home residents.
#Epidemiology #Immunology #Neurology #sflorg
https://www.sflorg.com/2026/08/epi08112601.html -
quote from article:
"Strangely enough, Kultima and colleagues found that the odds of developing MS in patients with a gene variant tied to a lower risk of the disease were instead much higher if they had been exposed to greater levels of PFOS.In fact, with increasing PFOS exposure, participants with this gene variant had a greater than fourfold higher risk of developing MS.
"This indicates that there is a complex interaction between inheritance and environmental exposure linked to the odds of MS," explains Kultima."
That's really interesting.
from the research article:
"This study observed a significant interaction between PFAS exposure, specifically PFOS, and the HLA class I alleles HLA-B*44:02. Although HLA-B*44:02 has been described as protective, carriers exposed to higher PFOS levels exhibited a stronger association with increased odds of MS. While the mechanism remains unclear, PFAS may modulate immune function by affecting cytokine signaling, redox balance, or antigen processing pathways, thereby potentially influencing the repertoire of peptides presented by HLA molecules. In the context of HLA-B*44:02, such environmental modulation could alter the activation threshold of autoreactive CD8+ T cells or affect regulatory cell function."
https://doi.org/10.1016/j.envint.2025.109993Endoplasmic reticulum stress could be added to the list of possible mechanisms.
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How a scrappy biotech startup backed by Microsoft’s co-founders set the stage for two Nobel winners - Mary Brunkow speaks at an event Tuesday at Seattle’s Institute for Systems Biolog... - https://www.geekwire.com/2025/how-a-scrappy-biotech-backed-by-microsofts-co-founders-set-the-stage-for-seattles-latest-nobel-winners/ #instituteforsystemsbiology #health/lifesciences #autoimmunedisease #fredramsdell #marybrunkow #immunology #nobelprize #startups #science
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Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
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https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
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#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS