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#immunology โ€” Public Fediverse posts

Live and recent posts from across the Fediverse tagged #immunology, aggregated by home.social.

  1. ๐ŸŒ vaccinesresearch2027.pagesconferences.org

    VACCINES-2027 | Innovation. Immunity. Impact.

    Explore breakthroughs in vaccine research, development & immunology with global experts.

    ๐Ÿ“ Milan | ๐Ÿ“… April 19โ€“20, 2027
    ๐Ÿ“ฉ [email protected]

    #VACCINES2027 #Immunology #VaccineScience

  2. The ๐—ค๐˜‚๐—ฎ๐—ป๐˜๐˜‚๐—บ ๐—•๐—ถ๐—ผ๐—น๐—ผ๐—ด๐˜† ๐—ฎ๐—ป๐—ฑ ๐—•๐—ถ๐—ผ๐—ฝ๐—ต๐—ผ๐˜๐—ผ๐—ป๐—ถ๐—ฐ๐˜€ section of CSBJ (A Science Partner Journal) is inviting submissions for its upcoming Special Issue:

    โ€œ๐—ค๐˜‚๐—ฎ๐—ป๐˜๐˜‚๐—บ ๐—œ๐—บ๐—บ๐˜‚๐—ป๐—ผ๐—น๐—ผ๐—ด๐˜† ๐—ฎ๐—ป๐—ฑ ๐˜๐—ต๐—ฒ ๐——๐˜†๐—ป๐—ฎ๐—บ๐—ถ๐—ฐ ๐—”๐—ฟ๐—ฐ๐—ต๐—ถ๐˜๐—ฒ๐—ฐ๐˜๐˜‚๐—ฟ๐—ฒ ๐—ผ๐—ณ ๐—œ๐—บ๐—บ๐˜‚๐—ป๐—ฒ ๐—ฆ๐˜†๐˜€๐˜๐—ฒ๐—บ๐˜€โ€

    โณ Submission Deadline: 30 November 2026

    ๐Ÿ”— For more information and submission guidelines, please visit: spj.science.org/journal/csbj/q

    #CallForPapers #QuantumImmunology #QuantumBiology #Immunology #SystemsBiology #Biophysics #SystemsImmunology #QuantumScience

  3. Rituximab (RTX), an intravenous drug primarily known for depleting B cells, has been found to also trigger positive metabolic changes in T cells, specifically improving energy production and lowering cellular stress in patients with nephrotic syndrome who respond favorably to the treatment.
    #Immunology #Nephrology #CellularBiology #sflorg
    sflorg.com/2026/09/imgy0909260

  4. ๐Ÿ๐Ÿ’‰ Tim Friede spent nearly 20 years gradually immunizing himself against #venom from over a dozen deadly #snakes, including #cobras and black #mambas.

    Scientists used #antibodies from his blood to create an experimental #antivenom that protected #mice from 13 types of snake venom. The work could lead to a single broad-spectrum antivenom.

    ๐Ÿ‘‰ sciencenews.org/article/antive

    #science #immunology #biology #wildlife #medicine #research #nature #wisconsin #newyork #biotech

  5. 2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.

    CBASS 3TMโ€‘SAVED effectors form cGAMPโ€‘linked filaments that shear membranes and induce death.

    #OpenAccess #virology #immunology #microbiology #phage #bacteriophage

    davidojcius.blogspot.com/2026/

  6. #Macrophages do not possess inherent long-term memory but instead rely on constant stimulation from residual interferon-gamma molecules sequestered on their surface to maintain a primed state against repeat infections.
    #Immunology #Genetics #sflorg
    sflorg.com/2026/02/imgy0218260

  7. ๐Ÿงฌ One amino acid to stabilize them all โ€” myth or molecular reality?

    ๐Ÿ”— Single-residue engineering of lambda (ฮป) antibody light chains reduces conformational flexibility and enhances thermal stability. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2025.10

    ๐Ÿ“š CSBJ: csbj.org/

    #MonoclonalAntibodies #mAbs #Immunology #ComputationalBiology #MolecularDynamics #Bioinformatics #ProteinStability #StructuralBiology

  8. So. How about this careful result demonstrating viral replication inside megakaryocyte immune cells?

    transmission electron microscopy pointed to the presence of viral particles inside bone marrow MK. Immunolabeling confirmed the presence of two SARS-CoV-2 proteins, spike and Orf3a, as well as double-stranded RNA suggesting a potential viral replication cycle.

    Note this study is from last month, but it's from hospitalized 2020-2021 patient data. It's existence proof, not population statistics.

    That said:

    bone marrow MK infection is not a strict determinant of mortality. However, all survivors experienced post-acute sequelae SARS-CoV-2 condition (PASC) diagnosed during post-intensive care follow-up

    short ๐Ÿงต

    #CovidIsAirborne #SARSCoV2 #COVID #COVID19 #CovidCompetent #AirborneAware #immunology

  9. AJ's got a new blog post! Some highlights:
    "a Nature Immunology study from January 2024 "Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2" reveals further harm through T cell dysregulation in long COVID patients. The research identified increased frequencies of exhausted SARS-CoV-2-specific CD8+ T cells, alongside CD4+ T cells primed for inflammation, and a lack of coordination between T and B cell responses."
    "a paper in JCI insight showing T cell exhaustion to other infections following a covid infection"
    "a Nature Immunology study from January 2022 "Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection" shows that COVID-19 leads to a prolonged reduction in naive T cells (both CD4+ and CD8+) in individuals with long COVID, persisting up to eight months post-infection."
    "Such a long-term impact on the naive T cell pool is not a standard feature of recovery from other acute viral infections like influenza, [...] This effect may not completely persist, however, what it represents is sloughing of the T cells."
    A study published in Immunity found "Even after vaccination, those with a history of COVID-19 showed weaker and less functional CD8+ T cell responses, a phenomenon likened to the immune damage seen in chronic viral infections like hepatitis C or HIV. This attenuation indicates that SARS-CoV-2 inflicts a lasting impairment on CD8+ T cell effector function"
    from https://www.easychair.info/p/5-years-later-covid-still-harms-t #AirborneAware #CovidCompetent #COVIDIsNotOver #COVID #COVID19 #SARSCoV2 #immunology #LongCOVID
  10. 'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-ฮฑ, -ฮฒ, and/or -ฯ‰ can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'

    #Immunology #Immunosky #interferon

    pnas.org/doi/10.1073/pnas.2402

  11. 'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNฮป-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNฮป.'
    #Preprint #Immunology #InnateImmunity #Interferon

    biorxiv.org/content/10.1101/20

  12. "Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota."
    Mao, Akiko Iwasaki et al
    #Immunology #Interferon

    pnas.org/doi/10.1073/pnas.2319

  13. 'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1ฮฒ production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
    #Immunology #Inflammation #inflammasome #Metabolism

    cell.com/cell-reports/fulltext

  14. Macrophages are essential immune cells that reside in all tissues. Some macrophages arise from monocytes in the blood, but during fetal development they also come from a unique pathway!

    We still have a lot to learn, but here I'll describe how Zhao et al. (2023) used mouse models to uncover hints about which progenitor cells create tissue-macrophages.

    doi.org/10.1016/j.celrep.2023.

    #Macrophages #MouseModel #Immunology #Immunity #scRNAseq #FlowCytometry #Research #JournalArticle #JournalClub

    1/9๐Ÿงต

  15. CW: The Aldehyde Hypothesis | Heran Darwin

    NIH presentation, Sept 27, 2023
    youtu.be/zLkq6a_W1nE?si=1GTVQA

    Reactive aldehydes enhance the antimicrobial effect of nitric oxide - possibly an explanation for the maintenance of ALDH2* in Asian populations.
    Acetaldehyde doesn't work - so drinking alcohol won't help treat TB infection.
    Warburg Effect - anaerobic glycolysis produces aldehydes (methylglyoxal) [22:12, 54:26].

    #ALDH2 #NitricOxide
    #Tuberculosis
    #Microbiology
    #Immunology #malondialdehyde #methylglyoxal #metabolism #WarburgEffect #Immunometabolism
    #AldehydeHypothesis

  16. Always been curious how different interferons that signal through same receptor can have different functional effect. Here's a paper that shows how:
    #interferon #immunology #receptor #receptors #Signalling science.org/doi/10.1126/scisig

  17. Now I cant stop singing "more than a spike gene" to the tune of the BeeGees (protein didnt fit the meter).

    'We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors.'
    #Covid #Covid19 #SarsCov2 #Interferon #Virology #Immunology #InnateImmunity

    sciencedirect.com/science/arti

  18. 'Here, we used CRISPR-based loss-of-function screens to identify a markedly limited set of ISGs that confer interferon-mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectorsโ€”ZAP, IFIT3, and IFIT1โ€”together constitute the majority of interferon-mediated restriction of VEEV, while accounting for <โ€‰0.5% of the interferon-induced transcriptome.'

    #Immunology #Virology #Interferon

    embopress.org/doi/full/10.1525

  19. "Our investigation reveals that the fetal HSCs respond to T.โ€‰gondii infection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. Furthermore, maternal IFNฮณ crosses the fetalโ€“maternal interface, where it is perceived by fetal HSCs."

    #Immunology #Interferon #Toxoplasma

    embopress.org/doi/full/10.1525

  20. CW: Long Hashtag List for the Life Sciences

    Life Sciences Hashtags

    โ€ข Animal Behaviour
    #AnimalBehavior #AnimalBehaviour #AnimalCognition #AnimalPsychology #AnimalResearch #AnimalSocieties #AnimalStudies #BehavioralEcology #BehaviouralEcology #BehavioralScience #BehaviouralScience #CameraTraps #ComparativeCognition #CriticalAnimalStudies #Learning #Memory #PositiveReinforcement #Sociobiology #TrailCam

    โ€ข Astrobiology
    #AlienLife #Astrobiology #Biosignatures #Cryosphere DeepIce #EarthScience #Exoplanets #GeoScience #Habitability #Karst #MicroHabitats #OceanWorlds #OriginOfLife #PlanetaryCaves #PlanetaryScience

    โ€ข Behaviour Science
    #AnthroZoology #Behavior #Behaviour #Behaviour2023 #BehavioralScience #BehaviouralScience #Biopsychology #CognitiveDevelopment #ComparativeCognition #DevelopmentalPsychology #Ethology #Learning #Memory #Neuroethology #PhilosophyOfMind #PleasureActivism #Psychology #SelfOrganisation #SelfOrganization #SocialNetwork

    โ€ข Biochemistry | Group: @biochemistry
    #Actin #AminoAcids #Biochemical #Biochemistry #Catalyst #Catalysis #DNA #Enzyme #Enzymes #Hormones #IonChannels #Kinetics #Metabolism #Metabolomics #mRNA #Peptides #Polymer #Protein #Proteins #RNA

    โ€ข Bioinformatics | Group: @bioinformatics
    #BigData #Bioinformatics #RStats

    โ€ข Biology | Group: [email protected]
    #Biochemistry #Biology #Biomes #Botany #Ecology #Ecosystem #Evolution #Genetics #Habitat #LifeCycle #MarineBiology #Microbiology #Zoology

    โ€ข Biomaterial Science
    #Biofilm #Biofilms #Biologics #Biomaterials #Biotechnology #MaterialsScience #Nanotechnology #SustainableDesign #SyntheticBiology

    โ€ข Biomedical Science
    #Biomedical #BiomedicalEngineering #BiomedicalScience #NetworkMedicine #SystemsBiology

    โ€ข Botany
    #Botany #Botanical #Botanist #FloraIncognita #Florespondence IAmABotanist #Phenology #PlantBiology #PlantCells #PlantID #PlantIdentification

    โ€ข Cell Biology | Group: @cellbiology
    #CellBiology #CellDivision #CellMigration #Chloroplast #Cilium #Cytoskeleton #EndoplasmicReticulum #Eukaryotes #Golgi #Lipids #Macrophages #Membrane #Membranes #Microtubules #Mitochondria #Nucleus #Organelle #Organoids #Ribosome #SingleCell

    โ€ข Developmental Biology
    #ChildDevelopment #Connectome #Connectomics #DevelopmentalBiology #Embryology #Embryos #EvoDevo #GeneRegulation #Pregnancy #Proteomics #ReproSci #SexDet #StemCells #Transcriptomics

    โ€ข Ecology | Group: @ecology
    #AgroEcology #BehavioralEcology #BehaviouralEcology #Biodiversity #BiodiversityCrisis #BiodiversityLoss #Biogeography #ConservationBiology #Ecocide #EcoGrief #Ecological #EcologicalMonitoring #EcologicalSurvey #Ecology #Ecosystem #ForestEcology #Habitat #InvasionEcology #InvasiveSpecies #MassExtinction #OldGrowth #Riparian #WildCounts

    โ€ข Entomology | Group: @entomology
    #Beetles #Bugs #Coleoptera #Crustaceans #Entomologia #Entomology #Hemiptera #Hymenoptera #iNaturalist #Insect #Insects #InsectPhotography #Invertebrates #Isopods #Lepidoptera #Metamorphosis #Orthoptera #Pupa #Taxonomy

    โ€ข Genetics
    #BasePair #CellDivision #Chromosome #Chromosomes #Clone #Epigenetics #DNA #Gene #GeneExpression #GeneRegulation #GeneticallyModified #Genetics #Genome #Genomics #GMO #Meiosis #Mitosis #Mutation #RNAseq #Telomeres #Variants

    โ€ข Immunology
    #Antibodies #Antibody #Antigen #AutoImmune #BCells #Immune #ImmuneSystem #Immunity #ImmunoCompromised #Immunology #ImmunoTherapy #Interferon #Macrophages #Monoclonal #MonoclonalAntibodies (#mAbs) #Neutrophils #TCell #Vaccinated #Vaccine #Viralimmunology

    โ€ข Marine Science
    #Acidification #Algae #Aquatic #Cetaceans #Coral #CoralBleaching #CoralReefs #DeepSea #Diatoms #Estuary #Eutrophication #Kelp #KelpForest #MarineBiology #MarineLife #MarineMammals #MarineScience #MarineTaxonomy #Oceanography #Oceans #OceanWarming #Phytoplankton #Reefs #SeaBed #SeaFloor #SeaGrass #Seaweed #ScubaDiving #Snorkeling #UnderWaterPhotography #Zooplankton

    โ€ข Microbiology | Group: @microbiology
    #Antibiotics #AntiMicrobial #AntiMicrobialResistance (#AMR) #Bacteria #Bacterial #Bacteriophage #Bacteriology #Cilia #Microbes #Microbial #MicrobialEcology #Microbiology #Microbiome #Microbiota #MicroOrganisms #Phage #Protists

    #EColi #Legionella #Pseudomonas #Salmonella #Streptomyces

    โ€ข Molecular Biology | Group: @molecularbiology
    #Biophysics #CellBiology #MolecularBiology #MolecularEvolution #ProteinEngineering #ProteinStructure #Proteomics #StructuralBiology

    โ€ข Mycology | Group: @mycology
    #Fungi #Fungiverse #Mushrooms #Mycelium #Mycologists #Mycology #Mycophile #Spores #Sporespondence

    โ€ข Ornithology | Group: @ornithology
    #BirdID #Birding #BirdMigration #BirdPhotography #BirdResearch #BirdsOfMastodon #Corvid #eBird #Migration #Nesting #Oology #Ornithology #Raptor #SeaBirds #ShoreBirds

    โ€ข Virology | Group: @virology
    #AntiViral #AvianFlu #Bacteriophage #BirdFlu #CoronaVirus #COVID #COVID19 #GiantViruses #HIV #InfectiousDisease #Ebola #Measles #Phage #SARS #SARSCoV2 #Vaccine #Vaccines #ViralLoad #Viralimmunology #ViralPersistence #Variants #Virology #Virome #Virus #Viruses

    โ€ข Zoology
    #Animals #Biology #Zoologist #Zoology

    (Click to access Scientists in the Formal, Natural & Social Sciences)

    (See Index for More Hashtags)

    #SciFedi #LifeSciences

  21. 05/2023 Issue โžก๏ธ bit.ly/3VPM25i
    text mining to assemble molecular mechanisms, modular organisation of human #proteome, transcriptional regulation of #metabolism...
    Cover (DrawImpacts): IFN-ฮฒ activation of inflammatory genes from Alex Hoffmann's lab, UCLA
    #immunology #signalling #systemsbiology

  22. "Our understanding of thymic blood vascular hemodynamics is limited due to technical challenges associated with accessing the native thymus in live mice. To overcome this challenge, we developed an intravital two-photon imaging method to visualize the native thymus in vivo and investigated functional changes to the vascular system following sublethal irradiation."
    #Preprint

    #Immunology #TwoPhoton #Intravital

    biorxiv.org/content/10.1101/20

  23. Interesting study showing balance between bacterial & host factors determining granuloma formation and control of infection. This example being #Yersinia.
    #granuloma #immunology #academia #Science #ScienceMastodon

    Inflammatory monocytes promote granuloma control of Yersinia infection | Nature Microbiology

    nature.com/articles/s41564-023

  24. 'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
    fm @BrodskyLab et al

    #InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

    nature.com/articles/s41564-023