#immunology — Public Fediverse posts

Rituximab (RTX), an intravenous drug primarily known for depleting B cells, has been found to also trigger positive metabolic changes in T cells, specifically improving energy production and lowering cellular stress in patients with nephrotic syndrome who respond favorably to the treatment.
#Immunology #Nephrology #CellularBiology #sflorg
https://www.sflorg.com/2026/09/imgy09092601.html

It is a remarkably humbling realization that a single, unnoticed bite from an arthropod the size of an apple seed can completely rewrite an individual's relationship with the global food chain. Alpha-gal syndrome reminds us that the human immune system, for all its staggering sophistication and atomic-level precision, remains intimately and sometimes precariously tethered to the natural world.
#WhatIs #Immunology #MolecularBiology #EvolutionaryBiology #Entomology #sflorg
https://www.sflorg.com/2026/09/wi09102601.html

First, a paper suggesting that random-sequence mRNA vaccines enhance anti-tumor effects, and now another claiming that random, nonspecific T cells are sufficient to eliminate tumors. So much for antigen specificity.

#science
#immunology

https://www.nature.com/articles/s41590-026-02642-z

Specialized white blood cells known as monocytes move from the bloodstream into the uterus during the menstrual cycle to regulate inflammation, tissue repair, and the maintenance of the womb lining.
#Immunology #ReproductiveBiology #sflorg
https://www.sflorg.com/2026/09/imgy09082601.html

How your body builds billions of custom antibodies in hours. Mind = blown. 🧬✨ #science #biology #cosmos #physics #klytron

#science #biology #cosmos #physics #immunology #klytron

🌐 vaccinesresearch2027.pagesconferences.org

ONE FIELD. MANY PERSPECTIVES. ONE GOAL.

Vaccine science moves forward when research, immunology, development, and global expertise come together.

Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.

📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]

#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth

🌐 vaccinesresearch2027.pagesconferences.org

ONE FIELD. MANY PERSPECTIVES. ONE GOAL.

Vaccine science moves forward when research, immunology, development, and global expertise come together.

Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.

📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]

#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth

🌐 vaccinesresearch2027.pagesconferences.org

ONE FIELD. MANY PERSPECTIVES. ONE GOAL.

Vaccine science moves forward when research, immunology, development, and global expertise come together.

Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.

📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]

#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth

🌐 vaccinesresearch2027.pagesconferences.org

ONE FIELD. MANY PERSPECTIVES. ONE GOAL.

Vaccine science moves forward when research, immunology, development, and global expertise come together.

Join VACCINES-2027 in Milan for meaningful scientific exchange, emerging ideas, and new perspectives shaping the future of vaccine research.

📍 Milan, Italy
📅 April 19–20, 2027
📩 [email protected]

#VACCINES2027 #VaccineResearch #Immunology #Vaccinology #ScientificResearch #GlobalHealth

https://www.europesays.com/ie/548937/ Prime and pull vaccine approach prevents genital herpes infection #Cell #Chemokine #DNA #Éire #flu #GenitalHerpes #Health #Herpes #IE #ImmuneSystem #immunity #Immunology #inflammation #Ireland #medicine #Molecule #Nanoparticle #Nanoparticles #Oligonucleotide #Preclinical #Vaccine #vagina #vaginal #virus

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

TRIM21 induces selective #autophagy of viruses & bacteria.

TRIM21 drives antibody‑directed #xenophagy , rapidly ubiquitinating pathogens & routing diverse viral & bacterial cargo to lysosomes.

#innateimmunity #immunity #microbiology #immunology

https://davidojcius.blogspot.com/2026/06/trim21-induces-selective-autophagy-of.html

my father died ravaged by #dementia, so this is a topic near and dear to me for more than 20 years now.

what is interesting to me about this study is that it validates the #immunology hypothesis about #Alzheimer's #dementia. some studies see it as a consequence of general inflammation, aka autoimmune reaction to unknown triggers. others pointed to #diabetes, suggesting it’s a Type 3.

and the knowledge of #herpes as a dementia trigger is much older.

🧵…

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11489

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

Postdoc at UConn health on host-microbe interaction and innate immunity
UConn Health

See the full job description on jobRxiv: https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/

#hostpathogeninteractions #immunology #innateimmunity #proximitylabeling #ScienceJobs #hiring #research
https://jobrxiv.org/job/uconn-health-27778-postdoc-at-uconn-health-on-host-microbe-interaction-and-innate-immunity-2/?fsp_sid=11225

The discovery that specific immune cells, known as tissue-resident memory T cells, migrate to and establish long-term residency within the #prostate to guard against infections and potentially combat disease.
#Immunology #Oncology #Urology #sflorg
https://www.sflorg.com/2026/04/imgy04072601.html

The discovery that specific immune cells, known as tissue-resident memory T cells, migrate to and establish long-term residency within the #prostate to guard against infections and potentially combat disease.
#Immunology #Oncology #Urology #sflorg
https://www.sflorg.com/2026/04/imgy04072601.html

The discovery that specific immune cells, known as tissue-resident memory T cells, migrate to and establish long-term residency within the #prostate to guard against infections and potentially combat disease.
#Immunology #Oncology #Urology #sflorg
https://www.sflorg.com/2026/04/imgy04072601.html

The discovery that specific immune cells, known as tissue-resident memory T cells, migrate to and establish long-term residency within the #prostate to guard against infections and potentially combat disease.
#Immunology #Oncology #Urology #sflorg
https://www.sflorg.com/2026/04/imgy04072601.html

The discovery that specific immune cells, known as tissue-resident memory T cells, migrate to and establish long-term residency within the #prostate to guard against infections and potentially combat disease.
#Immunology #Oncology #Urology #sflorg
https://www.sflorg.com/2026/04/imgy04072601.html

Systemic candidiasis is a severe, opportunistic #fungal infection caused by Candida albicans. Recent research demonstrates that reprogramming the metabolic pathways of a host's immune cells offers a viable strategy to clear the infection, circumventing the need for traditional #antifungal medications.
#Immunology #Microbiology #sflorg
https://www.sflorg.com/2026/04/imgy04032601.html

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

“Inflammasome Activation by the Fungal Pathogen, #Aspergillus fumigatus”

#inflammation #mycology #microbiology #immunity #immunology #innateimmunity

https://hsri.ucmerced.edu/events/valley-fever-seminar-series-david-ojcius-phd

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Our data indicate that BCG vaccination impacts both the gene expression and epigenetic profiles of HSPCs for at least 90 days and that these changes are predictive of corresponding functional changes in donor-matched PBMCs challenged with Candida albicans.'
#Immunology #InnateImmunity
https://www.sciencedirect.com/science/article/pii/S1074761324003704?dgcid=coauthor

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Thus, here we asked whether B. bassiana could damage the Drosophila brain via Toll-1, Wek and Sarm. We show that exposure to B. bassiana reduced fly lifespan and impaired locomotion. B. bassiana entered the brain and induced the up-regulation of AMPs, as well as wek and sarm, within the brain. Exposure to B. bassiana caused neuronal and glial loss in the adult Drosophilabrain. Importantly, RNAi knockdown of Toll-1, wek or sarm concomitantly with infection prevented B. bassiana induced cell loss.'
#Immunology #InnateImmunity
#Preprint
https://www.biorxiv.org/content/10.1101/2024.04.29.591341v1

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

'Here we studied the endogenous TLR pathways in human and mouse macrophages. We provide evidence that myddosomes are dynamic and long-lived entities, numbering in the dozens within individual cells. We demonstrate that the complex cellular responses of the entire TLR pathway are coordinated and executed from within these structures.'
#Immunology #InnateImmunity
https://www.nature.com/articles/s41586-024-07614-7