#immunology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunology, aggregated by home.social.
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Rituximab (RTX), an intravenous drug primarily known for depleting B cells, has been found to also trigger positive metabolic changes in T cells, specifically improving energy production and lowering cellular stress in patients with nephrotic syndrome who respond favorably to the treatment.
#Immunology #Nephrology #CellularBiology #sflorg
https://www.sflorg.com/2026/09/imgy09092601.html -
It is a remarkably humbling realization that a single, unnoticed bite from an arthropod the size of an apple seed can completely rewrite an individual's relationship with the global food chain. Alpha-gal syndrome reminds us that the human immune system, for all its staggering sophistication and atomic-level precision, remains intimately and sometimes precariously tethered to the natural world.
#WhatIs #Immunology #MolecularBiology #EvolutionaryBiology #Entomology #sflorg
https://www.sflorg.com/2026/09/wi09102601.html -
First, a paper suggesting that random-sequence mRNA vaccines enhance anti-tumor effects, and now another claiming that random, nonspecific T cells are sufficient to eliminate tumors. So much for antigen specificity.
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Specialized white blood cells known as monocytes move from the bloodstream into the uterus during the menstrual cycle to regulate inflammation, tissue repair, and the maintenance of the womb lining.
#Immunology #ReproductiveBiology #sflorg
https://www.sflorg.com/2026/09/imgy09082601.html -
Press release - 2 Sept 2026
Teva Announces Positive Topline Results from Phase 2a Study in Celiac Disease for Its Anti-IL-15 Antibody...
TEV'408 is also in Phase 1b testing for the treatment of vitiligo.
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A novel, targeted therapy for multiple sclerosis utilizes the body's own red blood cells to train the immune system to tolerate endogenous structures, preventing it from attacking the central nervous system.
#Immunology #Neurology #ClinicalPathology #Biotechnology #sflorg
https://www.sflorg.com/2026/09/imgy09012601.html -
Researchers evaluated two experimental Zika virus vaccines to understand the roles of antibodies and T cells, discovering that long-term viral protection requires a coordinated immune response from both components rather than relying on T cells alone.
#Immunology #Virology #Epidemiology #sflorg
https://www.sflorg.com/2026/08/imgy08262601.html -
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#Vaccines #PlantBasedVaccines #VaccineResearch #Biotechnology #Immunology
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Receiving the shingles vaccine to prevent the reactivation of the Varicella zoster virus is associated with a significantly reduced risk of developing dementia in older adults. An epidemiological study observed up to a 24% lower risk of dementia over four years among vaccinated nursing home residents.
#Epidemiology #Immunology #Neurology #sflorg
https://www.sflorg.com/2026/08/epi08112601.html -
Quantum computing
Квантовые вычисления, Квантові обчислення
t.me/scilib_yura15cbx/112Programming languages
Мови програмування, Языки программирования
t.me/scilib_yura15cbx/110Computability
Вычислимость, Обчислюваність
t.me/scilib_yura15cbx/109Natural language
Природні мови, Естественные языки
t.me/scilib_yura15cbx/108Image processing
Обработка изображений, Обробка зображень
t.me/scilib_yura15cbx/106Information theory
Теорія інформації, Теория информации
t.me/scilib_yura15cbx/105Formal methods
t.me/scilib_yura15cbx/103Genetic, neural
t.me/scilib_yura15cbx/104Data mining
Сбор данных, Видобуток даних
t.me/scilib_yura15cbx/102Discrete math
Дискретная математика, Дискретна математика
t.me/scilib_yura15cbx/101Databases, базы данных, бази даних
t.me/scilib_yura15cbx/100Cryptography, Криптография, Криптографія
t.me/scilib_yura15cbx/99Computational geometry
Обчислювальна геометрія, Вычислительная геометрия
t.me/scilib_yura15cbx/98Concurrent, distributed
t.me/scilib_yura15cbx/97Computer algebra
Компьютерная алгебра, Комп'ютерна алгебра
t.me/scilib_yura15cbx/96Bioinformatics, Біоінформатика, Биоинформатика
t.me/scilib_yura15cbx/95Algorithms, Алгоритмы, Алгоритми
t.me/scilib_yura15cbx/93AI, artificial intelligence, Искусственный интеллект
штучний інтелект, искусственный интеллект, ИИ, ШІ, artificial intelligence Machine learning Natural language processing Neural networks Data mining Evolutionary computation Fuzzy systems Logic and Functional Programming Robotics Кибернетика Логическое и декларативное программирование ИИ Мозг и моделирование мышления Нейронные сети Нечеткая логика Обработка естественного языка Распознавание образов Робототехника Статьи Эволюционное моделирование Экспертные системы Кібернетика Логічне та декларативне програмування ІІ Мозок та моделювання мислення Нейронні мережі Нечітка логіка Обробка природної мови Розпізнавання образів Робототехніка Статті Еволюційне моделювання Експертні системи
t.me/scilib_yura15cbx/92Органическая химия
Organic chemistry, Органічна хімія
t.me/scilib_yura15cbx/90Химия и химическая технология
Хімія та хімічна технологія, Chemistry and chemical technology
t.me/scilib_yura15cbx/89Chemistry-Environmental-Material
t.me/scilib_yura15cbx/88School-level Chemistry
Химия школьного уровня, Хімія на шкільному рівні
t.me/scilib_yura15cbx/87Physical chemistry
Фізична хімія, Физическая химия
t.me/scilib_yura15cbx/86Encyclopaediae of chemistry
химическая энциклопедия, chemical encyclopedias, Енциклопедія хімії
t.me/scilib_yura15cbx/85Computational chemistry
Комп'ютерна хімія, Вычислительная химия
t.me/scilib_yura15cbx/84Chemistry, Хімія, Химия
history
t.me/scilib_yura15cbx/83Biology, биология, біологія
t.me/scilib_yura15cbx/81Biology - Genetics
генетика
t.me/scilib_yura15cbx/80Biology- Human
Человек, Людина
t.me/scilib_yura15cbx/79mathematical papers
Математичні статті
математические статьи
t.me/scilib_yura15cbx/76The New Yorker [1925 - 2021]
t.me/scilib_yura15cbx/75Grill, barbecue, steak, jerky, curing, smoking, sausage, charcuterie, outdoor kitchen
#кулинария, #готовка, #кухня, #природа, #cooking, #kitchen, #nature, #кулінарія, #готування,
t.me/scilib_yura15cbx/73Азбука кино , Cinema
Периодика, журналы Periodicals, magazines, journals Искусство Кино
t.me/scilib_yura15cbx/71Азбука кино , Cinema
История кино
t.me/scilib_yura15cbx/69_Компьютерная библиотека Ихтика
компьютер, компьютеры, техника, программирование, программы, софт, железо, базы данных computer, computers, programming, programs, software, hardware, databases
t.me/scilib_yura15cbx/64MolBiol Biological library BioLib biolibrary
Библиотека биологической литературы Бібліотека біологічної літератури
#биология #зоология #ботаника #генетика #методы #протоколы #иммунология #рак #протеомика #нейрология #физиология #нейробиология #анатомия и др. #Біологія #зоологія #ботаніка #генетика #методи #протоколи #імунологія #рак #протеоміка #нейрологія #фізіологія #нейробіологія #анатомія та ін. #biology #zoology #botany #genetics #methods #protocols #immunology #cancer #proteomics #neurology #physiology #neurobiology #anatomy, etc.
t.me/scilib_yura15cbx/63 -
more on immunological effects of sucralose:
Artificial sweetener sucralose: a possible modulator of autoimmune diseases [2023]
https://doi.org/10.1038/s41392-023-01607-0 -
Artificial sweetener may interfere with immunotherapy | Damon Runyon Cancer Research Foundation
17 Dec 2025
https://www.damonrunyon.org/discovery/artificial-sweetener-may-interfere-immunotherapy -
mathematical papers
Математичні статті
математические статьи
https://t.me/scilib_yura15cbx/76The New Yorker [1925 - 2021]
https://t.me/scilib_yura15cbx/75Grill, barbecue, steak, jerky, curing, smoking, sausage, charcuterie, outdoor kitchen
#кулинария, #готовка, #кухня, #природа, #cooking, #kitchen, #nature, #кулінарія, #готування,
https://t.me/scilib_yura15cbx/73Азбука кино , Cinema
Периодика, журналы Periodicals, magazines, journals Искусство Кино
https://t.me/scilib_yura15cbx/71Азбука кино , Cinema
История кино
https://t.me/scilib_yura15cbx/69_Компьютерная библиотека Ихтика
компьютер, компьютеры, техника, программирование, программы, софт, железо, базы данных computer, computers, programming, programs, software, hardware, databases
https://t.me/scilib_yura15cbx/64MolBiol Biological library BioLib biolibrary
Библиотека биологической литературы Бібліотека біологічної літератури
#биология #зоология #ботаника #генетика #методы #протоколы #иммунология #рак #протеомика #нейрология #физиология #нейробиология #анатомия и др. #Біологія #зоологія #ботаніка #генетика #методи #протоколи #імунологія #рак #протеоміка #нейрологія #фізіологія #нейробіологія #анатомія та ін. #biology #zoology #botany #genetics #methods #protocols #immunology #cancer #proteomics #neurology #physiology #neurobiology #anatomy, etc.
https://t.me/scilib_yura15cbx/63 -
The Odyssey of macrophages.
This issue spans immune regulation, #macrophage functions, T‑cell tolerance, #AI in infection, #cardiac repair, pelvic care, PDT #inflammation & diverse clinical studies.
https://www.sciencedirect.com/science/article/pii/S2319417026000235 #OpenAccess #microbiology #immunology
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Types of ELISA Quick Lab Guide from BioResire!
Direct, Indirect, Sandwich, Competitive—master antigen/antibody detection methods.#ELISA #TypesOfELISA #SandwichELISA #IndirectELISA #DirectELISA #CompetitiveELISA #Immunology #Biotechnology #Biochemistry #LabTechniques #BioResire #Diagnostics #AntibodyDetection #Biotech #LifeSciences #MolecularBiology #Immunoassay #ELISAtest #ScienceLab #BiotechInternship
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Symptom: Mast Cell Itching
https://www.illmarks.com/symptom-mast-cell-itching/
#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs
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Symptom: Mast Cell Itching
https://www.illmarks.com/symptom-mast-cell-itching/
#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs
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Symptom: Mast Cell Itching
https://www.illmarks.com/symptom-mast-cell-itching/
#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs
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Symptom: Mast Cell Itching
https://www.illmarks.com/symptom-mast-cell-itching/
#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs
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Symptom: Mast Cell Itching
https://www.illmarks.com/symptom-mast-cell-itching/
#allergicreactions #Allergies #allergy #art #bodyHorror #bodyMapping #buildingSafety #chonicillness #chronicIllness #claws #eds #ehlersdanlossyndrome #environmentalIllness #environmentalillness #fingers #formaldehyde #heds #hypermobile #hypermobility #hypermobilityspectrumdisorder #immunology #itched #itching #longCovid #longcovid #mastCell #mastCellActivationSyndrome #mastcell #mastcellactivationsyndrome #mastcelldisease #mastocytosis #mcas #medicalArt #MillionsMissing #nails #POTS #prop65 #publicHealth #publicHealth #pwLC #pwme #scratched #scratching #scratchy #severeallergy #vocs
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Sez6L2 autoimmunity induces cerebellar ataxia in mice | Journal of Neuroinflammation
Garza M, Piquet AL. Update in autoimmune movement disorders: newly described antigen targets in autoimmune and paraneoplastic cerebellar…
#NewsBeep #News #Health #AU #Australia #Autoantibodies #Autoimmuneencephalitis #Autoimmunemovementdisorders #Autoimmunity #Cerebellarataxia #Immunology #neurobiology #Neurology #Neurosciences #Sez6L2
https://www.newsbeep.com/au/307273/ -
New research by UCLA Health has identified a sex-chromosome linked #gene that drives #inflammation in the #female brain, offering insight into why #women are disproportionately affected by conditions such as #Alzheimer’s disease and multiple #sclerosis as well as offering a potential target for intervention.
#Neuroscience #Immunology #Biochemistry #MS #sflorg
https://www.sflorg.com/2025/10/ns10152502.html -
🇮🇳 INDIA’S TOP HIGH-QUALITY CSIR NET LIFE SCIENCES CRASH COURSE
🚀 LEARN FROM EXPERT MENTORS
#csirnet #biochemistry #biotechnology #zoology #biology #microbiology #science #ugcnet #neet #lifescience #gate #icmr #genetics #iitjam #jrf #csirnetlifesciences #net #phd #iit #research #tifr #icar #instagram #iisc #university #india #education #molecularbiology #immunology #aiims -
Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
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https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
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#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS -
Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
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https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
--
#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS -
Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
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https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
--
#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS -
Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
--
https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
--
#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS -
Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
--
https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
--
#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS -
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#csirnet #biotechnology #biochemistry #zoology #biology #microbiology #science #neet #ugcnet #gate #lifescience #genetics #iitjam #icmr #net #csirnetlifesciences #phd #jrf #instagram #iisc #university #research #india #education #molecularbiology #immunology #iit #gateexam #cellbiology #dbt
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The #neurological #damage caused by #EV71 #infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway
Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.00844-24?af=R
ABSTRACT
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria. However, the pathological damage was alleviated with the decrease of EV71 viral load. The cell experiment in vitro showed that EV71 infection significantly reduced ATP levels and promoted Schwann cell apoptosis, thus inhibiting cell growth. The extended infection time and the decreased viral load resulted in the gradual improvement of cell growth status. Meanwhile, EV71 inhibited the expression of miR-29b and promoted the expression of PMP22 in a time-dependent manner at both mRNA and protein levels, with the most significant change at 36 h of infection. Subsequently, the expression of miR-29b and PMP22 was gradually restored with the reduction of EV71 viral load. In addition, EV71 regulated the expression of hsa_circ_0069335, which could bind and co-localize with miR-29b. Therefore, EV71 infection can cause significant damage to the nervous system and may be related to hsa_circ_0069335/miR-29b/PMP22 pathway. The present study provides a new therapeutic target for neurological damage induced by EV71 infection.____
#abstract #COVID19 #encephalitis #enterovirus #ENTEROVIRUS71 #ev71 #health #HFMD #immunology #neuroinvasion #nutrition #research #wellness
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The #neurological #damage caused by #EV71 #infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway
Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.00844-24?af=R
ABSTRACT
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria. However, the pathological damage was alleviated with the decrease of EV71 viral load. The cell experiment in vitro showed that EV71 infection significantly reduced ATP levels and promoted Schwann cell apoptosis, thus inhibiting cell growth. The extended infection time and the decreased viral load resulted in the gradual improvement of cell growth status. Meanwhile, EV71 inhibited the expression of miR-29b and promoted the expression of PMP22 in a time-dependent manner at both mRNA and protein levels, with the most significant change at 36 h of infection. Subsequently, the expression of miR-29b and PMP22 was gradually restored with the reduction of EV71 viral load. In addition, EV71 regulated the expression of hsa_circ_0069335, which could bind and co-localize with miR-29b. Therefore, EV71 infection can cause significant damage to the nervous system and may be related to hsa_circ_0069335/miR-29b/PMP22 pathway. The present study provides a new therapeutic target for neurological damage induced by EV71 infection.____
#abstract #COVID19 #encephalitis #enterovirus #ENTEROVIRUS71 #ev71 #health #HFMD #immunology #neuroinvasion #nutrition #research #wellness
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The #neurological #damage caused by #EV71 #infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway
Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.00844-24?af=R
ABSTRACT
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria. However, the pathological damage was alleviated with the decrease of EV71 viral load. The cell experiment in vitro showed that EV71 infection significantly reduced ATP levels and promoted Schwann cell apoptosis, thus inhibiting cell growth. The extended infection time and the decreased viral load resulted in the gradual improvement of cell growth status. Meanwhile, EV71 inhibited the expression of miR-29b and promoted the expression of PMP22 in a time-dependent manner at both mRNA and protein levels, with the most significant change at 36 h of infection. Subsequently, the expression of miR-29b and PMP22 was gradually restored with the reduction of EV71 viral load. In addition, EV71 regulated the expression of hsa_circ_0069335, which could bind and co-localize with miR-29b. Therefore, EV71 infection can cause significant damage to the nervous system and may be related to hsa_circ_0069335/miR-29b/PMP22 pathway. The present study provides a new therapeutic target for neurological damage induced by EV71 infection.____
#abstract #COVID19 #encephalitis #enterovirus #ENTEROVIRUS71 #ev71 #health #HFMD #immunology #neuroinvasion #nutrition #research #wellness
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The #neurological #damage caused by #EV71 #infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway
Source: Journal of Virology, https://journals.asm.org/doi/full/10.1128/jvi.00844-24?af=R
ABSTRACT
Enterovirus 71 (EV71) infection is usually accompanied by neurological damage, which is the leading cause of death in children with hand-foot-mouth disease. In this study, we demonstrated that EV71 infection can cause pathological damage in the nervous system, such as neuronal vacuolar degeneration, shrinkage of some neurons, edema of brain tissues in the hippocampus, and a decreased number of Nissl bodies in the infarction area. Also, EV71 infection caused apparent structural damage to Schwann cells, including a decreased number of cytoplasmic organelles and severe damage of rough endoplasmic reticulum and mitochondria. However, the pathological damage was alleviated with the decrease of EV71 viral load. The cell experiment in vitro showed that EV71 infection significantly reduced ATP levels and promoted Schwann cell apoptosis, thus inhibiting cell growth. The extended infection time and the decreased viral load resulted in the gradual improvement of cell growth status. Meanwhile, EV71 inhibited the expression of miR-29b and promoted the expression of PMP22 in a time-dependent manner at both mRNA and protein levels, with the most significant change at 36 h of infection. Subsequently, the expression of miR-29b and PMP22 was gradually restored with the reduction of EV71 viral load. In addition, EV71 regulated the expression of hsa_circ_0069335, which could bind and co-localize with miR-29b. Therefore, EV71 infection can cause significant damage to the nervous system and may be related to hsa_circ_0069335/miR-29b/PMP22 pathway. The present study provides a new therapeutic target for neurological damage induced by EV71 infection.____
#abstract #COVID19 #encephalitis #enterovirus #ENTEROVIRUS71 #ev71 #health #HFMD #immunology #neuroinvasion #nutrition #research #wellness
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Just Published
Intricate Synergy of Mechanical and Biochemical Cues in the Transmigration of Cancer Cells Across the Endothelium
https://link.springer.com/chapter/10.1007/16833_2024_237
#Cancer #CancerResearch #CancerTherapy #Metastasis #Immunology #CellBiology
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Please #vaccinate if you are able - to protect yourself, your loved ones, and those who are unable to be vaccinated.
Many people don’t realize that some “childhood diseases” can have serious side effects years down the road, nor that some can wipe out existing immune protections by causing immune amnesia.
https://www.nbcnews.com/news/amp/rcna138583
#Vaccination
#Measles
#Science
#Immunology
#PreventativeMedicine
#PreventableDisease
#Health -
CW: Long Hashtag List for the Life Sciences
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Il nostro sistema immunitario come attacca le cellule tumorali? Ecco un linfocita T citotossico killer (in rosso) che attacca una cellula tumorale del linfoma (in blu).
Il nostro sistema immunitario è una meraviglia e non sappiamo ancora tutto di come funziona!🦠Source: Cambridge University
#science #immunology
#17Aprile -
'As of yet, none of the improved IL-2-based compounds gained regulatory approval for the treatment of cancer or autoimmune diseases. Three compounds treating cancer have entered phase 3 trials with two studies still ongoing. NKTR-214 is the only compound that has completed phase 3 studies.'
#Immunology #Immunotherapy #IL2 #Preprint
https://www.medrxiv.org/content/10.1101/2022.12.02.22283042v1
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"A close examination of the IL-2–IL-2Rα binding interface reveals a putative “pH Switch” consisting of the interaction between Arg38 in IL-2 and His120 in IL-2Rα (Fig. 2F). We hypothesized that, at the low pH in the TME, His120 would become protonated, resulting in release of IL-2 from IL-2Rα and therefore lack of signaling."
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One for the skin Th17 affecionado crowd... (that may just be me, I know! 😉) #immunology #skin #Th17 #IL23
https://www.science.org/doi/full/10.1126/sciimmunol.abq3254?et_rid=79524916&utm_campaign=IMMeToc&af=R&et_cid=4495660&utm_medium=email&utm_content=alert&utm_source=sfmc -
One for the skin Th17 affecionado crowd... (that may just be me, I know! 😉) #immunology #skin #Th17 #IL23
https://www.science.org/doi/full/10.1126/sciimmunol.abq3254?et_rid=79524916&utm_campaign=IMMeToc&af=R&et_cid=4495660&utm_medium=email&utm_content=alert&utm_source=sfmc -
One for the skin Th17 affecionado crowd... (that may just be me, I know! 😉) #immunology #skin #Th17 #IL23
https://www.science.org/doi/full/10.1126/sciimmunol.abq3254?et_rid=79524916&utm_campaign=IMMeToc&af=R&et_cid=4495660&utm_medium=email&utm_content=alert&utm_source=sfmc -
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