#immunology — Public Fediverse posts

Rituximab (RTX), an intravenous drug primarily known for depleting B cells, has been found to also trigger positive metabolic changes in T cells, specifically improving energy production and lowering cellular stress in patients with nephrotic syndrome who respond favorably to the treatment.
#Immunology #Nephrology #CellularBiology #sflorg
https://www.sflorg.com/2026/09/imgy09092601.html

It is a remarkably humbling realization that a single, unnoticed bite from an arthropod the size of an apple seed can completely rewrite an individual's relationship with the global food chain. Alpha-gal syndrome reminds us that the human immune system, for all its staggering sophistication and atomic-level precision, remains intimately and sometimes precariously tethered to the natural world.
#WhatIs #Immunology #MolecularBiology #EvolutionaryBiology #Entomology #sflorg
https://www.sflorg.com/2026/09/wi09102601.html

First, a paper suggesting that random-sequence mRNA vaccines enhance anti-tumor effects, and now another claiming that random, nonspecific T cells are sufficient to eliminate tumors. So much for antigen specificity.

#science
#immunology

https://www.nature.com/articles/s41590-026-02642-z

Specialized white blood cells known as monocytes move from the bloodstream into the uterus during the menstrual cycle to regulate inflammation, tissue repair, and the maintenance of the womb lining.
#Immunology #ReproductiveBiology #sflorg
https://www.sflorg.com/2026/09/imgy09082601.html

How your body builds billions of custom antibodies in hours. Mind = blown. 🧬✨ #science #biology #cosmos #physics #klytron

#science #biology #cosmos #physics #immunology #klytron

A novel, targeted therapy for multiple sclerosis utilizes the body's own red blood cells to train the immune system to tolerate endogenous structures, preventing it from attacking the central nervous system.
#Immunology #Neurology #ClinicalPathology #Biotechnology #sflorg
https://www.sflorg.com/2026/09/imgy09012601.html

A huge congratulations to an incredibly motivated and enthusiastic Master Class in T Cell Biology! 🧬🧫
It was inspiring to see such curiosity, energy, and passion especially for Tregs 😉!

#TCellBiology #Immunology #Science #MasterClass #Research #Learning #ScientificCommunity #CRID

🌱 Plant-Based Vaccine Innovation

How can plant-based technologies transform vaccine manufacturing?

Explore plant-derived platforms, scalable production, and sustainable bioprocessing at #VACCINES2027.

📍 Milan, Italy
📅 April 19–20, 2027
🔗 Learn more: https://vaccinesresearch2027.pagesconferences.org/

📩 Contact: [email protected]

#Vaccines #PlantBasedVaccines #VaccineResearch #Biotechnology #Immunology

_Этология, етологія, Ethology
#Этология, #етологія, #Ethology
t.me/scilib_yura15cbx/494

_Энтомология, Entomology, Ентомологія
#Энтомология, #Entomology, #Ентомологія
t.me/scilib_yura15cbx/493

Эмбрио, Ембріо, Embryo
эмбриология биология развития Embryology developmental biology
#Эмбрио, #Ембріо, #Embryo
#эмбриология #биологияразвития #Embryology #developmental biology
t.me/scilib_yura15cbx/492

_Экология, Ecology, Екологія
эко окружающая среда энвайронментализм, экосистемы, популяции,
#Экология, #Ecology, #Екологія
t.me/scilib_yura15cbx/491

_эволюция, еволюція, evolution
теория эволюции, эволюционная теория
#эволюция, #еволюція, #evolution
t.me/scilib_yura15cbx/490

_Флора и фауна Украины
Flora and fauna of Ukraine
Флора і фауна України
t.me/scilib_yura15cbx/489

_систематика, taxonomy
#систематика, #taxonomy
t.me/scilib_yura15cbx/488

_Палеонтология, Paleontology, Палеонтологія
#Палеонтология, #Paleontology, #Палеонтологія
t.me/scilib_yura15cbx/487

_Орнитология, Орнітологія, Ornithology
#Орнитология, #Орнітологія, #Ornithology
t.me/scilib_yura15cbx/486

B Biology, Біологія, Биология
#Biology, #Біологія, #Биология
t.me/scilib_yura15cbx/485

_нейро, neuro
Нейробиология, нейрология, Нейробіологія, нейрологія, Neurobiology, neurology,
#нейро, #neuro
#Нейробиология, #нейрология, #Нейробіологія, #нейрологія, #Neurobiology, #neurology
t.me/scilib_yura15cbx/483

_Нематология, Nematology
#Нематология, #Nematology
t.me/scilib_yura15cbx/482

Определители растений, лишайников, грибов
Визначники рослин, лишайників, грибів
#Определители
t.me/scilib_yura15cbx/481

_Микробиология и Вирусология
Мікробіологія та вірусологія
Microbiology and Virology
#Микробиология и #Вирусология
#Мікробіологія та #вірусологія
#Microbiology and #Virology
t.me/scilib_yura15cbx/480

_Микология, Mycology, Мікологія
#Микология, #Mycology, #Мікологія
t.me/scilib_yura15cbx/479

_Макология
#Макология
t.me/scilib_yura15cbx/478

_Microscopy, Мікроскопія, Микроскопия
#Microscopy, #Мікроскопія, #Микроскопия
t.me/scilib_yura15cbx/476

Cell
Cell biology, Клітина, клітинна біологія, біологія клітини, Клетка, клеточная биология, биология клетки
#Cell
#Cell biology, #Клітина, #клітиннабіологія, #біологіяклітини, #Клетка, #клеточнаябиология, #биология клетки
t.me/scilib_yura15cbx/475

Клетка, клеточная биология
#Клетка, #клеточнаябиология
t.me/scilib_yura15cbx/474

_Красная книга
Червона книга, the Red Book,
t.me/scilib_yura15cbx/473

История биологии
History of biology
Історія біології
t.me/scilib_yura15cbx/472

Иммунология, Імунологія, Immunology
#Иммунология, #Імунологія, #Immunology
t.me/scilib_yura15cbx/471

Гистология, Histology, Гістологія
#Гистология, #Histology, #Гістологія
t.me/scilib_yura15cbx/469

_Грибы
mushrooms, Мікологія, Микология, Mycology
#Грибы
#mushrooms, #Мікологія, #Микология, #Mycology
t.me/scilib_yura15cbx/470

Зоология, Зоологія, Zoology
#Зоология, #Зоологія, #Zoology
t.me/scilib_yura15cbx/468

Genome, Геном,
геномика, Genomics, геноміка
#Genome, #Геном,
#геномика, #Genomics, #геноміка
t.me/scilib_yura15cbx/466

Genetics, генетика
#Genetics, #генетика
t.me/scilib_yura15cbx/465

Вода, Water
#Вода, #Water
t.me/scilib_yura15cbx/464

Владивосток, Vladivostok, Приморье, Приморский край
природа, наука, в основном биология, ДВГУ, дипломные работы
#Владивосток, #Vladivostok, #Приморье, #Приморскийкрай
#природа, #наука, в основном #биология, #ДВГУ, #дипломныеработы
t.me/scilib_yura15cbx/463

Анатомия и морфология растений
Анатомія і морфологія рослин
Anatomy and morphology of plants
t.me/scilib_yura15cbx/462

Сосудистые растения,
Судинні рослини
Vascular plants
t.me/scilib_yura15cbx/460

Низшие растения
Lower plants
Нижчі рослини
t.me/scilib_yura15cbx/459

Геоботаника, Геоботаніка, Geobotany
#Геоботаника, #Геоботаніка, #Geobotany
t.me/scilib_yura15cbx/458

Биоэтика, Біоетика, Bioethics
#Биоэтика, #Біоетика, #Bioethics
t.me/scilib_yura15cbx/456

Биохимия, молекулярная биология
Biochemistry, molecular biology
Біохімія, молекулярна біологія
#Биохимия, #молекулярнаябиология
#Biochemistry, #molecular biology
#Біохімія, #молекулярнабіологія
t.me/scilib_yura15cbx/455

Биология моря, морская биология
Marine biology, Біологія моря, морська Біологія
#Биологияморя, #морскаябиология
#Marine biology, #Біологіяморя, #морськаБіологія
t.me/scilib_yura15cbx/453

Альгология, Альгологія, Algology
#Альгология, #Альгологія, #Algology
t.me/scilib_yura15cbx/452

Bioinformatics, Биоинформатика, Біоінформатика
#Bioinformatics, #Биоинформатика, #Біоінформатика
t.me/scilib_yura15cbx/450

🐍💉 Tim Friede spent nearly 20 years gradually immunizing himself against #venom from over a dozen deadly #snakes, including #cobras and black #mambas.

Scientists used #antibodies from his blood to create an experimental #antivenom that protected #mice from 13 types of snake venom. The work could lead to a single broad-spectrum antivenom.

👉 https://www.sciencenews.org/article/antivenom-snakebite-tim-friede#msdynmkt_trackingcontext=8c2b5212-1894-4d71-8f8a-03d5c1aa0300

#science #immunology #biology #wildlife #medicine #research #nature #wisconsin #newyork #biotech

Researchers developed small-molecule drug candidates that mimic a rare, protective variant of the #CARD9 gene to treat #Crohn's disease and other inflammatory bowel diseases.
#MolecularBiology #MolecularScience #Immunology #Genetics #sflorg
https://www.sflorg.com/2026/01/molb01162601.html

Brayden Yellman, MD | Underappreciated Co-Morbidities in ME/CFS
video uploaded Oct. 16, 2025
https://youtu.be/od0epKW19og

[13:03] hydroxyurea used to treat a person with POTS and MCAS

Here's an article on the topic:

Efficacy and toxicity of hydroxyurea in mast cell activation syndrome patients refractory to standard medical therapy: retrospective case series [2022]
https://pmc.ncbi.nlm.nih.gov/articles/PMC9388361/

"First used 60 years ago for chronic myeloproliferative neoplasms, HU is now standard of care in reducing the severity of sickle cell disease (SCD) (McGann and Ware 2015). In this context, it is of interest that in animal models and human subjects with SCD, medications that reduce MC activation decreased bone pain (Vincent et al. 2013, 2016). HU also inhibits replication of human immunodeficiency virus-1 (HIV-1) and has been used in therapy of cyanotic congenital heart disease (Lori and Lisziewicz 2000; Reiss et al. 2007). A theoretic explanation for effectiveness of HU in these diseases include reducing MC activity independent of anti-proliferative effects. HU could decrease activity and ability of GI mucosal MCs that capture HIV-1 and mediate trans-infection of CD4 + T cells (Jiang et al. 2015). Similarly, HU could reduce the activity of the increased numbers of chymase-containing MCs in lung tissue of congenital heart disease patients and, thereby, decrease severity of these pulmonary and cardiac diseases (Hamada et al. 1999)."

The mechanisms are probably quite complex. One facet is that hydroxyurea increases fetal hemoglobin production and RBC membrane flexibility - which could increase O2 perfusion. Hypoxia activates mast cells.

#MECFS #MCAS #POTS #DrugRepurposing #hydroxyurea #MastCells #immunology

2025-8-9 I almost went in to anaphylaxis from drinking water.

https://www.illmarks.com/2025-8-9-i-almost-went-in-to-anaphylaxis-from-drinking-water/

#allergy #art #autoimmune #bodyHorror #bodyMapping #chronicIllness #immune #immunology #longCovid #longcovid #mastCell #mastcell #mcas #medArt #medBlog #medart #medicalArt #MillionsMissing #pwLC #pwme #sciArt #sciBlog #SciArt

From "Predictors of Nonseroconversion after SARS-CoV-2 Infection," published in September, 2021 in Emerging Infectious Diseases:

"26 participants remained seronegative, despite the testing of up to 3 samples per person for IgA, IgM, and IgG against multiple antigens as well as neutralizing antibodies. Thus, 36% of our cohort represented serologic nonresponders."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386781/

#covid #covid19 #SARSCoV2 #serology #immunology #PublicHealth #CovidIsNotOver

Glycoproteins and longevity: an interview with Professor Gordan Lauc

https://doi.org/10.1080/14728222.2024.2375809

#aging #longevity #glycobiology #immunology #biomarkers #inflammation #IgG #glycoproteins #glycans

In 1895, Albert Calmette created the first antivenom using blood serum from horses treated with cobra venom. #Poetry #Science #History #Immunology #Antivenom #Calmette (https://sharpgiving.com/thebookofscience/items/p1895d.html)

2021: "Not all persons recovering from [SARS-CoV-2] infection develop SARS-CoV-2–specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle threshold values and identify SARS-CoV-2 viral loads in the nasopharynx as a major correlate of the systemic antibody response.

[...] 36% of our cohort represented serologic nonresponders."

https://wwwnc.cdc.gov/eid/article/27/9/21-1042_article

#SARSCoV2 #immunology #serology #covid #covid19 #pandemic #PublicHealth

Eosinophilic Esophagitis (EoE): Lessons Learned from Medicaid and the UVA EoE Cohort

https://www.youtube.com/live/wt4gW_asI7g?si=m-jNljWnzwM5FH9X

presentation by Dr Emily McGowan at Fralin Biomedical Research Institute, Feb 9, 2024

- EoE incidence increasing [18:28]

- EoE is induced in mouse model with SDS, a detergent used in toothpaste. [21:28]

- even when eosinophils are cleared with anti-IL-5 Ab, symptoms remain [29:00]

comment: I & many others with MCAS have dysphagia. If eosinophils are at the party, it is usually b/c mast cells invited them. Also, MCAS affects women more.

- they usually take more than 5 biopsy samples when trying to diagnose EoE [16:10]

- EoE is IgG4 mediated [44:26]

- EoE associated with high socioeconomic status; Dr McGowan suspects this is due to underdiagnosis in ppl w/ less access to care.

comment: it would be interesting to know of EoE is associated with high PFAS burden, which is higher in ppl w/ higher income. PFAS have surfactant properties, like SDS. Also, there's increasing use of powerful surfactants in herbicides due to development of herbicide resistance.

- the Cytosponge for minimally invasive diagnostic testing [37:56]

#Allergy #Immunology #Gastroeneterology #EosinophilicEsophagitis #Eosinophils #MastCells #MCAS #dysphagia

"Host cell environments and antibiotic efficacy in tuberculosis"

Nice figure showing the challenges of #antibiotics to get into a cell and target #Mycobacterium tuberculosis

#tuberculosis #TB #IDMastodon #infectiousdiseases #immunology
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(23)00253-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0966842X23002536%3Fshowall%3Dtrue

"Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma"

Nice new work based on #scRNAseq from our Drost group colleagues at the #PrincessMaximaCenter. a.o., a potential role of #NECTIN3 and #TIGIT in #tumour-induced T cell dysfunction.
https://www.nature.com/articles/s41467-023-38886-8

#OpenAccess
#rhabdomyosarcoma
#immunology #ImmuneSuppression

wow. i LOVE this type of science.
the one that re-writes text books.
Seems that igM in the blood stream never comes alone and interacts with CD5L (a protein that is not generated by B cells). Congrats to the teams of Albert Heck and my dear colleagues and their teams from #Sanquin, #Gestur Vidarsson and #Theo Rispens

https://www.biorxiv.org/content/10.1101/2023.05.27.542462v1

#immunology #Bcells #textbook

Interesting study showing balance between bacterial & host factors determining granuloma formation and control of infection. This example being #Yersinia.
#granuloma #immunology #academia #Science #ScienceMastodon

Inflammatory monocytes promote granuloma control of Yersinia infection | Nature Microbiology

https://www.nature.com/articles/s41564-023-01338-6?utm_source=nmicrobiol_etoc&utm_medium=email&utm_campaign=toc_41564_8_4&utm_content=20230404

'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al

#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

https://www.nature.com/articles/s41564-023-01338-6

"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"

#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis

https://www.cell.com/cell/fulltext/S0092-8674(22)01581-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015811%3Fshowall%3Dtrue

#introduction Long overdue, but here goes:

I'm Arjan, during working hours researching a specific children's #cancer, #neuroblastoma, mostly by means of #bioinformatics analyses of #sequencing data; right now lots of #scRNAseq . I might occasionally toot about this, or related stuff like #immunology , #rstats , #atherosclerosis and other scientific interests and/or fields that I've worked in.

Hash tags if you are looking someone to follow. I have diverse interests and while I identify as a #Nephrologist = #kidneydoc,
I will tweet about #statistics, #highperformancecomputing #bioinformatics , #RNAsequencing , #immunology and random funny (at least to me) stuff.
I absolutely think the civilization should eliminate kale - I am a #zerokale account , because of the harm and injury caused by kale salads worldwhile.