#immunology — Public Fediverse posts

A Window into the Hidden World of Immunity Inside Human Bone Marrow

Newswise — The cells that keep vaccines working for decades have long remained a mystery deep within human…
#NewsBeep #News #Health #AllJournalNews #AU #Australia #Biotech #BoneMarrow;plasmacells;ImmuneMemory;vaccineprotection;humantissuemodel;CellMigration;Microenvironment;Immunology #Cancer #cellbiology #GeorgiaInstituteofTechnology #Healthcare #Immunology #Newswise #publichealth #vaccines
https://www.newsbeep.com/au/891587/

A Window into the Hidden World of Immunity Inside Human Bone Marrow

Newswise — The cells that keep vaccines working for decades have long remained a mystery deep within human…
#NewsBeep #News #Health #AllJournalNews #AU #Australia #Biotech #BoneMarrow;plasmacells;ImmuneMemory;vaccineprotection;humantissuemodel;CellMigration;Microenvironment;Immunology #Cancer #cellbiology #GeorgiaInstituteofTechnology #Healthcare #Immunology #Newswise #publichealth #vaccines
https://www.newsbeep.com/au/891587/

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Children’s Colorado launches new program to expand treatment options for children with food allergies https://www.diningandcooking.com/us/6420/ #allergen #Allergy #children #colorado #ColoradoDining #ColoradoFood #ColoradoGroceryStores #ColoradoRestaurants #food #healthcare #Hospital #Immunology #Immunotherapy #Research #Therapy #Tongue

Scientists discover a hidden switch that shuts off inflammation and prevents harmful immune cells from building up

https://www.sciencedaily.com/releases/2026/09/260911214306.htm

#wellness #immunology #research

Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html

Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html

Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html

Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html

Researchers have engineered lipid nanoparticles that deliver mRNA technology to tumor-associated macrophages (TAMs), reprogramming these immune cells from tumor-supporting to cancer-fighting.
#Immunology #Oncology #BiomedicalEngineering #ChemicalEngineering #sflorg
https://www.sflorg.com/2026/09/imgy09122601.html

Quantum computing
Квантовые вычисления, Квантові обчислення
t.me/scilib_yura15cbx/112

Programming languages
Мови програмування, Языки программирования
t.me/scilib_yura15cbx/110

Computability
Вычислимость, Обчислюваність
t.me/scilib_yura15cbx/109

Natural language
Природні мови, Естественные языки
t.me/scilib_yura15cbx/108

Image processing
Обработка изображений, Обробка зображень
t.me/scilib_yura15cbx/106

Information theory
Теорія інформації, Теория информации
t.me/scilib_yura15cbx/105

Formal methods
t.me/scilib_yura15cbx/103

Genetic, neural
t.me/scilib_yura15cbx/104

Data mining
Сбор данных, Видобуток даних
t.me/scilib_yura15cbx/102

Discrete math
Дискретная математика, Дискретна математика
t.me/scilib_yura15cbx/101

Databases, базы данных, бази даних
t.me/scilib_yura15cbx/100

Cryptography, Криптография, Криптографія
t.me/scilib_yura15cbx/99

Computational geometry
Обчислювальна геометрія, Вычислительная геометрия
t.me/scilib_yura15cbx/98

Concurrent, distributed
t.me/scilib_yura15cbx/97

Computer algebra
Компьютерная алгебра, Комп'ютерна алгебра
t.me/scilib_yura15cbx/96

Bioinformatics, Біоінформатика, Биоинформатика
t.me/scilib_yura15cbx/95

Algorithms, Алгоритмы, Алгоритми
t.me/scilib_yura15cbx/93

AI, artificial intelligence, Искусственный интеллект
штучний інтелект, искусственный интеллект, ИИ, ШІ, artificial intelligence Machine learning Natural language processing Neural networks Data mining Evolutionary computation Fuzzy systems Logic and Functional Programming Robotics Кибернетика Логическое и декларативное программирование ИИ Мозг и моделирование мышления Нейронные сети Нечеткая логика Обработка естественного языка Распознавание образов Робототехника Статьи Эволюционное моделирование Экспертные системы Кібернетика Логічне та декларативне програмування ІІ Мозок та моделювання мислення Нейронні мережі Нечітка логіка Обробка природної мови Розпізнавання образів Робототехніка Статті Еволюційне моделювання Експертні системи
t.me/scilib_yura15cbx/92

Органическая химия
Organic chemistry, Органічна хімія
t.me/scilib_yura15cbx/90

Химия и химическая технология
Хімія та хімічна технологія, Chemistry and chemical technology
t.me/scilib_yura15cbx/89

Chemistry-Environmental-Material
t.me/scilib_yura15cbx/88

School-level Chemistry
Химия школьного уровня, Хімія на шкільному рівні
t.me/scilib_yura15cbx/87

Physical chemistry
Фізична хімія, Физическая химия
t.me/scilib_yura15cbx/86

Encyclopaediae of chemistry
химическая энциклопедия, chemical encyclopedias, Енциклопедія хімії
t.me/scilib_yura15cbx/85

Computational chemistry
Комп'ютерна хімія, Вычислительная химия
t.me/scilib_yura15cbx/84

Chemistry, Хімія, Химия
history
t.me/scilib_yura15cbx/83

Biology, биология, біологія
t.me/scilib_yura15cbx/81

Biology - Genetics
генетика
t.me/scilib_yura15cbx/80

Biology- Human
Человек, Людина
t.me/scilib_yura15cbx/79

mathematical papers
Математичні статті
математические статьи
t.me/scilib_yura15cbx/76

The New Yorker [1925 - 2021]
t.me/scilib_yura15cbx/75

Grill, barbecue, steak, jerky, curing, smoking, sausage, charcuterie, outdoor kitchen
#кулинария, #готовка, #кухня, #природа, #cooking, #kitchen, #nature, #кулінарія, #готування,
t.me/scilib_yura15cbx/73

Азбука кино , Cinema
Периодика, журналы Periodicals, magazines, journals Искусство Кино
t.me/scilib_yura15cbx/71

Азбука кино , Cinema
История кино
t.me/scilib_yura15cbx/69

_Компьютерная библиотека Ихтика
компьютер, компьютеры, техника, программирование, программы, софт, железо, базы данных computer, computers, programming, programs, software, hardware, databases
t.me/scilib_yura15cbx/64

MolBiol Biological library BioLib biolibrary
Библиотека биологической литературы Бібліотека біологічної літератури
#биология #зоология #ботаника #генетика #методы #протоколы #иммунология #рак #протеомика #нейрология #физиология #нейробиология #анатомия и др. #Біологія #зоологія #ботаніка #генетика #методи #протоколи #імунологія #рак #протеоміка #нейрологія #фізіологія #нейробіологія #анатомія та ін. #biology #zoology #botany #genetics #methods #protocols #immunology #cancer #proteomics #neurology #physiology #neurobiology #anatomy, etc.
t.me/scilib_yura15cbx/63

A new toolkit named #CyCLoPs (cytokine cellular locating platforms) enables the precise tagging and visualization of cells that receive #cytokine signals, illuminating previously invisible #immune communication pathways.
#Immunology #MolecularBiology #sflorg
https://www.sflorg.com/2026/02/imgy02112601.html

Researchers developed small-molecule drug candidates that mimic a rare, protective variant of the #CARD9 gene to treat #Crohn's disease and other inflammatory bowel diseases.
#MolecularBiology #MolecularScience #Immunology #Genetics #sflorg
https://www.sflorg.com/2026/01/molb01162601.html

2025-8-9 I almost went in to anaphylaxis from drinking water.

https://www.illmarks.com/2025-8-9-i-almost-went-in-to-anaphylaxis-from-drinking-water/

#allergy #art #autoimmune #bodyHorror #bodyMapping #chronicIllness #immune #immunology #longCovid #longcovid #mastCell #mastcell #mcas #medArt #medBlog #medart #medicalArt #MillionsMissing #pwLC #pwme #sciArt #sciBlog #SciArt

'We discovered that the Neisseria gonorrhoeae transcriptional response to PMNs has features in common with the transcriptional response to nutrient metals and oxidative stress, which enhance Neisseria gonorrhoeae resistance to hydrogen peroxide & polymorphonuclear leukocytes.'
#Immunology #HostPathogen

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012369#sec010

'By employing a metabolic compartmentalization approach, we observed enhanced glycolysis and accumulation of the TCA-cycle derivative itaconate in splenic monocyte-derived dendritic cells from Plasmodium chabaudi (Pc)-infected mice.'
#Malaria #Plasmodium #HostPathogen #Metabolism #immunology

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00008-1

"The current call targets advanced female PhD fellows, postdoctoral scholars, and tenure-track group leaders holding a primary affiliation with a research group/programme based in Africa."
#InfectiousDisease #InfectionImmunity #ResearchFunding #Immunology

https://www.embl.org/about/info/scientific-visitor-programme/fellowships/embl-unesco-fellowships/

"Overall, these data demonstrate that IL-15C treatment, via its induction of IL-10 from NK cells, modulates the dysregulated inflammation during Plasmodium infection to promote Tfh differentiation & Ab generation, correlating with improved survival from reinfection."
#Plasmodium #Malaria #InfectionImmunity #immunology

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300525/266661/IL-15-Complex-Induced-IL-10-Enhances-Plasmodium?redirectedFrom=fulltext

"Although type 1 conventional dendritic cells (cDC1s) were not required for initial priming of CD4+ T cells, cDC1s were required for CD4+ T cell expansion and gut homing. cDC1s were also a major source of IL-12 that was not required for priming but promoted full differentiation of CD4+ T cells and local production of IFN-γ. Together, these studies reveal distinct roles for cDC1s in shaping CD4+ T cell responses to enteric infection: first to drive early expansion in the mesLN and second to drive effector responses in the gut."
#InfectionImmunity #Immunology #MucosalImmunology #parasitology #Preprint

https://www.biorxiv.org/content/10.1101/2023.11.11.566669v1

Steroids are very effective immunomodulating drugs. BUT they do increase the risk of some infections.

This is a nice review describing what infections steroids make you susceptible. The immunology affected is discussed but harder to pin down, as likely context dependent.
#corticosteroids #steroids #medicine #infections #infectiousdiseases #IDMastodon #immunology #opportunisticinfections #PCP #HBV #VZV #zoster #CMV
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciad474/7260874?utm_source=advanceaccess&utm_campaign=cid&utm_medium=email&nbd=39370074470&nbd_source=campaigner#415942086

Live long & prosper. And host pathogens.

"The white-footed deermouse Peromyscus leucopus, a long-lived rodent, is a key reservoir for agents of several zoonoses, including Lyme disease. While persistently infected, this deermouse is without apparent disability or diminished fitness"
#immunology #InfectiousDisease #HostPathogen #ResistanceTolerance

https://elifesciences.org/reviewed-preprints/90135

'Hence, a parasite protein known to bind two host cytokine receptor subunits has evolved a third receptor specificity, which serves to raise the avidity and cell type–specific potency of TGF-β signaling in mammalian cells.'
#immunology #Parasitology #HostPathogen

https://www.pnas.org/doi/10.1073/pnas.2302370120#sec-2

'Together, these results demonstrate that host cGAS–STING senses T. cruzi infection, enhancing parasite growth at the site of entry, and contributes to acute-phase parasite restriction in the heart, a major site of tissue damage in chronic T. cruzi infection.'
#immunology #InnateImmunity #HostPathogen

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300373/265860/cGAS-STING-Pathway-Activation-during-Trypanosoma?redirectedFrom=fulltext

'Although infection and these translocated effector proteins are restricted to intestinal epithelial cells (IEC), type I dendritic cells (cDC1) were required to generate CD8+ T cell responses to these model antigens.'

#Preprint #Immunology #HostPathogen #MucosalImmunology

https://www.biorxiv.org/content/10.1101/2023.08.16.553566v1

'In conclusion, mitochondrial perturbation of the epithelium causes dysbiotic expansion of Bacteroides spp., supporting the concept that microbe-host cross-talk contributes to metabolic injury in intestinal inflammation.'

#Preprint #HostPathogen #metabolism #Immunology #MucosalImmunology

https://www.biorxiv.org/content/10.1101/2023.07.27.549844v1

IL-6 is such a fascinating cytokine.

Here it is modulating different dendritic cell subsets
@JExpMed
#immunology #DC #cytokine #science
https://rupress.org/jem/article/220/10/e20221757/214227/IL-6-selectively-suppresses-cDC1-specification-via?guestAccessKey=48cccc06-d788-423c-889f-51498d95a918&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2ph4e3-co3ru7-cwe4ixj2

" Instead, #Hepatoblastoma #tumors contain a large suppressive #myeloid compartment which poses opportunities for targeting. Specifically, therapeutic antibodies
targeting the #tumor antigen #GPC3 to induce ADCP by #macrophages, in combination with myeloid
#ImmuneCheckpointBlockade (#CD47/SIRPa, or VISTA) could be a feasible strategy to explore in future studies"

Krijgsman et al. from Vercoulen lab in the #UMCUtrecht, on #bioRXiv:
https://www.biorxiv.org/content/10.1101/2023.06.28.546852v1

#scRNAseq #spatial #CyTOF #immunology

'To study regulators of bacterial pathogenicity that are the major drivers of infectious disease outcome, we developed scPAIR-seq, an approach to functionally analyze the effects of bacterial mutants on host immunity at single-cell resolution.'

#Immunology #HostPathogen

https://www.pnas.org/doi/10.1073/pnas.2218812120

"In this study, we provide a more comprehensive understanding of the relationship among these cellular subsets, uncover a novel homeostatic function in human NK cells, and illuminate how HIV-1 infection disrupts these cellular subsets and their functions"

#HIV #InfectiousDisease #HostPathogen #Immunology #virology

Wang et al @embojournal

https://www.embopress.org/doi/full/10.15252/embj.2023114153

'Tuberculosis (TB) is a heterogenous disease in humans with individuals exhibiting a wide range of susceptibility. This heterogeneity is not captured by standard laboratory mouse lines. We used a new collection of 19 wild-derived inbred mouse lines collected from diverse geographic sites to identify novel phenotypes during Mycobacterium tuberculosis (Mtb) infection.'

#Preprint #Tuberculosis #Immunology #HostPathogen #InfectiousDisease

https://www.biorxiv.org/content/10.1101/2023.06.29.547125v1

Rare myocarditis after COVID shots: Study rules out some common culprits - Enlarge / Heart scan. (credit: Getty | BSIP)

The mRNA-based CO... - https://arstechnica.com/?p=1937872 #vaccinesideeffects #covid-19vaccine #immuneresponses #inflammation #mrnavaccines #pericarditis #myocarditis #antibodies #autoimmune #immunology #youngmales #maleteens #covid-19 #cytokine #science #vaccine #heart #teens #boys #mrna

'We now provide compelling evidence that in hypoxic conditions, an autocrine IL-24/IL-24-receptor signaling/STAT3 loop is induced, which then sustains the HIF1α-mediated expression of epidermal IL-24. In turn, IL-24 acts in an autocrine and paracrine fashion to coordinate re-epithelialization, re-vascularization, dermal fibroblast proliferation, and collagen deposition to restore the damaged tissue to homeostasis.'
Liu, @mucida, Fuchs et al

#WoundHealing #Immunology #Cytokine #InnateImmunity

https://www.cell.com/cell/fulltext/S0092-8674(23)00328-8

"However, T cell responses to dietary antigen have primarily been characterized using monoclonal T cell receptor (TCR) transgenic systems which do not represent a physiological immune response. Polyclonal CD4+ T cell responses to food, including TCR-specific selection and functional differentiation, remain largely uncharacterized and are critical for understanding mechanisms of tolerance and allergy."
Lockhart, @mucida et al

#Preprint #Immunology #OralTolerance #MucosalImmunology

https://www.biorxiv.org/content/10.1101/2023.04.11.536475v1

'Using fluorescence microscopy, we show that B. burgdorferi associates with mouse and human cells in culture, and we document that internalized spirochetes colocalize with the pattern recognition receptor cyclic GMP-AMP synthase (cGAS).'

#Immunology #InnateImmunity #Borrelia #HostPathogen

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2200354/263621/Borrelia-burgdorferi-Engages-Mammalian-Type-I-IFN?redirectedFrom=fulltext

"With IL-8-humanized mouse strain, we demonstrate that IL-8-producing CD4+ T, myeloid, and tumor cells orchestrate myeloid-derived suppressor cell infiltration and angiogenesis, which results in enhanced tumor growth but reduced ICB efficacy."

#Immunology #Immunotherapy #cytokine

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00077-6?dgcid=raven_jbs_aip_email

"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."

#immunology #cytokine #Monoclonal

https://www.science.org/doi/10.1126/scitranslmed.abo0205

"Here, we investigated the fetal hematopoietic response to maternal infection with Toxoplasma gondii (T. gondii), an intracellular parasite that elicits Type II IFNγ-mediated maternal immunity."

#immunology #Parasitology #Toxoplasma #HostPathogen #InfetionImmunity #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.29.518417v3

"Our findings underscore the importance of cell death in defense against intracellular bacterial pathogens and provide an example of how layered and hierarchical immune pathways can provide robust defense against pathogens that have evolved a broad arsenal of virulence factors."

#Shigella #HostPathogen #CellDeath #Apoptosis #InnateImmunity #Pathogen #Microbiology #Immunology

https://elifesciences.org/articles/83639

My first post on Mastodon after a whole lot of lurking and boosting, so I'm treating this as a mini #introduction for myself

I'm an #immunology PhD candidate at #ColumbiaUniversity medical center, and we just published a study of #TissueSpecifity of human #Tcell identity and clonal expansion in barrier sites, using #CyTOF, #scRNAseq, and #TCR #sequencing!

https://www.nature.com/articles/s41590-022-01395-9

"We observed a significant increase in the expression of IL-31RA, but not its cognate ligand IL-31 during house dust mite- and Schistosoma mansoni soluble egg antigen-induced allergic asthma. In support of this, IFN-γ and Th2 cytokines, IL-4 and IL-13, upregulated IL-31RA but not IL-31 in airway smooth muscle cells (ASMC). Importantly, the loss of IL-31RA attenuated AHR but had no effects on inflammation and goblet cell hyperplasia in allergic asthma or mice treated with IL-13 or IFNγ."

#Immunology #Asthma #Preprint #cytokine

https://www.biorxiv.org/content/10.1101/2022.12.15.520615v1

"Preprint #Immunology #HumanGenetics #PrimaryImmuneDeficiency #NFKB

'We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens including those from the herpes, retro- and polyoma-virus families.'

https://www.medrxiv.org/content/10.1101/2022.11.24.22282707v1