#antiinflammatory — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #antiinflammatory, aggregated by home.social.
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https://www.europesays.com/ie/678070/ Could scorpion venom inspire new treatments for liver disease? #AntiInflammatory #Antigen #ArtificialIntelligence #Cell #Chromatography #Chronic #diet #DrugDiscovery #Éire #fibrosis #HBV #Health #Hepatitis #IE #Immunomodulatory #inflammation #Interferon #Ion #Ireland #LiquidChromatography #Liver #LiverDisease #Macrophage #medicine #Pain #peptides #Potassium #Protein #Receptor #Research #SmallMolecules #Therapeutics #Venom #virus
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pink pineapple
dreaming… a random bit
** in the ending of The Daily Post’s Weekly Photo Challenges from WordPress, here’s your Sunday Weekly Photo Prompt: travel **
medicine buddha mantra: Tayata Om Bekandze Bekandze Maha Bekandze Radza Samudgate Soha
health, wealth, and prosperity: Om Vasudhare Svaha
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#antiInflammation #antiInflammatory #bbq #beverage #collage #colorful #cookout #dailyPost #drink #flowers #food #foodPorn #foodie #fruit #ginger #gingerPieces #grill #hibiscus #hibiscusPineappleSkinTea #homemade #homemadeTea #ingredients #liveCollage #livecollage #photography #pineapple #pineappleSkin #pink #pinkPineapple #postaday #quench #red #sorrel #summertime #tea #thirst #weeklyPhotoChallenge #zobo -
{...that the #antiinflammatory and #antiviral potential are shown not only by well-known cannabinoids, such as #cannabidiol (#CBD), but also secondary #cannabinoids, such as #cannabigerolicacid (#CBGA) and #terpenes, emphasizing the role of all of the plant’s compounds and the #entourageeffect. ...} learn more: ➡️ ➡️ ➡️ https://pmc.ncbi.nlm.nih.gov/articles/PMC9025270/ 🌱
#Gesundheit #Medizin #Wissenschaft #hanf #hemp #marijuana #Merz #Soder #Reiche #Klingbeil #weedmob #hanfgeschichten #Cannabis #health #Medizin
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#Cannabinoids as novel #AntiInflammatory drugs
by Prakash Nagarkatti, et al.
October, 2009Abstract:
"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."
Executive summary
- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).
- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.
- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.
- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.
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#Cannabidiol (#CBD): a killer for #inflammatory rheumatoid #arthritis synovial fibroblasts
Published: 01 September 2020
by Torsten Lowin, et al.Abstract:
"Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions."