#genomics — Public Fediverse posts

Yesterday, as part of a long thread on ME/CFS Awareness Day, I posted that the SequenceME research project had gotten partial funding.

"Major funding secured for Sequence ME & Long Covid, a DecodeMe project"

https://www.actionforme.org.uk/major-funding-secured-for-sequence-me-long-covid-a-decodeme-project/

This is good news! 🎉 More funding is still needed, but this is a good start.

I'm re-posting today because it was buried in my long thread & may have been missed by a lot of folks.

@mecfs @longcovid

#MEcfs #LongCovid #Genomics #SequenceME #DecodeME #MedMastodon

📰 "Parallel adaptive responses to postponed reproduction increase lifespan and immune defense"
https://doi.org/doi:10.64898/2026.02.25.708047
https://pubmed.ncbi.nlm.nih.gov/42124689/
#DrosophilaMelanogaster
#Evolution
#Drosophila #Genomics #Immunity

More details about the Sequence ME and Long Covid research are in this government press release:

"Thousands of ME/CFS patients to benefit from first genomics study"

https://www.gov.uk/government/news/thousands-of-mecfs-patients-to-benefit-from-first-genomics-study

"…the study will enable the SequenceME programme to sequence the genomes of up to 6,000 ME/CFS patients, generating a world-first high-resolution genetic map of the illness."

20/n

@mecfs @longcovid

#MEcfs #LongCovid #SequenceME #DecodeME #Genomics #MedMastodon

📰 "Modeling human neurodegenerative disorders in Drosophila: strategies and translational opportunities"
https://doi.org/doi:10.1007/s11033-026-11844-5
https://pubmed.ncbi.nlm.nih.gov/42118343/
#DrosophilaMelanogaster
#Drosophila #Genomics

Postdoctoral scholar Neuroimmunology/Pain
Michigan State University

Excited to recruit a Postdoctoral scholar to join the Laumet Lab www.laumetpainlab.com
We study Neuroimmunology of pain in mice and human samples.

See the full job description on jobRxiv: https://jobrxiv.org/job/michigan-state-university-27778-postdoctoral-scholar-neuroimmunology-pain/

#chronicpain #genomics #i...
https://jobrxiv.org/job/michigan-state-university-27778-postdoctoral-scholar-neuroimmunology-pain/?fsp_sid=11921

RE: https://genomic.social/@mdziemann/116436554148418446

Last chance to register for our workshop on reproducible pathway enrichment analysis. There are 2 sessions, 1st one is focused on GUI-web tools and 2nd will be based on R Markdown. We'll also be discussing best practices from our related article in PLOS Comp Biol
Register here: https://tinyurl.com/ye262hzx
#Bioinformatics #genomics

📰 "Genome-wide architecture of prolonged starvation adaptation in experimentally evolved Drosophila and comparative enrichment in human orthologs"
https://www.biorxiv.org/content/10.64898/2026.05.01.722137v1?rss=1
#DrosophilaMelanogaster
#Mitochondria #Drosophila #Genomics

📰 "LGL-1 and the RhoGAP protein PAC-1 redundantly polarize the Caenorhabditis elegans embryonic epidermis"
https://doi.org/doi:10.1083/jcb.202601031
https://pubmed.ncbi.nlm.nih.gov/42084878/
#Drosophila #Genomics #Embryo #Larva

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0089

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

🧬 Could a single metric decode how genes are regulated across cells?

🔗 Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#GeneRegulation #Genomics #MultiOmics #SystemsBiology #Bioinformatics #ComputationalBiology #MolecularBiology #RNA #GeneExpression #Epigenetics #Transcriptomics

🧬 Could a single metric decode how genes are regulated across cells?

🔗 Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#GeneRegulation #Genomics #MultiOmics #SystemsBiology #Bioinformatics #ComputationalBiology #MolecularBiology #RNA #GeneExpression #Epigenetics #Transcriptomics

🧬 Could a single metric decode how genes are regulated across cells?

🔗 Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#GeneRegulation #Genomics #MultiOmics #SystemsBiology #Bioinformatics #ComputationalBiology #MolecularBiology #RNA #GeneExpression #Epigenetics #Transcriptomics

🧬 Could a single metric decode how genes are regulated across cells?

🔗 Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#GeneRegulation #Genomics #MultiOmics #SystemsBiology #Bioinformatics #ComputationalBiology #MolecularBiology #RNA #GeneExpression #Epigenetics #Transcriptomics

🧬 Could a single metric decode how genes are regulated across cells?

🔗 Regulation Ratio: A Singular Multi-Omic Measurement of Gene Regulatory Mechanisms. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0044

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#GeneRegulation #Genomics #MultiOmics #SystemsBiology #Bioinformatics #ComputationalBiology #MolecularBiology #RNA #GeneExpression #Epigenetics #Transcriptomics

Demography and life histories across the Roman frontier in Germany 400–700 ce

"Population genetic analyses reveal a major demographic shift coinciding with the late fifth century collapse of Roman state structures, when a founding population of northern European ancestry mixed with genetically diverse Roman provincial groups. Pedigree reconstruction and filia, a method for inferring the ancestry of unsampled relatives, indicate widespread intermarriage and minimal cultural differentiation"

Blöcher, J., Vallini, L., Velte, M. et al. Demography and life histories across the Roman frontier in Germany 400–700 ce. Nature (2026). https://doi.org/10.1038/s41586-026-10437-3.

#OpenAccess #OA #Research #Study #Archaeology #Science #Biology #Genetics #Genomics #Demography #History #Histodons #Europe #Germany #RomanEmpire #Academia

Demography and life histories across the Roman frontier in Germany 400–700 ce

"Population genetic analyses reveal a major demographic shift coinciding with the late fifth century collapse of Roman state structures, when a founding population of northern European ancestry mixed with genetically diverse Roman provincial groups. Pedigree reconstruction and filia, a method for inferring the ancestry of unsampled relatives, indicate widespread intermarriage and minimal cultural differentiation"

Blöcher, J., Vallini, L., Velte, M. et al. Demography and life histories across the Roman frontier in Germany 400–700 ce. Nature (2026). https://doi.org/10.1038/s41586-026-10437-3.

#OpenAccess #OA #Research #Study #Archaeology #Genetics #Genomics #Demography #History #Histodons #Europe #Germany #RomanEmpire #Academia

J. Craig Venter, genomics pioneer and founder of JCVI, dies at 79

https://www.jcvi.org/media-center/j-craig-venter-genomics-pioneer-and-founder-jcvi-and-diploid-genomics-inc-dies-79

#HackerNews #JCraigVenter #Genomics #Pioneer #JCVI #Science #Innovation #Legacy

The highly complex process of embryonic development and cell differentiation, driven by DNA methylation, is fundamentally governed by simple, universal physical laws rather than isolated biochemical networks. This organization allows initially identical cells to adopt specific identities and form diverse tissues.
#Biophysics #Epigenetics #Genomics #sflorg
https://www.sflorg.com/2026/04/phy04292601.html

Arizona State University: Largest genomic dataset of Indigenous Americans to date sheds light on history, diversity and health. “In a new study published today in Nature, an international team led by the Institute of Evolutionary Biology, with partners at the University of São Paulo and Arizona State University, analyzed genomes from Indigenous populations spanning North America to Patagonia. […]

This week, I visited the Department of Biochemistry and Biotechnology at the University of Thessaly to give lectures on Long Read Genomics. It was a great experience with many interesting discussions, and I am very grateful for the kind hospitality.

More details: https://www.izmb.uni-bonn.de/en/pbb/news#thessaly2026

#Genomics #LongReadSequencing #Bioinformatics #OpenScience #AcademicLife #Erasmus
@PuckerLab

This week, I visited the Department of Biochemistry and Biotechnology at the University of Thessaly to give lectures on Long Read Genomics. It was a great experience with many interesting discussions, and I am very grateful for the kind hospitality.

More details: https://www.izmb.uni-bonn.de/en/pbb/news#thessaly2026

#Genomics #LongReadSequencing #Bioinformatics #OpenScience #AcademicLife #Erasmus
@PuckerLab

This week, I visited the Department of Biochemistry and Biotechnology at the University of Thessaly to give lectures on Long Read Genomics. It was a great experience with many interesting discussions, and I am very grateful for the kind hospitality.

More details: https://www.izmb.uni-bonn.de/en/pbb/news#thessaly2026

#Genomics #LongReadSequencing #Bioinformatics #OpenScience #AcademicLife #Erasmus
@PuckerLab

This week, I visited the Department of Biochemistry and Biotechnology at the University of Thessaly to give lectures on Long Read Genomics. It was a great experience with many interesting discussions, and I am very grateful for the kind hospitality.

More details: https://www.izmb.uni-bonn.de/en/pbb/news#thessaly2026

#Genomics #LongReadSequencing #Bioinformatics #OpenScience #AcademicLife #Erasmus
@PuckerLab

This week, I visited the Department of Biochemistry and Biotechnology at the University of Thessaly to give lectures on Long Read Genomics. It was a great experience with many interesting discussions, and I am very grateful for the kind hospitality.

More details: https://www.izmb.uni-bonn.de/en/pbb/news#thessaly2026

#Genomics #LongReadSequencing #Bioinformatics #OpenScience #AcademicLife #Erasmus
@PuckerLab

the stars of this week's feature in #CurrentBiology are more than 400 cuddly #koalas! It's all about #conservation #genomics, also covering eg #SnowLeopards, #SeaSnails, #lemurs https://proseandpassion.blogspot.com/2026/04/survival-secrets-of-koalas.html

#science #genome

🧩 Could RNA and proteins share the same “shape language” for binding drugs?

🔗 Eigenvalue Ratios Reveal Shared Binding Pocket Shapes in RNA and Protein Structures. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0022

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#DrugDiscovery #StructuralBiology #ComputationalBiology #RNAResearch #ProteinScience #Bioinformatics #MolecularModeling #Genomics #Proteomics #Cheminformatics #LigandBinding

🧬 What if disease isn’t written in DNA, but in how RNA is edited and spliced?

🔗 Long-Read Sequencing Reveals RNA Splicing Complexity in Human Diseases. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0052

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#RNASequencing #Genomics #Transcriptomics #PrecisionMedicine #MolecularBiology #Bioinformatics #NextGenSequencing #RNA #DNA

my features published in @CurrentBiology this year, issue 8: More than 400 #koala genomes provide the peg for this feature on #conservation #genomics. Also included: #snowLeopards, #seaSnails and #lemurs

https://proseandpassion.blogspot.com/2026/04/survival-secrets-of-koalas.html #science #ecology #genome

my features published in @CurrentBiology this year, issue 8: More than 400 #koala genomes provide the peg for this feature on #conservation #genomics. Also included: #snowLeopards, #seaSnails and #lemurs

https://proseandpassion.blogspot.com/2026/04/survival-secrets-of-koalas.html #science #ecology #genome

my features published in @CurrentBiology this year, issue 8: More than 400 #koala genomes provide the peg for this feature on #conservation #genomics. Also included: #snowLeopards, #seaSnails and #lemurs

https://proseandpassion.blogspot.com/2026/04/survival-secrets-of-koalas.html #science #ecology #genome

my features published in @CurrentBiology this year, issue 8: More than 400 #koala genomes provide the peg for this feature on #conservation #genomics. Also included: #snowLeopards, #seaSnails and #lemurs

https://proseandpassion.blogspot.com/2026/04/survival-secrets-of-koalas.html #science #ecology #genome

https://www.europesays.com/ie/444170/ Proteomics and AI bring earlier risk prediction into sharper focus #Aging #ArtificialIntelligence #Biomarker #Chronic #DrugDiscovery #Drugs #Éire #Genes #Genetic #genomics #Health #Healthcare #Heart #HeartFailure #IE #Ireland #medicine #NeurodegenerativeDiseases #Physiology #PrecisionMedicine #Protein #Proteomics #Research

Hunter-gatherers in Malaysia have better-preserved smell genes than farmers — and new genomics research explains why. How you live shapes what your nose can detect, all the way down to your DNA.
#HumanEvolution #Genomics #Olfaction https://www.anthropology.net/p/what-hunter-gatherers-kept-that-farmers

Hey, gonna try my luck here with something technical:

Anyone has or knows of software or have public code to randomly select SNPs from a population or vcf file based on properties which as MAF, distance to TSS of nearest genes?

I can write something, but I'm hoping to save time here and can't find anything. I need it to do an enrichment analysis where I test real hits from the SNPs vs hits from the random ones.

#genomics #bioinformatics #gwas #academia #science #computationalbiology

Microbes adapt to entirely new habitats—such as migrating from soil to freshwater lakes—by utilizing two divergent evolutionary pathways: expanding their genome to acquire new functional traits, or drastically reducing their genome to minimize resource dependency.
#EvolutionaryBiology #MicrobialEcology #Genomics #Limnology #Bioinformatics #sflorg
https://www.sflorg.com/2026/04/ebio04142601.html

I found a sample with a "Klinefelter syndrome" (XXY) in my WGS data.

#genomics #bioinformatics #bam

📰 "Maternal IntS11 primes embryonic totipotency by organizing early zygotic transcription initiation"
https://doi.org/doi:10.1073/pnas.2531899123
https://pubmed.ncbi.nlm.nih.gov/41955115/
#Drosophila #Genomics #Embryo

🤔How do TAD-associated chromatin dynamics and CGVs shape transcriptional plasticity, stress responses, and adaptive #evolution in #plants?
🗝️3D #genomics, chromatin accessibility, and multi-omics data hold the key!
🌱 https://doi.org/10.1111/jipb.70241
@WileyLifeSci
#PlantSci #JIPB #CropSci

🧬 Can AI truly decode gene expression, or is it being misled by too much data?

🔗 Artificial Intelligence in Bulk RNA-Seq: Challenges and Potential Solutions. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0039

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#ArtificialIntelligence #MachineLearning #Bioinformatics #Genomics #RNAseq #ComputationalBiology #SystemsBiology #AI #PrecisionMedicine #BigData #AIinHealthcare

https://www.europesays.com/ie/410416/ Space Biology: CBIOMES Preflight Microscopic Imagery Of C. elegans #CElegans #CBIOMES #Éire #genomics #IE #Ireland #Microbiome #Microfluidics #microgravity #nematode #Science #SpaceBiology #SpaceLifeScience #Spaceflight

Recent ancient DNA analysis has identified domestic dogs at archaeological sites dating to the Late Upper Paleolithic, roughly 16,000 to 14,000 years ago. This discovery pushes back the earliest confirmed genetic record of dog domestication by approximately 5,000 years, firmly placing their emergence prior to the advent of agriculture.
#Archaeogenetics #EvolutionaryBiology #Paleontology #Archaeology #Genomics #sflorg
https://www.sflorg.com/2026/03/arch03252601.html

📰 "Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila"
https://www.biorxiv.org/content/10.64898/2026.03.21.713357v1?rss=1
#Mitochondria #Drosophila #Genomics #Immunity #Adult
#Toll
#Larva

The Old Irish Goat Carries 3,000 Years Of Irish History In Its DNA

“Goats tell us how human values changed through time by showing how and where we moved animals through trade or migration.”

#SciComm by @GrrlScientist

#history #Archaeology #ancientDNA #genomics #proteomics https://www.forbes.com/sites/grrlscientist/2026/03/22/the-old-irish-goat-carries-3000-years-of-irish-history-in-its-dna/

The Old Irish Goat Carries 3,000 Years Of Irish History In Its DNA

“Goats tell us how human values changed through time by showing how and where we moved animals through trade or migration.”

#SciComm by @grrlscientist

#history #Archaeology #ancientDNA #genomics #proteomics https://www.forbes.com/sites/grrlscientist/2026/03/22/the-old-irish-goat-carries-3000-years-of-irish-history-in-its-dna/

🧬 Could the hidden genetic diversity of probiotics unlock the future of health and food innovation?

🔗 From Fermentation to Function: Genomic Diversity and Probiotic Potential in the Reclassified Lactobacillus Lineage. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0004

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Probiotics #GutHealth #Microbiome #Lactobacillus #FunctionalFoods #FoodScience #Genomics #Microbiology #HealthyLiving