#oligodendrocytes — Public Fediverse posts

Rapid info processing in vertebrates depends on #myelin, but how are CNS axons selected for #myelination? This study shows that axonal target selection by #oligodendrocytes depends on a redundant set of #AdhesionMolecules; simultaneous loss abolishes myelination @PLOSBiology https://plos.io/4vyW63S

Interestingly, #Virchow also introduced the concept of #neuroglia as a distinct #cellular component of the #NervousSystem. This was a crucial step in understanding the cellular composition of the nervous system and laid the groundwork for later #neuroscience research on glial cells.

#glia #GliaCells #Astrocytes #Oligodendrocytes #Microglia #NeuroscienceHistory

Quiescent #NeuralStemCells (qNSCs) in the adult mouse SVZ have a limited capacity to generate #glia. This study shows that a subpopulation of multipotent qNSCs with high Gas1 expression can produce #oligodendrocytes throughout life & after demyelinating injury @PLOSBiology https://plos.io/4iY4nbh

Neurons are presumed the main source of pathogenic Aβ in #AlzheimersDisease (AD). But @RikeshRajani @marcaurelbusche &co show that #oligodendrocytes also contribute significantly; suppressing oligo Aβ rescues neuronal dysfunction in mouse AD #PLOSBiology https://plos.io/3zYNU56

`#Oligodendrocytes (from Greek 'cells with a few branches'), also known as oligodendroglia, are a type of #neuroglia whose main functions are to provide support and insulation to #axons within the central nervous system (CNS) of jawed vertebrates. Their function is similar to that of Schwann cells, which perform the same task in the peripheral nervous system`

https://en.wikipedia.org/wiki/Oligodendrocyte

Injecting fractalkine into mouse models of multiple sclerosis increased the number of oligodendrocytes. Findings suggest fractalkine may help to slow the progression, or potentially halt Multiple Sclerosis.

#Neuroscience #Brain #Neurology #NeurologicalDiseases #NeurodegenerativeDiseases #Neuroimmunology #Neuroinflammation #Demyelination #DemyelinatingDiseases #MultipleSclerosis #Oligodendrocytes #Fractalkine

https://neurosciencenews.com/multiple-sclerosis-fractslkine-222344/

Just curious, has anyone else around here been following studies on #remyelination involving #clemastine fumarate (and its impact on #oligodendrocytes, etc.)? It's not my dissertation area, but every year or so I go back into check research, and it seems there's always a new treasure trove. Like, say, this one: https://www.frontiersin.org/articles/10.3389/fcell.2021.733945/full

Did you know that #myelination of neuronal axons by #oligodendrocytes in our #brain is a plastic process in which #myelin structure (white matter) can change in response to neuronal activity?

Here is a very interesting review article by Juliet Knowles and colleagues at Stanford University:

Adaptive and maladaptive myelination in health and disease

#OpenAccess article in Nature Reviews #Neurology: https://www.nature.com/articles/s41582-022-00737-3

#neuroscience #psychiatricdiseases

😀 Delighted to announce that our #neuroscience paper has just been published in Cell Reports:

"Spread of pathological human #Tau from #neurons to #oligodendrocytes and loss of high-firing pyramidal neurons in aging #mice"

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01517-0