#virology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #virology, aggregated by home.social.
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#science #virology
My last, last author paper now published in Science Advances https://doi.org/10.1126/sciadv.aed4872; a year since my retirement. "Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins"All credit to graduate student Caroline Langley who did brilliant work, super tech Michelle Lily who finished the experimental work after Caroline graduated, and my ever astute collaborator (and Caroline’s co-mentor), Harmit Malik @harmitmalik.bsky.social
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#science #virology
My last, last author paper now published in Science Advances https://doi.org/10.1126/sciadv.aed4872; a year since my retirement. "Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins"All credit to graduate student Caroline Langley who did brilliant work, super tech Michelle Lily who finished the experimental work after Caroline graduated, and my ever astute collaborator (and Caroline’s co-mentor), Harmit Malik @harmitmalik.bsky.social
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How Viral Proteases Trigger Lytic Cell Death for Universal mRNA Therapy
#pyroptosis #virology #microbiology
https://davidojcius.blogspot.com/2026/07/how-viral-proteases-trigger-lytic-cell.html
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How Viral Proteases Trigger Lytic Cell Death for Universal mRNA Therapy
#pyroptosis #virology #microbiology
https://davidojcius.blogspot.com/2026/07/how-viral-proteases-trigger-lytic-cell.html
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The Bourbon virus is an emerging, rare viral pathogen transmitted by the lone star tick (Amblyomma americanum) that causes severe, influenza-like illness in humans.
#Epidemiology #InfectiousDiseases #Virology #Entomology #Immunology #sflorg
https://www.sflorg.com/2026/07/epi07212601.html -
The Bourbon virus is an emerging, rare viral pathogen transmitted by the lone star tick (Amblyomma americanum) that causes severe, influenza-like illness in humans.
#Epidemiology #InfectiousDiseases #Virology #Entomology #Immunology #sflorg
https://www.sflorg.com/2026/07/epi07212601.html -
Current advances in the development of #NipahVirus vaccines
#OpenAccess #NiV #zoonosis #Nipah #microbiology #virology https://davidojcius.blogspot.com/2026/07/current-advances-in-development-of.html
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Current advances in the development of #NipahVirus vaccines
#OpenAccess #NiV #zoonosis #Nipah #microbiology #virology https://davidojcius.blogspot.com/2026/07/current-advances-in-development-of.html
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Molecular Virology of Human Pathogenic Viruses (2017) by Wang-Shick Ryu
Author: Wang-Shick Ryu
File Type: PDF
Download at https://unitedvrg.com/2022/01/23/pdf-molecular-virology-of-human-pathogenic-viruses-2017-by-wang-shick-ryu/
#Virology, #Wang-ShickRyu -
Molecular Virology of Human Pathogenic Viruses (2017) by Wang-Shick Ryu
Author: Wang-Shick Ryu
File Type: PDF
Download at https://unitedvrg.com/2022/01/23/pdf-molecular-virology-of-human-pathogenic-viruses-2017-by-wang-shick-ryu/
#Virology, #Wang-ShickRyu -
Researchers have discovered that specific bacteriophages infecting agriculturally significant bacterial plant pathogens can remain genetically stable for decades, challenging the widespread assumption that all viruses mutate rapidly.
#Virology #PlantPathology #Microbiology #Genomics #EvolutionaryBiology #sflorg
https://www.sflorg.com/2026/07/vi07132602.html -
Researchers have discovered that specific bacteriophages infecting agriculturally significant bacterial plant pathogens can remain genetically stable for decades, challenging the widespread assumption that all viruses mutate rapidly.
#Virology #PlantPathology #Microbiology #Genomics #EvolutionaryBiology #sflorg
https://www.sflorg.com/2026/07/vi07132602.html -
Hepatitis E viruses undergo dynamic genetic mutations during the first few weeks of an acute infection, altering their population structure early in the disease progression.
#Virology #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/vi07132601.html -
Hepatitis E viruses undergo dynamic genetic mutations during the first few weeks of an acute infection, altering their population structure early in the disease progression.
#Virology #MolecularBiology #sflorg
https://www.sflorg.com/2026/07/vi07132601.html -
Novel bat-origin CoV identified, causing severe pneumonia.
🦠 Found in 5 patients from Wuhan with shared symptoms.
🔬 Closest to bat SARS-like CoV.
#Virology #CoronavirusResearch https://dev.tnyp.me/ZRAgtQ06/m -
Novel bat-origin CoV identified, causing severe pneumonia.
🦠 Found in 5 patients from Wuhan with shared symptoms.
🔬 Closest to bat SARS-like CoV.
#Virology #CoronavirusResearch https://dev.tnyp.me/ZRAgtQ06/m -
A novel bat CoV linked to severe pneumonia emerged in humans.
🔍 99.8-99.9% genetic similarity among isolates
🧫 5 patients studied; 1 fatality
🦠 Virus closely related to bat SARS-like CoV
#COVID19 #Virology https://tnyp.me/ocinAFkw/m -
A novel bat CoV linked to severe pneumonia emerged in humans.
🔍 99.8-99.9% genetic similarity among isolates
🧫 5 patients studied; 1 fatality
🦠 Virus closely related to bat SARS-like CoV
#COVID19 #Virology https://tnyp.me/ocinAFkw/m -
I have a question for Science & Medicine Fedi:
When countries reduced their isolation and quarantine recomendations for covid, was there any science to back that up (or was it just about politics)?
If there's science, can you point me at resources or give me tips on where/how to find that info? Thank you.
*I'm looking for answers with sources, not speculation or venting. Thank you.
#MedMastodon #ScienceMastodon #AskFedi #Virology #Epidemiology #PublicHealth #Covid19
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I have a question for Science & Medicine Fedi:
When countries reduced their isolation and quarantine recomendations for covid, was there any science to back that up (or was it just about politics)?
If there's science, can you point me at resources or give me tips on where/how to find that info? Thank you.
*I'm looking for answers with sources, not speculation or venting. Thank you.
#MedMastodon #ScienceMastodon #AskFedi #Virology #Epidemiology #PublicHealth #Covid19
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The Powassan virus (Orthoflavivirus powassanense) is a highly pathogenic, positive-sense, single-stranded RNA virus endemic to North America that causes severe, rapidly progressing neuroinvasive disease and encephalitis in human hosts.
#WhatIs #Virology #Epidemiology #VectorEcology #Immunology #Neuropathology #sflorg
https://www.sflorg.com/2026/07/wi07122601.html -
The Powassan virus (Orthoflavivirus powassanense) is a highly pathogenic, positive-sense, single-stranded RNA virus endemic to North America that causes severe, rapidly progressing neuroinvasive disease and encephalitis in human hosts.
#WhatIs #Virology #Epidemiology #VectorEcology #Immunology #Neuropathology #sflorg
https://www.sflorg.com/2026/07/wi07122601.html -
The First Pandemic? Scientists Find 214 Ancient Pathogens In Prehistoric DNA
Shutterstock Scientists have uncovered DNA from 214 ancient pathogens in prehistoric humans, including the oldest known evidence of plague. The findings show zoonotic diseases began spreading around 6,500 years ago, likely triggered by farming and animal domestication. These ancient infections may still influence us today, and help guide the vaccines of tomorrow…….Continue reading…. By: University of Copenhagen – The Faculty of Health and Medical […] -
The First Pandemic? Scientists Find 214 Ancient Pathogens In Prehistoric DNA
Shutterstock Scientists have uncovered DNA from 214 ancient pathogens in prehistoric humans, including the oldest known evidence of plague. The findings show zoonotic diseases began spreading around 6,500 years ago, likely triggered by farming and animal domestication. These ancient infections may still influence us today, and help guide the vaccines of tomorrow…….Continue reading…. By: University of Copenhagen – The Faculty of Health and Medical […] -
Lots of new #sciart in the shop, including this beautiful #watercolor grid of viruses https://artologica.etsy.com/listing/4534055171 #art #virology
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Lots of new #sciart in the shop, including this beautiful #watercolor grid of viruses https://artologica.etsy.com/listing/4534055171 #art #virology
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The viral ORFeome is a comprehensive genetic library containing 13,000 physical DNA sequences that encode approximately 9,000 proteins from 513 different viruses, enabling scientists to study thousands of viral proteins simultaneously.
#Virology #MolecularBiology #Genetics #Immunology #sflorg
https://www.sflorg.com/2026/07/vi07102601.html -
The viral ORFeome is a comprehensive genetic library containing 13,000 physical DNA sequences that encode approximately 9,000 proteins from 513 different viruses, enabling scientists to study thousands of viral proteins simultaneously.
#Virology #MolecularBiology #Genetics #Immunology #sflorg
https://www.sflorg.com/2026/07/vi07102601.html -
Pipeline release! nf-core/viralmetagenome v1.1.3 - v1.1.3 - Cerulean Crane !
A nf-core pipeline for untargeted whole genome reconstruction with iSNV detection from metagenomic samples.
Please see the changelog: https://github.com/nf-core/viralmetagenome/releases/tag/1.1.3#epidemiology #fastq #ngs #viralmetagenomics #virology #virusgenomes #nfcore #openscience #nextflow #bioinformatics
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Pipeline release! nf-core/viralmetagenome v1.1.3 - v1.1.3 - Cerulean Crane !
A nf-core pipeline for untargeted whole genome reconstruction with iSNV detection from metagenomic samples.
Please see the changelog: https://github.com/nf-core/viralmetagenome/releases/tag/1.1.3#epidemiology #fastq #ngs #viralmetagenomics #virology #virusgenomes #nfcore #openscience #nextflow #bioinformatics
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What’s the risk of humans getting sick from bird flu?
#BirdFlu #H5N1 #Health #AvianFlu #Virus #Influenza #Pandemic #Australia #Biosecurity #Poultry #Wildlife #FoodSafety #Virology #Epidemiology #DiseasePrevention #GlobalHealth #FlueVaccines #Research
https://the-14.com/whats-the-risk-of-humans-getting-sick-from-bird-flu/ -
What’s the risk of humans getting sick from bird flu?
#BirdFlu #H5N1 #Health #AvianFlu #Virus #Influenza #Pandemic #Australia #Biosecurity #Poultry #Wildlife #FoodSafety #Virology #Epidemiology #DiseasePrevention #GlobalHealth #FlueVaccines #Research
https://the-14.com/whats-the-risk-of-humans-getting-sick-from-bird-flu/ -
Mutant Drug-Resistant Ebola Created by U.S., China, U.K., Germany Just Before Africa Outbreak: Journal ‘npj Viruses’
Gain-of-function experiments that mutate pathogens to resist drugs are baked into virological drug development.
An international research consortium involving major institutions from the United States, China, the United Kingdom, and Germany claims to have successfully created mutant strains of Orthoebolavirus that are resistant to the neutralizing effects of the monoclonal antibody mAb 11886.
They published their work in npj Viruses on May 7, just days before the 2026 Ebola outbreak was first officially reported by the Democratic Republic of the Congo’s Ministry of Public Health.
These Ebola experiments, which were conducted under BSL-4 conditions at Philipps University Marburg, involved the intentional generation and selection of purported viral variants that bypass therapeutic neutralization.
The experiments align with published gain-of-function (GOF) definitions.
According to a 2022 review published in Advances in Applied Microbiology:
“Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness.”
The new Ebola study was said to have resulted in the generation of mutated, drug-resistant Ebola pathogens in the name of drug development.
It raises international security concerns, as Congress, the White House, the Department of Energy, the FBI, the CIA, and Germany’s Federal Intelligence Service (BND) all acknowledged that the COVID-19 pandemic was “likely” the result of a laboratory incident involving engineered pathogens.
You can contact NIAID here, NIH here, and HHS here to voice opposition to taxpayer-funded research on pandemic pathogens.
Multiple U.S. government Ebola preparedness and response programs were administratively updated on the federal Assistance Listings database in mid-January 2026—roughly three to four months before health authorities in the Democratic Republic of the Congo announced the latest Ebola outbreak.
The Trump administration is now seeking more than $1.4 billion in Ebola funding from Congress, just after the CDC activated $107 million in emergency funding for Ebola response.
U.S. taxpayers are now paying for both the creation of mutated, drug-resistant Ebola pathogens while also paying for the government’s expensive response to Ebola.
Researchers Force the Virus to Become Resistant
To produce these drug-resistant mutants, researchers claim to have used a replication-competent version of the virus known as EbolaΔVP30.
The team says they forced the evolution of the virus by subjecting it to three consecutive 6-day passage cycles.
During these cycles, the virus was said to be exposed to increasing concentrations of the antibody mAb 11886, starting at 0.63 µg/mL and escalating to 5.0 µg/mL to drive the selection of mutations that could survive the treatment.
After this process, the team isolated individual plaques that were able to survive in the presence of 10 µg/mL of the antibody.
Finally, the researchers claim they extracted viral RNA and sequenced the glycoprotein gene to identify the specific genetic mutations responsible for the acquired resistance.
The Experiments Identified Two Specific Genetic Mutations That Resist Drugs
The sequencing analysis was said to have identified two specific genetic mutations that directly negated the effectiveness of the antibody.
The first mutation, known as V505I, is located in the GP2 N-terminus and was identified as the primary driver of resistance against mAb 11886.
The second mutation, known as T402I, is said to be located in the mucin-like domain and contributed to resistance through indirect effects on how the virus processes its purported surface proteins.
Experimental data from the study confirmed that each of these mutations, when present individually, was sufficient for the virus to evade neutralization at a concentration of 10 µg/mL.
Research Supported by an International Network of Funding & Institutions
The creation of these drug-resistant Ebola variants was made possible by a global network of funding agencies and academic-industry partnerships.
In the United Kingdom, the research was supported by the UK Medical Research Council through an iCASE PhD studentship to FRD (MR/N01796X/1), and the Wellcome Trust through a Senior Fellowship to SJD (106917/Z/15/Z).
In Germany, the work was supported by the German Research Foundation via a grant to TS (197785619/SFB1021).
In China, funding was provided by the Chinese Academy of Medical Sciences Innovation Fund for Medical Science grants to PR and AT (2024-12M-2-001-1 and 2018-12M-2-002).
In the United States, the research was supported by the National Institutes of Health through grant U19 AI109762 to EOS.
#birdFlu #h5n1 #health #news #virology -
🇫🇷 "Ebola : un premier cas identifié en France, chez un médecin de retour de RDC"
Il s’agit du premier cas jamais diagnostiqué sur le territoire français. La situation est suivie « de très près » par le premier ministre, Sébastien Lecornu, selon son entourage cité par l’Agence France Presse. "
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🇫🇷 "Ebola : un premier cas identifié en France, chez un médecin de retour de RDC"
Il s’agit du premier cas jamais diagnostiqué sur le territoire français. La situation est suivie « de très près » par le premier ministre, Sébastien Lecornu, selon son entourage cité par l’Agence France Presse. "
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Endogenous Retroviruses (ERVs) are the fossilized genetic remnants of ancient infectious viruses that successfully invaded the mammalian germline tens of millions of years ago. Comprising roughly five to eight percent of the human genome, these elements exist as a latent virome that provides critical evolutionary functions while posing significant pathological risks if reactivated.
#WhatIs #EvolutionaryBiology #MolecularGenetics #Virology #Epigenetics #Oncology #sflorg
https://www.sflorg.com/2026/06/wi06242601.html -
Endogenous Retroviruses (ERVs) are the fossilized genetic remnants of ancient infectious viruses that successfully invaded the mammalian germline tens of millions of years ago. Comprising roughly five to eight percent of the human genome, these elements exist as a latent virome that provides critical evolutionary functions while posing significant pathological risks if reactivated.
#WhatIs #EvolutionaryBiology #MolecularGenetics #Virology #Epigenetics #Oncology #sflorg
https://www.sflorg.com/2026/06/wi06242601.html -
The giant viruses that orchestrate life in the polar regions
#Science #Environment #ClimateChange #Arctic #Antarctica #PolarRegions #GiantViruses #Virology #Microbiology #DNA #Ecology #Biodiversity #GlobalWarming #Parasites #ArcticOcean #PolarIce #Viruses
https://the-14.com/the-giant-viruses-that-orchestrate-life-in-the-polar-regions/ -
The giant viruses that orchestrate life in the polar regions
#Science #Environment #ClimateChange #Arctic #Antarctica #PolarRegions #GiantViruses #Virology #Microbiology #DNA #Ecology #Biodiversity #GlobalWarming #Parasites #ArcticOcean #PolarIce #Viruses
https://the-14.com/the-giant-viruses-that-orchestrate-life-in-the-polar-regions/ -
Which of the following is not a viral disease?
A. Chickenpox
B. Hepatitis
C. Typhoid
D. Measles
#viraldisease #viruses #virology #infection ... Continue to: https://www.facebook.com/1130092409221646/posts/1355563796674505 -
Which of the following is not a viral disease?
A. Chickenpox
B. Hepatitis
C. Typhoid
D. Measles
#viraldisease #viruses #virology #infection ... Continue to: https://www.facebook.com/1130092409221646/posts/1355563796674505 -
World’s first AI‑designed vaccine explained
#AI #Vaccine #Vaccines #MedicalResearch #Health #DNA #Science #Technology #COVID19 #Coronavirus #Pandemic #PublicHealth #Biotechnology #DNAVaccines #Innovation #Immunology #VirusResearch #Medicine #Virology
https://the-14.com/worlds-first-ai-designed-vaccine-explained/ -
World’s first AI‑designed vaccine explained
#AI #Vaccine #Vaccines #MedicalResearch #Health #DNA #Science #Technology #COVID19 #Coronavirus #Pandemic #PublicHealth #Biotechnology #DNAVaccines #Innovation #Immunology #VirusResearch #Medicine #Virology
https://the-14.com/worlds-first-ai-designed-vaccine-explained/ -
New drug 'functionally cures' many hepatitis B virus infections
#HackerNews #newdrug #hepatitisB #functionalcure #medicalresearch #virology #healthnews
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New drug 'functionally cures' many hepatitis B virus infections
#HackerNews #newdrug #hepatitisB #functionalcure #medicalresearch #virology #healthnews
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Molecular evolutionary analysis of the current Bundibugyo virus disease outbreak in DRC and Uganda
This is an informal analysis … based on the 10 available outbreak-associated #Bundibugyo virus (BDBV) sequences available as of 28 May 2026.
The sampled viruses appear to share a most recent common ancestor in early-to-mid March 2026.
[The] level of diversity suggests that the sampled viruses do not represent the very beginning of transmission, but instead reflect an outbreak that had already been circulating, at least partly undetected, for several weeks.
The estimated epidemic doubling time is relatively slow but highly uncertain … [ranging] from 15.2 to 24.5 days.
The corresponding reproduction number (𝑅0) estimates are centred above 1, with mean estimates ranging from 1.31 to 1.55.
These estimates should be interpreted cautiously. The analysis is based on only 10 sequences collected over a short sampling window.
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Molecular evolutionary analysis of the current Bundibugyo virus disease outbreak in DRC and Uganda
This is an informal analysis … based on the 10 available outbreak-associated #Bundibugyo virus (BDBV) sequences available as of 28 May 2026.
The sampled viruses appear to share a most recent common ancestor in early-to-mid March 2026.
[The] level of diversity suggests that the sampled viruses do not represent the very beginning of transmission, but instead reflect an outbreak that had already been circulating, at least partly undetected, for several weeks.
The estimated epidemic doubling time is relatively slow but highly uncertain … [ranging] from 15.2 to 24.5 days.
The corresponding reproduction number (𝑅0) estimates are centred above 1, with mean estimates ranging from 1.31 to 1.55.
These estimates should be interpreted cautiously. The analysis is based on only 10 sequences collected over a short sampling window.
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Prenatal exposure to the Zika virus can cause subtle, long-term neurodevelopmental and sensory processing disorders in infants who are born without visible physical defects.
#Virology #Neurobiology #DevelopmentalBiology #Pediatrics #sflorg
https://www.sflorg.com/2026/06/vi06042601.html -
If I can smell their perfume, does that mean that it is also possible to be impacted by exhaled contagions even in spite of it being an outdoor setting?
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Pipeline release! nf-core/viralmetagenome v1.1.2 - v1.1.2 - Blush Bunting!
A nf-core pipeline for untargeted whole genome reconstruction with iSNV detection from metagenomic samples.
Please see the changelog: https://github.com/nf-core/viralmetagenome/releases/tag/1.1.2#epidemiology #fastq #ngs #viralmetagenomics #virology #virusgenomes #nfcore #openscience #nextflow #bioinformatics
