#il6 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #il6, aggregated by home.social.
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The work on the DC - quite descriptive - is published. Find it here: https://mastodon.social/@tinyspheresof/109681388538649498
The T cell work has not been published. I think I have a mostly complete manuscript that I could put on bioRXv. I'll discuss it with my former PI.
The short version: #IL6 and #TNF were very abundant, and were in the way of Treg-Teff interaction, #Teff not reacting to #Treg suppression anymore. Possibly partly explaining why drugs against these work in #arthritis. -
@gpollara @JExpMed Intriguing. In an earlier postdoc position I had a look at #DendriticCells, and especially the #cDC1 were abundant, but seemed to be just sitting in the inflammatory environment, doing little. One of the very abundant cytokines: #IL6
We also looked at the effect of that and other #cytokines, but mostly on #Tcells, among others due to the low abundance of cDC1 in HC blood to be able to do many in vitro experiments.
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#ML outperforms classic scores. One of these is the end-stage liver disease prediction model for 90-day mortality (#MELD)
- We derived an ML model AMELD which outperforms MELD, MELD-Na, MELD 3.0, and MELD-Plus7
- How? AMELD extends the classic MELD predictors INR, bilirubin, and cystatin C / creatinine to include total protein, cholinesterase and #IL6
https://doi.org/10.1515/labmed-2022-0162
Using more accurate AMELD prediction may improve #CDS for performing liver transplants