#liver — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #liver, aggregated by home.social.
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Researchers put olive and fish oil IV nutrition under the microscope
As hospitals move beyond traditional soybean oil-ba…
#dining #cooking #diet #food #mediterranean #MediterraneanDiet #MediterraneanFood #MediterraneanOliveOil #OliveOil ##inflammation #anti-inflammatory #fattyacids #Fish #fishoil #Hospital #Interleukin #liver #Mediterranean #microscope #nutrition #Olive #Oral #Research
https://www.diningandcooking.com/2776811/researchers-put-olive-and-fish-oil-iv-nutrition-under-the-microscope/ -
Researchers put olive and fish oil IV nutrition under the microscope
As hospitals move beyond traditional soybean oil-based nutrition, researchers are probing whether olive …
#dining #cooking #diet #food #MediterraneanOliveOil #OliveOil ##inflammation #anti-inflammatory #fattyacids #Fish #fishoil #Hospital #Interleukin #liver #Mediterranean #microscope #nutrition #Olive #Oral #Research
https://www.diningandcooking.com/2776811/researchers-put-olive-and-fish-oil-iv-nutrition-under-the-microscope/ -
Researchers put olive and fish oil IV nutrition under the microscope https://www.diningandcooking.com/2776811/researchers-put-olive-and-fish-oil-iv-nutrition-under-the-microscope/ ##inflammation #AntiInflammatory #FattyAcids #Fish #FishOil #Hospital #Interleukin #liver #Mediterranean #MediterraneanOliveOil #microscope #nutrition #Olive #OliveOil #Oral #Research
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#FoodLee #food #luncheons #porks #pork #liver #redpepper #cabbage #eggs #cheese #tomatoes #tomatobulion #bulion #5ůmA
"Mi Locale"
Import Specials -
Collagen peptide ingestion alters lipid metabolism-related gene expression
and the unfolded protein response in mouse liver [2017]
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/3575189416F7861B875ED46B2E5A815E/S0007114516004384a.pdf/collagen_peptide_ingestion_alters_lipid_metabolismrelated_gene_expression_and_the_unfolded_protein_response_in_mouse_liver.pdfLowering ER stress might also be beneficial in autoimmune disease:
IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases [2018]
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01289/full#EndoplasmicReticulum #Liver #cholesterol #CollagenPeptides #AutoimmuneDiseases #autoimmunity
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https://www.europesays.com/ie/635674/ New vaccination approach turns mosquito bites into immunity boosters #Biopharmaceutical #Cell #DNA #Drugs #education #Éire #Health #IE #ImmuneResponse #ImmuneSystem #immunity #InfectiousDiseases #Ireland #Laboratory #Liver #Malaria #Mosquito #Preclinical #Research
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https://www.europesays.com/ie/623560/ Study identifies a novel direct drug target for head and neck squamous cell carcinoma #Bone #Brain #cancer #carcinoma #Cell #chemotherapy #Cisplatin #DrugDiscovery #Éire #Gene #Genetic #HeadAndNeckCancer #Health #IE #Ireland #Liver #MedicinalChemistry #medicine #Metastasis #Molecule #Neck #pH #pharmacy #Prostate #ProstateCancer #Protein #Research #SquamousCellCarcinoma #StemCells #Therapeutics #therapy #Tumor
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Daily tomatoes lowered a key marker of liver fat in MASLD trial
A six-week tomato-rich diet outperformed a tomato…
#dining #cooking #diet #food #MediterraneanDiet #BodyMassIndex #carcinoma #Cardiometabolic #chronic #Cirrhosis #Fibrosis #HepatocellularCarcinoma #insulin #insulinresistance #liver #liverdisease #Lycopene #Mediterranean #metabolism #nutrients #obesity #Steatosis #stress #Tomato
https://www.diningandcooking.com/2755813/daily-tomatoes-lowered-a-key-marker-of-liver-fat-in-masld-trial/ -
Daily tomatoes lowered a key marker of liver fat in MASLD trial https://www.diningandcooking.com/2755813/daily-tomatoes-lowered-a-key-marker-of-liver-fat-in-masld-trial/ #BodyMassIndex #carcinoma #Cardiometabolic #chronic #Cirrhosis #diet #Fibrosis #food #HepatocellularCarcinoma #insulin #InsulinResistance #liver #LiverDisease #Lycopene #Mediterranean #MediterraneanDiet #metabolism #nutrients #obesity #Steatosis #stress #Tomato
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Повреждение печени, вызванное лекарственными препаратами, связанное с потреблением биологически активных добавок на основе куркумы и черного перца: отчет о клиническом случае.
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Drug‐Induced #Liver Injury Associated With #Turmeric and Black Pepper Based Dietary Supplements Consumption: A Case Report
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#BloodSugar #Alcohol #Glucose #Health #Liver #Nutrition #Diet #SugarRush #BloodSugar #SugarHigh #BloodSugarBalance #Glucose #BloodSugarPalette #SugarDetox #BloodSugarControl #Sugary #BloodGlucose #SugarMama #Sugars #BloodSugarDiet #GlucoseTest https://mastodon.social/@biohackingpathway/116980999300581727
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https://www.europesays.com/ie/599655/ Occult hepatitis B mutations drive liver cancer growth via Akt mTOR pathway #Bases #cancer #carcinoma #Cell #CellBiology #CellCycle #CellProliferation #Éire #Gene #Genes #Genomic #Gerontology #GlobalHealth #HBV #Health #Hepatitis #HepatitisB #HepatitisBVirus #HepatocellularCarcinoma #IE #InVitro #Ireland #Laboratory #Liver #LiverDisease #medicine #Proliferation #Protein #Research #Therapeutics #Tumor #Tumorigenesis #virus
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https://www.europesays.com/ie/590775/ Study reveals mechanism underlying HBV-induced liver inflammation #Antioxidant #Bases #carcinoma #Cell #CellBiology #Chronic #Cirrhosis #Cytokine #Cytokines #Éire #Gene #Genes #HBV #Health #Hepatitis #HepatitisB #HepatitisBVirus #HepatocellularCarcinoma #IE #inflammation #Ireland #Liver #medicine #OxidativeStress #Oxygen #Phosphorylation #Research #ResearchProject #Respiratory #Stress #Therapeutics #Transgenic #virus
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Kidney and Liver Tissue Bioprinted on the ISS for the First Time, A Step Toward Orbital Medicine
https://1ban.news/kidney-liver-tissue-bioprinted-iss-auxilium/
#1ban #kidney #liver #tissue #bioprinted #science -
Spaceflight Speeds Up Aging, UCF Researchers Warn -- And Your Liver Feels It First
https://1ban.news/space-speeds-up-aging-liver/
#1ban #space #speeds #aging #liver #astronomy -
https://www.europesays.com/ie/571969/ Men face higher risk of late-stage cancer diagnoses than women #Bladder #cancer #doctor #Éire #Epidemiology #Genetics #Health #HealthCare #IE #Ireland #Liver #LymphNodes #Melanoma #Mortality #OropharyngealCancer #Research #SalivaryGland #Stomach #StomachCancer #Thyroid #ThyroidCancer #Tongue #TongueCancer
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A Somewhat #Mindblowing Way To #Express #Pi : Medium
First #Pig #Liver and #Kidneys #Transplanted into a person — strategy could ease #Organ shortages ($) : Nature
#Speedy, #Spiraling #Electrical waves may be key to #Brain’s #Information flow : Science
Latest #KnowledgeLinks
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#liver : a large vital organ in the body
- French: foie
- German: die Leber
- Italian: fegato
- Portuguese: fígado
- Spanish: hígado
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Fill in missing or incorrect translations @ https://wordofthehour.org/r/translations
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The village of three hundred inhabitants where you can taste all the oils of Empordà https://www.diningandcooking.com/2679010/the-village-of-three-hundred-inhabitants-where-you-can-taste-all-the-oils-of-emporda/ #And #are #cheeses #Emporda #fonteta #in #liver #Mediterranean #MediterraneanOliveOil #oils #Olive #OliveOil #Pate #Sausage #shop #sweet #Tasted #that #the #unique #with
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The village of three hundred inhabitants where you can taste all the oils of Empordà
You might be interested in New shooting in Barcelona: a man dies from a gunshot to the …
#dining #cooking #diet #food #MediterraneanOliveOil #OliveOil #And #are #cheeses #Emporda #fonteta #in #liver #Mediterranean #oils #Olive #Pate #Sausage #shop #sweet #Tasted #that #the #unique #with
https://www.diningandcooking.com/2679010/the-village-of-three-hundred-inhabitants-where-you-can-taste-all-the-oils-of-emporda/ -
Researchers Propose Liver as a Potential Magnetoreceptor in Pigeons
📰 Original title: New study targets liver as magnetic sensor behind pigeon’s long-range navigation
🤖 IA: It's clickbait ⚠️
👥 Users: It's clickbait ⚠️View full AI summary https://en.killbait.com/researchers-propose-liver-as-a-potential-magnetoreceptor-in-pigeons.html?utm_source=mastodon_world&utm_medium=social&utm_campaign=killbait.mastodon_world
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🐦🧭 A team at the University of #Bonn found that #pigeons rely on iron-rich #macrophages in their livers to sense #Earth’s magnetic fields.
When researchers deactivated these #cells, the #birds lost their way on overcast days – but navigated fine under sunny skies, confirming a backup magnetic system that kicks in when visual cues aren’t available.
👉 https://arstechnica.com/science/2026/05/how-pigeons-exploit-magnetic-fields-for-navigation/
#navigation #science #biology #liver #biodiversity #zoology #germany #animals #magneticfield #research
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https://www.europesays.com/ie/474741/ Metformin targets the gut instead of the liver to lower glucose #Biochemistry #blood #BloodSugar #Cell #Citrulline #diabetes #Éire #Enzyme #Genetics #Glucose #IE #Insulin #InsulinResistance #Ireland #Liver #medicine #Metabolism #Metformin #Mitochondria #Science #supplements #Type2Diabetes
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Fasting Health Benefits -
'According to the findings, a decrease in total and "bad" cholesterol was recorded at a rate approaching 10%, while improvement was also shown in markers related to liver and kidney function. At the same time, a drop in marker of inflammation was observed.' -
#liver : one whose course of life has some marked characteristic (expressed by an adjective)
- French: foie
- German: die Leber
- Italian: fegato
- Portuguese: fígado
- Spanish: hígado
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Fill in missing or incorrect translations @ https://wordofthehour.org/r/translations
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Occurrence And Tissue Distribution Of Per- And Polyfluoroalkyl Substances (PFAS) In Fishes From Waterbodies With Point And Non-Point Sources In Massachusetts, USA
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https://doi.org/10.1016/j.aquatox.2025.107499 <-- shared paper
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#GIS #spatial #mapping #spatialanalysis #Massachusetts #USA #PFAs #Largemouthbass #bass #Bandedkillifish #killifish #Pointsources #waterbody #Histology #Healthassessment #bioaccumulation #pfa #immunology #AshumetPond #SudburyRiver #pollution #contamination #toxicology #environmental #contaminants #PFOs #fish #fisheries #species #plasma #liver #muscle #cost #economics #publichealth #publicsafety #exposurepathways #testing #landuse #NLCD #recreationalfishing #angling #spatiotemporal #sediment
@USGS -
https://pubmed.ncbi.nlm.nih.gov/38957734/ Hepatic injury and hepatic failure adverse events in 3,4-methylenedioxymethamphetamine users reported to the FDA Adverse Event Reporting System (Makunts, et al, 2024) #mdma #dili #liver #psychedelic #psychedelicresearch #faers #fda #psychedelics #mdmaassistedtherapy — finding in estimated 20 million, perhaps 1 case of liver damage from MDMA, increased risk with poly drug use.
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#TheMetalDogArticleList #BraveWords FEAR FACTORY Guitarist DINO CAZARES On The Rise Of AI - "There's Gonna Be A Lot Of Changes Coming Up, And People Need To Be Prepared For It" (Video) bravewords.com/news/fear-fa... #FearFactory #DinoCazares #AI #HeavyMetal #Technology #Nanobots #Cancer #Liver
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#TheMetalDogArticleList
#BraveWords
FEAR FACTORY Guitarist DINO CAZARES On The Rise Of AI - "There's Gonna Be A Lot Of Changes Coming Up, And People Need To Be Prepared For It" (Video)#FearFactory #DinoCazares #AI #HeavyMetal #Technology #Nanobots #Cancer #Liver
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"In 1979, an internal company report deemed #PFOS 'certainly more #toxic than anticipated' and recommended longer-term studies. That year, #3M executives flew to San Francisco to consult Harold Hodge, a respected toxicologist. They told Hodge only part of what they knew: that PFOS had sickened and even killed laboratory animals and had caused #liver abnormalities in factory workers. According to a 3M document that was marked 'CONFIDENTIAL,' Hodge urged the executives to study whether the company’s fluorochemicals caused reproductive issues or cancer. After reviewing more data, he told one of them to find out whether the chemicals were present 'in man,' and he added, 'If the levels are high and widespread and the half-life is long, we could have a serious problem.' Yet Hodge’s warning was omitted from official meeting notes, and the company’s fluorochemical production increased over time."
https://www.propublica.org/article/3m-forever-chemicals-pfas-pfos-inside-story
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Study came out last month, sez Yeah, we know 10-30% of ppl who got COVID will get Long-COVID. But we're finding that 50 to 70%(!) of ppl who got COVID have organ or organs damaged, and have no idea!
#MaskUp #CovidKills #MasksWork #permanent #scarring #lungs #heart #murmur #intestine #damage #reduced #function #brain #cells #merge #lower #cognitive #ability #age #premature #aging #liver #kidney #LongCovid #risk #women #children #adolescent #respirator #mask #face #shield https://whn.global/scientific/spectrum-of-covid-19-from-asymptomatic-organ-damage-to-long-covid-syndrome/?fbclid=IwZXh0bgNhZW0CMTAAAR0FEWVKJ3P1xqBfUk30Q-ylF0Gs-GMns_H_HyNobTzjIji26m5w8B_La9k_aem_AXxP73QhzqaaByJ-1FwV7J9oIeg42g75GtmFbgrKVRdji21kzjbKLOI1wmUpyJXKkg1njcLvlP34JcUtSuAlSxM2 -
#Chemical companies’ #PFAS payouts are huge – but the problem is even bigger
#3M, #DuPont, #Chemours and #Corteva have agreed settlement in the billions for #polluting drinking #water with ‘forever chemicals’
by Tom Perkins, Aug 3, 2023
"“When the chemical giant 3M agreed in early June to pay up to $12.5bn to settle a lawsuit over PFAS contamination in water systems across the nation, it was hailed by attorneys as 'the largest drinking water settlement in American history', and viewed as a significant win for the public in the battle against toxic 'forever chemicals'.
“A second June settlement with the PFAS manufacturers DuPont, Chemours and Corteva tallied a hefty $1.1bn. But while the sums are impressive on their face, they represent just a fraction of the estimated $400bn some estimate will be needed to clean and protect the nation’s drinking water. Orange county, California, alone put the cost of cleaning its system at $1bn.
“‘While over a billion dollars is real money, it is a virtual drop in the bucket of potential utility costs to monitor, remove and dispose of these contaminants in accordance with anticipated federal regulations,' the American Municipal Water Association trade group said in a statement.
“Moreover, the two settlements include just over 6,000 water systems nationwide. Utilities that were not part of the suits but have PFAS in their systems can claim some of the settlement money, or they can sue the chemical manufacturers on their own.
“That means the settlements only represent the first wave of utility lawsuits to hit #ChemicalManufacturers, legal observers say. Because PFAS are so widely used and the scale of their harm is so great, chemical makers will get hit from a range of legal angles, and some suspect the industry’s final bill could exceed the $200bn paid by #BigTobacco in the 1990s.
“The number will be 'very large', said Kevin McKie, an attorney with the Environmental Litigation Group who represented a water management company in the 3M case. Though the 3M settlement does not cover all the nation’s costs, it is a strong start, he added.
“‘A good settlement is one where both sides walk away a bit frustrated’ is the old saying,' McKie said. 'Of course I would have liked a bit more money but I do believe they got as much as they could at this time, and there’s a lot more to go.'
“PFAS are a class of about 15,000 compounds used to make products across dozens of industries resistant to water, stains and heat. They are called 'forever chemicals' because they do not naturally break down, and are linked to #cancer, #KidneyDisease, #liver conditions, #immune disorders, #BirthDefects and other health problems.
“The chemicals are thought to be contaminating drinking water for over 200 million Americans. Tens of thousands of contaminated #PrivateWells are not included in the settlement. The chemicals are also widely used in thousands of consumer products from #DentalFloss to #cookware to #clothing, and have been found to #contaminate #food, #soil and #air.
“PFAS constantly cycle and accumulate throughout the environment, and removing them from water is costly. The highly mobile chemicals can slip through most utilities’ filtration systems. Granular activated carbon and reverse osmosis are considered the best options.
“Leaders in Stuart, Florida, which was the bellwether case in the 3M settlement, chose to take what they could get without further litigation. Bellwethers are cases that represent all the other plaintiffs in a multi-district lawsuit. Stuart estimated damages at up to $120m, and the city acknowledged the settlement would fall short.
“‘I don’t think we’ll ever get close to that much net to the city, so I think there is no making us whole,' Stuart’s city manager told the New York Times.
“Among those utilities going at it alone is the Cape Fear Public Utility Authority (CFPUA) near Wilmington, North Carolina, which sits on the #CapeFear River about 75 miles downstream from a Chemours PFAS manufacturing plant. It cost the utility about $46m to develop a granular activated carbon system to remove PFAS, and officials estimate an additional $5m in annual operational costs.
“The utility declined to comment, citing ongoing litigation, but in a late June op-ed, the CFPUA director Kenneth Waldrop explained the motivation for not joining the settlements: 'The information currently available suggests that the proposed settlement, when divided among thousands of other utilities with similar needs, would be insufficient to meet the needs of our community.'
“The utility has a 'strong case' against Chemours which has the reserves to cover the full cost, Waldrop added. There is generally support for that approach among Wilmington-area residents, said Emily Donovan, a public health advocate who lives in the region.
“‘This is not our fault, but it has been made our problem, and the community mostly understands what’s going on,' she said.
“The settlements also drew unlikely opponents in 22 state attorneys general who urged the judge to reject the 3M settlement because it 'does not adequately account for the pernicious damage that 3M has done in so many of our communities', said the California attorney general, Rob Bonta.
“Beyond water utility settlements, chemical makers face personal injury suits. Most US states will also probably sue over #contamination of #lakes, #rivers and other #NaturalResources #Minnesota alone found eliminating PFAS contamination from its wastewater could run to $28bn.
“Local water systems that are not made whole will need help from the federal government, which 'basically abandoned public water infrastructure a long time ago', said Oday Salim, director of the Environmental Law and Sustainability Clinic at the University of Michigan.
“‘Any amount of money that gets shifted to the victims is helpful,' he added.
“The government could implement an excise tax on PFAS to help cover costs, McKie said, and he noted the chemical manufacturers are taking a significant hit. By some estimates, 3M’s PFAS liabilities may soar to as much as $30bn as claims roll in.
“‘That’s a pretty big chunk of the total size of their corporation,' McKie said."#EPA #EPAFail #PFOS #WaterIsLife #ToxicWaste #ChemicalIndustries #ForeverChemicals
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Randomly selected image:
EMC_Phase3:images/cats/cats.ham/kitten04.ham #Dog #Liver #DogBreed #Carnivore #Fawn #CompanionDog #TerrestrialAnimal #WorkingAnimal #GunDog #Canidae -
Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients
Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk JaegerTargeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases
#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.
the microenvironment of #liver metastases of #colorectal cancer (#CRC).
the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.
the effects of CCR5 blockade on the #tissue level.
Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.
The microenvironment of the invasive margin of #liver metastases.
There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.
#CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).
The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.
A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.
CCR5 blockade, is a type of #therapy used to treat #cancer.
The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.
