#arthritis — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #arthritis, aggregated by home.social.
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How to setup your computer for better ergonomics, using FOSS
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https://www.europesays.com/ch/126504/ Novartis India eyes therapy-aligned acquisition, Tier 2-3 market push | Company News #arthritis #CardiovascularDisease #ChronicAndLifestyleLinkedDiseases #diabetes #GreaterInsurancePenetration #HealthcareInfrastructure #India #ManagingDirectorAndChiefExecutiveOfficer #Myfortic #NeurologicalDisorders #Neuroscience #Novartis #NOVARTISINDIALTD #Pain #PainManagement #Pharmaceuticals(NEC) #sandoz #Simulect #VikasGupta
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I think pre-emptive dosing myself with co-codamol before the arthritis hits my fingers is working. I've only had to use the splints for relief once this week so far.
The GP has increased the co-codamol strength so hopefully even that'll improve. -
I think pre-emptive dosing myself with co-codamol before the arthritis hits my fingers is working. I've only had to use the splints for relief once this week so far.
The GP has increased the co-codamol strength so hopefully even that'll improve. -
I think pre-emptive dosing myself with co-codamol before the arthritis hits my fingers is working. I've only had to use the splints for relief once this week so far.
The GP has increased the co-codamol strength so hopefully even that'll improve. -
I think pre-emptive dosing myself with co-codamol before the arthritis hits my fingers is working. I've only had to use the splints for relief once this week so far.
The GP has increased the co-codamol strength so hopefully even that'll improve. -
I think pre-emptive dosing myself with co-codamol before the arthritis hits my fingers is working. I've only had to use the splints for relief once this week so far.
The GP has increased the co-codamol strength so hopefully even that'll improve. -
New blog post on living with rheumatoid arthritis (RA) and moving to biologics as a treatment:
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New blog post on living with rheumatoid arthritis (RA) and moving to biologics as a treatment:
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New blog post on living with rheumatoid arthritis (RA) and moving to biologics as a treatment:
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New blog post on living with rheumatoid arthritis (RA) and moving to biologics as a treatment:
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New blog post on living with rheumatoid arthritis (RA) and moving to biologics as a treatment:
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2025-12-4 Celebrating my 10 year physical disability* anniversary in a rather eerie way.*Known disability, it’s possible to be disabled or have infection risk factors you don’t know about.
I started this in December and only finished it last week. Crip time!
https://www.illmarks.com/2025-12-4-exactly-10-years-since-mobility-impairment-broke-same-leg/ #anatomyArt #arthritis #bodyart #bodymapping #ChronicIlllness #CripTime #crutches #disabilityart #disabilitypride #DisabilityPrideMonth #dissociation #eds #heds #hsd #hypermobility #injury #medicalart #orthopedics #posttraumaticArthritis #proprioception -
Nice skeptic article as any true science should be. Anything that links the 2011 Russo paper "Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects" is to be celebrated. Here is the link again in case somebody missed it.
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x
Russo's paper has been cited 1,161 times and it deals with exogenous cannabinoids and terpenes synergy, not just endogenous o made inside our body, as did the original 1998 Mechoulam research.
Indeed, due to obsolete prohibitionism and sad profit-comes-first mentality, the current cannabis and hemp markets are a wild west of fake adultered product and unproven claims.
Yet since 2011 hundreds of studies have confirmed the entourage effect. Here is a small and incomplete collection of full spectrum extract papers 2004-2023.
https://www.cvresearch.info/full-spectrum-hemp-extracts-studies
OPs article calls for more standarized extract testing, even though Big Pharmas really prefers patentable, cheap to make, single molecule, symptom masking drugs. Good luck with that.
I agree with the article bottomline: governments should step up to the research task instead of trusting this critical matter to profit-driven corporations. Mixed isolate cannabis pharmaceuticals have been in the market for over a decade and proven their capabilities and limitations.
That is the case of Sativex, a 700 US$ 1:1 (thc:cbd) oral spray that controls some symptoms of MS yet fails to work for other conditions. Three separate studies ( Israeli, Brazilian and American) have since proven that full flower artisanal extracts are up to 6x more effective than expensive isolate preparations like Sativex
https://sensiseeds-com.translate.goog/es/blog/sativex-el-pionero-de-los-farmacos-derivados-del-cannabis/?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=es-419&_x_tr_pto=wapp#Cannabis #cannabismedicinal #thc #thca #cbd #cbda #entourageeffect
#cannabislegal #Cannabisgesetz
#cannabislegalisierung #ganja
#maconha #weed #cannabisculture
#cannabisresearch #chronicillness
#ptsd #arthritis #stress #depression
#multiplesclerosis #ImmuneSystem -
"A bias against cannabis still exists today. While the roots of weed prohibition have many unfortunate layers, storytelling played a huge role in negative public opinion around the plant. Some publications continue to feed into the modern version of “Reefer Madness,” what I call Reefer Madness 2.0. One article from a respected legacy publication just last year centered on how to get your neighbor evicted for smelling like weed. Not only is this type of storytelling cruel and inhumane (what if they are a medical patient, or a child with epilepsy?), most importantly, it’s not based on science."
Nice sunday read. The article goes on to propose to 1. Reframe Weed As Wellness, 2. Lean On Peer-Review Studies and 3. Dare To Question Existing Tech Platforms (and censorship). It advocates for invite-only discord grow diaries, yet fails to mention the #fediverse and #mastodon as great tools to keep #freedomofexpression and #humanrights going.
Lets get that corrected. Help me share this and let Rolling Stone know about our existence.
#medical #cannabismedicinal
#marijuana #weed #thc #thca #cbd #Cannabis
#Cannabisgesetz #cannabislegal
#marihuana #maconha #pain #ganja
#adhd #depression #sleep #stress #hemp #healthcare #nervepain
#righttorepair #pot #health #cannabismedicine #ChronicFatigueSyndrome #arthritis
#epilepsy #cancer #Lupus -
#Cannabidiol (#CBD): a killer for #inflammatory rheumatoid #arthritis synovial fibroblasts
Published: 01 September 2020
by Torsten Lowin, et al.Abstract:
"Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions."