#arthritis — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #arthritis, aggregated by home.social.
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Arthritis Drug Demonstrates Substantial Hair Regrowth in 1,400 Alopecia Patients
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Calgary boy’s arthritis diagnosis highlights a disease many still associate only with old age, Mark Villani reports. Read more at canadahealthwatch.ca #CdnHealth #Arthritis
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Calgary boy’s arthritis diagnosis highlights a disease many still associate only with old age, Mark Villani reports. Read more at canadahealthwatch.ca #CdnHealth #Arthritis
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Calgary boy’s arthritis diagnosis highlights a disease many still associate only with old age, Mark Villani reports. Read more at canadahealthwatch.ca #CdnHealth #Arthritis
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Calgary boy’s arthritis diagnosis highlights a disease many still associate only with old age, Mark Villani reports. Read more at canadahealthwatch.ca #CdnHealth #Arthritis
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Calgary boy’s arthritis diagnosis highlights a disease many still associate only with old age, Mark Villani reports. Read more at canadahealthwatch.ca #CdnHealth #Arthritis
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Dr Amir Khan shares heartbreaking reason millions of NHS patients are being dismissed
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Carly Simon diagnosed with Parkinson’s and cancer as she explains absence from public eye
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#Cannabidiol (#CBD): a killer for #inflammatory rheumatoid #arthritis synovial fibroblasts
Published: 01 September 2020
by Torsten Lowin, et al.Abstract:
"Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis. However, CBD binds to several receptors and enzymes and, therefore, its mode of action remains elusive. In this study, we show that CBD increases intracellular calcium levels, reduces cell viability and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF). These effects were pronounced under inflammatory conditions by activating transient receptor potential ankyrin (TRPA1), and by opening of the mitochondrial permeability transition pore. Changes in intracellular calcium and cell viability were determined by using the fluorescent dyes Cal-520/PoPo3 together with cell titer blue and the luminescent dye RealTime-glo. Cell-based impedance measurements were conducted with the XCELLigence system and TRPA1 protein was detected by flow cytometry. Cytokine production was evaluated by ELISA. CBD reduced cell viability, proliferation, and IL-6/IL-8 production of RASF. Moreover, CBD increased intracellular calcium and uptake of the cationic viability dye PoPo3 in RASF, which was enhanced by pre-treatment with TNF. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and PoPo3 uptake. In addition, an inhibitor of the mitochondrial permeability transition pore, cyclosporin A, also blocked the effects of CBD on cell viability and IL-8 production. PoPo3 uptake was inhibited by the voltage-dependent anion-selective channel inhibitor DIDS and Decynium-22, an inhibitor for all organic cation transporter isoforms. CBD increases intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of RASF by activating TRPA1 and mitochondrial targets. This effect was enhanced by pre-treatment with TNF suggesting that CBD preferentially targets activated, pro-inflammatory RASF. Thus, CBD possesses anti-arthritic activity and might ameliorate arthritis via targeting synovial fibroblasts under inflammatory conditions."
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👋 hello~ time for an #introduction!
this is my chill-space (aka, a personal side account)
📝 basics:
- hi hi i'm beso! ("kiss" in spanish)
- xe/he pronouns (more info on https://en.pronouns.page/viralvulpes)
- late 20s
- i'm a #singer and #artist, though i can't take art commissions often due to my health. (i post my creations in the tag #BesoMakesThings)👤 identity:
- soy xicano! i live in the usa
#xicano #chicano #latino
- i'm bi and polyam, in a throuple relationship
#bisexual #polyamory
- i'm a nonbinary just-some-guy (tme)
#trans #bigender #nonbinary
- mentally ill and neurodivergent
#depression #adhd #autistic #AuDHD #kinetic #KineticAutistic
- proudly (and exhaustedly) disabled
#disabled #fibro #mecfs #cfs #arthritis💖 likes:
- #tech #FOSS #libre
- #VideoGames #IndieGames #TTRPGs
- #manga #manhwa #manhua #webtoon #anime #WebNovel🔗 links:
- main: @[email protected]
- fandom: @[email protected]
- tumblr: https://foxpunk.tumblr.com
- discord: dm me to ask! -
📌 new pinned post! so i don't keep editing the old one haha
this is my main account, where i'll mostly post about tech, news, activism, and similar subjects.
📝 basics:
- hola~ i'm beso! ("kiss" in spanish 😚)
- xe/he pronouns (more info on https://en.pronouns.page/viralvulpes)
- late 20s
- i'm a #singer and #artist, though i can't take art commissions often due to my health. (i've posted some are here in my #BesoMakesThings tag)👤 identity:
- i'm a latino who lives along la frontera in the usa
#xicano #chicano #latino
- bi and polyam, in a throuple relationship
#bisexual #polyamory
- i'm a nonbinary just-some-guy (tme)
#trans #bigender #nonbinary
- mentally ill and neurodivergent
#depression #adhd #autistic #AuDHD #kinetic
- proudly (and exhaustedly) disabled
#disabled #fibro #mecfs #cfs #arthritis #CripplePunk
- very VERY vocal leftist💖 likes:
- #tech #FOSS #libre #accessibility #design #art
- #VideoGames #manga #anime #WebNovel🔗 links:
- personal: @[email protected]
- fandom: @[email protected]
- discord: dm me to ask! -
Just flown back to #geneva from #valencia where I presented at the international conference on #urbanhealth. I’m hoping to make that my #lastflight ever. #globalheating I’m 66, have been lucky to travel the world for my work in #globalhealth research. And leisure. I don’t need to go far anymore. Some long #train rides and using my #ev #tesla 😬 will suffice. #arthritis precludes cycling or much walking. #local