#monocytes — Public Fediverse posts

Question to anyone familar with #TransHealthcare #Hematology

Is there a relationship between elevated #WBC (#neutrophils, #lymphocytes, #monocytes) & #Platelets, decreased #RBC, #Hemocrit, #Anemia, #Hgb, #mpv and #HRT for male to female #transgender individuals with no other evidence of blood disease, infection or #cancer?

#CTScans are clean, #BoneMarrowBiopsy clean. Doc wants to repeat however.

Infiltrating #monocytes drive #cardiac #dysfunction in a #cardiomyocyte-restricted mouse model of #SARS-CoV-2 infection, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.01179-24?af=R

These findings establish a mouse #model of SARS-CoV-2 cardiomyocyte infection that recapitulates features of cardiac dysfunctions of COVID-19 and suggests that both viral replication and resultant innate immune responses contribute to cardiac pathology.

" The insights derived from this analysis do not only support a CD19 CAR T cell-mediated reset of the memory B cell compartment, but also the parallel inhibition of the interferon signature
in #monocytes and #Tcells of #SLE patients"

https://insight.jci.org/articles/view/179433

Striking that this apparently works better in getting rid of certain memory #Bcells than anti-CD20 antibodies.

#scRNAseq #TCR #carTcells #OpenAccess #science

#Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived #monocytes for enhanced tumor growth
Tsuyoshi Osawa et al show that low-oxygen conditions induce lineage-specific activation of #SREBP2 via #Golgi-ER fusion, promoting lipid biosynthesis, myeloid cell infiltration, and #tumorigenesis
https://www.embopress.org/doi/full/10.15252/embj.2023114032

Very exciting that this paper is out now in #cancercell: https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00216-7

In brief: we show that in esophageal #adenocarcinoma #checkpoint #therapy success is predicted by an independent combination of mutation burden and the amount of #monocytes in the tumour pre-treatment (as measured by RNAseq). Very exciting link between #myeloid cells and #immune response to #cancer!