#interferon — Public Fediverse posts

Antiviral type I #interferon responses must be tightly restrained to prevent damage. This study identifies ZC3H10 as a novel negative regulator that binds TTTC motifs in interferon-stimulated gene promoters to limit #antiviral gene expression during infection @PLOSBiology https://plos.io/3TFfe1M

Antiviral type I #interferon responses must be tightly restrained to prevent damage. This study identifies ZC3H10 as a novel negative regulator that binds TTTC motifs in interferon-stimulated gene promoters to limit #antiviral gene expression during infection @PLOSBiology https://plos.io/3TFfe1M

Study reveals coffee triggers distinct cytokine responses compared with pure caffeine

A controlled human study reveals that coffee’s complex chemical matrix may shape immune responses differently than pure caffeine,…
#NewsBeep #News #Health #AU #Australia #Biomarker #Caffeine #Coffee #Cytokine #Cytokines #Interferon #Metabolism #Nutrition #Pharmacokinetics #Physiology #publichealth #research
https://www.newsbeep.com/au/489828/

Study reveals coffee triggers distinct cytokine responses compared with pure caffeine

A controlled human study reveals that coffee’s complex chemical matrix may shape immune responses differently than pure caffeine,…
#NewsBeep #News #Health #AU #Australia #Biomarker #Caffeine #Coffee #Cytokine #Cytokines #Interferon #Metabolism #Nutrition #Pharmacokinetics #Physiology #publichealth #research
https://www.newsbeep.com/au/489828/

Differential modulation of #Interferon and Cell Death Responses defines #Human vs Avian #Influenza A Virus Strain-Specific Virulence and guides Combination #Therapy, https://etidiohnew.blogspot.com/2025/08/differential-modulation-of-interferon.html

Differential modulation of #Interferon and Cell Death Responses defines #Human vs Avian #Influenza A Virus Strain-Specific Virulence and guides Combination #Therapy, https://etidiohnew.blogspot.com/2025/08/differential-modulation-of-interferon.html

Prevalence of #EBV, #HHV6, #HCMV, #HAdV, #SARS-CoV-2, and #Autoantibodies to Type I #Interferon in #Sputum from Myalgic Encephalomyelitis / #CFS Patients, https://etidiohnew.blogspot.com/2025/03/prevalence-of-ebv-hhv6-hcmv-hadv-sars.html

Prevalence of #EBV, #HHV6, #HCMV, #HAdV, #SARS-CoV-2, and #Autoantibodies to Type I #Interferon in #Sputum from Myalgic Encephalomyelitis / #CFS Patients, https://etidiohnew.blogspot.com/2025/03/prevalence-of-ebv-hhv6-hcmv-hadv-sars.html

'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α, -β, and/or -ω can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'

#Immunology #Immunosky #interferon

https://www.pnas.org/doi/10.1073/pnas.2402983121

'Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-α, -β, and/or -ω can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition.'

#Immunology #Immunosky #interferon

https://www.pnas.org/doi/10.1073/pnas.2402983121

Im #Alter erhöht sich die Anfälligkeit für #Infektionen. Das kann auch daran liegen, dass der #Körper Autoantikörper gegen den wichtigen Immunbotenstoff #Interferon bildet. Was das bedeutet und wie wir uns schützen können: #covid #viren @UlrikeGebhardt https://www.riffreporter.de/de/wissen/erhoehte-infektanfaelligkeit-alter-immunabwehr-autoantikoerper-interferon-viren

Im #Alter erhöht sich die Anfälligkeit für #Infektionen. Das kann auch daran liegen, dass der #Körper Autoantikörper gegen den wichtigen Immunbotenstoff #Interferon bildet. Was das bedeutet und wie wir uns schützen können: #covid #viren @UlrikeGebhardt https://www.riffreporter.de/de/wissen/erhoehte-infektanfaelligkeit-alter-immunabwehr-autoantikoerper-interferon-viren

Human #SARSCoV2 challenge uncovers local and systemic response dynamics | Nature https://www.nature.com/articles/s41586-024-07575-x “observed that the #interferon response in blood preceded the nasopharyngeal response. Moreover, #nasopharyngeal immune infiltration occurred early in samples from individuals with only transient infection and later in samples from individuals with sustained infection. High expression of #HLADQA2 before inoculation was associated with preventing sustained infection” #COVID

'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNλ-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNλ.'
#Preprint #Immunology #InnateImmunity #Interferon

https://www.biorxiv.org/content/10.1101/2024.05.21.595218v1

'Here we examine the contribution of Mitogen Activated Protein Kinase (MAPK) signaling on IFNλ-mediated antiviral activity. We find that extracellular-signal-regulated kinase 5 (ERK5), a poorly characterized member of the conventional MAPK family, potentiates the antiviral efficacy of IFNλ.'
#Preprint #Immunology #InnateImmunity #Interferon

https://www.biorxiv.org/content/10.1101/2024.05.21.595218v1

"Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota."
Mao, Akiko Iwasaki et al
#Immunology #Interferon

https://www.pnas.org/doi/10.1073/pnas.2319566121

"Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota."
Mao, Akiko Iwasaki et al
#Immunology #Interferon

https://www.pnas.org/doi/10.1073/pnas.2319566121

A University of Cambridge-led study identifies the #protein #interferon gamma (IFN-γ) as a potential #biomarker for Long #COVID fatigue and highlights an #immunological mechanism underlying the disease
#Virology #Medical #sflorg
https://www.sflorg.com/2024/02/vi02212401.html

A University of Cambridge-led study identifies the #protein #interferon gamma (IFN-γ) as a potential #biomarker for Long #COVID fatigue and highlights an #immunological mechanism underlying the disease
#Virology #Medical #sflorg
https://www.sflorg.com/2024/02/vi02212401.html

#Omicron #Spike confers enhanced #infectivity and #interferon #resistance to #SARS-CoV-2 in #human nasal tissue https://www.nature.com/articles/s41467-024-45075-8

#Omicron #Spike confers enhanced #infectivity and #interferon #resistance to #SARS-CoV-2 in #human nasal tissue https://www.nature.com/articles/s41467-024-45075-8

Longitudinal single #cell #atlas identifies complex temporal #relationship between type I #interferon response and #COVID19 severity https://www.nature.com/articles/s41467-023-44524-0

Longitudinal single #cell #atlas identifies complex temporal #relationship between type I #interferon response and #COVID19 severity https://www.nature.com/articles/s41467-023-44524-0

from ⬆️ "These nettles are renowned for inflicting extremely painful stings that are characterized by acute electric shocklike, piercing, pricking and burning sensations lasting for many hours, followed by intermittent painful flares and allodynia that persists for days or even weeks."

Similarities to other types of neuropathic pain, including small fiber neuropathy and Long Covid associated neuropathy.

~

"These results provide important insights into the function of NaV channels in sensory neurons, identify TMEM233 as a previously unknown NaV1.7interacting protein, and describe the dispanins as bifunctional proteins that cause allosteric changes in channel gating upon binding of pain causing venom peptides."

~

Not finding much on TMEM233. Some dispanins are interferon activated.

review article from 2012:
- The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members
https://doi.org/10.1371%2Fjournal.pone.0031961

"The IFITM1–3 proteins were identified 25 years ago as being upregulated by interferons (IFN) [6]. Recently they received considerable attentions as IFITM1–3 were found to prevent infection of a growing list of viruses such as HIV-1, SARS influenza A H1N1, West Nile and Dengue fever viruses [7], [8], [9], [10]. Hence, proteins of the IFITM family mediate part of the antiviral response orchestrated by IFNs. However, the IFITM family is also involved in other processes such as oncogenesis, bone mineralization (IFITM5) and germ cell development (IFITM1 and 3) and IFITM5 has not been identified as interferon-inducible [11], [12], [13], [14]. Although the biological roles of the IFITM genes are emerging, no thorough evolutionary analysis has been performed on this group.

In this study, we sought to infer the evolutionary history of the human IFITM genes and identify potential homologues. We mined 36 eukaryotic species, covering all major eukaryotic groups, and found that the IFITMs form a subfamily in a larger novel family that has ten human members in addition to the four IFITM genes. We propose Dispanins as a novel name for this family, which refers to their common 2TM structure. "

#TMEM233 #dispanins #IFITM #interferon #Pain #neuropathy

Always been curious how different interferons that signal through same receptor can have different functional effect. Here's a paper that shows how:
#interferon #immunology #receptor #receptors #Signalling https://www.science.org/doi/10.1126/scisignal.adf5494

Always been curious how different interferons that signal through same receptor can have different functional effect. Here's a paper that shows how:
#interferon #immunology #receptor #receptors #Signalling https://www.science.org/doi/10.1126/scisignal.adf5494

Researchers found that #interferon-gamma signaling caused hyperactivation of ERK in human #melanoma cell lines. The #ERK protein, when hyperactive, causes stress in the #cell, and this stress ultimately leads to cell death through specific proteins called #DR5 and #NOXA
#Cancer #Medical #sflorg
https://www.sflorg.com/2023/10/med10102301.html

Researchers found that #interferon-gamma signaling caused hyperactivation of ERK in human #melanoma cell lines. The #ERK protein, when hyperactive, causes stress in the #cell, and this stress ultimately leads to cell death through specific proteins called #DR5 and #NOXA
#Cancer #Medical #sflorg
https://www.sflorg.com/2023/10/med10102301.html

Now I cant stop singing "more than a spike gene" to the tune of the BeeGees (protein didnt fit the meter).

'We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors.'
#Covid #Covid19 #SarsCov2 #Interferon #Virology #Immunology #InnateImmunity

https://www.sciencedirect.com/science/article/pii/S1931312823003281

Now I cant stop singing "more than a spike gene" to the tune of the BeeGees (protein didnt fit the meter).

'We assessed the role of ORF6 during infection using recombinant viruses carrying a deletion or loss-of-function (LoF) mutation in ORF6. ORF6 plays key roles in interferon antagonism and viral pathogenesis by interfering with nuclear import and specifically the translocation of IRF and STAT transcription factors.'
#Covid #Covid19 #SarsCov2 #Interferon #Virology #Immunology #InnateImmunity

https://www.sciencedirect.com/science/article/pii/S1931312823003281

Some evidence type I IFN being beneficial in airway infections.

But lots of caveats, context-specific issues, mouse models, etc....
#IFN #Interferon #bacteria #infection #MAIT #immunology #Science @JExpMed
https://rupress.org/jem/article/220/10/e20230037/276132/Type-I-interferons-drive-MAIT-cell-functions?guestAccessKey=9a754261-0c2a-4913-b3b7-d98c2395c025&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2pnqf6-cox1lz-cwe4ixj5

Some evidence type I IFN being beneficial in airway infections.

But lots of caveats, context-specific issues, mouse models, etc....
#IFN #Interferon #bacteria #infection #MAIT #immunology #Science @JExpMed
https://rupress.org/jem/article/220/10/e20230037/276132/Type-I-interferons-drive-MAIT-cell-functions?guestAccessKey=9a754261-0c2a-4913-b3b7-d98c2395c025&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2pnqf6-cox1lz-cwe4ixj5

'Here, we used CRISPR-based loss-of-function screens to identify a markedly limited set of ISGs that confer interferon-mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectors—ZAP, IFIT3, and IFIT1—together constitute the majority of interferon-mediated restriction of VEEV, while accounting for < 0.5% of the interferon-induced transcriptome.'

#Immunology #Virology #Interferon

https://www.embopress.org/doi/full/10.15252/embr.202356901

'Here, we used CRISPR-based loss-of-function screens to identify a markedly limited set of ISGs that confer interferon-mediated suppression of a model alphavirus, Venezuelan equine encephalitis virus (VEEV). We show via combinatorial gene targeting that three antiviral effectors—ZAP, IFIT3, and IFIT1—together constitute the majority of interferon-mediated restriction of VEEV, while accounting for < 0.5% of the interferon-induced transcriptome.'

#Immunology #Virology #Interferon

https://www.embopress.org/doi/full/10.15252/embr.202356901

Issue 14:
Highlight on #ROR1 and #pancreatic #malignancy

Review on viral recognition and #antiviral #interferon response

#Autophagy news from plants and mammals
How #p97 disassembles a regulatory protein complex
Developmental #axon pruning by a #phospholipid #scramblase

Cover: Elisa Nerli, Caren Norden and colleagues

https://www.embopress.org/toc/14602075/2023/42/14

Issue 14:
Highlight on #ROR1 and #pancreatic #malignancy

Review on viral recognition and #antiviral #interferon response

#Autophagy news from plants and mammals
How #p97 disassembles a regulatory protein complex
Developmental #axon pruning by a #phospholipid #scramblase

Cover: Elisa Nerli, Caren Norden and colleagues

https://www.embopress.org/toc/14602075/2023/42/14

New review by Rune Hartmann and colleagues:
Viral recognition and the #antiviral #interferon response
https://www.embopress.org/doi/full/10.15252/embj.2022112907

New review by Rune Hartmann and colleagues:
Viral recognition and the #antiviral #interferon response
https://www.embopress.org/doi/full/10.15252/embj.2022112907

"Our investigation reveals that the fetal HSCs respond to T. gondii infection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. Furthermore, maternal IFNγ crosses the fetal–maternal interface, where it is perceived by fetal HSCs."

#Immunology #Interferon #Toxoplasma

https://www.embopress.org/doi/full/10.15252/embj.2022112693

"Our investigation reveals that the fetal HSCs respond to T. gondii infection with virulence-dependent changes in proliferation, self-renewal potential, and lineage output. Furthermore, maternal IFNγ crosses the fetal–maternal interface, where it is perceived by fetal HSCs."

#Immunology #Interferon #Toxoplasma

https://www.embopress.org/doi/full/10.15252/embj.2022112693

#Interferon-inducible #phospholipids govern #IFITM3-dependent #endosomal #antiviral immunity

#Phosphatidylinositol(3,4,5)-trisphosphate enhances inhibition of #endocytic viral entry via binding to the intracellular loop of interferon-induced transmembrane protein 3

Anna Kajaste-Rudnitski, Giulia Unali et al

https://www.embopress.org/doi/10.15252/embj.2022112234

#Interferon-inducible #phospholipids govern #IFITM3-dependent #endosomal #antiviral immunity

#Phosphatidylinositol(3,4,5)-trisphosphate enhances inhibition of #endocytic viral entry via binding to the intracellular loop of interferon-induced transmembrane protein 3

Anna Kajaste-Rudnitski, Giulia Unali et al

https://www.embopress.org/doi/10.15252/embj.2022112234

The dose & duration of type I #interferon exposure is interpreted by a signaling module with a stimulus-contingent positive feedback loop. A secondary potentiated phase of ISGF3 activates pro-inflammatory gene expression ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211294 #cellsignaling #SystemsBiology
from Alex Hoffmann, UCLA

The dose & duration of type I #interferon exposure is interpreted by a signaling module with a stimulus-contingent positive feedback loop. A secondary potentiated phase of ISGF3 activates pro-inflammatory gene expression ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211294 #cellsignaling #SystemsBiology
from Alex Hoffmann, UCLA

'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'

#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity

https://onlinelibrary.wiley.com/doi/10.1002/art.42482

'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'

#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity

https://onlinelibrary.wiley.com/doi/10.1002/art.42482

This week's #Coronavirus Tidbits newsletter has clips abt #Marburg, new virus, #interferon, persistent organ damage, #LongCovid, #masks, #ventilation, anti-#Trans bills, #BannedBooks, #NorfolkSouthern, #Covid, #politics and more, incl #FeelGood stories

https://www.drjudystone.com/coronavirus-tidbits-233-2-19-22/

@czarbucks

This week's #Coronavirus Tidbits newsletter has clips abt #Marburg, new virus, #interferon, persistent organ damage, #LongCovid, #masks, #ventilation, anti-#Trans bills, #BannedBooks, #NorfolkSouthern, #Covid, #politics and more, incl #FeelGood stories

https://www.drjudystone.com/coronavirus-tidbits-233-2-19-22/

@czarbucks

Viral mimicry of a #DCAF #ubiquitin #ligase adaptor: #CryoEM shows how rodent #cytomegalovirus #CMV E27/M27 hijacks host cell #CRL4 #cullin-RING E3s to degrade #STAT2 and suppress #antiviral #interferon signaling
https://www.embopress.org/doi/10.15252/embj.2022112351

One-and-done injection halves risk of COVID hospitalization in large trial

An injectable interferon drug significantly reduced the risk that people with COVID-19 would be hospitalized with the disease.

#Covid19 #MedicalTrials #Interferon #Covid #CovidIsNotOver #MedMastodon

https://www.livescience.com/one-and-done-injection-halves-risk-of-covid-hospitalization-in-large-trial