#cytoskeleton — Public Fediverse posts

New preprint:

Mutating the interprotofilament interface allows microtubules to assemble in GDP

Yean Ming Chew and Rob Cross

#cytoskeleton #microtubule

https://www.biorxiv.org/content/10.64898/2026.07.09.737542v1

New preprint:

Mutating the interprotofilament interface allows microtubules to assemble in GDP

Yean Ming Chew and Rob Cross

#cytoskeleton #microtubule

https://www.biorxiv.org/content/10.64898/2026.07.09.737542v1

So far we heard from Marija Zanic who talked about SSNA1, a sensor for microtubule damage and microtubule stabiliser, that increases their rigidity and protects against breakage.

Next, Varun Ramaswamy described how he tackled the difficult problem of determining the structure of full length HSET motor.

#Biophysics #Cytoskeleton

So far we heard from Marija Zanic who talked about SSNA1, a sensor for microtubule damage and microtubule stabiliser, that increases their rigidity and protects against breakage.

Next, Varun Ramaswamy described how he tackled the difficult problem of determining the structure of full length HSET motor.

#Biophysics #Cytoskeleton

Meharry Medical College student Mudiare Ikoba highlights a publication in the Journal of Cell Biology from SBGrid member Antonina Roll-Mecak and colleagues in which the authors analyze the structure of the RPGR-TTLL5 complex to shed light on the pathomechanism of retititis pigmentosa.

Read more here: https://medium.com/sbgrid-community-news/how-proteins-work-together-to-support-our-vision-e4e1a30a6850

#SBGrid #Cytoskeleton #Retina

Today's talk will be:

Isaac Wong (Dunn School, Oxford)

Mechanical Principles of Centrosome Assembly and Function

CTU 0.08/09 at 13.05

#CellBiology #cytoskeleton

Today's talk will be:

Isaac Wong (Dunn School, Oxford)

Mechanical Principles of Centrosome Assembly and Function

CTU 0.08/09 at 13.05

#CellBiology #cytoskeleton

🚨 NEW PAPER 🚨

Vishakha and colleagues in the Cross group show that ATPγS causes single kinesin molecules to pause under load in an Await-Isomerisation (AI) state that leaks hand-over-hand backsteps.

"ATPγS substantially defeats the biasing mechanism for kinesin steps”

https://www.nature.com/articles/s41467-026-69573-z

#biophysics #cytoskeleton #cellbiology #MotorHeads

🚨 NEW PAPER 🚨

Vishakha and colleagues in the Cross group show that ATPγS causes single kinesin molecules to pause under load in an Await-Isomerisation (AI) state that leaks hand-over-hand backsteps.

"ATPγS substantially defeats the biasing mechanism for kinesin steps”

https://www.nature.com/articles/s41467-026-69573-z

#biophysics #cytoskeleton #cellbiology #MotorHeads

📰 "Active Force Dynamics in Red Blood Cells Under Non-Invasive Optical Tweezers"
https://doi.org/doi:10.1002/advs.202514778
https://pubmed.ncbi.nlm.nih.gov/41431175/
#Cytoskeleton #Mechanical #Force

📰 "Actin and vimentin jointly control cell viscoelasticity and compression stiffening"
https://doi.org/doi:10.1091/mbc.E24-12-0584
https://pubmed.ncbi.nlm.nih.gov/41400926/
#Cytoskeleton #Mechanical #Actin

📰 "Active Force Dynamics in Red Blood Cells Under Non-Invasive Optical Tweezers"
https://arxiv.org/abs/2512.01417 #Physics.Bio-Ph #Cytoskeleton #Mechanical #Q-Bio.Sc #Q-Bio.Bm #Q-Bio.Cb #Force

Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here:

https://tinyurl.com/mechanochemistry

#CellBiology #Cytoskeleton #MotorHeads #Cytoskeleton

Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here:

https://tinyurl.com/mechanochemistry

#CellBiology #Cytoskeleton #MotorHeads #Cytoskeleton

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=5562

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=5562

"Charting the landscape of cytoskeletal diversity in microbial eukaryotes", Mikus et al. 2025 (Dudin lab)
https://www.cell.com/cell/fulltext/S0092-8674(25)01127-4

CC @davi

#CellBiology #cytoskeleton #ExM

"Charting the landscape of cytoskeletal diversity in microbial eukaryotes", Mikus et al. 2025 (Dudin lab)
https://www.cell.com/cell/fulltext/S0092-8674(25)01127-4

CC @davi

#CellBiology #cytoskeleton #ExM

Anne says: The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.

#biophysics #cytoskeleton #motorheads

Anne says: The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.

#biophysics #cytoskeleton #motorheads

@sellathechemist @compoundchem phallotoxins like phalloidin, also fascinating. Used extensively in #CellBiology research to label #Actin #Cytoskeleton, but i don't really know the route of toxicity in animals.

@sellathechemist @compoundchem phallotoxins like phalloidin, also fascinating. Used extensively in #CellBiology research to label #Actin #Cytoskeleton, but i don't really know the route of toxicity in animals.

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=3812

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=3812

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=2699

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=2699

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=1628

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=1628

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=501

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=501

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

📰 "The influence of hydrogel stiffness on axonal regeneration after spinal cord injury"
https://doi.org/doi:10.1371/journal.pone.0325798
https://pubmed.ncbi.nlm.nih.gov/40560940/
#Cytoskeleton #Mechanical

📰 "Missense and Inframe Pathogenic Variants in PLEC Lead to Minimal or Delayed-Onset Muscular Dystrophy in Autosomal Recessive Epidermolysis Bullosa Simplex: A Genotype-Phenotype Correlation in Nine Cases"
https://doi.org/doi:10.1111/1346-8138.17785
https://pubmed.ncbi.nlm.nih.gov/40525783/
#Cytoskeleton #Mechanical

📰 "Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis"
https://doi.org/doi:10.1063/5.0255473
https://pubmed.ncbi.nlm.nih.gov/40502441/
#Mechanotransduction #Extracellular #Cytoskeleton #Mechanical

📰 "The divergent intron-containing actin in sponge morphogenetic processes"
https://doi.org/doi:10.1093/nargab/lqaf071
https://pubmed.ncbi.nlm.nih.gov/40491973/
#Cytoskeleton #Mechanical #Actin

📰 "Defect states in compressible active polar fluids with turnover"
https://arxiv.org/abs/2506.03795 #Physics.Bio-Ph #Cond-Mat.Soft #Cytoskeleton #Mechanical

📰 "Computational modeling of biomechanical response of osteocyte integrin and cytoskeleton based on the piezoelectricity of bone matrix"
https://doi.org/doi:10.1016/j.jbiomech.2025.112778
https://pubmed.ncbi.nlm.nih.gov/40446493/
#Cytoskeleton #Mechanical #Matrix

📰 "Plectin affects cell viscoelasticity at small and large deformations"
https://www.biorxiv.org/content/10.1101/2025.05.28.656588v1?rss=1 #Cytoskeleton #Mechanical #Cell

📰 "Mechanical Responses of the Giant Nesprin-2"
https://www.biorxiv.org/content/10.1101/2025.05.30.657030v1?rss=1 #Mechanotransduction #Cytoskeleton #Mechanical

📰 "The impact of Talin2, a signaling protein regulating the focal adhesion complex, on asthma"
https://doi.org/doi:10.1093/intimm/dxaf026
https://pubmed.ncbi.nlm.nih.gov/40401633/
#Cytoskeleton #Mechanical #Adhesion

📰 "Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery"
https://doi.org/doi:10.1016/j.mbm.2024.100040
https://pubmed.ncbi.nlm.nih.gov/40395451/
#Cytoskeleton #Mechanical

📰 "Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC"
https://doi.org/doi:10.1039/d4mo00154k
https://pubmed.ncbi.nlm.nih.gov/40353692/
#Morphogenesis #Cytoskeleton #Mechanical #Adhesion

🚨NEW PREPRINT 🚨 from the Cross lab.

Karnawat et al.

ATPγS unbiases kinesin

https://doi.org/10.1101/2025.05.01.651652

#motorheads #cytoskeleton #cellBiology #biophysics

🚨NEW PREPRINT 🚨 from the Cross lab.

Karnawat et al.

ATPγS unbiases kinesin

https://doi.org/10.1101/2025.05.01.651652

#motorheads #cytoskeleton #cellBiology #biophysics

Our Director, Rob Cross is giving a BMS Seminar today

Interlocking nanomechanics of kinesin and microtubules.

1pm IBRB LT

#CellBiology #Cytoskeleton #MotorHeads #Biophysics

Our Director, Rob Cross is giving a BMS Seminar today

Interlocking nanomechanics of kinesin and microtubules.

1pm IBRB LT

#CellBiology #Cytoskeleton #MotorHeads #Biophysics

James and Selena's paper is out in JCB!

We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.

https://doi.org/10.1083/jcb.202407002

#CellBiology #StructBio #cytoskeleton

New preprint from the Balasubramanian lab

"Fluorescent protein tags for human tropomyosin isoform comparison”

https://doi.org/10.1101/2025.02.25.640032

#CellBiology #Microscopy #Cytoskeleton

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

📰 "Mechanics of Single Cytoskeletal Filaments"
https://doi.org/doi:10.1146/annurev-biophys-030722-120914
https://pubmed.ncbi.nlm.nih.gov/39929532/
#Cytoskeletal #Cytoskeleton #Mechanical #Mechanics

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

Kicking off 2025 with a new paper by Ferdos Abid Ali & Alex Zwetsloot et al.

KIF1C activates and extends dynein movement through the FHF cargo adapter. Nat Struct Mol Biol (2025).

https://doi.org/10.1038/s41594-024-01418-z

#cytoskeleton #biophysics #cryoEM #MotorHeads #CellBiology