#cytoskeleton — Public Fediverse posts

📰 "Entropy-Driven Initiation and Cellular Uptake Mediated by Viscoelastic Cytoskeleton: A Kinetic Phase Diagram from Onsager Variational Principle"
https://arxiv.org/abs/2607.12766 #Cond-Mat.Stat-Mech #Physics.Bio-Ph #Cond-Mat.Soft #Cytoskeleton #Q-Bio.Sc #Force

📰 "A multiscale cytoskeletal network model for shear rheological property and its evolutionary mechanism"
https://www.biorxiv.org/content/10.64898/2026.07.13.738349v1?rss=1 #Cytoskeletal #Cytoskeleton #Mechanical

📰 "A multiscale cytoskeletal network model for shear rheological property and its evolutionary mechanism"
https://www.biorxiv.org/content/10.64898/2026.07.13.738349v1?rss=1 #Cytoskeletal #Cytoskeleton #Mechanical

Study explains how environmental acidity destabilizes internal cellular traffic https://www.byteseu.com/2054442/ #Actin #Cancer #Cell #CellularTraffic #Cytoskeleton #diabetes #environment #GolgiApparatus #neuroscience #pH #Protein #Research #stress #Tumor

Meharry Medical College student Mudiare Ikoba highlights a publication in the Journal of Cell Biology from SBGrid member Antonina Roll-Mecak and colleagues in which the authors analyze the structure of the RPGR-TTLL5 complex to shed light on the pathomechanism of retititis pigmentosa.

Read more here: https://medium.com/sbgrid-community-news/how-proteins-work-together-to-support-our-vision-e4e1a30a6850

#SBGrid #Cytoskeleton #Retina

Meharry Medical College student Mudiare Ikoba highlights a publication in the Journal of Cell Biology from SBGrid member Antonina Roll-Mecak and colleagues in which the authors analyze the structure of the RPGR-TTLL5 complex to shed light on the pathomechanism of retititis pigmentosa.

Read more here: https://medium.com/sbgrid-community-news/how-proteins-work-together-to-support-our-vision-e4e1a30a6850

#SBGrid #Cytoskeleton #Retina

Meharry Medical College student Mudiare Ikoba highlights a publication in the Journal of Cell Biology from SBGrid member Antonina Roll-Mecak and colleagues in which the authors analyze the structure of the RPGR-TTLL5 complex to shed light on the pathomechanism of retititis pigmentosa.

Read more here: https://medium.com/sbgrid-community-news/how-proteins-work-together-to-support-our-vision-e4e1a30a6850

#SBGrid #Cytoskeleton #Retina

📰 "Actin and vimentin jointly control cell viscoelasticity and compression stiffening"
https://doi.org/doi:10.1091/mbc.E24-12-0584
https://pubmed.ncbi.nlm.nih.gov/41400926/
#Cytoskeleton #Mechanical #Actin

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=5562

@sellathechemist @compoundchem phallotoxins like phalloidin, also fascinating. Used extensively in #CellBiology research to label #Actin #Cytoskeleton, but i don't really know the route of toxicity in animals.

@sellathechemist @compoundchem phallotoxins like phalloidin, also fascinating. Used extensively in #CellBiology research to label #Actin #Cytoskeleton, but i don't really know the route of toxicity in animals.

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=3812

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=2699

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=1628

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=501

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

📰 "Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis"
https://doi.org/doi:10.1063/5.0255473
https://pubmed.ncbi.nlm.nih.gov/40502441/
#Mechanotransduction #Extracellular #Cytoskeleton #Mechanical

📰 "The divergent intron-containing actin in sponge morphogenetic processes"
https://doi.org/doi:10.1093/nargab/lqaf071
https://pubmed.ncbi.nlm.nih.gov/40491973/
#Cytoskeleton #Mechanical #Actin

📰 "Kinesin-Driven De-Mixing of Cytoskeleton Composites Drives Emergent Mechanical Properties"
https://doi.org/doi:10.1002/marc.202401128
https://pubmed.ncbi.nlm.nih.gov/40205878/
#Cytoskeleton #Mechanical #Kinesin

James and Selena's paper is out in JCB!

We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.

https://doi.org/10.1083/jcb.202407002

#CellBiology #StructBio #cytoskeleton

James and Selena's paper is out in JCB!

We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.

https://doi.org/10.1083/jcb.202407002

#CellBiology #StructBio #cytoskeleton

James and Selena's paper is out in JCB!

We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.

https://doi.org/10.1083/jcb.202407002

#CellBiology #StructBio #cytoskeleton

James and Selena's paper is out in JCB!

We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.

https://doi.org/10.1083/jcb.202407002

#CellBiology #StructBio #cytoskeleton

James and Selena's paper is out in JCB!

We present a structural model of the interaction between TACC3 and ch-TOG. Then we discover Affimers that can inhibit this interaction. Expression of the Affimers in cells uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis.

https://doi.org/10.1083/jcb.202407002

#CellBiology #StructBio #cytoskeleton

📰 "Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus"
https://doi.org/doi:10.1073/pnas.2501264122
https://pubmed.ncbi.nlm.nih.gov/40042901/
#Mechanosensing #Cytoskeleton #Cell

📰 "Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus"
https://doi.org/doi:10.1073/pnas.2501264122
https://pubmed.ncbi.nlm.nih.gov/40042901/
#Mechanosensing #Cytoskeleton #Cell

📰 "Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus"
https://doi.org/doi:10.1073/pnas.2501264122
https://pubmed.ncbi.nlm.nih.gov/40042901/
#Mechanosensing #Cytoskeleton #Cell

📰 "Nanoscale distribution of bioactive ligands on biomaterials regulates cell mechanosensing through translocation of actin into the nucleus"
https://doi.org/doi:10.1073/pnas.2501264122
https://pubmed.ncbi.nlm.nih.gov/40042901/
#Mechanosensing #Cytoskeleton #Cell

📰 "The keratin cortex stabilizes cells at high strains"
https://www.biorxiv.org/content/10.1101/2025.02.24.639846v1?rss=1 #Cytoskeleton #Mechanical #Keratin

📰 "The keratin cortex stabilizes cells at high strains"
https://www.biorxiv.org/content/10.1101/2025.02.24.639846v1?rss=1 #Cytoskeleton #Mechanical #Keratin

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

📰 "Mechanics of Single Cytoskeletal Filaments"
https://doi.org/doi:10.1146/annurev-biophys-030722-120914
https://pubmed.ncbi.nlm.nih.gov/39929532/
#Cytoskeletal #Cytoskeleton #Mechanical #Mechanics

📰 "Mechanics of Single Cytoskeletal Filaments"
https://doi.org/doi:10.1146/annurev-biophys-030722-120914
https://pubmed.ncbi.nlm.nih.gov/39929532/
#Cytoskeletal #Cytoskeleton #Mechanical #Mechanics