#cytoskeleton — Public Fediverse posts

So far we heard from Marija Zanic who talked about SSNA1, a sensor for microtubule damage and microtubule stabiliser, that increases their rigidity and protects against breakage.

Next, Varun Ramaswamy described how he tackled the difficult problem of determining the structure of full length HSET motor.

#Biophysics #Cytoskeleton

Meharry Medical College student Mudiare Ikoba highlights a publication in the Journal of Cell Biology from SBGrid member Antonina Roll-Mecak and colleagues in which the authors analyze the structure of the RPGR-TTLL5 complex to shed light on the pathomechanism of retititis pigmentosa.

Read more here: https://medium.com/sbgrid-community-news/how-proteins-work-together-to-support-our-vision-e4e1a30a6850

#SBGrid #Cytoskeleton #Retina

Today's talk will be:

Isaac Wong (Dunn School, Oxford)

Mechanical Principles of Centrosome Assembly and Function

CTU 0.08/09 at 13.05

#CellBiology #cytoskeleton

🚨 NEW PAPER 🚨

Vishakha and colleagues in the Cross group show that ATPγS causes single kinesin molecules to pause under load in an Await-Isomerisation (AI) state that leaks hand-over-hand backsteps.

"ATPγS substantially defeats the biasing mechanism for kinesin steps”

https://www.nature.com/articles/s41467-026-69573-z

#biophysics #cytoskeleton #cellbiology #MotorHeads

https://www.europesays.com/ie/305585/ Physical behavior reveals aggressive cancer cells in a simple new approach #Actin #cancer #Cell #CellNucleus #Cytoskeleton #Diagnostic #Éire #Genes #Genetic #Health #IE #Ireland #Laboratory #Metastasis #Nanoscience #Nanotechnology #Research #Technology #Tumor

Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here:

https://tinyurl.com/mechanochemistry

#CellBiology #Cytoskeleton #MotorHeads #Cytoskeleton

Axons and dendrites are fundamentally different. An example from #Drosophila:

"axons and dendrites can accumulate different microtubule-binding proteins; protein synthesis machinery is concentrated in the cell body; pre- and post-synaptic sites localize to distinct regions of the neuron; and specializations similar to the initial segment are present. In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity."

"Polarity and intracellular compartmentalization of Drosophila neurons", Rolls et al. 2007
https://link.springer.com/article/10.1186/1749-8104-2-7

To collapse axons and dendrites into point neurons in a simulation of neural circuits is, at this point, malpractice.

#neuroscience #cytoskeleton #axons #dendrites

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=5562

"Charting the landscape of cytoskeletal diversity in microbial eukaryotes", Mikus et al. 2025 (Dudin lab)
https://www.cell.com/cell/fulltext/S0092-8674(25)01127-4

CC @davi

#CellBiology #cytoskeleton #ExM

Anne says: The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.

#biophysics #cytoskeleton #motorheads

@sellathechemist @compoundchem phallotoxins like phalloidin, also fascinating. Used extensively in #CellBiology research to label #Actin #Cytoskeleton, but i don't really know the route of toxicity in animals.

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=3812

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=2699

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=1628

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)
UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/

#biologicalphysics #biophysics #cellbiology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?fsp_sid=501

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97647

Postdoc in the Hueschen Lab, UCSD (biophysics, cell biology, parasites)

UC San Diego

See the full job description on jobRxiv: https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

#biological_physics #biophysics #cell_biology #cytoskeleton #parasites #ScienceJobs #hiring #research
https://jobrxiv.org/job/uc-san-diego-27778-postdoc-in-the-hueschen-lab-ucsd-biophysics-cell-biology-parasites/?feed_id=97640

📰 "The influence of hydrogel stiffness on axonal regeneration after spinal cord injury"
https://doi.org/doi:10.1371/journal.pone.0325798
https://pubmed.ncbi.nlm.nih.gov/40560940/
#Cytoskeleton #Mechanical

📰 "Missense and Inframe Pathogenic Variants in PLEC Lead to Minimal or Delayed-Onset Muscular Dystrophy in Autosomal Recessive Epidermolysis Bullosa Simplex: A Genotype-Phenotype Correlation in Nine Cases"
https://doi.org/doi:10.1111/1346-8138.17785
https://pubmed.ncbi.nlm.nih.gov/40525783/
#Cytoskeleton #Mechanical

📰 "Emerging mechanomedicines informed by mechanotransduction along the integrin-cytoskeleton-nucleus axis"
https://doi.org/doi:10.1063/5.0255473
https://pubmed.ncbi.nlm.nih.gov/40502441/
#Mechanotransduction #Extracellular #Cytoskeleton #Mechanical

📰 "The divergent intron-containing actin in sponge morphogenetic processes"
https://doi.org/doi:10.1093/nargab/lqaf071
https://pubmed.ncbi.nlm.nih.gov/40491973/
#Cytoskeleton #Mechanical #Actin

📰 "Defect states in compressible active polar fluids with turnover"
https://arxiv.org/abs/2506.03795 #Physics.Bio-Ph #Cond-Mat.Soft #Cytoskeleton #Mechanical

📰 "Computational modeling of biomechanical response of osteocyte integrin and cytoskeleton based on the piezoelectricity of bone matrix"
https://doi.org/doi:10.1016/j.jbiomech.2025.112778
https://pubmed.ncbi.nlm.nih.gov/40446493/
#Cytoskeleton #Mechanical #Matrix

📰 "Plectin affects cell viscoelasticity at small and large deformations"
https://www.biorxiv.org/content/10.1101/2025.05.28.656588v1?rss=1 #Cytoskeleton #Mechanical #Cell

📰 "Mechanical Responses of the Giant Nesprin-2"
https://www.biorxiv.org/content/10.1101/2025.05.30.657030v1?rss=1 #Mechanotransduction #Cytoskeleton #Mechanical

📰 "The impact of Talin2, a signaling protein regulating the focal adhesion complex, on asthma"
https://doi.org/doi:10.1093/intimm/dxaf026
https://pubmed.ncbi.nlm.nih.gov/40401633/
#Cytoskeleton #Mechanical #Adhesion

📰 "Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery"
https://doi.org/doi:10.1016/j.mbm.2024.100040
https://pubmed.ncbi.nlm.nih.gov/40395451/
#Cytoskeleton #Mechanical

📰 "Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC"
https://doi.org/doi:10.1039/d4mo00154k
https://pubmed.ncbi.nlm.nih.gov/40353692/
#Morphogenesis #Cytoskeleton #Mechanical #Adhesion

🚨NEW PREPRINT 🚨 from the Cross lab.

Karnawat et al.

ATPγS unbiases kinesin

https://doi.org/10.1101/2025.05.01.651652

#motorheads #cytoskeleton #cellBiology #biophysics

Our Director, Rob Cross is giving a BMS Seminar today

Interlocking nanomechanics of kinesin and microtubules.

1pm IBRB LT

#CellBiology #Cytoskeleton #MotorHeads #Biophysics

📰 "Kinesin-Driven De-Mixing of Cytoskeleton Composites Drives Emergent Mechanical Properties"
https://doi.org/doi:10.1002/marc.202401128
https://pubmed.ncbi.nlm.nih.gov/40205878/
#Cytoskeleton #Mechanical #Kinesin

📰 "The keratin cortex stabilizes cells at high strains"
https://www.biorxiv.org/content/10.1101/2025.02.24.639846v1?rss=1 #Cytoskeleton #Mechanical #Keratin

Yean Ming and Rob wrote a review on MT lattice switching. They discuss evidence that protofilament-level structural switching is ancient and fundamental and conserved; and that tubulation creates new allosteric interfaces that operate on essentially the same structural switch.

https://doi.org/10.1042/BST20240360

#cytoskeleton #microtubules #cellBiology #WarwickUni

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

It's time to consider the Arcellinida shell as a weapon https://www.isep-protists.com/post/arcellinida-shell-weapon

"why is there such a large morphological diversity in shell-bearing #amoebae and what is the function of shells anyway? We knew for a long time that #Arcellinida are masters of the #cytoskeleton as they use it to build their elaborate shells. It was unknown that they use both, the cytoskeleton and shell, in combination to function as small apex #predators in their systems."

#Protists #ISEPpapers #Microbes

📰 "Vimentin and Desmin Intermediate Filaments Maintain Mitochondrial Membrane Potential"
https://doi.org/doi:10.1134/S0006297924110154
https://pubmed.ncbi.nlm.nih.gov/39647830/
#Cytoskeleton #Mechanical #Vimentin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

@mechanobio

A new #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure and give interpretations of the thermodynamic constraints on the dynamics of #myosin molecular motors.

#cytoskeleton #rheology #activeMatter #softMatter

Evidence for a special role of mitofusin-2 in regulating the #actin #cytoskeleton through #calcium, #RhoA, and #actomyosin contractility. https://elifesciences.org/articles/88828?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Are you interested in the #cytoskeleton ...?

#actin, #actomyosin, #myosin, #microtubule, #kinesin, #intermediatefilament, #vimentin, #keratin, #desmin, #GFAP, #peripherin, #syncoilin, #internexin, #neurofilament, #synemin, #syncoilin, #lamin

are hashtags used by @Rxiv_cytoskeleton bot.

Unfortunately, if you search / follow one of these hashtags, most of the posts from this bot will be invisible because a recent policy makes them "unlisted", see https://botsin.space/@muffinista/110378654504428500

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Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?

Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation

https://www.embopress.org/doi/10.15252/embj.2022112847