#crc — Public Fediverse posts

RE: https://wisskomm.social/@dfg_public/116577537743809428

#MainzUniversity is successful with five funding applications for Collaborative Research Centers: Approval of the German Research Foundation boosts JGU's research profile 👉 https://press.uni-mainz.de/johannes-gutenberg-university-mainz-successful-with-five-funding-applications-for-collaborative-research-centers/

#CRC #DeutscheForschungsgemeinschaft #DFG #GermanResearchFoundation #CollaborativeResearchCenter
@dfg_public

RE: https://wisskomm.social/@dfg_public/116577537743809428

#MainzUniversity is successful with five funding applications for Collaborative Research Centers: Approval of the German Research Foundation boosts JGU's research profile 👉 https://press.uni-mainz.de/johannes-gutenberg-university-mainz-successful-with-five-funding-applications-for-collaborative-research-centers/

#CRC #DeutscheForschungsgemeinschaft #DFG #GermanResearchFoundation #CollaborativeResearchCenter
@dfg_public

RE: https://wisskomm.social/@dfg_public/116577537743809428

#MainzUniversity is successful with five funding applications for Collaborative Research Centers: Approval of the German Research Foundation boosts JGU's research profile 👉 https://press.uni-mainz.de/johannes-gutenberg-university-mainz-successful-with-five-funding-applications-for-collaborative-research-centers/

#CRC #DeutscheForschungsgemeinschaft #DFG #GermanResearchFoundation #CollaborativeResearchCenter
@dfg_public

RE: https://wisskomm.social/@dfg_public/116577537743809428

#MainzUniversity is successful with five funding applications for Collaborative Research Centers: Approval of the German Research Foundation boosts JGU's research profile 👉 https://press.uni-mainz.de/johannes-gutenberg-university-mainz-successful-with-five-funding-applications-for-collaborative-research-centers/

#CRC #DeutscheForschungsgemeinschaft #DFG #GermanResearchFoundation #CollaborativeResearchCenter
@dfg_public

RE: https://wisskomm.social/@dfg_public/116577537743809428

#MainzUniversity is successful with five funding applications for Collaborative Research Centers: Approval of the German Research Foundation boosts JGU's research profile 👉 https://press.uni-mainz.de/johannes-gutenberg-university-mainz-successful-with-five-funding-applications-for-collaborative-research-centers/

#CRC #DeutscheForschungsgemeinschaft #DFG #GermanResearchFoundation #CollaborativeResearchCenter
@dfg_public

🌱🧬 The Collaborative Research Centre (CRC) 1530 “Elucidation and targeting of pathogenic mechanisms in B cell malignancies” and the CRC TRR/341 “Plant Ecological Genetics” will receive follow-up funding from the German Research Foundation. A total of 16.9 million euros for the University of Cologne.

More about the projects ▶️ https://uni.koeln/SYQ65

#uniköln #unicologne #sfb #crc #Forschung #Research @Uniklinik Köln

🎉Zwei Sonderforschungsbereiche an der Universität zu Köln werden verlängert

🌱🧬Der Sonderforschungsbereich (SFB) 1530 „Aufklärung und Targeting pathogener Mechanismen bei B-Zell-Neoplasien“ und der SFB/TRR 341 „Ökologische Genetik der Pflanzen“ gehen in die zweite Förderperiode der Deutschen Forschungsgemeinschaft. Insgesamt 16,9 Millionen Euro für die Universität zu Köln.

Mehr zu den Forschungsschwerpunkten ▶️ https://uni.koeln/J5KLR

#uniköln #unicologne #sfb #crc #Forschung #Research

https://www.europesays.com/it/433573/ George Clooney a Cuneo: «Con Trump si è superato il limite della decenza» #aggiungendo #AggiungendoPuoi #AggiungendoPuoiSostenere #alba #AlbaMondovì #attore #attori #clooney #crc #credo #cuneo #decenza #diritti #divo #Entertainment #errori #fondazione #FondazioneCRC #george #GeorgeClooney #incontro #Intrattenimento #IT #Italia #Italy #lunga #primarie #sì #spiegato #trattate #trump

EJELS just published this paper by the eminent Jon Kåre Skiple and myself:

"Bringing Rights Back Home? How Judges Handle Multilayered Constitutional and International Human Rights Laws on the Supreme Court of Norway"
https://publicera.kb.se/ejels/article/view/55649

#OpenAccess #JudicialPolitics #FundamentalRights #echr #iccpr #crc #constitution #JudicialEngagement #Norway #SupremeCourt #CaseComplexity #ConstitutionalLaw

EJELS just published this paper by the eminent Jon Kåre Skiple and myself:

"Bringing Rights Back Home? How Judges Handle Multilayered Constitutional and International Human Rights Laws on the Supreme Court of Norway"
https://publicera.kb.se/ejels/article/view/55649

#OpenAccess #JudicialPolitics #FundamentalRights #echr #iccpr #crc #constitution #JudicialEngagement #Norway #SupremeCourt #CaseComplexity #ConstitutionalLaw

EJELS just published this paper by the eminent Jon Kåre Skiple and myself:

"Bringing Rights Back Home? How Judges Handle Multilayered Constitutional and International Human Rights Laws on the Supreme Court of Norway"
https://publicera.kb.se/ejels/article/view/55649

#OpenAccess #JudicialPolitics #FundamentalRights #echr #iccpr #crc #constitution #JudicialEngagement #Norway #SupremeCourt #CaseComplexity #ConstitutionalLaw

EJELS just published this paper by the eminent Jon Kåre Skiple and myself:

"Bringing Rights Back Home? How Judges Handle Multilayered Constitutional and International Human Rights Laws on the Supreme Court of Norway"
https://publicera.kb.se/ejels/article/view/55649

#OpenAccess #JudicialPolitics #FundamentalRights #echr #iccpr #crc #constitution #JudicialEngagement #Norway #SupremeCourt #CaseComplexity #ConstitutionalLaw

EJELS just published this paper by the eminent Jon Kåre Skiple and myself:

"Bringing Rights Back Home? How Judges Handle Multilayered Constitutional and International Human Rights Laws on the Supreme Court of Norway"
https://publicera.kb.se/ejels/article/view/55649

#OpenAccess #JudicialPolitics #FundamentalRights #echr #iccpr #crc #constitution #JudicialEngagement #Norway #SupremeCourt #CaseComplexity #ConstitutionalLaw

[video] SUOMISETTII QUEST MIX WITH TJ TAKAHAHMO - Finnish Electronic Mysick (1993-2018) (4 March 2026).

https://www.youtube.com/watch?v=RukmZdhzoTU

#FinnishTechno #DJmixes #techno #electro #IDM #electropop #electronic #FinnishElectronicMusic #Aavikko #Blastromen #Brothomstates #CRC #8BitsHigh #DroneAndDjital #Ercola #ImatranVoima #KCD #Mesak #Mulletronic #DrRobotnik #TottiAndCash #RikosRecords #Rikos #KostamusRecords #Finland

[video] SUOMISETTII QUEST MIX WITH TJ TAKAHAHMO - Finnish Electronic Mysick (1993-2018) (4 March 2026).

https://www.youtube.com/watch?v=RukmZdhzoTU

#FinnishTechno #DJmixes #techno #electro #IDM #electropop #electronic #FinnishElectronicMusic #Aavikko #Blastromen #Brothomstates #CRC #8BitsHigh #DroneAndDjital #Ercola #ImatranVoima #KCD #Mesak #Mulletronic #DrRobotnik #TottiAndCash #RikosRecords #Rikos #KostamusRecords #Finland

[video] SUOMISETTII QUEST MIX WITH TJ TAKAHAHMO - Finnish Electronic Mysick (1993-2018) (4 March 2026).

https://www.youtube.com/watch?v=RukmZdhzoTU

#FinnishTechno #DJmixes #techno #electro #IDM #electropop #electronic #FinnishElectronicMusic #Aavikko #Blastromen #Brothomstates #CRC #8BitsHigh #DroneAndDjital #Ercola #ImatranVoima #KCD #Mesak #Mulletronic #DrRobotnik #TottiAndCash #RikosRecords #Rikos #KostamusRecords #Finland

[video] SUOMISETTII QUEST MIX WITH TJ TAKAHAHMO - Finnish Electronic Mysick (1993-2018) (4 March 2026).

https://www.youtube.com/watch?v=RukmZdhzoTU

#FinnishTechno #DJmixes #techno #electro #IDM #electropop #electronic #FinnishElectronicMusic #Aavikko #Blastromen #Brothomstates #CRC #8BitsHigh #DroneAndDjital #Ercola #ImatranVoima #KCD #Mesak #Mulletronic #DrRobotnik #TottiAndCash #RikosRecords #Rikos #KostamusRecords #Finland

[video] SUOMISETTII QUEST MIX WITH TJ TAKAHAHMO - Finnish Electronic Mysick (1993-2018) (4 March 2026).

https://www.youtube.com/watch?v=RukmZdhzoTU

#FinnishTechno #DJmixes #techno #electro #IDM #electropop #electronic #FinnishElectronicMusic #Aavikko #Blastromen #Brothomstates #CRC #8BitsHigh #DroneAndDjital #Ercola #ImatranVoima #KCD #Mesak #Mulletronic #DrRobotnik #TottiAndCash #RikosRecords #Rikos #KostamusRecords #Finland

Способы Повышения Надежности Встраиваемого ПО

В этом тексте я бы хотел перечислить способы повышения надежности для встраиваемого ПО. Cуществует много приемов, которые помогают повысить надежность встраиваемого ПО. Как прошивка может противостоять всяческим флунктуациям во время своей работы и обезопасить себя от зависания или повреждения исходных данных?

https://habr.com/ru/articles/1002662/

#mpu #watchdog #Bit_Stuffing #Stack_Painting #Lockstep #critical_section #feedback #ECC #CRC #parity

Способы Повышения Надежности Встраиваемого ПО

В этом тексте я бы хотел перечислить способы повышения надежности для встраиваемого ПО. Cуществует много приемов, которые помогают повысить надежность встраиваемого ПО. Как прошивка может противостоять всяческим флунктуациям во время своей работы и обезопасить себя от зависания или повреждения исходных данных?

https://habr.com/ru/articles/1002662/

#mpu #watchdog #Bit_Stuffing #Stack_Painting #Lockstep #critical_section #feedback #ECC #CRC #parity

Способы Повышения Надежности Встраиваемого ПО

В этом тексте я бы хотел перечислить способы повышения надежности для встраиваемого ПО. Cуществует много приемов, которые помогают повысить надежность встраиваемого ПО. Как прошивка может противостоять всяческим флунктуациям во время своей работы и обезопасить себя от зависания или повреждения исходных данных?

https://habr.com/ru/articles/1002662/

#mpu #watchdog #Bit_Stuffing #Stack_Painting #Lockstep #critical_section #feedback #ECC #CRC #parity

Способы Повышения Надежности Встраиваемого ПО

В этом тексте я бы хотел перечислить способы повышения надежности для встраиваемого ПО. Cуществует много приемов, которые помогают повысить надежность встраиваемого ПО. Как прошивка может противостоять всяческим флунктуациям во время своей работы и обезопасить себя от зависания или повреждения исходных данных?

https://habr.com/ru/articles/1002662/

#mpu #watchdog #Bit_Stuffing #Stack_Painting #Lockstep #critical_section #feedback #ECC #CRC #parity

Oh, the smell of 8-bit file transfers from a BBS ...

(on the sending end, at RC-BOX BBS, the CP/M program KMD.COM is being used)

#xmodem
#crc
#CCGMSfuture
#Commodore64
#Striketerm

Oh, the smell of 8-bit file transfers from a BBS ...

(on the sending end, at RC-BOX BBS, the CP/M program KMD.COM is being used)

#xmodem
#crc
#CCGMSfuture
#Commodore64
#Striketerm

Oh, the smell of 8-bit file transfers from a BBS ...

(on the sending end, at RC-BOX BBS, the CP/M program KMD.COM is being used)

#xmodem
#crc
#CCGMSfuture
#Commodore64
#Striketerm

Oh, the smell of 8-bit file transfers from a BBS ...

(on the sending end, at RC-BOX BBS, the CP/M program KMD.COM is being used)

#xmodem
#crc
#CCGMSfuture
#Commodore64
#Striketerm

Oh, the smell of 8-bit file transfers from a BBS ...

(on the sending end, at RC-BOX BBS, the CP/M program KMD.COM is being used)

#xmodem
#crc
#CCGMSfuture
#Commodore64
#Striketerm

#Leonard #Leo’s status as the world’s third most powerful figure soon made him a rich man.

During his time at the Federalist Society,
he had hardly been a pauper,
bringing in around $400,000 a year.

But with six children attending The Heights and Oakcrest, the two Opus Dei schools that charged up to $30,000 tuition annually per student,
and a burgeoning taste for good food and expensive wines,
it didn’t take long to burn through his salary.

But his life had taken a lavish turn after Trump’s victory
and his appointment as an unpaid advisor to the president on judicial appointments.

The dramatic uptick in his personal fortune dovetailed with his joining a for-profit entity called "CRC Advisors", alongside another CIC board member #Greg #Mueller.

Mueller had spearheaded the "National Organization for Marriage" vitriolic public relations strategy,
and #CRC quickly established itself as the go-to advisory firm for the dark-money network of nonprofit entities that Leo had helped set up over the years.

Once again, the Corkery name was all over the money flow.

The majority of CRC’s income came from
👉 "The 85 Fund",
a dark money non-profit that
⚠️ Leo repurposed to fund conservative causes nationwide,
and
💥that fund paid $34 million in fees to his new advisory firm over a single two-year period.

As the money rolled in, Leo began to enjoy some of the same luxuries as the billionaires he had spent years courting.

For most of his three decades in Washington, Leo had led a modest home life,
living for years in a small apartment in the Randolph Towers complex in downtown Arlington,
before moving to a single-story five-bedroom family home in suburban McLean in 2010.

But in the years since 2016, he had spent millions of dollars on two new mansions in Maine,
bought four new cars,
and hired a wine buyer and locker at Morton’s, an upscale steakhouse three blocks from the Catholic Information Center.

It was only a foretaste of what was to come.

➡️ In 2020, Leo stepped back from his duties at the Federalist Society to focus on the
dark-money network he had fostered as a side hustle during his time there.

With him, he took one of the Federalist Society’s biggest donors:
a manufacturing billionaire from Chicago called
#Barre #Seid, who was Jewish by heritage but who shared many of Leo’s conservative views.

🧨Over two decades, Seid had pumped at least $775 million into campaigns for libertarian and conservative causes,
quietly transforming himself into one of the most important donors on the political right.

Almost ninety, Seid had decided to leave his money continuing that work
— and concluded that Leo was the man to oversee that largesse.

🔥Leo had betrayed his bosses, who had tasked him with wooing the billionaire as a potential donor for the Federalist Society.

Instead, Leo had cultivated him for his own network.

Seid signed his business over to Leo, giving him control over a
🔥$1.6 billion war chest and
👉transforming him from a proxy for
dark-money donors into a donor himself.

Ecological and Human Health Impacts of Contaminated Food and Environments by Ming Hung Wong, 2025

This book discusses linkages between the natural and disturbed chemical composition of the earth's surface and ecological and human health. It reviews the environmental geochemical cycles of natural elements and persistent toxic substances (PTS) in the environment.

@bookstodon
#books
#nonfiction
#EnvironmentalChemicals
#environment
#food
#contamination
#PTS
#CRC

@explainpaper

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk Jaeger

Targeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases

#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.

the microenvironment of #liver metastases of #colorectal cancer (#CRC).

the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.

the effects of CCR5 blockade on the #tissue level.

Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.

The microenvironment of the invasive margin of #liver metastases.

There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.

#CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).

The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.

A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.

CCR5 blockade, is a type of #therapy used to treat #cancer.

The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.

@explainpaper

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk Jaeger

Targeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases

#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.

the microenvironment of #liver metastases of #colorectal cancer (#CRC).

the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.

the effects of CCR5 blockade on the #tissue level.

Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.

The microenvironment of the invasive margin of #liver metastases.

There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.

#CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).

The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.

A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.

CCR5 blockade, is a type of #therapy used to treat #cancer.

The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.

@explainpaper

Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients

Niels Halama, Inka Zoernig, Anna Berthel, Christoph Kahlert, Fee Klupp, Meggy Suarez-Carmona,Thomas Suetterlin, Karsten Brand, Juergen Krauss, Felix Lasitschka, Tina Lerchl, Claudia Luckner-Minden, Alexis Ulrich, Moritz Koch, Juergen Weitz, Martin Schneider, Markus W. Buechler, Laurence Zitvogel,
Thomas Herrmann, Axel Benner, Christina Kunz, Stephan Luecke, Christoph Springfeld, Niels Grabe, Christine S. Falk, and Dirk Jaeger

Targeting Tumor-Promoting Microenvironment Through CCR5 Blockade in #Colorectal #Cancer #Liver Metastases

#Cancer progression is a process in which cancer cells and #immune cells interact with each other in a way that can lead to the growth and spread of cancer. In #colorectal cancer, when the cancer has spread to other parts of the body, it is called #metastasis and it is very difficult to treat. Treatments such as PD-1/PD-L1 blockade and #chemokine modulation have been successful in modifying the interactions between the immune system and cancer, leading to the rejection or suppression of progression. Cancer cells can also alter the immune microenvironment, leading to #immunosuppression and #immune evasion. In this research paper, the authors studied the microenvironment in #CRC #liver metastases and identified a network of #tumor cells and immune cells that exploit the CCL5-CCR5 axis. They then investigated and characterized the effects of blocking the CCL5-CCR5 axis.

the microenvironment of #liver metastases of #colorectal cancer (#CRC).

the environment induces migration of T lymphocytes, which produce a #cytokine called CCL5. This CCL5 then supports tumor growth and spread by influencing macrophages and #tumor cells. The environment is immunosuppressive and the tumor cells are exploiting the host's #immune cells to their advantage. In other words, the tumor cells are using the host's immune cells to help them grow and spread.

the effects of CCR5 blockade on the #tissue level.

Tumor #cell death and a specific pattern of #cytokine and #chemokine modulation are observed in the #ExplantModel and in #tumor biopsies from a #ClinicalTrial. Macrophages are the key for these anti-tumoral effects, as they produce IFNs and reactive oxygen species which cause tumor cell death. #CCR5 blockade induces a phenotypic shift in the macrophages, which is referred to as a switch from an M2 to an M1 phenotype. This repolarization also reduces levels of CD163+ cells, reshaping the #myeloid cell composition in the microenvironment. The influx of new effector cells due to CCR5 inhibition can shift the effects of CCL5 towards beneficial effects, such as reduction of #immunosuppression , #angiogenesis, and #chemotherapy resistance.

The microenvironment of the invasive margin of #liver metastases.

There was no relevant Th1, Th2, or Th17 #cytokine signature present in any of the samples. However, the authors did find that #chemokines and #macrophage-related cytokines were significantly increased at the invasive margin. Chemokines are molecules that help to attract #immune cells to the area, and macrophage-related cytokines are molecules that help to regulate the activity of #macrophages, which are a type of immune cell. 98% of the CD3+ #lymphocyte s in the resection specimens were positive for PD-1, which is a molecule that helps to regulate the activity of the immune system.

#CCL5 is a protein produced by T cells, which are a type of white blood cell. #CCR5 is a receptor found on metastatic tumor cells, which are cancer cells that have spread from the primary #tumor to other parts of the body. In this research paper, it was found that CCL5 has #pleiotropic tumor-promoting effects on #tumor cells and tumor-associated #macrophage s. This means that CCL5 has multiple effects on both the cancer cells and the macrophages, which are a type of white #blood #cell, that are associated with the #tumor. CCL5 was produced mainly by T cells located at the invasive margin and #peritumoral stroma of metastases, and that CCR5 was dominantly expressed by metastatic tumor cells. CCL5 also had effects on tumor #CellProliferation, invasive tumor #CellBehavior, and increased production of matrix #metalloproteinas es by tumor-associated macrophages. Finally, they found that CCR5 inhibition had an effect on key molecules of #epithelial to #mesenchymal transition ( #EMT ).

The researchers wanted to test the effects of #CCR5 blockade, which is a way of blocking the CCR5 receptor on cells, using a drug called maraviroc. They used human #tumor #explantmodel s, which are samples of #tissue from advanced #CRC patients with #liver metastases. Maraviroc led to morphologically overt tumor #CellDeath in the #explants, which means that the tumor cells died and changed in appearance. The researchers then tested the hypothesis that #macrophage s, (type of white blood cell), were required for the tumor cell death-inducing effects of CCR5 blockade. They used clodronate #liposome s to deplete CD163+ TAMs, ( #macrophage s associated with tumors) and found that combining clodronate with CCR5 inhibition abrogated the immediate tumor cell death-inducing effects of #CCR5 inhibition. This confirmed the role of macrophages in this process. IFN-g induced stromal CD163+ #macrophage #cell death and led to a reconfiguration of the #myeloid cell compartment. Inhibition of macrophage-derived reactive oxygen species could partially block the anti-tumoral effects of CCR5 inhibition. Finally, they tested the effects of CCL5/CCR5 inhibition and found that both a CCL5 neutralizing antibody and a CCR5 blocking #antibody had similar functional effects to maraviroc.

A #ClinicalTrial (MARACON) was conducted to test the effects of a drug called maraviroc on patients with advanced-stage #metastatic colorectal #cancer. The #trial involved taking biopsies of the patients before and after treatment with maraviroc, and the results showed that the drug had beneficial effects on the tumor-promoting #microenvironment and led to objective clinical responses. These responses included induction of central #TumorNecrosis, reduction of tumor cell death, and reduction of key #cytokine s and growth factors that promote tumor growth. The drug was also found to be very well tolerated, with mild elevation of #liver enzymes being the most common side effect. Finally, the trial showed that partial responses were achieved in patients with previously refractory disease.

CCR5 blockade, is a type of #therapy used to treat #cancer.

The MARACON clinical trial, showed that CCR5 blockade had a positive effect on the tumor microenvironment and led to a higher response rate in subsequent chemotherapies. The authors suggest that this effect is not limited to the #liver metastases, but is a systemic feature. They also suggest that the local presence of multiple layers of #immune subversion in cancers depends on the individual tissue, #treatment, tumor type, and the difference between primary #tumor and metastatic lesion. The authors also found that the results of the #ClinicalTrial were in line with the results of a fully human organotypic tumor #ExplantModel, which is a simple model with a straightforward approach. The authors also note that the survival data from the trial is not conclusive due to the limited number of patients, but that the objective treatment responses are very encouraging. They suggest that CCR5 blockade may be a promising approach and needs to be evaluated further scientifically and clinically.

Протокол TBFP

В этом тексте я бы хотел рассказать про простой бинарный протокол, который я сам придумал для всяческих нужд при разработке приборов на микроконтроллерах. Называется он TBFP (Trivial Binary Frame Protocol)

https://habr.com/ru/articles/969948/

#TBFP #icmp #протокол #uart #CAN #crc #iso26262 #preamble #serial_number #wireless

Звоним через полстраны по dial-up модему в 2025 году

Приветствую всех! Многие из нас застали лично и всё ещё помнят «модемную» эпоху. И даже мне самому доводилось ими пользоваться, а много позже я писал про то, каково в нынешних реалиях сидеть в интернете через старый аналоговый модем. Но вот мне стало интересно: а как насчёт попробовать позвонить не через мини-АТС, а на модем в другом районе или даже в другом городе? Именно этим мы сейчас и займёмся. Итак, в сегодняшней статье проверим на практике, реально ли заставить два модема связаться друг с другом в наши дни заката эпохи медных линий. Узнаем, насколько стабильным будет соединение и будет ли оно вообще. Традиционно будет много интересного.

https://habr.com/ru/companies/timeweb/articles/812137/

#timeweb_статьи #телефон #модем #gpon #линия #rs232 #uart #xmodem #ymodem #zmodem #crc #ppp #putty #hyperterminal #norton_commander

#GoldCup The #SLV #CRC match ending before a corner kick because a Salvadorian player was stalling is sooooo unsatisfying #CopaOro

John Hiatt, Bring the Family, 1987 on A&M

John Hiatt’s eighth studio album and his first on A&M. What a fantastic songwriter! Actually paid for by Demon Records in the UK, but picked up after being completed by A&M in the US.

Guests include Ry Cooder (doing harmony vocals on “Have a Little Faith in Me” as well as electric guitar and sitar work), Nick Lowe on bass, and Jim Keltner on drums, making this something of a proto-Little Village album. Also includes “Thing Called Love” that was later a hit for Bonnie Raitt.

My copy—via Waterloo Records in Austin TX—is a Columbia House club pressing (Carrollton) with CRC on the bottom of the rear cover.

#1980s #1987 #AustinTX #ColumbiaHouseRecordClub #CRC #JimKeltner #JohnHiatt #LittleVillage #NickLowe #RyCooder #vinyl #vinylcollection #vinylfinds #WaterlooRecords

Ich bin noch etwas unschlüssig, ob ich die Textausgaben vom #TNC im Hostmode parsen möchte oder in den KISS-Mode schalte und die Telegramme selbst zusammenklöppel (der TNC arbeitet dann nur als dummes Modem, das alle Frames mundgerecht vormontiert angeliefert bekommt und einfach durchreicht).

Da ich im simpleren UNPROTO-Mode (das #AX25-Äquivalent zu UDP) arbeiten will, macht letzteres vermutlich mehr Sinn.

Und was ist schon Retro-Feeling ohne #HDLC und #CRC-Berechnung zu Fuß... 😬

#HamRadio

----------------

🎥 Video
===================

Executive summary: A technical demonstration walks through converting arbitrary files into video containers for storage on YouTube. The project documents practical constraints (YouTube file/length limits, metadata stripping, and aggressive transcoding) and presents a workflow combining chunking, integrity checks, and forward error correction to enable file reconstruction after upload.

Technical details:
• Encapsulation: The workflow targets standard video containers and uses video and audio tracks as the durable carriers because YouTube strips most metadata and can reject subtitle payloads.
• Integrity checks: Uses multiple CRC flavors to detect corrupted chunks prior to reconstruction.
• Forward error correction: Implements Wirehair (an O(N) fountain code) to create redundant symbols so that the original file can be recovered despite dropped or heavily altered chunks during YouTube transcoding.
• Encoding channel: Embeds payload bits into transform-domain coefficients — specifically leveraging the Discrete Cosine Transform (DCT) used by common codecs — to hide data within compressed frames while balancing capacity and survivability.

Implementation concepts:
• Chunking strategy: Files are split into chunks sized to fit per-video capacity limits (YouTube supports up to 256 GB or 12 hours), then encoded into frames or audio payloads with added FEC symbols.
• Hybrid error-proof algorithm: Combines CRC validation for corruption detection with fountain-code-based redundancy for recovery of missing symbols.
• Codec selection: Emphasizes that codec choice and compression aggressiveness materially affect recoverability; lower-loss codecs and control of quantization on DCT coefficients increase success rates.

Use cases and limitations:
• Practical use cases include long-term archival of very large files and covert transport where traditional storage is unavailable. The approach is constrained by platform policy, upload limits, potential content removal, and the non-deterministic nature of platform transcoding pipelines.

Detection and considerations:
• Detection vectors are platform-specific; artifacts include atypical frame-level entropy patterns and persistent non-media payloads in transform coefficients. The talk notes that subtitles/metadata are unreliable for storage because of sanitization.

References and tooling:
• The presentation references the Wirehair fountain codec and recommends studying CRC variants and video compression internals. Visualizations were created with Manim and DaVinci Resolve.

🔹 wirehair #fountaincode #crc #dct #tool

🔗 Source: https://www.youtube.com/watch?v=l03Os5uwWmk

DATE: January 16, 2026 at 05:30PM
SOURCE: BioWorld MedTech

Direct article link at end of text block below.

Colostat, Genetype pairing sharpens #cancer screening pathway

https://t.co/lTKLhIDgM0

#medtech #CRC

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https://t.co/lTKLhIDgM0

#medtech

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#healthcare #healthtech #healthcaretech #healthtechnology #medgadget #medicine #doctor #hospital #medtech

Hello Bielefeld 👋 #linguistics #crc #networking

🎉Follow-up funding for two Collaborative Research Centres at the University of Cologne

🌍🧬 The Collaborative Research Centre (CRC) 1310 ‘Predictability in Evolution’ and the CRC/Transregio 228 ‘Future Rural Africa’ will receive funding from the German Research Foundation for a further four years. A total of 16.1 million euros for the University of Cologne

More About the projects 🔗 http://ukoeln.de/YEUZC

#uniköln #unicologne #sfb #crc #Forschung #Research

🎉Zwei Sonderforschungsbereiche an der Universität zu Köln werden verlängert

🌍🧬Der Sonderforschungsbereich (SFB) 1310 „Vorhersagbarkeit in der Evolution“ und der SFB/Transregio 228 „Zukunft im ländlichen Afrika“ werden vier weitere Jahre von der Deutschen Forschungsgemeinschaft gefördert. Insgesamt 16,1 Millionen Euro für die Universität zu Köln

Mehr zu den Forschungsschwerpunkten ▶️ https://uni.koeln/WBTZS

#uniköln #unicologne #sfb #crc #Forschung #Research

Все об устройстве MSK144 с примерами на Python (часть 2)

MSK144 — цифровой протокол, разработанный Джо Тейлором (K1JT) и его командой в 2016 году для проведения связей через метеорное рассеивание. В предыдущей части были рассмотрены общие характеристики протокола, а также алгоритмы, формирующие сигнал. В этой части статьи рассматриваются механизмы детектирования и декодирования сигналов в протоколе MSK144. Статья может быть интересна радиолюбителям и людям, интересующимся темой цифровой обработки сигналов.

https://habr.com/ru/articles/956582/

#ham #hamradio #python #python3 #scipy #numpy #msk #msk144 #ldpc #crc

🚀 Proud to announce one more #NGISargasso-funded project: ARC – #Cancer Patient Application powered by #GenerativeAI!

ARC is an innovative, #AI-powered medical device designed to support patients and healthcare professionals, starting with #ColorectalCancer (#CRC).

Developed by Arcella Bio 🇳🇱 and Identity Woman in Business 🇺🇸

🔗 Discover more solutions creating an #InternetOfHumans: https://ngisargasso.eu/2025/02/28/discover-the-last-13-ngi-sargasso-innovators-from-our-open-call-5-creating-an-internet-of-humans-across-continents/

#DigitalHealth #MedTech #InternetOfTrust #NextGenerationInternet #NGISargassoInnovators

DATE: October 01, 2025 at 05:00PM
SOURCE: BioWorld MedTech

Direct article link at end of text block below.

.@GeneoscopyCo seeks coverage for #Colosense, but specificity a problem

https://t.co/r8M1BmEeIZ

#medtech #crc #colorectalcancer @ExactSciences @CMSGov

Here are any URLs found in the article text:

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#medtech

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Metal Ions and the Route to Life by Dr Wolfgang Nitschke & Dr Simon Duval, 2025

Metal Ions and the Route to Life provides the empirical groundwork to interested researchers and the general public for revisiting their preconceived ideas about the origin of life and for appreciating the absolute indispensability of metal ions in life.

#books
#nonfiction
#LifeOrigins
#MetalIons
#CRC

Коротко об устройстве протокола MSK144 с примерами на Python

MSK144 — цифровой протокол, разработанный Джо Тейлором (K1JT) и его командой в 2016 году для проведения связей через метеорное рассеивание. В этой статье будут рассмотрены подробности работы протокола. Статья может быть интересна радиолюбителям, как знакомым, так и не знакомым с MSK144 и связью через метеорное рассеивание, а также тем, кто хочет понять устройство этого протокола.

https://habr.com/ru/articles/946898/

#ham #hamradio #python #python3 #scipy #numpy #msk #msk144 #ldpc #crc

Every Molecule Matters by Simon Cotton, 2025

Every Molecule Matters is a successor to the author’s earlier Every Molecule Tells a Story and tells the story of a wide range of molecules.

These range from the familiar odours that enhance the pleasure of eating (and the spices that add piquancy) to the vitamins vital to our survival, as well as the ways in which insects and plants use chemicals to protect themselves.

#books
#nonfiction
#chemistry
#molecules
#CRC

Morphology (a.k.a. Michael Diekmann & Matti Turunen) -
Live @ Punto Electro (venue: Kaiku, Kaikukatu 4, Kallio, Helsinki, Finland).

26 September 2025. 22-04. 16€ (22-23 0€).

DJs: Erkko, Jennijay, ERBR. VJ: Twilight Courier.

https://soundcloud.com/punto-electro

https://clubkaiku.fi/

#Morphology #MorphologyElectro #MichaelDiekmann #MattiTurunen #electro #IDM #techno #electrobass #electronic #CRC #PuntoElectro #DJErkko #Erkko #Jennijay #ERBR #VJTwilightCourier #Kaiku #Kallio #Helsinki #Finland

The Old and New Persistent Organic Pollutants; Sources, Risks, Regulations, and Remediation by Ravi Naidu, 2025

This book provides a comprehensive coverage of new and old hazardous chemicals, their physical and chemical properties, their breakdown products, their fate in the environment, and the environmental and human risk impact.

@bookstodon
#books
#nonfiction
#pollutants
#POPs
#CRC