#structuralbiology — Public Fediverse posts

🧫 #AMR #PhD open @[email protected]! How does #Cdifficile protein "armour" help it resist antimicrobials? Join me and @[email protected] to find out using: 🔬 #Structuralbiology, #microbiology #microscopy #genetics 📅 Deadline 20 May 2026 #PhD #PhDLife Pls share! (UK home only)

C. difficile S-layer’s role in...

@sflorg #Structuralbiology is an important #basicresearch direction that aims to gain information about dynamics and interactions of #biological molecules. This research relies on high-tech, including #cryoelectronmicroscopy (EM), nuclear magnetic resonance (#NMR) spectroscopy, and X-ray #crystallography. Goals are a better understanding and e.g. the creation of #molecular #dynamicssimulations.
StefanFWirth

reading

https://humantechnopole.it/en/research-centres/structural-biology/

H. Schwalbe et al. (2024)
https://doi.org/10.1016/j.str.2024.08.014

The Architectures of Permanence: Unmasking the Giant Virus

Scientists mapped giant virus structures, finding 'cementing' proteins that help them survive for thousands of years. This discovery could explain the origin of the cell nucleus.

#GiantVirus, #StructuralBiology, #VirusOrigin, #CellNucleus, #AncientLife

https://newsletter.tf/giant-virus-structure-cement-proteins-ancient-survival/

New research shows giant viruses have 'cementing' proteins, making them incredibly stable. This is like finding the strong glue that holds together ancient biological structures.

#GiantVirus, #StructuralBiology, #VirusOrigin, #CellNucleus, #AncientLife
https://newsletter.tf/giant-virus-structure-cement-proteins-ancient-survival/

🦴 Could a naturally occurring “biological lubricant” redefine how we treat joint health and gout?

🔗 Lubricin’s Mucin Domain Has Strong Polyproline Type II Helical Character. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0021

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #ProteinScience #Biophysics #ComputationalBiology #Osteoarthritis #Glycoproteins #MolecularBiology

https://www.europesays.com/ie/404405/ The molecular mechanism that turns cool temps into nerve signals #Brain #Cell #CellMembrane #Cold #Éire #Electron #ElectronMicroscopy #heat #IE #imaging #Ion #IonChannel #Ireland #medicine #Membrane #Microscopy #Molecule #Nerve #Pain #Physiology #Protein #Research #Science #StructuralBiology

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?

🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI

🧩 Could structural AI finally decode the complex language of T-cell antigen recognition?

🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ProteinLanguageModels #Immunotherapy #ComputationalBiology #Bioinformatics #MachineLearning #Immunology #ProteinEngineering #TCR #HLA #DrugDiscovery #AI

🧬 Can entropy help us decode how hormone receptors make real-time decisions?

🔗 Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.024

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #Biophysics #GPCR #Entropy #MolecularPharmacology #AllostericModulation #DrugDiscovery #MolecularDynamics

💊 Can understanding receptor bias help us design safer, more selective GPCR drugs?

🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039

📚 CSBJ: https://www.csbj.org/

#GPCR #StructuralBiology #MolecularDynamics #NMR #Pharmacology #ProteinStructure #DrugDiscovery #ComputationalBiology #CellSignaling

🧬 Ever wondered how the genome actually looks when it folds inside the nucleus — and how fast we can simulate it?

🔗 Multiscale molecular modeling of chromatin with MultiMM: From nucleosomes to the whole genome. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.025

📚 CSBJ: https://www.csbj.org/

#ChromatinModeling #3DGenome #ComputationalBiology #Genomics #MolecularModeling #GenomeArchitecture #ChromatinStructure #HiC #ATACSeq #Biophysics #StructuralBiology

🧬 One amino acid to stabilize them all — myth or molecular reality?

🔗 Single-residue engineering of lambda (λ) antibody light chains reduces conformational flexibility and enhances thermal stability. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.045

📚 CSBJ: https://www.csbj.org/

#MonoclonalAntibodies #mAbs #Immunology #ComputationalBiology #MolecularDynamics #Bioinformatics #ProteinStability #StructuralBiology

New #preprint about PENSA, our flexible #OpenSource software package for comprehensive and thorough investigation of biomolecular conformational ensembles:

https://arxiv.org/abs/2212.02714

In three real-world examples, we show how it can be used to understand an #enzyme mechanism, #DNA #forcefield parameters, and #signaling in an #opioid #receptor.

Please share widely with the #MolecularDynamics #simulation #CompChem #MolBio #StructuralBiology #GPCR communities!
Feedback and ideas are always welcome.

Hi all - new to #Mastodon (fleeing the 🦃 #TwitterMigration).

I'm an Associate Investigator & #StructuralBiologist at HWI in Buffalo #NY. I direct the National High-Throughput #Crystallization Center 💎.

My group uses X-ray #crystallography, #microED, #computationalbiology, & other #biophysical tools to study #protein structure & function.

Especially interested in #metalloproteins & coupling #crystallography & #spectroscopy.

#Introduction #Science #SciComm #structuralbiology #WomeninSTEM