#ace2 — Public Fediverse posts

Detection of a #Merbecovirus with potential #ACE2 usage in #France, https://etidiohnew.blogspot.com/2026/04/detection-of-merbecovirus-with.html

#Species - and #variant - specific #ACE2 compatibility shapes #SARS-CoV-2 #spillover potential in North American #cervids, https://etidiohnew.blogspot.com/2026/04/species-and-variant-specific-ace2.html

🧬 How did changes at the atomic scale reshape viral infectivity?

🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034

📚 CSBJ: https://www.csbj.org/

#COVID19 #SARSCoV2 #SpikeProtein #ACE2 #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology

HKU25 clade #MERS-related #coronaviruses use #ACE2 as a functional #receptor, https://etidiohnew.blogspot.com/2025/11/hku25-clade-mers-related-coronaviruses.html

#Bat #sarbecovirus WIV1-CoV bears an adaptive #mutation that alters #spike dynamics and enhances #ACE2 binding, https://etidiohnew.blogspot.com/2025/10/bat-sarbecovirus-wiv1-cov-bears.html

HKU5 #bat #merbecoviruses engage bat and #mink #ACE2 as entry #receptors, https://etidiohnew.blogspot.com/2025/07/hku5-bat-merbecoviruses-engage-bat-and.html

#ACE2-like enzymatic activity in #COVID19 #convalescents with persistent pulmonary symptoms associated with #immunoglobulin, https://etidiohnew.blogspot.com/2025/07/ace2-like-enzymatic-activity-in-covid19.html

In vitro and in vivo characterization of a #bat #merbecovirus with #ACE2- and #DPP4-independent cell entry, https://etidiohnew.blogspot.com/2025/06/in-vitro-and-in-vivo-characterization.html

A #MERS-CoV-like #mink #coronavirus uses #ACE2 as entry receptor, https://etidiohnew.blogspot.com/2025/04/a-mers-cov-like-mink-coronavirus-uses.html

#Bat #sarbecovirus WIV1-CoV bears an adaptive #mutation that alters spike dynamics and enhances #ACE2 binding, https://etidiohnew.blogspot.com/2025/04/bat-sarbecovirus-wiv1-cov-bears.html

#Bat-infecting #merbecovirus HKU5-CoV #lineage 2 can use #human #ACE2 as a cell entry receptor, https://etidiohnew.blogspot.com/2025/02/bat-infecting-merbecovirus-hku5-cov.html

Structural and molecular #basis of the #epistasis effect in enhanced affinity between #SARS-CoV-2 #KP3 and #ACE2 http://biorxiv.org/cgi/content/short/2024.09.03.610799v1?rss=1

KP.3, featuring F456L and Q493E, exhibits a markedly enhanced ACE2 binding affinity compared to #KP2 and #JN1 #variant due to synergistic effects between these mutations.

Reminder: a housecat that can bite through your skin is unlike a tiger that can puncture any organ!

SARS-CoV-2 is unlike all common colds, because it can infect almost every organ in the body (through ACE2 and synctia) unlike every common cold.

"Vaccines have not turned covid into a common cold."

"Multiple infections will not turn covid into a common cold."

https://www.donotpanic.news/p/why-covid-can-never-be-just-a-cold

#ACE2 #SARS2 #COVID #COVID19 #maskUp #CleanTheAir #CovidIsNotOver

I can see why https://www.donotpanic.news/p/why-covid-can-never-be-just-a-cold is rising on the #zeroes list.

Accessible and packing citations, it might help people who are on the fence to understand and risk model.

Takeaways:

"Vaccines have not turned covid into a common cold."

"Multiple infections will not turn covid into a common cold."

SARS-CoV-2 is unlike all common colds, because it can effectively infect almost every organ in the body (through ACE2) unlike every common cold.

But like SARS1.

#ACE2 #SARS2 #COVID #COVID19 #maskup #CovidIsNotOver

#StanfordMedicine study flags unexpected cells in lung as suspected source of severe #COVID | https://med.stanford.edu/news/all-news/2024/04/covid-lung-cells.html “Important covid clues! Researchers find that #macrophages - the cells that usually scavenge and destroy viruses - are the cells most susceptible to being infected/hijacked by #SARSCoV2. To enter macrophages, SARS-CoV-2 uses #CD209 receptors (not #ACE2). Interfering with SARS-CoV-2/CD209 binding could be a promising target for new and better prevention and/or treatment!”

#Molecular #basis of #hippopotamus #ACE2 binding to #SARS-CoV-2, J Virol.: https://doi.org/10.1128/jvi.00451-24

These results provide crucial molecular insights into the susceptibility of hippopotami to SARS-CoV-2 and suggest the potential risk of SARS-CoV-2 VOCs #spillover and the necessity for #surveillance.

-- #JN1’s #spike protein has just 1 more #mutation than #BA286’s spike. That mutation, called #L455S, enhances the virus’ ability to bind to the angiotensin-converting enzyme 2 (#ACE2) #receptor, SARS-CoV-2’s doorway into cells, Nicole Doria-Rose, PhD, chief of the Humoral Immunology Core at the NIAIDs’ Vaccine Research Center, noted in an interview with JAMA.

Convergent #evolution of #SARS-CoV-2 #XBB #lineages on #RBD 455–456 synergistically enhances #antibody #evasion and #ACE2 binding https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011868

@teresabuecker

In der Schweiz gilt auch, Kinder bekommen kein Corona darum testet man die armen Kinder auch nicht. 🫣

Weiss doch jeder das die keine #ACE2 Rezeptoren haben 🫠

@EricCarroll
The trick is to wear a properly fitted mask that doesn't fog up your glasses. Which I do.

#Ocular #transmission #SARS2 #CovidIsAirborne #CO2 #SARSCOV2 #ACE2 #COVID19 #transmission #Virus #COVID19 #riskManagement #COVID

Creative Launches Aurvana Ace Series Earbuds; Retails From US$129.99 #ace #ace2 #audio #aurvanaace #aurvanaace2 #creative #creativeaurvana #earbuds #solidstatedrivers #solidstateearbuds #xmemsearbuds

https://www.lowyat.net/2023/311414/creative-launches-aurvana-ace-series-earbuds-retails-from-us129-99/

"Close relatives of MERS-CoV in bats use ACE2 as their functional receptors"

OH GOOD

https://www.nature.com/articles/s41586-022-05513-3

#MERS #ACE2 #ItsThoseDamnedBatsAgain

A nifty simple-language educational video by 3D Molecular Designs on Youtube.

Tim Herman, Ph.D. explains the parts of the coronavirus spike protein, and how it attaches to the ACE2 binding receptors in our cells.

https://youtube.com/watch?v=vH3TZ6n1obQ

#covid #covid19 #coronavirus #spikeprotein #ACE2 #educational #youtube

@shonin go figure #Ace2 receptors compromised

Regulatory T cell-like response to #SARS-CoV-2 in Jamaican fruit #bats (Artibeus jamaicensis) transduced with #human #ACE2 https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011728

@croissant If only mutation weren't a thing.

If only.

My work simulating the folding of proteins (e.g. the #ace2 receptor binding surface used for initial infection) from #COVID might never end.

Computational physical simulation of rather absurd chemistry? Absurd because the "folding" process—taking a printed strip of chemicals and forming a functional 3D shape—takes milliseconds to /microseconds/ in reality. Up to three days to accurately simulate.

Better than getting infected, even once.