#molecularevolution — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #molecularevolution, aggregated by home.social.
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Creating a GPCR family activated by an inert ligand
🧪 Evolved muscarinic GPCRs, responsive only to CNO
⚙️ Achieved cell signaling without native ligands
📊 Used mutant receptors to study signaling pathways for msd#GPCR #MolecularEvolution #DREADD #Pharmacology #CellEngineering
https://dev.https://tnyp.me/CcS0q4hQ/m
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Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Darwin, C. On the Origin of Species (Cambridge Univ. Press, 1859). Simpson, G. G. The Major Features of…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Evolutionarygenetics #HumanitiesandSocialSciences #Molecularevolution #multidisciplinary
https://www.newsbeep.com/us/644536/ -
Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Darwin, C. On the Origin of Species (Cambridge Univ. Press, 1859). Simpson, G. G. The Major Features of…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #Evolutionarygenetics #HumanitiesandSocialSciences #Molecularevolution #multidisciplinary
https://www.newsbeep.com/us/644536/ -
https://www.europesays.com/uk/959167/ Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes #EvolutionaryGenetics #HumanitiesAndSocialSciences #MolecularEvolution #multidisciplinary #Science #UK #UnitedKingdom
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Bridging continuous and discrete evolution through a controllable, hypermutagenic phage-bacteria system
General methods All E. coli and phage strains created in this study are listed in Supplementary Table 1,…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #AppliedMicrobiology #Bacteriophages #DNASynthesis #general #InfectiousDiseases #LifeSciences #MedicalMicrobiology #microbiology #Molecularevolution #Parasitology #virology
https://www.newsbeep.com/us/618962/ -
Bridging continuous and discrete evolution through a controllable, hypermutagenic phage-bacteria system
General methods All E. coli and phage strains created in this study are listed in Supplementary Table 1,…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Science #AppliedMicrobiology #Bacteriophages #DNASynthesis #general #InfectiousDiseases #LifeSciences #MedicalMicrobiology #microbiology #Molecularevolution #Parasitology #virology
https://www.newsbeep.com/us/618962/ -
https://www.europesays.com/uk/932413/ Bridging continuous and discrete evolution through a controllable, hypermutagenic phage-bacteria system #AppliedMicrobiology #Bacteriophages #DNASynthesis #general #InfectiousDiseases #LifeSciences #MedicalMicrobiology #Microbiology #MolecularEvolution #Parasitology #Science #UK #UnitedKingdom #Virology
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https://www.europesays.com/uk/912766/ Chromosomal fusions trigger rediploidization of autopolyploid genomes #Chromosomes #EvolutionaryGenetics #HumanitiesAndSocialSciences #MolecularEvolution #multidisciplinary #Polyploidy #Science #UK #UnitedKingdom
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Here this sum over organs/tissues shows a strong excess of positive selection on regulatory sequences in human nervous system evolution 😎. And to a lesser extent in male reproductive system. #MolecularEvolution #EvoDevo
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https://www.europesays.com/ie/365909/ Phenogenomics reveals the ecology and evolution of Trichoderma fungi for sustainable agriculture #EcologicalGenetics #Éire #FungalBiology #FungalGenomics #general #IE #InfectiousDiseases #Ireland #LifeSciences #MedicalMicrobiology #Microbiology #MolecularEvolution #Parasitology #Science #Virology
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Congratulations to @nextstrain for this great paper! Studying the evolution of moulting beyond insects has been challenging, and we are starting to see how moulting is both deeply conserved and evolving differently in pancrustacean lineages. #EvoDevo #ArthropodEvolution #MolecularEvolution
https://bsky.app/profile/nextstrain.bsky.social/post/3mfc344teo22w -
The next step in a great scientific adventure led by Marina Brasó Vives on amphioxus evolution: population genomics of a species with 3% heterozygosity! Read the thread and the preprint 😁 #amphioxus #EvoDevo #PopulationGenomics #MolecularEvolution
https://bsky.app/profile/mbrasovives.bsky.social/post/3mctuhgks7k2q -
https://www.europesays.com/ie/270228/ The visual system of the longest-living vertebrate, the Greenland shark #ComparativeGenomics #Éire #EvolutionaryEcology #HumanitiesAndSocialSciences #IE #Ireland #MolecularEvolution #multidisciplinary #Science #Wildlife
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The visual system of the longest-living vertebrate, the Greenland shark
Bloch, M.E. and J.G. Schneider. M.E. Blochii, Systema ichthyologiae iconibus CX illustratum. Vol. [Atlas]. Berolini: Sumtibus auctoris impressum…
#NewsBeep #News #Wildlife #AU #Australia #Comparativegenomics #Evolutionaryecology #HumanitiesandSocialSciences #Molecularevolution #multidisciplinary #Science
https://www.newsbeep.com/au/395182/ -
I'm excited to present this new model to detect positive selection on regulatory sequences, which has been 3 years in the making!
Thanks to Alexandre Laverré and @Phylogenetrips for their amazing work on this project. 😃
https://doi.org/10.1101/2025.11.26.690685Thread! #bioinformatics #molecularEvolution
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🧩 What if the diverse functions of a single protein all trace back to one structural superfamily?
🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #ComputationalBiology #MolecularEvolution #ProteinScience #Genomics #Proteomics #AlphaFold #MembraneProteins #Genetics #Bioinformatics
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🧩 What if the diverse functions of a single protein all trace back to one structural superfamily?
🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #ComputationalBiology #MolecularEvolution #ProteinScience #Genomics #Proteomics #AlphaFold #MembraneProteins #Genetics #Bioinformatics
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🧩 What if the diverse functions of a single protein all trace back to one structural superfamily?
🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #ComputationalBiology #MolecularEvolution #ProteinScience #Genomics #Proteomics #AlphaFold #MembraneProteins #Genetics #Bioinformatics
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🧩 What if the diverse functions of a single protein all trace back to one structural superfamily?
🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003
📚 CSBJ: https://www.csbj.org/
#StructuralBiology #ComputationalBiology #MolecularEvolution #ProteinScience #Genomics #Proteomics #AlphaFold #MembraneProteins #Genetics #Bioinformatics
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Somatic mutation and selection at population scale
Cohort selection The TwinsUK study contains around 16,000 participants. From a preselection of 4,800 donors, we invited 1,796…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #Cancerepidemiology #Cancergenomics #dnasequencing #HumanitiesandSocialSciences #Molecularevolution #multidisciplinary #Mutation #Science
https://www.newsbeep.com/us/210388/ -
Somatic mutation and selection at population scale
Cohort selection The TwinsUK study contains around 16,000 participants. From a preselection of 4,800 donors, we invited 1,796…
#NewsBeep #News #US #USA #UnitedStates #UnitedStatesOfAmerica #Genetics #Cancerepidemiology #Cancergenomics #dnasequencing #HumanitiesandSocialSciences #Molecularevolution #multidisciplinary #Mutation #Science
https://www.newsbeep.com/us/210388/ -
https://www.europesays.com/uk/483765/ Somatic mutation and selection at population scale #CancerEpidemiology #CancerGenomics #DNASequencing #Health #HumanitiesAndSocialSciences #MolecularEvolution #multidisciplinary #Mutation #Science #UK #UnitedKingdom
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Update of our preprint on Inter-individual gene expression variability in fishes! We improved statistical analyses of continuous variables, and especially added machine learning on promoters which confirms cis-regulation of organ-specific expression variability, under stronger sequence constraint in the organs 🧠 whose genes have lower expression variability.
https://www.biorxiv.org/content/10.1101/2024.11.11.623020v3
#EvoDevo #MolecularEvolution #GeneExpression #RNAseq -
Starting #ESEB2025 a bit late, with an exciting symposium on whole genome duplication. They couldn’t fit all of the talks in, I’ll be talking on “Gene expression variability and evolutionary outcomes after whole-genome duplication in fishes” tomorrow in the Genetics symposium. #GeneDuplication #GenomeDuplication #MolecularEvolution
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Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science #UK #UnitedKingdom
https://www.newsbeep.com/uk/14338/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science #UK #UnitedKingdom
https://www.newsbeep.com/uk/14338/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science #UK #UnitedKingdom
https://www.newsbeep.com/uk/14338/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science #UK #UnitedKingdom
https://www.newsbeep.com/uk/14338/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #AU #Australia #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science
https://www.newsbeep.com/au/11663/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #AU #Australia #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science
https://www.newsbeep.com/au/11663/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #AU #Australia #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science
https://www.newsbeep.com/au/11663/ -
Experimental evolution in an era of molecular manipulation
Monod, J. Chance and Necessity: an Essay on the Natural Philosophy of Modern Biology (Vintage Books, 1972). Blount,…
#NewsBeep #News #Genetics #Agriculture #AnimalGeneticsandGenomics #AU #Australia #Biomedicine #CancerResearch #Experimentalevolution #GeneFunction #general #HumanGenetics #Molecularevolution #Science
https://www.newsbeep.com/au/11663/ -
https://www.europesays.com/uk/280830/ Experimental evolution in an era of molecular manipulation #Agriculture #AnimalGeneticsAndGenomics #Biomedicine #CancerResearch #ExperimentalEvolution #GeneFunction #general #Genetics #HumanGenetics #MolecularEvolution #Science #UK #UnitedKingdom
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https://www.europesays.com/uk/261245/ Researchers develop tool to improve genetic predictions #AnimalHusbandry #biochemistry #Bioinformatics #BiologicalEngineering #Biology #biotechnology #BranchesOfGenetics #crispr #Gene #Genetics #Genome #GenomeEditing #Genomics #HealthSciences #HumanGenome #LifeSciences #ModificationOfGeneticInformation #MolecularBiology #MolecularEvolution #MolecularGenetics #omics #Science #SingleNucleotidePolymorphism #UK #UnitedKingdom
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Exciting work led by Giulia Zancolli on the venomless Uloboridae spiders. They lost their venom glands and venom injecting duct, but wrap their prey in toxic digestive fluids.
The paper: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-025-02248-1
The press release (in 🇫🇷) https://www.unil.ch/news/1749727639234 #Venom #Spiders #EvoDevo #MolecularEvolution -
Nice highlight of our recent work on the evolution of venom production in marine predatory snails
https://www.nature.com/articles/s41559-025-02763-y
#EvoDevo #MolecularEvolution #Venom -
You can still apply: Postdoc job opportunity! We're looking for early career researcher in evolutionary genomics to study the relation between intra-specific gene expression variability, polymorphism, and macro-evolutionary rates. We have all of the data in 3 fishes and amphioxus, just waiting for your expertise and enthusiasm!
https://tinyurl.com/3aewk286
#EvoDevo #MolecularEvolution #bioinformatics #PopulationGenomics #RNAseq #PostDoc -
Postdoc job opportunity! We're looking for early career researcher in evolutionary genomics to study the relation between intra-specific gene expression variability, polymorphism, and macro-evolutionary rates. We have all of the data in 3 fishes and amphioxus, just waiting for your expertise and enthusiasm!
https://tinyurl.com/3aewk286
#EvoDevo #MolecularEvolution #bioinformatics #PopulationGenomics #RNAseq #PostDoc -
Nice RNAseq atlas of small but important crustacean Daphnia pulex, and study of "selection operating on genes expressed in different tissues" https://www.biorxiv.org/content/10.1101/2025.05.01.651673v1 #EvoDevo #MolecularEvolution #RNAseq #Daphnia #Crustacean
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Local adaptation has a role in reducing vulnerability to climate change in a widespread Amazonian forest lizard https://www.byteseu.com/984721/ #Biomedicine #Climate #ClimateChange #ConservationGenomics #Cytogenetics #ecology #EvolutionaryBiology #EvolutionaryEcology #General #GlobalWarming #HumanGenetics #MolecularEvolution #PlantGeneticsAndGenomics
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Great to see this out in society journal @molbioevol @officialSMBE!
Cone snails are venomous 🐚🍽️🐟 and have evolved from non venomous marine snails. We show how their venom gland evolved from homologous glands, and how this affected the evolution of their digestive system.
https://doi.org/10.1093/molbev/msaf095 #MolecularEvolution #EvoDevo #Venom -
This is the best explanation I've ever seen for lungfish genome sizes
https://xkcd.com/3064/
#XKCD #Genomes #MolecularEvolution #lungfish -
Ah now for something lighter: a horseshoe crab genome, whole genome duplications, and a cartoon:
https://doi.org/10.1093/molbev/msaf021
https://tapas.io/episode/3123425
#EvoDevo #MolecularEvolution #Genomics -
Like sex chromosomes and supergenes, the non-recombining region accumulates transposable elements, nonsynonymous substitutions, and gene presence/absence polymorphisms—a hallmark of recombination suppression. #MolecularEvolution
5/5 -
Intriguing: modeling and empirical data support that after whole genome duplication (autotetraploids) genetic variation rises, and mutation load increases because deleterious mutations are masked by additional chromosome copies
https://www.biorxiv.org/content/10.1101/2025.01.12.632621v1
#WholeGenomeDuplication #paralog #MolecularEvolution #PopulationGenetics #Arabidopsis -
Intriguing: modeling and empirical data support that after whole genome duplication (autotetraploids) genetic variation rises, and mutation load increases because deleterious mutations are masked by additional chromosome copies
https://www.biorxiv.org/content/10.1101/2025.01.12.632621v1
#WholeGenomeDuplication #paralog #MolecularEvolution #PopulationGenetics #Arabidopsis -
Intriguing: modeling and empirical data support that after whole genome duplication (autotetraploids) genetic variation rises, and mutation load increases because deleterious mutations are masked by additional chromosome copies
https://www.biorxiv.org/content/10.1101/2025.01.12.632621v1
#WholeGenomeDuplication #paralog #MolecularEvolution #PopulationGenetics #Arabidopsis -
Intriguing: modeling and empirical data support that after whole genome duplication (autotetraploids) genetic variation rises, and mutation load increases because deleterious mutations are masked by additional chromosome copies
https://www.biorxiv.org/content/10.1101/2025.01.12.632621v1
#WholeGenomeDuplication #paralog #MolecularEvolution #PopulationGenetics #Arabidopsis -
Intriguing: modeling and empirical data support that after whole genome duplication (autotetraploids) genetic variation rises, and mutation load increases because deleterious mutations are masked by additional chromosome copies
https://www.biorxiv.org/content/10.1101/2025.01.12.632621v1
#WholeGenomeDuplication #paralog #MolecularEvolution #PopulationGenetics #Arabidopsis