#phage — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #phage, aggregated by home.social.
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Here's a nice bit of Citizen Science anyone can get involved in! WooHoo!
Apply for a sample kit, and fill it with the dirtiest water you can find 😆
Send it off and you could get to name your own phage! -
A family of lanthipeptides with anti- #phage function.
Lanthivirin gene clusters in Actinobacteria yield matured peptides that block phage DNA replication, revealing new anti‑phage natural products.
#bacteriophage #microbiology https://davidojcius.blogspot.com/2026/07/how-lanthipeptide-natural-products.html
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A phabulous #phage in ink https://artologica.etsy.com/listing/4528504088 #sciart
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CBASS limits #bacteriophage production while maintaining cell viability in #Pseudomonas aeruginosa
https://davidojcius.blogspot.com/2026/06/cbass-limits-bacteriophage-production.html
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#Biofilm matrices containing filamentous phages help #Pseudomonas aeruginosa tolerate antibiotics. @tbharat_lab &co show that #nanobody disruption of #phage Pf4 #LiquidCrystalline droplets restores #antibiotic susceptibility @PLOSBiology https://plos.io/4xkd6Mw
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2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity.
CBASS 3TM‑SAVED effectors form cGAMP‑linked filaments that shear membranes and induce death.
#OpenAccess #virology #immunology #microbiology #phage #bacteriophage
https://davidojcius.blogspot.com/2026/04/23-cgamp-induced-membrane-shearing.html
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How do #bacteriophage life history strategies influence host invasion & inter- #phage competition in #biofilms? This study shows that spatial structure shapes invasion success, favoring temperate phages over lytic ones when diffusion is limited @PLOSBiology https://plos.io/47Aripq
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Molecular basis for anti-jumbo phage #immunity by AVAST type 5.
Avs5 detects an early jumbo‑phage activator and halts infection by rapidly hydrolyzing NAD+.
https://www.sciencedirect.com/science/article/pii/S1097276526000249 #phage #bacteriophage #microbiology
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"The very discovery of phage was the subject of a prolonged dispute between two camps: on one side was Félix d’Herelle,Citation5 the French-Canadian autodidact who first recognize ..."
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A pleasure to have @mfwhite2.bsky.social for our first #BiosciencesInstitute seminar this year and hearing all about #bacterial #phage defences
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#AI can now design functional #viruses - not the computer kind, either
Inject this synthetic #phage into #Ecoli and it kills better than the real thing
#Bacteriophages, are viruses that infect bacteria, have been widely studied since their discovery in the early 20th century. The end result of the AI portion of the project was a pool of 302 candidate #genomes, 285 of which were able to generate full genomes. Of those, 16 were found to inhibit growth of E. coli #bacteria.
https://www.theregister.com/2025/09/18/researchers_just_created_a_working/ -
1/5
Today I finished reading the non-fiction book The Good Virus, by Tom Ireland. Picked it up somewhat at random since I don't usually read non-fiction, and I'm not usually into biology.
But it turned out to be an excellent book, perhaps the best book I've read this year.
https://www.amazon.com/Good-Virus-Amazing-Forgotten-Promise-ebook/dp/B0BHPRSWFT/
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"Entelli-02 exhibits 88% host coverage against The Alfred Hospital’s ECC isolate collection (n = 206), confirmed by plaque formation and reduced bacterial load in septicaemic mice by >99%. We produced this cocktail as a therapeutic-grade product, ready for clinical use. Entelli-02 represents a hospital-specific phage cocktail with frontline efficacy and on-demand availability."
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I'm having a blast testing out Phold from @GB13Faithless - new preprint available here:
https://www.biorxiv.org/content/10.1101/2025.08.05.668817v1
Protein language model & structural alignment aided annotation. It immediately picked out some interesting replication genes from a prophage region I've been wrecking my head over for a while now.
https://github.com/gbouras13/phold
Worth checking out!
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Interesting.
BBC News: I found a bacteria-eating #virus in my loo - could it save your life?
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A precursor procapsid is initially formed during #bacteriophage assembly, but how? The #cryoEM structure of the scaffolding protein complex & portal within #phage P22 procapsid reveals how this complex orchestrates the initiation of procapsid assembly @PLOSBiology https://plos.io/44B71iE
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PHORCE allows measurement of lytic #phage amplification rates in bacterial populations. This study uses PHORCE to reveal phenotypic diversity among #Ecoli & #Paeruginosa phages; phage- #antibiotic interactions are mainly determined by the drug @PLOSBiology https://plos.io/3G2myhf
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How does the lysogenic-lytic cycle work in intestinal #bacteriophages? @dbikard &co show that hankyphage produces defective viral particles & identify RepCHP as master repressor of this #phage's lytic cycle #plosbiology https://plos.io/41Rr22S
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The Zorya Anti-Phage Defense System sounds like a hardcore sci-fi missile defense deployed by the Xanthan Conglomerate over their Ytterbium mines. It isn’t, but it kinda sounds like it is.
https://phys.org/news/2025-01-bacteria-anti-missile-defense-fend.html
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Nice work by Sanika Vaidya (and collegues)
done during our PhDs together at @maxplanckgesellschaft and @unibaselPeptidoglycan triggers #biofilm formation across bacterial species.
https://www.nature.com/articles/s41564-024-01886-5
#openaccess #mpg #mpitm #phage #V_cholerae #bacteria #nature #microbiology #science #research
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"We developed a method of #phage-assisted continuous evolution we call IntePACE..to systematically improve activity of PhiC31 & Bxb1 serine integrases..hyperactive mutants were generated..resulting in integration of a multi-gene cargo at rates as high as 80%..Hyperactive integrases inserted a 15.7 kb therapeutic #DNA cargo..This #technology could accelerate #gene delivery #therapeutics & our directed evolution strategy can easily be adapted to improve novel #integrases"
https://academic.oup.com/nar/article/52/14/e64/7702507?login=false
