home.social

#recognizing — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #recognizing, aggregated by home.social.

  1. Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
    but they have been unable to perform their roles properly due to suppression by the tumor.

    KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

    KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
    when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
    (a #cancer-#recognizing device) proteins on their own...
    and are converted into anticancer immune cells known as "#CAR-#macrophages."

    ❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

    As a result, the effectiveness of existing immune cell therapies has been limited.

    ✅ CAR-macrophages,
    which have recently attracted attention as a next-generation immunotherapy,
    have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

    ⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

    This process is time-consuming, costly, and has limited feasibility for
    real-world patient applications.

    To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

    ⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
    —designed to be readily absorbed by macrophages
    —with both mRNA encoding
    cancer-recognition information
    and an immunostimulant that activates immune responses.

    In other words, in this study,
    CAR-macrophages were created by
    👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
    news-medical.net/news/20260102