#phagocytosis — Public Fediverse posts

https://www.europesays.com/ie/317445/ Immunotherapy Blocking Microglial FcγR Prevents Neuron Loss in Parkinson’s Disease #Éire #IE #ImmuneCells #immunotherapy #Ireland #MonoclonalAntibodies #mouse #News #Parkinson'sDisease #Phagocytosis #Technology #topics #TranslationalMedicine

Smell loss emerges as the early behavioural sign of Alzheimer’s

New research reveals that immune cells attack brainstem nerve fibers linked to smell, making loss of smell the…
#NewsBeep #News #Health #Brain #CA #Canada #Cell #Cortex #Dementia #genes #Locus #Microglia #Nerve #Phagocytosis #Physiology #Protein #research #RNA
https://www.newsbeep.com/ca/119251/

@roylelab Nice work! This reminds me of a paper published while I was in my PhD lab addressing ER membrane contribution to the Phagocytic cup.

It still stands as a fantastic example of structured hypothesis testing.

https://doi.org/10.1016/j.cell.2005.08.018

#EndoplasmicReticulum #Phagocytosis #macrophages #ScienceMastodon

Study finds widespread '#cell_cannibalism' and related phenomena across #tree_of_life

#phagocytosis #evolution #phylogenomics

https://phys.org/news/2024-05-widespread-cell-cannibalism-phenomena-tree.html

Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer’s disease. https://doi.org/10.1186/s13195-023-01311-9 #Alzheimer’s #Hyperhomocysteinemia #Microglia #Phagocytosis #Hypomethylation

Next is Melanie Samuel from BCM
https://thesamuellab.org/

Molecular regulation of #immune cell #plasticity and function in the #brain

"Our brain is the ultimate time machine" 🙂

How to target #synapses (for intervention) while preserving them (to avoid "turning back the clock"

Possibility that #microglia could be harnessed

partnered with IMPC (impc.org) to find microglia regulators in retina
one cool hit: SIRPα
it's NOT involved in #phagocytosis... surprise

#CSSingleCells23

1/2

Uptake-independent killing of macrophages by extracellular #Mycobacterium #tuberculosis aggregates

Chiara Toniolo et al show that Mtb aggregates evade #phagocytosis by inducing #macrophage #pyroptosis via a mechanism involving its type VII secretion system ESX-1 and surface lipid PDIM

https://www.embopress.org/doi/10.15252/embj.2023113490