#cellmigration — Public Fediverse posts

Cell migration is fundamental to many biological processes (cancer metastasis, cellular immunity, development, ...). Here we introduce a new computational method & free tool to evaluate high-throughput cell migration assays.
#cancer #cellmigration #Bayes #quantitativebiology
https://doi.org/10.1371/journal.pcbi.1014472

Cell migration is fundamental to many biological processes (cancer metastasis, cellular immunity, development, ...). Here we introduce a new computational method & free tool to evaluate high-throughput cell migration assays.
#cancer #cellmigration #Bayes #quantitativebiology
https://doi.org/10.1371/journal.pcbi.1014472

Anneline is giving today's CMCB Lab Talk:

Manipulating cell-microenvironment interactions by inducing rapid integrin endocytosis in Ovarian Cancer

#CellBiology #CellMigration

Anneline is giving today's CMCB Lab Talk:

Manipulating cell-microenvironment interactions by inducing rapid integrin endocytosis in Ovarian Cancer

#CellBiology #CellMigration

📰 "Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma."
https://www.biorxiv.org/content/10.64898/2025.12.23.696151v1?rss=1 #CellMigration #Cell

📰 "Alkaloids isolated from Scutellaria Barbata D. Don trigger apoptosis and inhibit migration by modulating the p38-p53 pathway in ovarian cancer"
https://doi.org/doi:10.1186/s13048-025-01840-x
https://pubmed.ncbi.nlm.nih.gov/41444660/
#CellMigration #Cell

📰 "WASH regulates B cell signaling, metabolism and function through STAT1"
https://doi.org/doi:10.1038/s41418-025-01647-9
https://pubmed.ncbi.nlm.nih.gov/41437147/
#CellMigration #Actin #Cell

📰 "Phenotype-structuring of non-local kinetic models of cell migration driven by environmental sensing"
https://arxiv.org/abs/2412.16258 #CellMigration #Q-Bio.Cb #Q-Bio.Pe #Cell

📰 "FSCN1 regulates TGF-beta signalling to promote esophageal squamous cell carcinoma metastasis via stabilizing THBS1 mRNA"
https://doi.org/doi:10.1038/s42003-025-09393-x
https://pubmed.ncbi.nlm.nih.gov/41430434/
#CellMigration #Cell

📰 "Cell-mediated matrix deformations and cell-cell adhesions determine epithelial collective cell migration phenotypes"
https://doi.org/doi:10.1063/5.0295506
https://pubmed.ncbi.nlm.nih.gov/41424915/
#CellMigration #Cell

📰 "Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration"
https://doi.org/doi:10.1038/s41467-025-67645-0
https://pubmed.ncbi.nlm.nih.gov/41423618/
#CellMigration #Dynamics #Cell

📰 "1Measuring the Traction Forces 1of Upstream-Migrating Hematopoietic-like KG1a Cells Under Shear Flow"
https://doi.org/doi:10.1016/j.bpj.2025.12.022
https://pubmed.ncbi.nlm.nih.gov/41422381/
#CellMigration #Cell

📰 "Hedgehog and Drosophila germ cell migration"
https://doi.org/doi:10.1242/dev.205291
https://pubmed.ncbi.nlm.nih.gov/41417005/
#CellMigration #Cell

📰 "Curved Microfluidic Confinement Reveals Cell-Shape-Dependent Nuclear Mechanotransduction in Adaptive Migration"
https://doi.org/doi:10.1021/acsnano.5c16455
https://pubmed.ncbi.nlm.nih.gov/41412733/
#Mechanotransduction #CellMigration #Extracellular #Cell

📰 "Mapping galectin-3 ligands in tear fluid establishes spliceoform-dependent lacritin binding"
https://doi.org/doi:10.1101/2025.11.24.690288
https://pubmed.ncbi.nlm.nih.gov/41394644/
#CellMigration #Cell

Substances that slow down migrating cancer cells could be anti-metastatic drug candidates. In this preprint we describe the first computational model for quantitative analysis of cell migration assays for substance screening. #bayes
#cellmigration #metastasis
https://www.biorxiv.org/content/10.1101/2025.06.12.659342v1

📰 "Quantifying cellular autonomy in multi-cue environments"
https://arxiv.org/abs/2410.12081 #Physics.Bio-Ph #CellMigration #Q-Bio.Mn #Cell

📰 "Substrate properties and actin polymerization speed dictate universal modes of cell migration: gripping, slipping, and stick-slip"
https://www.biorxiv.org/content/10.1101/2025.06.20.660727v1?rss=1 #CellMigration #Mechanical #Actin #Cell

📰 "Cell-mechanical parameter estimation from 1D cell trajectories using simulation-based inference"
https://doi.org/doi:10.1371/journal.pone.0310669
https://pubmed.ncbi.nlm.nih.gov/40531866/
#CellMigration #Mechanical #Cell

📰 "In vivo nuclear envelope adaptation during cell migration across confining embryonic tissue environments"
https://www.biorxiv.org/content/10.1101/2025.06.05.658077v1?rss=1 #CellMigration #Mechanical #Cell

📰 "Chemotaxis of branched cells in complex environments"
https://arxiv.org/abs/2505.21949 #Physics.Bio-Ph #CellMigration #Q-Bio.Cb #Cell

📰 "Chemotaxis of branched cells in complex environments"
https://arxiv.org/abs/2505.21949 #Physics.Bio-Ph #CellMigration #Q-Bio.Cb #Cell

📰 "Entropy Production in Epithelial Monolayers Due to Collective Cell Migration"
https://doi.org/doi:10.3390/e27050483
https://pubmed.ncbi.nlm.nih.gov/40422438/
#CellMigration #Mechanical #Cell

📰 "Spatial regulation of mitochondrial membrane potential by 51 integrin engagement in collective cell migration"
https://doi.org/doi:10.1242/jcs.263665
https://pubmed.ncbi.nlm.nih.gov/40223421/
#CellMigration #Mechanical #Cell

📰 "Fixation and extinction in time-fluctuating spatially structured metapopulations"
https://arxiv.org/abs/2504.08433 #Cond-Mat.Stat-Mech #Physics.Bio-Ph #CellMigration #Q-Bio.Pe #Nlin.Ao #Cell

📰 "Single-Cell Trajectory Reconstruction Reveals Migration Potential of Cell Populations"
https://arxiv.org/abs/2504.07553 #Physics.Bio-Ph #CellMigration #Cell

📰 "A multiscale theory for mesenchymal cell migration in straight or curved channel confinement"
https://www.biorxiv.org/content/10.1101/2025.02.26.640464v1?rss=1 #Extracellular #CellMigration #Mechanical #Cell

📰 "Active gel theory for cell migration with two myosin isoforms"
https://arxiv.org/abs/2502.11833 #Physics.Bio-Ph #Cond-Mat.Soft #CellMigration #Q-Bio.Cb #Myosin #Force #Cell

📰 "Collective migration and topological phase transitions in confluent epithelia"
https://arxiv.org/abs/2502.09554 #Cond-Mat.Stat-Mech #Physics.Bio-Ph #Cond-Mat.Soft #CellMigration #Cell

📰 "Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers in metazoans"
https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1?rss=1 #CellMigration #Actin

📰 "Elevated SUN1 promotes aging-related polarity defects through mechanical coupling microtubules to the nuclear lamina"
http://biorxiv.org/cgi/content/short/2025.01.15.633301v1?rss=1 #CellMigration #Mechanical #Cell

📰 "Emergent cell migration from cell shape deformations and T1 transitions"
https://arxiv.org/abs/2412.19686 #Physics.Bio-Ph #Cond-Mat.Soft #CellMigration #Cell

📰 "Spiral waves speed up cell cycle oscillations in the frog cytoplasm"
https://arxiv.org/abs/2412.16094 #Physics.Bio-Ph #CellMigration #Q-Bio.Cb #Nlin.Ps #Cell

📰 "Spiral waves speed up cell cycle oscillations in the frog cytoplasm"
https://arxiv.org/abs/2412.16094 #Physics.Bio-Ph #CellMigration #Q-Bio.Cb #Nlin.Ps #Cell

📰 "Inferring nonlinear dynamics of cell migration"
https://arxiv.org/abs/2404.07390 #Physics.Bio-Ph #Cond-Mat.Soft #CellMigration #Dynamics #Q-Bio.Cb #Cell

#Cells can surf, we maintain, with a revised version of our paper on #arXiv now !

What they need to be is nothing more than the schematic below – a treadmilling bar in frictional contact with a soft elastic substrate. If soft enough, #symmetry breaking occurs because of the #nonlocal #feedback of these friction forces via the substrate and the cell starts to move.

#mechanobiology of #cellmigration
https://arxiv.org/abs/2303.09666

How does #centrosome #amplification -common in #cancer- promote #cellmigration through confined spaces?
Susana Godinho and colleagues show that it alters intracellular organization via effects on #tubulin #acetylation and #organelle transport along #microtubules
https://www.embopress.org/doi/full/10.15252/embj.2022112812

Are high-content #cellmigration #imaging data reproducible? Staffan Strömblad et al find that the highest variability occurs between labs & the variance can be substantially reduced by batch effect removal ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211490
#microscopy #reproducibility #SystemsBiology

aka "Surfing one's own wave"

In this preprint, Pierre and I show that a #cell which is not polarised at all but is only #treadmilling in a symmetric way can spontaneously start to migrate if it is spread on an sufficiently soft substrate.

This is something like #surfing, as the cell is carried away by an #elastic #wave... which it has itself created with its treadmilling!

#cellMigration #motility #mechanobiology #migration

PhD Candidature (Biophysics, Bioimaging) @anuobig

https://jobrxiv.org/job/john-curtin-school-of-medical-research-australian-national-university-27778-phd-candidature-biophysics-bioimaging/?feed_id=33026
#ScienceJobs #imagingscience #biophysics #cellmigration #optics
Canberra/ACT, #Australia #PhDStudent
https://jobrxiv.org/job/john-curtin-school-of-medical-research-australian-national-university-27778-phd-candidature-biophysics-bioimaging/?feed_id=33026

I'm super excited how well #ScienceMastodon is working out! Here's a proper introduction:

I'm a Postdoc doing #biophysics #theory at #ISTA (Vienna). I work on #cellmigration & #stemcells from a physics perspective - trying to understand how cells communicate to self-organize into complex pattern that shape embryos.

➡️ For more info on my work, check out my website www.davidbrueckner.de