#connectomics — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #connectomics, aggregated by home.social.
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📰 "Multisensory learning recruits visual neurons into an olfactory memory engram"
https://arxiv.org/abs/2604.28007
#Connectomics
#Drosophila #Q-Bio.Nc #Sensory -
📰 "Cross-Platform Neurotransmitter & Alias Ambiguity for OA-AL2b1 and OA-AL2b2 Neurons in Drosophila melanogaster"
https://doi.org/doi:10.1007/s12021-026-09783-4
https://pubmed.ncbi.nlm.nih.gov/42043632/
#DrosophilaMelanogaster
#Connectomics
#Drosophila -
2+2 years position for a software engineer / data scientist with serious programming chops in my lab at the #MRCLMB to develop tech for #connectomics and #neuroscience :
Please do share with suitable candidates, and feel free to reach out via email to discuss details.
Deadline for application: May 10th.
Starting date: any within 2026.
Requires Masters plus industry experience, or a PhD in a suitable field – and demonstrable experience in software engineering.
Please help disseminate – either here or by copy-pasting onto emails or messages. Thank you!
#PhDJobs #neuroscience #SoftwareEngineering #jobs #ScienceJobs
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2+2 years position for a software engineer / data scientist with serious programming chops in my lab at the #MRCLMB to develop tech for #connectomics and #neuroscience :
Please do share with suitable candidates, and feel free to reach out via email to discuss details.
Deadline for application: May 10th.
Starting date: any within 2026.
Requires Masters plus industry experience, or a PhD in a suitable field – and demonstrable experience in software engineering.
Please help disseminate – either here or by copy-pasting onto emails or messages. Thank you!
#PhDJobs #neuroscience #SoftwareEngineering #jobs #ScienceJobs
-
2+2 years position for a software engineer / data scientist with serious programming chops in my lab at the #MRCLMB to develop tech for #connectomics and #neuroscience :
Please do share with suitable candidates, and feel free to reach out via email to discuss details.
Deadline for application: May 10th.
Starting date: any within 2026.
Requires Masters plus industry experience, or a PhD in a suitable field – and demonstrable experience in software engineering.
Please help disseminate – either here or by copy-pasting onto emails or messages. Thank you!
#PhDJobs #neuroscience #SoftwareEngineering #jobs #ScienceJobs
-
2+2 years position for a software engineer / data scientist with serious programming chops in my lab at the #MRCLMB to develop tech for #connectomics and #neuroscience :
Please do share with suitable candidates, and feel free to reach out via email to discuss details.
Deadline for application: May 10th.
Starting date: any within 2026.
Requires Masters plus industry experience, or a PhD in a suitable field – and demonstrable experience in software engineering.
Please help disseminate – either here or by copy-pasting onto emails or messages. Thank you!
#PhDJobs #neuroscience #SoftwareEngineering #jobs #ScienceJobs
-
2+2 years position for a software engineer / data scientist with serious programming chops in my lab at the #MRCLMB to develop tech for #connectomics and #neuroscience :
Please do share with suitable candidates, and feel free to reach out via email to discuss details.
Deadline for application: May 10th.
Starting date: any within 2026.
Requires Masters plus industry experience, or a PhD in a suitable field – and demonstrable experience in software engineering.
Please help disseminate – either here or by copy-pasting onto emails or messages. Thank you!
#PhDJobs #neuroscience #SoftwareEngineering #jobs #ScienceJobs
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📰 "Sensory-motor integration in a nonspiking interneuron contributes to active sensor control in Drosophila"
https://www.biorxiv.org/content/10.64898/2026.04.16.718965v1?rss=1
#Connectomics
#Drosophila #Behaviour #Sensory -
📰 "A central somatotopic map of the fly leg supports spatially targeted grooming"
https://doi.org/doi:10.1016/j.cub.2026.03.045
https://pubmed.ncbi.nlm.nih.gov/41966690/
#Sensorimotor
#Connectomics
#Drosophila -
If interested in this topic, Prof. Bing Brunton gave a talk at #Cosyne2026 which is very much worth watching:
https://youtu.be/yhUBq5R01qA?t=3430
Among other topics, Bing presents the minimal network for the oscillatory behaviour that sustains walking, and also the embodiment of a connectome by plugging it into a virtual mechanical model of the fly, #MuJoCo from the #AnyBrain #HHMIJanelia project team.
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Postdoc position: Career Returner Fellowship
"The LMB is proud to launch a three-year fully funded fellowship for scientists who have had a career break of 12 months or more."
"At the LMB, we understand that stepping away from research – even briefly – can affect career progression. That is why we have created a dedicated postdoctoral fellowship to support researchers who have taken a career break of 12 months or more, for any reason, for example parental leave, health reasons, caregiving, a career change or other personal circumstances."
https://mrclmb.ac.uk/careers-and-people/postdocs/career-returner-fellowship/
Happy to discuss applications to our lab in #Drosophila #connectomics, #ElectronMicroscopy or #ComputerVision applied to #BioimageInformatics.
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Postdoc position: Career Returner Fellowship
"The LMB is proud to launch a three-year fully funded fellowship for scientists who have had a career break of 12 months or more."
"At the LMB, we understand that stepping away from research – even briefly – can affect career progression. That is why we have created a dedicated postdoctoral fellowship to support researchers who have taken a career break of 12 months or more, for any reason, for example parental leave, health reasons, caregiving, a career change or other personal circumstances."
https://mrclmb.ac.uk/careers-and-people/postdocs/career-returner-fellowship/
Happy to discuss applications to our lab in #Drosophila #connectomics, #ElectronMicroscopy or #ComputerVision applied to #BioimageInformatics.
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Postdoc position: Career Returner Fellowship
"The LMB is proud to launch a three-year fully funded fellowship for scientists who have had a career break of 12 months or more."
"At the LMB, we understand that stepping away from research – even briefly – can affect career progression. That is why we have created a dedicated postdoctoral fellowship to support researchers who have taken a career break of 12 months or more, for any reason, for example parental leave, health reasons, caregiving, a career change or other personal circumstances."
https://mrclmb.ac.uk/careers-and-people/postdocs/career-returner-fellowship/
Happy to discuss applications to our lab in #Drosophila #connectomics, #ElectronMicroscopy or #ComputerVision applied to #BioimageInformatics.
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Postdoc position: Career Returner Fellowship
"The LMB is proud to launch a three-year fully funded fellowship for scientists who have had a career break of 12 months or more."
"At the LMB, we understand that stepping away from research – even briefly – can affect career progression. That is why we have created a dedicated postdoctoral fellowship to support researchers who have taken a career break of 12 months or more, for any reason, for example parental leave, health reasons, caregiving, a career change or other personal circumstances."
https://mrclmb.ac.uk/careers-and-people/postdocs/career-returner-fellowship/
Happy to discuss applications to our lab in #Drosophila #connectomics, #ElectronMicroscopy or #ComputerVision applied to #BioimageInformatics.
-
Postdoc position: Career Returner Fellowship
"The LMB is proud to launch a three-year fully funded fellowship for scientists who have had a career break of 12 months or more."
"At the LMB, we understand that stepping away from research – even briefly – can affect career progression. That is why we have created a dedicated postdoctoral fellowship to support researchers who have taken a career break of 12 months or more, for any reason, for example parental leave, health reasons, caregiving, a career change or other personal circumstances."
https://mrclmb.ac.uk/careers-and-people/postdocs/career-returner-fellowship/
Happy to discuss applications to our lab in #Drosophila #connectomics, #ElectronMicroscopy or #ComputerVision applied to #BioimageInformatics.
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Shawn Mikula's https://connectomes.org/ doesn't load, but the domain name is registered. Does anyone know who is maintaining the site?
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📰 "A central somatotopic map of the fly leg supports spatially targeted grooming"
https://www.biorxiv.org/content/10.64898/2026.02.27.708590v1?rss=1
#Connectomics
#Sensorimotor
#Drosophila #Behaviour -
Now out as a version of record:
"Neural connectome of the ctenophore statocyst", Jokura et sl. 2026 (Jékely lab)
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By the way, unlike what the piece says, Murrhy and Seung did NOT "have the idea to use those images to identify and map the connections between each visible neuron, creating a connectome".
That idea had been floating about the field since Brenner and his C. elegans connectome, and those in a position to execute were the groups at Janelia with discretionary HHMI finding, like Rubin, Bock and myself. And we did.
What the Seung lab did was capitalise on the published EM volume of the adult female fly brain to apply more effective image registration and neuron segmentation approaches than the ones tried so far at that point by the Fly EM Project Team at Janelia. Synapses were detected by Julia Buhmann in saalfeld's lab at Janelia as well. The research groups led by Seung, Jefferis (at MRC LMB) and Murthy then put in the gargantuan effort of proofreading to deliver the published connectome.
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Sunday slow rereading on #neuroscience #drosophila #flybrain #electromicroscopy #connectomics #omics
Holy Molly forgot this top notch quotation!?
,There is a before and after connectome—B.C. and A.C.’
@albertcardona referencing a well-known quote from #columbiaun #TheoreticalNeuroscience Larry Abbott
with this follow-up:
,It’s the end of the beginning’
https://www.science.org/content/article/complete-map-fruit-fly-brain-circuitry-unveiled
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We are hiring! SPecifically, a PostDoc for data management and connectomics as part of a large clinical research group. The details can be found here: https://www.linkedin.com/posts/epiconn_open-position-apply-now-the-epiconn-activity-7413211951125688320-Wqi5
Please apply if you are interested in up to four years in Vienna, one of the most liveable cities in the world!
#university #medicaluniversityofvienna
#research #vienna #austria #ismrm #mri #7Tesla #epilepsy #connectomics #data_management -
Can neuroscientists decode memories solely from a map of synaptic connections?
| Five experts discuss the progress, possibilities and hurdles of decoding a “nontrivial” memory from an organism just by analyzing its brain connectivity patterns |
The Transmitter: Neuroscience News and Perspectives
🎧🤷
https://www.thetransmitter.org/brain-inspired/can-neuroscientists-decode-memories-solely-from-a-map-of-synaptic-connections/ -
📰 "Whole-brain connectomics of Drosophila reveals a robust, distributed architecture for the suppression of feeding during escape"
https://www.biorxiv.org/content/10.64898/2025.12.14.694122v1?rss=1
#Connectomics
#Drosophila -
Our dispatch:
https://www.sciencedirect.com/science/article/pii/S0960982225014691
on the recent Hydra volume EM paper by Zhang, Rafa Yuste and colleagues:
#connectomics, without synapses
https://www.sciencedirect.com/science/article/pii/S0960982225013090
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X-ray imaging at under 40 nm resolution without destroying the tissue: a demonstration by Wanner, Díaz, Schaefer and Bosch.
Based on radiation-had epoxy resin borrowed from the aerospace and nuclear industries.
"Tissue samples were resistant to radiation doses exceeding 1.15 × 1010 Gy, and sub-40 nm isotropic resolution allowed identifying axon bundles, dendrites and synapses in mouse brain tissue without physical sectioning."
"Nondestructive X-ray tomography of brain tissue ultrastructure", Bosch et al. 2025
https://www.nature.com/articles/s41592-025-02891-0 -
📰 "Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes"
https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1?rss=1
#DrosophilaMelanogaster
#Connectomics
#Neuroscience
#Drosophila -
"Just use Postgres until it breaks."
https://topicpartition.io/blog/postgres-pubsub-queue-benchmarksWe are far from that – we use #postgres to power #CATMAID for #connectomics and so far so good.
"Donald Knuth warned us in 1974 - premature optimization is the root of all evil. ... The point of this article is to show you that this “small scale” number has grown further than what people remember it to be - it can comfortably mean many megabytes per second. We are in a Postgres Renaissance for a reason: Postgres is frequently good enough. Modern NVMEs and cheap RAM allow it to scale absurdly high."
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"Just use Postgres until it breaks."
https://topicpartition.io/blog/postgres-pubsub-queue-benchmarksWe are far from that – we use #postgres to power #CATMAID for #connectomics and so far so good.
"Donald Knuth warned us in 1974 - premature optimization is the root of all evil. ... The point of this article is to show you that this “small scale” number has grown further than what people remember it to be - it can comfortably mean many megabytes per second. We are in a Postgres Renaissance for a reason: Postgres is frequently good enough. Modern NVMEs and cheap RAM allow it to scale absurdly high."
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"Just use Postgres until it breaks."
https://topicpartition.io/blog/postgres-pubsub-queue-benchmarksWe are far from that – we use #postgres to power #CATMAID for #connectomics and so far so good.
"Donald Knuth warned us in 1974 - premature optimization is the root of all evil. ... The point of this article is to show you that this “small scale” number has grown further than what people remember it to be - it can comfortably mean many megabytes per second. We are in a Postgres Renaissance for a reason: Postgres is frequently good enough. Modern NVMEs and cheap RAM allow it to scale absurdly high."
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"Just use Postgres until it breaks."
https://topicpartition.io/blog/postgres-pubsub-queue-benchmarksWe are far from that – we use #postgres to power #CATMAID for #connectomics and so far so good.
"Donald Knuth warned us in 1974 - premature optimization is the root of all evil. ... The point of this article is to show you that this “small scale” number has grown further than what people remember it to be - it can comfortably mean many megabytes per second. We are in a Postgres Renaissance for a reason: Postgres is frequently good enough. Modern NVMEs and cheap RAM allow it to scale absurdly high."
-
"Just use Postgres until it breaks."
https://topicpartition.io/blog/postgres-pubsub-queue-benchmarksWe are far from that – we use #postgres to power #CATMAID for #connectomics and so far so good.
"Donald Knuth warned us in 1974 - premature optimization is the root of all evil. ... The point of this article is to show you that this “small scale” number has grown further than what people remember it to be - it can comfortably mean many megabytes per second. We are in a Postgres Renaissance for a reason: Postgres is frequently good enough. Modern NVMEs and cheap RAM allow it to scale absurdly high."
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Songbird connectomics, from my colleague Joergen Kornfeld:
https://www.songbird-connectomics.org/Includes the first connectome of basal ganglia.
Three key papers:
"The songbird basal ganglia connectome", Rother et al. 2025 (Kornfeld lab)
https://www.biorxiv.org/content/10.1101/2025.10.25.684569v1"An anatomical substrate of credit assignment in reinforcement learning", Kornfeld et al. 2025 (with Michael Fee as senior author)
https://www.biorxiv.org/content/10.1101/2020.02.18.954354v2"Songbird connectome reveals tunnelling of migratory neurons in the adult striatum", Shvedov et al. 2025 (B.B. Scott's lab)
https://www.biorxiv.org/content/10.1101/2025.10.24.684388v1#neuroscience #connectomics #ZebraFinch #songbirds #BasalGanglia
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📰 "Synapse Detection Efficiency in EM Drosophila Connectomics"
https://www.biorxiv.org/content/10.1101/2025.10.16.682869v1?rss=1
#Connectomics
#Drosophila -
For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
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For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
-
For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
-
For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
-
For the worm there's the additional problem that the field has been working with point neurons for decades, ignoring the fact that most neurons in C. elegans have a very clear axon separate from its dendrite. I'd like to see a cleaned up connectome where there are 4 synaptic connectivity matrices and not one (axo-dendritic, axon-axonic, etc.), and I fear I may have to do so myself.
Modeling a connectome while mixing axo-dendritic with axo-axonic synapses with a point-neuron model is only asking for trouble and confusion.
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The much awaited connectome of the male central nervous system of the fruit fly, Drosophila melanogaster:
"Sexual dimorphism in the complete connectome of the Drosophila male central nervous system", Berg et al. 2025 https://www.biorxiv.org/content/10.1101/2025.10.09.680999v1
"contains 166,696 neurons spanning the brain and ventral nerve cord, fully proofread and comprehensively annotated including fruitless and doublesex expression and 11,691 cell types."
A collaboration between #HHMIJanelia, #MRCLMB and many others.
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On descending control of thoracic GABAergic neurons that presynaptically (i.e., axo-axonically) modulate leg proprioprioceptive axons. So cool to see Wolf and Burrows 1995 in locust revisited in fruit flies:
"Selective presynaptic inhibition of leg proprioception in behaving Drosophila", Dallmann et al (Tuthill lab @tuthill ) 2025
https://www.nature.com/articles/s41586-025-09554-2 -
If neuroscience ever delivers a volume of the human brain in sufficient resolution to map its connectome, the file system to store it will be like #TernFS :
https://www.xtxmarkets.com/tech/2025-ternfs/Immutable, redundant, with structural sharing, snapshots, and distributed. In other words built from the ground up for concurrent reading and writing.
#connectomics -
My colleage Donglai Wei is seeking to recruit postdocs and students at his lab in Boston College, Massachussets.
The topic: develop and implement machine learning methods for connectomics and for bioimagery more generally.
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Our lab member Samia Mohinta @Mohinta2892 is featured in this outreach video prepared by the Accelerate Program for Scientific Discovery, explaining in lay terms how we map neural circuits in the fruit fly brain using machine learning approaches, AKA computer vision:
https://www.youtube.com/watch?v=68fQ7ZGTxAQThe eFIB-SEM instrument is featured, setup in the lab, as well as various views of the #MRCLMB.
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"A Developmental Atlas of the Drosophila Nerve Cord Uncovers a Global Temporal Code for Neuronal Identity", Cachero et al. (Jefferis lab) 2025
https://www.biorxiv.org/content/10.1101/2025.07.16.664682v2 -
📰 "Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite"
https://www.biorxiv.org/content/10.1101/2025.08.25.671815v1?rss=1
#InternalState
#Connectomics
#Sensorimotor
#Drosophila -
📰 "Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite"
https://www.biorxiv.org/content/10.1101/2025.08.25.671815v1?rss=1
#InternalState
#Connectomics
#Sensorimotor
#Drosophila -
📰 "Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite"
https://www.biorxiv.org/content/10.1101/2025.08.25.671815v1?rss=1
#InternalState
#Connectomics
#Sensorimotor
#Drosophila -
📰 "Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite"
https://www.biorxiv.org/content/10.1101/2025.08.25.671815v1?rss=1
#InternalState
#Connectomics
#Sensorimotor
#Drosophila -
📰 "Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite"
https://www.biorxiv.org/content/10.1101/2025.08.25.671815v1?rss=1
#InternalState
#Connectomics
#Sensorimotor
#Drosophila