#computationalbiology — Public Fediverse posts

⚛️ Would today’s antibiotics still work if bacterial biology were flipped at the molecular level?

🔗 Molecular Dynamics Simulations Demonstrate Reduced Antibiotic Affinity to Mirror Bacterial Targets. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0198

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#MolecularDynamics #Antibiotics #Biosecurity #ComputationalBiology #SyntheticBiology #DrugDiscovery #AntimicrobialResearch #ComputationalChemistry

📢 Call for Papers: AI for Real-World Evidence Generation in Biomedicine

⏳ Submission Deadline: 31 January 2027

🔗 Submit your work: https://spj.science.org/journal/csbj/si/ai-real-world-evidence-generation

#CallForPapers #RealWorldEvidence #RWE #ArtificialIntelligence #AIinHealthcare #BiomedicalAI #MachineLearning #ClinicalInformatics #ComputationalBiology #CausalAI #Multiomics #BiomarkerDiscovery #PrecisionMedicine #DigitalHealth #RegulatoryScience #BiomedicalResearch

A mathematical modeling approach used to optimize the composition, diversity, and timing of bacteriophage cocktails for treating drug-resistant bacterial infections.
#ComputationalBiology #MathematicalBiology #Microbiology #InfectiousDiseases #sflorg
https://www.sflorg.com/2026/08/cobi08292601.html

The nuclear pore complex (7R5J & 7R5K) – one of the largest molecular machines in biology.

The nuclear pore complex is the gatekeeper of the cell nucleus – controlling everything that enters or leaves. We captured it in two states: open (dilated) and closed (constricted).

961665 quantum records

https://www.exxogen.hu/

​#StructuralBiology #Biophysics #Bioinformatics #Topology #InformationTheory #DNAFolding #ComputationalBiology #ComplexSystems #Genomics #OpenScience #EXXOGEN

What if the biological sequence of these 3 billion base pairs is completely irrelevant... and the human genome was never written to be read, but folded? What if the information isn't carried by the linear code, but by the spatial geometry the molecule closes around itself, and we are merely trying to decipher a 3D shadow cast by a higher-dimensional structure?

https://www.exxogen.hu/

​#Biophysics #Bioinformatics #InformationTheory #DNA #ComputationalBiology #ComplexSystems #Genomic #EXXOGEN

📢 Call for Papers: Deep Learning for Next-Generation Bio-Data Mining

⏳ Submission Deadline: 30 November 2026

🔗 Submit your work: https://spj.science.org/journal/csbj/si/deep-learning-bio-data

#CallForPapers #DeepLearning #BioDataMining #ArtificialIntelligence #MachineLearning #Bioinformatics #ComputationalBiology #BiomedicalAI #Genomics #Transcriptomics #Multiomics #BiomedicalNLP #DrugDiscovery #SystemsBiology #HealthcareAI

🤖 Can artificial intelligence reveal how bacterial strains differ beneath the surface?

🔗 Predicting Strain-Specific Metabolic Capabilities in the Genus Pseudomonas with a Flux-to-AI Approach Reveals Hidden Cell Envelope Properties. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0190

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#Microbiology #ComputationalBiology #SystemsBiology #ArtificialIntelligence #Biotechnology #SyntheticBiology

🧬 Can we trust membrane protein annotations when databases tell different stories?

🔗 MetaMP Ecosystem for Unified, Auditable, and Benchmark-Ready Data for Reliable Membrane Protein Annotation. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0165

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#MembraneProteins #StructuralBiology #Bioinformatics #ComputationalBiology #ProteinScience #DataScience #DrugDiscovery #AIinScience #OpenScience

🧬 How can we make nucleosome profiling more scalable, quantitative, and reproducible?

🔗 A Scalable MNase-seq Framework for Reproducible Nucleosome Profiling across Pluripotent Stem Cell and Cardiomyocyte Models. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0204

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#ChromatinBiology #Epigenomics #Epigenetics #Genomics #StemCells #MolecularBiology #GenomeResearch #Bioinformatics #ComputationalBiology

📢 Call for Papers: Computational and Experimental Advances in Carbohydrate-Active Enzymes

⏳ Submission Deadline: 31 May 2027

🔗 Submit your work: https://spj.science.org/journal/csbj/si/carbohydrate-active-enzymes

#CallForPapers #CAZymes #CarbohydrateActiveEnzymes #EnzymeEngineering #ComputationalBiology #StructuralBiology #Bioinformatics #ArtificialIntelligence #MachineLearning #ProteinEngineering #SyntheticBiology #Metagenomics #Biotechnology #BiomassValorization #CircularBioeconomy

A comprehensive analysis of anti-aging intervention studies utilizing blood-based DNA tests, known as epigenetic clocks, to determine which therapies genuinely slow the biological aging process.
#Epigenetics #ComputationalBiology #Bioinformatics #Gerontology #sflorg
https://www.sflorg.com/2026/08/epig08222601.html

Computational Biologist - Fully Remote
micro1

Computational Biologists (MSc or PhD) needed for fully remote contract work (up to $120/hour!). Ideally looking for experience in medicinal chemistry

See the full job description on jobRxiv: https://jobrxiv.org/job/micro1-27778-computational-biologist-fully-remote/

#bioinformatics #cheminformatics #computationalbiology #drugdiscovery #medicinalchemistry #S...
https://jobrxiv.org/job/micro1-27778-computational-biologist-fully-remote/?fsp_sid=14384

Bioinformatics Scientist - Fully Remote
micro1

Bioinformatics scientists (MSc or PhD) needed for fully remote contract work (up to $120/hour!). Ideally looking for experience in medicinal chemistry

See the full job description on jobRxiv: https://jobrxiv.org/job/micro1-27778-bioinformatics-scientist/

#bioinformatics #computationalbiology #drugdesign #medicinalchemistry #structureactivityrelationships #ScienceJobs...
https://jobrxiv.org/job/micro1-27778-bioinformatics-scientist/?fsp_sid=14248

Postdoctoral Research Scientist
Korem Lab at Columbia University

See the full job description on jobRxiv: https://jobrxiv.org/job/korem-lab-at-columbia-university-27778-postdoctoral-research-scientist-4/

#computationalbiology #machinelearning #microbiome #ScienceJobs #hiring #research
https://jobrxiv.org/job/korem-lab-at-columbia-university-27778-postdoctoral-research-scientist-4/?fsp_sid=14036

I entered grad school #Academia not knowing anything about #Bioinformatics or #ComputationalBiology. I thought it probably wasn't for me. But I ended up enjoying it.

What I can't stand about it in an academic setting is the double-edged sword. It's too important to not have, but not important enough to pay for. I help a lot of people with analysis. Many of them are jerks who I sacrifice time to and they use my effort to get their funding and never pay for the work. Others are great.

University of Michigan researchers utilized advanced artificial intelligence to demonstrate that passerine birds (order Passeriformes) underwent rapid bursts of morphological evolution that directly coincided with major historical climate shifts.
#EvolutionaryBiology #Ornithology #Paleoclimatology #ComputationalBiology #AI #sflorg
https://www.sflorg.com/2026/07/ebio07202601.html

Postdoctoral Fellow in Pulmonary Vascular Biology
University of California, Los Angeles (UCLA)

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-california-los-angeles-ucla-27778-postdoctoral-fellow-in-pulmonary-vascular-biology/

#CellMolecularBiology #computationalbiology #pulmonarybiology #translationalresearch #vascularbiol...
https://jobrxiv.org/job/university-of-california-los-angeles-ucla-27778-postdoctoral-fellow-in-pulmonary-vascular-biology/?fsp_sid=13738

I wonder that there seem to be so few #ISMB2026 posts on here, usually a massive #ComputationalBiology conference, despite a good #bioinformatics pool of posters here.

Is it a Mastodon European skew? And/or privacy/visa/travel fears attending the #ISMB conference in Washington under the second Trump administration? I personally wouldn’t willingly travel to the USA for now even if I had a travel budget to cover it 🤷‍♂️

You know what floats to the top of my thoughts pretty often?

Globally, how much better #Bioinformatics, #ComputationalBiology, and #FOSS #OpenSource software would be with universal basic income. So many people would be happy to keep making their products better for the greater good if they didn't have to worry about shelter, food security, and healthcare.

References

https://www.bio-focus.co.uk/biotechnology/basecamp-research-launches-the-trillion-gene-atlas?hl=en-US#:~:text=Nearly%20all%20current%20sequence%2Dbased,narrow%20fraction%20of%20Earth's%20biodiversity.

https://rewire.it/blog/eden-28-billion-parameters-for-programming-biology/?hl=en-US#:~:text=In%20January%202026%2C%20Basecamp%20Research,not%20just%20another%20foundation%20model.

https://www.prnewswire.com/news-releases/basecamp-research-launches-trillion-gene-atlas-to-scale-ai-designed-therapeutics-302716624.html?hl=en-US#:~:text=By%20learning%20from%20an%20unprecedented,laws%20for%20AI%20in%20biology.

https://astrobiology.com/2026/06/11/planetary-genomics-basecamp-research-launches-the-trillion-gene-atlas/?hl=en-US#:~:text=%E2%80%9CEDEN%20showed%20that%20performance%20in,Global%20Biodiversity%20Partnerships

https://basecamp-research.com/?hl=en-US#:~:text=By%20learning%20from%20biology%20at,step%20what%20once%20took%20many.

https://www.prnewswire.com/news-releases/basecamp-research-brings-edens-antibiotic-and-vaccine-design-models-to-claude-science-302814440.html?hl=en-US#:~:text=In%20collaboration%20with%20University%20of,when%20tested%20in%20the%20lab.

https://www.biorxiv.org/content/10.64898/2026.01.12.699009v1?hl=en-US#:~:text=First%2C%20we%20demonstrate%20AI%2Dprogrammable,from%20the%20desired%20target%20site.

https://scienceandculture.com/2021/10/dragonflies-make-the-most-of-a-tiny-brain/?hl=en-US#:~:text=The%20story%2C%20%E2%80%9CFast%2C%20Efficient,at%20Sandia%20Labs%20on%20dragonflies.

https://www.clay.com/dossier/basecamp-research-funding?hl=en-US

https://www.redalpine.com/post/redalpine-invests-in-basecamp-research-to-revolutionize-genome-design?hl=en-US#:~:text=Founded%20in%202019%20in%20London,AI%20platform%20and%20proprietary%20datasets.

https://schedule.sxsw.com/contributors/2239849?hl=en-US

https://www.biospace.com/press-releases/basecamp-research-initiates-genetic-medicine-collaboration-with-the-liu-laboratory-and-completes-60-million-series-b-financing?hl=en-US#:~:text=The%20Basecamp%20Research%20and%20the,a%20wide%20range%20of%20diseases.

https://techfundingnews.com/biodiversity-meets-ai-basecamp-research-raises-60m-to-disrupt-biological-systems-design/?hl=en-US#:~:text=In%20addition%20to%20this%2C%20the,Institute%20of%20MIT%20and%20Harvard.

https://www.caplight.com/company/basecamp-research?hl=en-US

https://sifted.eu/articles/basecamp-research-60m-series-b?hl=en-US#:~:text=Other%20investors%20included%20S32%2C%20redalpine,A%20database%20of%20life

https://www.biopharmadive.com/news/basecamp-broad-david-liu-ai-genetic-medicine-series-b/729129/?hl=en-US#:~:text=The%20London%2Dbased%20company%20said,of%20%E2%80%9Cprogrammable%E2%80%9D%20genetic%20medicines.

#bioinformatics #computationalbiology #syntheticbiology #synbio #datascience

A newly developed evaluative framework that tests the reliability, transparency, and chemical reasoning of artificial intelligence (AI) models used in the development of new antibiotics.
#Cheminformatics #ComputationalBiology #Pharmacology #Microbiology #ArtificialIntelligence #sflorg
https://www.sflorg.com/2026/06/cobi06262601.html

A novel drug-screening platform that integrates 3D bioprinting, advanced imaging, and artificial intelligence to evaluate the efficacy of cancer therapeutics on patient-derived tumor organoids in real time.
#Oncology #Bioengineering #ComputationalBiology #Pathology #ArtificialIntelligence (ML & DL) #sflorg
https://www.sflorg.com/2026/06/ongy06232601.html

Prime editing is a precise genome-editing technology that replaces disease-causing DNA sequences with corrected segments without requiring double-strand DNA breaks.
#MolecularBiology #MedicalGenetics #ComputationalBiology #Nanotechnology #sflorg
https://www.sflorg.com/2026/06/mbio06152601.html

🤖 Have we built AI powerful enough to design proteins, but too complicated for most scientists to use?

🔗 BioPipelines: Accessible Computational Protein and Ligand Design for Chemical Biologists. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0129

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#BioPipelines #ProteinEngineering #ComputationalBiology #ProteinDesign #SyntheticBiology #Bioinformatics #AlphaFold #SystemsBiology #AI

🧬 If structure determines function, how can we optimize DNA therapeutics without accurately predicting their 3D shape?

🔗 Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0127

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#StructuralBiology #DNA #ComputationalBiology #Bioinformatics #MolecularBiology #Aptamers #DNANanotechnology #GenomeEngineering #NucleicAcids

A complete connectome is a highly detailed, three-dimensional wiring diagram mapping all neural connections between the brain and the nerve cord (the spinal cord equivalent) of an adult fruit fly. This comprehensive map allows scientists to observe all neurons and their synaptic connections as a single, holistic functional unit.
#Neuroscience #Neurobiology #Connectomics #ComputationalBiology #sflorg
https://www.sflorg.com/2026/06/ns06092601.html