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#computationalbiology — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #computationalbiology, aggregated by home.social.

  1. Researchers have identified specific structural features in the spleen, visible on MRI scans, that are associated with an increased risk of coronary artery disease (CAD).
    #Genetics #ComputationalBiology #ArtificialIntelligence (Machine Learning) #Radiology #sflorg
    sflorg.com/2026/09/med09122601

  2. rarelens: building a rare-disease variant triage platform, and the four things I got wrong

    An end-to-end rare-disease variant triage platform: a Nextflow pipeline, three execution backends behind one API call, Terraform for two cloud tracks, and a phenotype-driven ranking measured against 10,178 published cases. Including the model metric that collapsed to exactly random once I removed the feature doing all the work.

    kemal.yaylali.uk/rarelens-tech

  3. 🔬 What if a tumor sample could serve as its own reference?

    🔗 Reference-Free Microsatellite Instability Detection from Tumor Sequencing Using Intrasample Variability Modeling. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0219

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #MicrosatelliteInstability #MSI #CancerGenomics #NextGenerationSequencing #ComputationalBiology #Genomics #PersonalizedMedicine #Oncology #Biomarkers #PrecisionMedicine

  4. ⚛️ Would today’s antibiotics still work if bacterial biology were flipped at the molecular level?

    🔗 Molecular Dynamics Simulations Demonstrate Reduced Antibiotic Affinity to Mirror Bacterial Targets. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0198

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #MolecularDynamics #Antibiotics #Biosecurity #ComputationalBiology #SyntheticBiology #DrugDiscovery #AntimicrobialResearch #ComputationalChemistry

  5. A mathematical modeling approach used to optimize the composition, diversity, and timing of bacteriophage cocktails for treating drug-resistant bacterial infections.
    #ComputationalBiology #MathematicalBiology #Microbiology #InfectiousDiseases #sflorg
    sflorg.com/2026/08/cobi0829260

  6. The nuclear pore complex (7R5J & 7R5K) – one of the largest molecular machines in biology.

    The nuclear pore complex is the gatekeeper of the cell nucleus – controlling everything that enters or leaves. We captured it in two states: open (dilated) and closed (constricted).

    961665 quantum records

    exxogen.hu/

    ​#StructuralBiology #Biophysics #Bioinformatics #Topology #InformationTheory #DNAFolding #ComputationalBiology #ComplexSystems #Genomics #OpenScience #EXXOGEN

  7. What if the biological sequence of these 3 billion base pairs is completely irrelevant... and the human genome was never written to be read, but folded? What if the information isn't carried by the linear code, but by the spatial geometry the molecule closes around itself, and we are merely trying to decipher a 3D shadow cast by a higher-dimensional structure?

    exxogen.hu/

    ​#Biophysics #Bioinformatics #InformationTheory #DNA #ComputationalBiology #ComplexSystems #Genomic #EXXOGEN

  8. 🤖 Can artificial intelligence reveal how bacterial strains differ beneath the surface?

    🔗 Predicting Strain-Specific Metabolic Capabilities in the Genus Pseudomonas with a Flux-to-AI Approach Reveals Hidden Cell Envelope Properties. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0190

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #Microbiology #ComputationalBiology #SystemsBiology #ArtificialIntelligence #Biotechnology #SyntheticBiology

  9. 🧬 Can we trust membrane protein annotations when databases tell different stories?

    🔗 MetaMP Ecosystem for Unified, Auditable, and Benchmark-Ready Data for Reliable Membrane Protein Annotation. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0165

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #MembraneProteins #StructuralBiology #Bioinformatics #ComputationalBiology #ProteinScience #DataScience #DrugDiscovery #AIinScience #OpenScience

  10. 🧬 How can we make nucleosome profiling more scalable, quantitative, and reproducible?

    🔗 A Scalable MNase-seq Framework for Reproducible Nucleosome Profiling across Pluripotent Stem Cell and Cardiomyocyte Models. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0204

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #ChromatinBiology #Epigenomics #Epigenetics #Genomics #StemCells #MolecularBiology #GenomeResearch #Bioinformatics #ComputationalBiology

  11. A comprehensive analysis of anti-aging intervention studies utilizing blood-based DNA tests, known as epigenetic clocks, to determine which therapies genuinely slow the biological aging process.
    #Epigenetics #ComputationalBiology #Bioinformatics #Gerontology #sflorg
    sflorg.com/2026/08/epig0822260

  12. I entered grad school #Academia not knowing anything about #Bioinformatics or #ComputationalBiology. I thought it probably wasn't for me. But I ended up enjoying it.

    What I can't stand about it in an academic setting is the double-edged sword. It's too important to not have, but not important enough to pay for. I help a lot of people with analysis. Many of them are jerks who I sacrifice time to and they use my effort to get their funding and never pay for the work. Others are great.

  13. University of Michigan researchers utilized advanced artificial intelligence to demonstrate that passerine birds (order Passeriformes) underwent rapid bursts of morphological evolution that directly coincided with major historical climate shifts.
    #EvolutionaryBiology #Ornithology #Paleoclimatology #ComputationalBiology #AI #sflorg
    sflorg.com/2026/07/ebio0720260

  14. I wonder that there seem to be so few #ISMB2026 posts on here, usually a massive #ComputationalBiology conference, despite a good #bioinformatics pool of posters here.

    Is it a Mastodon European skew? And/or privacy/visa/travel fears attending the #ISMB conference in Washington under the second Trump administration? I personally wouldn’t willingly travel to the USA for now even if I had a travel budget to cover it 🤷‍♂️

  15. You know what floats to the top of my thoughts pretty often?

    Globally, how much better #Bioinformatics, #ComputationalBiology, and #FOSS #OpenSource software would be with universal basic income. So many people would be happy to keep making their products better for the greater good if they didn't have to worry about shelter, food security, and healthcare.

  16. References

    bio-focus.co.uk/biotechnology/.

    rewire.it/blog/eden-28-billion.

    prnewswire.com/news-releases/b.

    astrobiology.com/2026/06/11/pl

    basecamp-research.com/?hl=en-U.

    prnewswire.com/news-releases/b.

    biorxiv.org/content/10.64898/2.

    scienceandculture.com/2021/10/.

    clay.com/dossier/basecamp-rese

    redalpine.com/post/redalpine-i.

    schedule.sxsw.com/contributors

    biospace.com/press-releases/ba.

    techfundingnews.com/biodiversi.

    caplight.com/company/basecamp-

    sifted.eu/articles/basecamp-re

    biopharmadive.com/news/basecam.

    #bioinformatics #computationalbiology #syntheticbiology #synbio #datascience

  17. A newly developed evaluative framework that tests the reliability, transparency, and chemical reasoning of artificial intelligence (AI) models used in the development of new antibiotics.
    #Cheminformatics #ComputationalBiology #Pharmacology #Microbiology #ArtificialIntelligence #sflorg
    sflorg.com/2026/06/cobi0626260

  18. 🧬 Can AI truly decode gene expression, or is it being misled by too much data?

    🔗 Artificial Intelligence in Bulk RNA-Seq: Challenges and Potential Solutions. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0039

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #ArtificialIntelligence #MachineLearning #Bioinformatics #Genomics #RNAseq #ComputationalBiology #SystemsBiology #AI #PrecisionMedicine #BigData #AIinHealthcare

  19. ⚛️ Can we design drugs that stabilize biomolecular interactions instead of blocking them?

    🔗 In Silico Analysis of Potential Stabilizer Binding Sites at Protein–RNA Interfaces. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0016

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #StructuralBiology #DrugDiscovery #ComputationalBiology #RNA #MolecularBiology #Bioinformatics #DrugDesign #SystemsBiology #MedicinalChemistry

  20. Senior Biocomputation Scientist
    Mimetics, LLC

    We are looking for a Senior Biocomputation Scientist to help build systems using transcriptomic data to improve clients' biomanufacturing processes.

    See the full job description on jobRxiv: jobrxiv.org/job/mimetics-llc-2

    #computationalbiology #dataanalyses #fermentation #RNAseq #transcriptomicdata #ScienceJobs #...
    jobrxiv.org/job/mimetics-llc-2

  21. 🧬 How can new AI architectures accelerate the path from molecule to medicine?

    🔗 MM-DRPNet: A multimodal dynamic radial partitioning network for enhanced protein–ligand binding affinity prediction. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2024.11

    📚 CSBJ: csbj.org/

    #StructuralBiology #ProteinLigandInteraction #DrugDesign #ComputationalChemistry #DrugDiscovery #ComputationalBiology #Bioinformatics #MachineLearning #ArtificialIntelligence

  22. 🧬 Can AI build peptides that tell your cells to fight back against oxidative stress?

    🔗 RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2025.02

    📚 CSBJ: csbj.org/

    #StructuralBiology #PeptideTherapeutics #RoseTTAFold #ProteinEngineering #MolecularDynamics #AIinDrugDiscovery #AntioxidantResearch #DrugDesign #Bioinformatics #ComputationalBiology

  23. Senior Biocomputation Scientist
    Mimetics, LLC

    We are looking for a Senior Biocomputation Scientist to help build systems using transcriptomic data to improve clients' biomanufacturing processes.

    See the full job description on jobRxiv: jobrxiv.org/job/mimetics-llc-2

    #computationalbiology #dataanalyses #fermentation #RNAseq #transcriptomicdata #ScienceJobs #...
    jobrxiv.org/job/mimetics-llc-2

  24. Senior Biocomputation Scientist
    Mimetics, LLC

    We are looking for a Senior Biocomputation Scientist to help build systems using transcriptomic data to improve clients' biomanufacturing processes.

    See the full job description on jobRxiv: jobrxiv.org/job/mimetics-llc-2

    #computationalbiology #dataanalyses #fermentation #RNAseq #transcriptomicdata #ScienceJobs #...
    jobrxiv.org/job/mimetics-llc-2

  25. 🩺 Can virtual models predict how drug-coated balloons work inside the human body?

    🔗 Computational modeling of drug-eluting balloons in peripheral artery disease: Mechanisms, optimization, and translational insights. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2025.08

    📚 CSBJ: csbj.org/

    #DrugElutingBalloons #PeripheralArteryDisease #CardiovascularResearch #BiomedicalEngineering #ComputationalBiology #AIinHealthcare #PrecisionMedicine #MedicalDevices

  26. Registration for the Computational Modeling in Biology Network (#COMBINE) meeting is open:

    co.mbine.org/events/

    HARMONY 2023 will be hosted by Herbert Sauro and the Center for Reproducible Biomedical Modeling at the University of Washington, Seattle, WA. It is going to be organized primarily as an in-person meeting, with individual breakout sessions responsible for enabling remote participation as needed.