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#hhmijanelia — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #hhmijanelia, aggregated by home.social.

  1. @tuthill

    If interested in this topic, Prof. Bing Brunton gave a talk at #Cosyne2026 which is very much worth watching:

    youtu.be/yhUBq5R01qA?t=3430

    Among other topics, Bing presents the minimal network for the oscillatory behaviour that sustains walking, and also the embodiment of a connectome by plugging it into a virtual mechanical model of the fly, #MuJoCo from the #AnyBrain #HHMIJanelia project team.

    #neuroscience #Drosophila #connectomics

  2. @tuthill

    If interested in this topic, Prof. Bing Brunton gave a talk at #Cosyne2026 which is very much worth watching:

    youtu.be/yhUBq5R01qA?t=3430

    Among other topics, Bing presents the minimal network for the oscillatory behaviour that sustains walking, and also the embodiment of a connectome by plugging it into a virtual mechanical model of the fly, #MuJoCo from the #AnyBrain #HHMIJanelia project team.

    #neuroscience #Drosophila #connectomics

  3. @tuthill

    If interested in this topic, Prof. Bing Brunton gave a talk at #Cosyne2026 which is very much worth watching:

    youtu.be/yhUBq5R01qA?t=3430

    Among other topics, Bing presents the minimal network for the oscillatory behaviour that sustains walking, and also the embodiment of a connectome by plugging it into a virtual mechanical model of the fly, #MuJoCo from the #AnyBrain #HHMIJanelia project team.

    #neuroscience #Drosophila #connectomics

  4. @tuthill

    If interested in this topic, Prof. Bing Brunton gave a talk at #Cosyne2026 which is very much worth watching:

    youtu.be/yhUBq5R01qA?t=3430

    Among other topics, Bing presents the minimal network for the oscillatory behaviour that sustains walking, and also the embodiment of a connectome by plugging it into a virtual mechanical model of the fly, #MuJoCo from the #AnyBrain #HHMIJanelia project team.

    #neuroscience #Drosophila #connectomics

  5. @tuthill

    If interested in this topic, Prof. Bing Brunton gave a talk at #Cosyne2026 which is very much worth watching:

    youtu.be/yhUBq5R01qA?t=3430

    Among other topics, Bing presents the minimal network for the oscillatory behaviour that sustains walking, and also the embodiment of a connectome by plugging it into a virtual mechanical model of the fly, #MuJoCo from the #AnyBrain #HHMIJanelia project team.

    #neuroscience #Drosophila #connectomics

  6. The much awaited connectome of the male central nervous system of the fruit fly, Drosophila melanogaster:

    "Sexual dimorphism in the complete connectome of the Drosophila male central nervous system", Berg et al. 2025 biorxiv.org/content/10.1101/20

    "contains 166,696 neurons spanning the brain and ventral nerve cord, fully proofread and comprehensively annotated including fruitless and doublesex expression and 11,691 cell types."

    A collaboration between #HHMIJanelia, #MRCLMB and many others.

    #neuroscience #connectomics #Drosophila

  7. @CurrentBiology

    Andreas Schoofs and Anton Miroschnikow in Michael Pankratz' lab have done an astonishing amount of work manually mapping the peripheral nervous system of the larval #Drosophila, with #CATMAID, in the STEM volume we imaged and they named "Igor". Congrats on seeing this gargantuan project through!

    The whole larval volume of "Igor", including all tissues, is available here, courtesy of the #OpenOrganelle project led by Aubrey Weigel @avweigel at #HHMIJanelia:
    openorganelle.janelia.org/data

    See it at 5x5x35 nm resolution in #neuroglancer: neuroglancer-demo.appspot.com/ (control-minus and control-plus to zoom; mouse click to pan, scroll wheel to browse in Z).

    Will appear at the #VirtualFlyBrain website soon as well.

    There are many more peripheral nervous system components mapped, yet to be published.

    This paper is open access:
    "Serotonergic modulation of swallowing in a complete fly vagus nerve connectome", Schoofs et al. 2024 cell.com/current-biology/fullt

    #neuroscience #connectomics

  8. @CurrentBiology

    Andreas Schoofs and Anton Miroschnikow in Michael Pankratz' lab have done an astonishing amount of work manually mapping the peripheral nervous system of the larval #Drosophila, with #CATMAID, in the STEM volume we imaged and they named "Igor". Congrats on seeing this gargantuan project through!

    The whole larval volume of "Igor", including all tissues, is available here, courtesy of the #OpenOrganelle project led by Aubrey Weigel @avweigel at #HHMIJanelia:
    openorganelle.janelia.org/data

    See it at 5x5x35 nm resolution in #neuroglancer: neuroglancer-demo.appspot.com/ (control-minus and control-plus to zoom; mouse click to pan, scroll wheel to browse in Z).

    Will appear at the #VirtualFlyBrain website soon as well.

    There are many more peripheral nervous system components mapped, yet to be published.

    This paper is open access:
    "Serotonergic modulation of swallowing in a complete fly vagus nerve connectome", Schoofs et al. 2024 cell.com/current-biology/fullt

    #neuroscience #connectomics

  9. @CurrentBiology

    Andreas Schoofs and Anton Miroschnikow in Michael Pankratz' lab have done an astonishing amount of work manually mapping the peripheral nervous system of the larval #Drosophila, with #CATMAID, in the STEM volume we imaged and they named "Igor". Congrats on seeing this gargantuan project through!

    The whole larval volume of "Igor", including all tissues, is available here, courtesy of the #OpenOrganelle project led by Aubrey Weigel @avweigel at #HHMIJanelia:
    openorganelle.janelia.org/data

    See it at 5x5x35 nm resolution in #neuroglancer: neuroglancer-demo.appspot.com/ (control-minus and control-plus to zoom; mouse click to pan, scroll wheel to browse in Z).

    Will appear at the #VirtualFlyBrain website soon as well.

    There are many more peripheral nervous system components mapped, yet to be published.

    This paper is open access:
    "Serotonergic modulation of swallowing in a complete fly vagus nerve connectome", Schoofs et al. 2024 cell.com/current-biology/fullt

    #neuroscience #connectomics

  10. @CurrentBiology

    Andreas Schoofs and Anton Miroschnikow in Michael Pankratz' lab have done an astonishing amount of work manually mapping the peripheral nervous system of the larval #Drosophila, with #CATMAID, in the STEM volume we imaged and they named "Igor". Congrats on seeing this gargantuan project through!

    The whole larval volume of "Igor", including all tissues, is available here, courtesy of the #OpenOrganelle project led by Aubrey Weigel @avweigel at #HHMIJanelia:
    openorganelle.janelia.org/data

    See it at 5x5x35 nm resolution in #neuroglancer: neuroglancer-demo.appspot.com/ (control-minus and control-plus to zoom; mouse click to pan, scroll wheel to browse in Z).

    Will appear at the #VirtualFlyBrain website soon as well.

    There are many more peripheral nervous system components mapped, yet to be published.

    This paper is open access:
    "Serotonergic modulation of swallowing in a complete fly vagus nerve connectome", Schoofs et al. 2024 cell.com/current-biology/fullt

    #neuroscience #connectomics

  11. @CurrentBiology

    Andreas Schoofs and Anton Miroschnikow in Michael Pankratz' lab have done an astonishing amount of work manually mapping the peripheral nervous system of the larval #Drosophila, with #CATMAID, in the STEM volume we imaged and they named "Igor". Congrats on seeing this gargantuan project through!

    The whole larval volume of "Igor", including all tissues, is available here, courtesy of the #OpenOrganelle project led by Aubrey Weigel @avweigel at #HHMIJanelia:
    openorganelle.janelia.org/data

    See it at 5x5x35 nm resolution in #neuroglancer: neuroglancer-demo.appspot.com/ (control-minus and control-plus to zoom; mouse click to pan, scroll wheel to browse in Z).

    Will appear at the #VirtualFlyBrain website soon as well.

    There are many more peripheral nervous system components mapped, yet to be published.

    This paper is open access:
    "Serotonergic modulation of swallowing in a complete fly vagus nerve connectome", Schoofs et al. 2024 cell.com/current-biology/fullt

    #neuroscience #connectomics

  12. Neuroscientist Nelson Spruston named new executive director of #HHMIJanelia, replacing cell biologist Ron Vale.

    #HHMI president's words are as transparent as it gets:

    "Erin O’Shea, President of HHMI, said, “Nelson is the right leader at the right time in this next chapter for Janelia. With his deep knowledge about what makes the Janelia model conducive to doing great science, he can help guide Janelia both strategically and operationally to pursue important questions in the life sciences.”"

    janelia.org/news/janelia-names

    #neuroscience

  13. @flypapers

    Dissecting neural circuits for cold nociception in the #Drosophila larva, by Atit Patel in D. Cox lab: biorxiv.org/content/10.1101/20

    Atit was a visitor of my former lab at #HHMIJanelia. Took years to map the circuit, identify GAL4 lines, design and run behavioral assays and make sense of it all. Atit, a PhD student, did all the mapping and all the experiments and wrote most of the paper, and did a great job at it.

    For the insiders: this is about class III md (multidendritic) somatosensory neurons in the fly larva, and their synaptic connectivity, primarily onto various Basin neurons (Ohyama, Schneider-Mizell et al. 2015 nature.com/articles/nature1429 , Jovanic, Schneider-Mizell et al. et al. 2016 sciencedirect.com/science/arti ) but also other neurons such as Down-and-Back (Burgos et al. 2018 elifesciences.org/articles/260 ) and PNs of the class IV mds (Gerhard et al. 2017 elifesciences.org/articles/290 ).

    In other words, how somatosensoty neurons for cold nociception (class III mds) feed into the local circuits that process nociception (class IV mds) and mechanoreception (chordotonals).

    Note this work is unrelated to how the larva senses and responds to cold and warm stimuli (Hernandez-Nunez et al. 2021 science.org/doi/abs/10.1126/sc )

    #neuroscience #nociception #connectomics

  14. The connectome of the adult female fly brain, Drosophila melanogaster:

    “Neuronal wiring diagram of an adult brain” by Dorkenwald et al. 2023 biorxiv.org/content/10.1101/20

    A project that started with Davi Bock and Wei Lee developing the TEMCA for the mouse visual cortex in Clay Reid’s lab (Bock et al. 2011 nature.com/articles/nature0980), then Bock moving to #HHMIJanelia and developing the instrument much further to deliver the #FAFB volume (Zheng et al. 2018 sciencedirect.com/science/arti ), and then the Seung, Murthy and Jefferis labs automatically re-registering, segmenting and annotating the whole volume via #FlyWire and more.

    Extraordinary!

    #Drosophila #connectomics #neuroscience #brain

  15. The connectome of the adult female fly brain, Drosophila melanogaster:

    “Neuronal wiring diagram of an adult brain” by Dorkenwald et al. 2023 biorxiv.org/content/10.1101/20

    A project that started with Davi Bock and Wei Lee developing the TEMCA for the mouse visual cortex in Clay Reid’s lab (Bock et al. 2011 nature.com/articles/nature0980), then Bock moving to #HHMIJanelia and developing the instrument much further to deliver the #FAFB volume (Zheng et al. 2018 sciencedirect.com/science/arti ), and then the Seung, Murthy and Jefferis labs automatically re-registering, segmenting and annotating the whole volume via #FlyWire and more.

    Extraordinary!

    #Drosophila #connectomics #neuroscience #brain

  16. The connectome of the adult female fly brain, Drosophila melanogaster:

    “Neuronal wiring diagram of an adult brain” by Dorkenwald et al. 2023 biorxiv.org/content/10.1101/20

    A project that started with Davi Bock and Wei Lee developing the TEMCA for the mouse visual cortex in Clay Reid’s lab (Bock et al. 2011 nature.com/articles/nature0980), then Bock moving to #HHMIJanelia and developing the instrument much further to deliver the #FAFB volume (Zheng et al. 2018 sciencedirect.com/science/arti ), and then the Seung, Murthy and Jefferis labs automatically re-registering, segmenting and annotating the whole volume via #FlyWire and more.

    Extraordinary!

    #Drosophila #connectomics #neuroscience #brain

  17. The connectome of the adult female fly brain, Drosophila melanogaster:

    “Neuronal wiring diagram of an adult brain” by Dorkenwald et al. 2023 biorxiv.org/content/10.1101/20

    A project that started with Davi Bock and Wei Lee developing the TEMCA for the mouse visual cortex in Clay Reid’s lab (Bock et al. 2011 nature.com/articles/nature0980), then Bock moving to #HHMIJanelia and developing the instrument much further to deliver the #FAFB volume (Zheng et al. 2018 sciencedirect.com/science/arti ), and then the Seung, Murthy and Jefferis labs automatically re-registering, segmenting and annotating the whole volume via #FlyWire and more.

    Extraordinary!

    #Drosophila #connectomics #neuroscience #brain

  18. The connectome of the adult female fly brain, Drosophila melanogaster:

    “Neuronal wiring diagram of an adult brain” by Dorkenwald et al. 2023 biorxiv.org/content/10.1101/20

    A project that started with Davi Bock and Wei Lee developing the TEMCA for the mouse visual cortex in Clay Reid’s lab (Bock et al. 2011 nature.com/articles/nature0980), then Bock moving to #HHMIJanelia and developing the instrument much further to deliver the #FAFB volume (Zheng et al. 2018 sciencedirect.com/science/arti ), and then the Seung, Murthy and Jefferis labs automatically re-registering, segmenting and annotating the whole volume via #FlyWire and more.

    Extraordinary!

    #Drosophila #connectomics #neuroscience #brain

  19. "Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation", by Marin et al. 2023 (Greg Jefferis lab at #MRCLMB in collaboration with #HHMIJanelia and others).

    biorxiv.org/content/10.1101/20

    On the analysis of the #Drosophila male adult nerve cord (#MANC), reconstructed from #VolumeEM by Takemura et al. 2023 (preprint still pending to come out).

    #neuroscience #connectomics

  20. "Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation", by Marin et al. 2023 (Greg Jefferis lab at #MRCLMB in collaboration with #HHMIJanelia and others).

    biorxiv.org/content/10.1101/20

    On the analysis of the #Drosophila male adult nerve cord (#MANC), reconstructed from #VolumeEM by Takemura et al. 2023 (preprint still pending to come out).

    #neuroscience #connectomics

  21. "Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation", by Marin et al. 2023 (Greg Jefferis lab at #MRCLMB in collaboration with #HHMIJanelia and others).

    biorxiv.org/content/10.1101/20

    On the analysis of the #Drosophila male adult nerve cord (#MANC), reconstructed from #VolumeEM by Takemura et al. 2023 (preprint still pending to come out).

    #neuroscience #connectomics

  22. "Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation", by Marin et al. 2023 (Greg Jefferis lab at #MRCLMB in collaboration with #HHMIJanelia and others).

    biorxiv.org/content/10.1101/20

    On the analysis of the #Drosophila male adult nerve cord (#MANC), reconstructed from #VolumeEM by Takemura et al. 2023 (preprint still pending to come out).

    #neuroscience #connectomics

  23. "Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation", by Marin et al. 2023 (Greg Jefferis lab at #MRCLMB in collaboration with #HHMIJanelia and others).

    biorxiv.org/content/10.1101/20

    On the analysis of the #Drosophila male adult nerve cord (#MANC), reconstructed from #VolumeEM by Takemura et al. 2023 (preprint still pending to come out).

    #neuroscience #connectomics

  24. Experimental instrumentation doesn't have to be expensive: Frank Loesche @fra_loe in the Reiser lab at #HHMIJanelia build "a complete ~$300 system, including a cold-anesthesia tethering stage, that is ideal for hands-on teaching laboratories." And released all the CAD files and software as open source. How cool is that:

    "We replaced expensive optomechanical and custom machined components with off-the-shelf and 3D-printed parts, and built the system around a low-cost camera that achieves 180 Hz imaging and an inexpensive tablet computer to present view-angle-corrected stimuli updated through a local network."

    frontiersin.org/articles/10.33

    Could easily be put to good use to modernize hands-on labs at the undergrad level, perhaps also at the senior high school level.

    #Drosophila #neuroscience #EducationalMaterials

  25. Ep, catalans! Taller de biofísica teòrica a #HHMIJanelia (prop de Washington DC), amb totes les despeses pagades.

    Del 1 al 6 d'octubre d'enguany.

    Envieu sol·licituds en anglès fins el 21 de juny, aquí: janelia.org/you-janelia/confer

    Organitzat per na Ann Hermunstad, en James Fitzgerald i na Allyson Sgro.

    #ciència #neurobiologia #biofísica #matemàtiques #modelització

  26. HHMI is raising the entry-level postdoc salary to $70,000.

    See the new salary scales: hhmi.org/sites/default/files/h

    I hope the UK takes note. Presently it's about 50% of that figure, despite costs of living being about the same, particularly child care and housing.

    But HHMI goes beyond that: there's flexibility to bring in entry-level postdocs at $91,000 when under heavy competition from industry (i.e., computer scientists).

    #HHMIJanelia has had this flexibility–using fancy alternative job descriptions–since at least 2012 and likely earlier. I know first hand, from having run a lab there.

    #HHMI #postdoc #academia #UK #USA

    hhmi.org/news/hhmi-announces-p

  27. Harald Hess awarded the 2023 James Prize in Science and Technology Integration by the US National Academy of Sciences: nasonline.org/programs/awards/

    At #HHMIJanelia, the lab of Harald Hess revolutionized electron microscopy with enhanced FIBSEM (C. Shan Xu et al. 2017 @eLife elifesciences.org/articles/259 ) –now in use by us at #MRCLMB, and applied to #Drosophila #connectomics; built an automated STEM to image the whole #Drosophila larval body at 5x5x35 nm; and so much more. Hats off! Congratulations!

  28. @flypapers This above is the "superfly" sample prep protocol for electron microscopy with #FIBSEM that scored the Fly EM Project Team at #HHMIJanelia the whole #Drosophila brain at 8x8x8 nm resolution. As developed by Zhiyuan Lu and imaged/tested by C. Shan Xu and Song Pang.

    Was available at the biorxiv since 2019 biorxiv.org/content/10.1101/85

  29. A huge THANK YOU to everyone that worked on this project for 10 years, starting with first co-authors Michael Winding and Ben Pedigo at University of Cambridge and Johns Hopkins. A collaboration with Marta Zlatic, Carey E. Priebe, and Joshua Vogelstein.

    This work started at #HHMIJanelia and continued at the #MRCLMB in Cambridge, UK.

    All neuron reconstructions were done painstakingly by hand with #CATMAID by over >80 people! Thanks so much!

    #neuroscience #connectomics
    /END