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#scrnaseq — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #scrnaseq, aggregated by home.social.

  1. "By using time-resolved analyses of scRNA-seq data, we determined the potential transitional trajectories of tumor cells and identified the metastasis-initiating subpopulations"

    link.springer.com/article/10.1

    Reading right now. The identification of cells that initiate #metastasis are of interest, although n=2 paired primary and #BoneMarrow samples may be a bit limited.

    #scRNAseq #tumour #Neuroblastoma #pseudotime

  2. How does exposure to non-mutagenic environmental factors during development contribute to cancer risk? #scRNAseq & spatial transcriptomics reveal how #EndocrineDisruption of #endometrial cell differentiation by #diethylstilbestrol alters the characteristics of stem & progenitor cells, leading to #cancer development. @WilliamsRepro #PLOSBiology plos.io/3QpjazO

  3. " Instead, #Hepatoblastoma #tumors contain a large suppressive #myeloid compartment which poses opportunities for targeting. Specifically, therapeutic antibodies
    targeting the #tumor antigen #GPC3 to induce ADCP by #macrophages, in combination with myeloid
    #ImmuneCheckpointBlockade (#CD47/SIRPa, or VISTA) could be a feasible strategy to explore in future studies"

    Krijgsman et al. from Vercoulen lab in the #UMCUtrecht, on #bioRXiv:
    biorxiv.org/content/10.1101/20

    #scRNAseq #spatial #CyTOF #immunology

  4. Yesterday, in the afternoon plenty of #scRNAseq work, a.o. Céline Delloye-Bourgeois showing her group's latest work on #neuroblastoma development and #metastatic progression. Including some of our own scRNA-seq data. Very cool.

    Furthermore, more #SingleCell, also spatial, sequencing on #tumour heterogeneity and early stages. And work on cells that persist during/after #therapy, dubbed persister cells.

    #anr2023

  5. Recent work from University of Basel in Nature Communications looking into #Tcell #exhaustion, indicating a role for the SNX9 #gene. Knocking out this gene led to phenotypical and functional changes, e.g. Tmem differentiation, IFNg production, reduced #tumour growth, and improved survival in certain models.

    nature.com/articles/s41467-022

    #Tcells #Cancer #Immunology #lymphocytes #CancerImmunology #SingleCell #scRNAseq #RNAseq

    Found via @sflorg