#morphogenesis — Public Fediverse posts

📰 "Investigating the axoneme CCDC40 protein reveals new insights in trypanosome morphogenesis and division"
https://www.biorxiv.org/content/10.64898/2026.05.22.727155v1?rss=1 #Morphogenesis #Cell

📰 "Investigating the axoneme CCDC40 protein reveals new insights in trypanosome morphogenesis and division"
https://www.biorxiv.org/content/10.64898/2026.05.22.727155v1?rss=1 #Morphogenesis #Cell

📰 "A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1"
https://www.biorxiv.org/content/10.64898/2026.05.22.727264v1?rss=1 #CellMigration #Morphogenesis #Cell

📰 "A screen for adherens junction proteins regulating collective cell migration and testis morphogenesis reveals important roles for the Rab GAP RN-tre and the kinase Par-1"
https://www.biorxiv.org/content/10.64898/2026.05.22.727264v1?rss=1 #CellMigration #Morphogenesis #Cell

📰 "Cell and Tissue Mechanics in 3-D Organ Morphogenesis: Insights from Drosophila Pupal Retina Development"
https://doi.org/doi:10.1016/j.ydbio.2026.05.005
https://pubmed.ncbi.nlm.nih.gov/42167643/
#Morphogenesis #Mechanics #Cell

📰 "Specification of bone marrow sinusoids requires TIE2-mediated positive feedback involving COUPTFII and VEGFR3"
https://www.biorxiv.org/content/10.64898/2026.05.17.725724v1?rss=1 #Morphogenesis #Cell

📰 "Specification of bone marrow sinusoids requires TIE2-mediated positive feedback involving COUPTFII and VEGFR3"
https://www.biorxiv.org/content/10.64898/2026.05.17.725724v1?rss=1 #Morphogenesis #Cell

📰 "3D mechano-geometric multicellular model of apical stem cell-driven plant morphogenesis"
https://arxiv.org/abs/2605.13070 #Physics.Bio-Ph #Morphogenesis #CellDivision #Q-Bio.To #Q-Bio.Cb #Cell

📰 "3D mechano-geometric multicellular model of apical stem cell-driven plant morphogenesis"
https://arxiv.org/abs/2605.13070 #Physics.Bio-Ph #Morphogenesis #CellDivision #Q-Bio.To #Q-Bio.Cb #Cell

📰 "WATER reveals heterochrony of molecular programs underlies developmental failure caused by minor spliceosome inhibition"
https://www.biorxiv.org/content/10.64898/2026.05.08.723603v1?rss=1 #Morphogenesis #Cell

📰 "Spinal lumen remodeling under the control of Gli signaling mechanically drives roof plate cells extension"
https://www.biorxiv.org/content/10.64898/2026.05.12.724326v1?rss=1 #Morphogenesis #Cell

📰 "WATER reveals heterochrony of molecular programs underlies developmental failure caused by minor spliceosome inhibition"
https://www.biorxiv.org/content/10.64898/2026.05.08.723603v1?rss=1 #Morphogenesis #Cell

📰 "Spinal lumen remodeling under the control of Gli signaling mechanically drives roof plate cells extension"
https://www.biorxiv.org/content/10.64898/2026.05.12.724326v1?rss=1 #Morphogenesis #Cell

📰 "EpCAM sustains crypt mechanics and prevents aberrant remodeling"
https://www.biorxiv.org/content/10.64898/2026.04.27.721034v1?rss=1 #Morphogenesis #Mechanics #Cell

📰 "EpCAM sustains crypt mechanics and prevents aberrant remodeling"
https://www.biorxiv.org/content/10.64898/2026.04.27.721034v1?rss=1 #Morphogenesis #Mechanics #Cell

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

📰 "Coupling Anisotropic Curvature and Nematic Order: Mechanisms of Membrane Shape Remodeling"
https://arxiv.org/abs/2506.14347 #Physics.Bio-Ph #Morphogenesis #Cond-Mat.Soft #Cell

📰 "TGF-β signaling regulates epithelial permeability in Drosophila ovaries by modulating adhesion independent of actomyosin contractility"
https://www.biorxiv.org/content/10.64898/2026.02.14.705893v1?rss=1 #Morphogenesis #Adhesion #Cell

I’m getting preoccupied by the parallels between the design theorist Christopher Alexander’s metaphysics of form and Margaret’s Archer morphogenetic approach. The best critique of Archer I’ve read is Mouzelis arguing that she systematically prioritises time over space, leading her to neglect the spatialised exercise over power. I’m increasingly wondering if Alexander’s (somewhat power-blind, it seems to me) architectural theory of morphogenesis as a spatialised process, could be integrated into Archer’s morphogenetic approach.

From Christopher Alexander’s The Process of Creating Life, pg 509:

Why is freedom associated with the morphogenetic character of social processes? Because it is the shape-creating, organization-generating, aspect of process which ultimately allows people to do what they want, what they desire, what they need, and what is deeply adapted to life as it is lived and to experience as it is felt. The humanity of the environment comes about only when the processes are morphogenetic, are whole-seeking, are placed in a context that gradually allows people to work towards a living whole in which each person plays a part. If this point is not clear from what you have read in this book, please read Book 1, chapter 10, to understand more fully what I mean.

I believe we may take on this task, collectively, and can gain effective, instrumental knowledge of our generative system, and thus some measure of awareness and control over the system of processes that generates the world. I choose to define society as that system which creates the human world, and say that its primary ongoing function, and the criterion we should use to judge it by, is its capacity to create and re-create a living world for us.

https://markcarrigan.net/2024/11/08/why-is-freedom-associated-with-the-morphogenetic-character-of-social-processes/

#ChristopherAlexander #margaretArcher #morphogenesis

I’m getting preoccupied by the parallels between the design theorist Christopher Alexander’s metaphysics of form and Margaret’s Archer morphogenetic approach. The best critique of Archer I’ve read is Mouzelis arguing that she systematically prioritises time over space, leading her to neglect the spatialised exercise over power. I’m increasingly wondering if Alexander’s (somewhat power-blind, it seems to me) architectural theory of morphogenesis as a spatialised process, could be integrated into Archer’s morphogenetic approach.

From Christopher Alexander’s The Process of Creating Life, pg 509:

Why is freedom associated with the morphogenetic character of social processes? Because it is the shape-creating, organization-generating, aspect of process which ultimately allows people to do what they want, what they desire, what they need, and what is deeply adapted to life as it is lived and to experience as it is felt. The humanity of the environment comes about only when the processes are morphogenetic, are whole-seeking, are placed in a context that gradually allows people to work towards a living whole in which each person plays a part. If this point is not clear from what you have read in this book, please read Book 1, chapter 10, to understand more fully what I mean.

I believe we may take on this task, collectively, and can gain effective, instrumental knowledge of our generative system, and thus some measure of awareness and control over the system of processes that generates the world. I choose to define society as that system which creates the human world, and say that its primary ongoing function, and the criterion we should use to judge it by, is its capacity to create and re-create a living world for us.

https://markcarrigan.net/2024/11/08/why-is-freedom-associated-with-the-morphogenetic-character-of-social-processes/

#ChristopherAlexander #margaretArcher #morphogenesis

📰 "Mechanical coupling between dorsal and ventral surfaces shapes the Drosophila haltere"
https://doi.org/doi:10.1016/j.cub.2025.05.040
https://pubmed.ncbi.nlm.nih.gov/40505664/
#Morphogenesis #Extracellular #Mechanical

📰 "Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle"
https://www.biorxiv.org/content/10.64898/2026.04.21.719880v1?rss=1 #Morphogenesis #Cadherin

📰 "DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue"
https://doi.org/doi:10.1016/j.bpj.2026.01.026
https://pubmed.ncbi.nlm.nih.gov/41548041/
#Morphogenesis #Cadherin #Cell

🎲 Randomness reveals hidden order in the plant world

https://phys.org/news/2025-11-randomness-reveals-hidden-world.html

#plants #biophysics #molbio #morphogenesis #forms #randomness #order #biology

#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @PLOSBiology study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: https://plos.io/4nmD8IW Primer: https://plos.io/3IjPkLR

What a week! A huge thank you to all the students and teachers for the for the engaged discussions, thoughtful questions, and good vibes. Rock on, and stay curious! 🤓 ✨ #VeniceEvoDevo #levels #morphogenesis #sysbio #evodevo

Hello :) The peer-reviewed version of our cephalic furrow paper is out:

Patterned invagination prevents mechanical instability during gastrulation https://doi.org/10.1038/s41586-025-09480-3

Back-to-back with:

Divergent evolutionary strategies pre-empt tissue collision in gastrulation https://doi.org/10.1038/s41586-025-09447-4

And a commentary piece:

Flies evolved a shock-absorber tissue used during embryonic development https://doi.org/10.1038/d41586-025-02532-8

#Drosophila #Diptera #Morphogenesis #Evolution #EvoDevo #DevBio #TissueMechanics

📰 "Multiscale wrinkling dynamics in epithelial shells"
https://www.biorxiv.org/content/10.1101/2025.06.30.662426v1?rss=1 #Morphogenesis #Cytoskeletal #Dynamics

📰 "Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis"
https://doi.org/doi:10.1016/j.mbm.2025.100134
https://pubmed.ncbi.nlm.nih.gov/40519214/
#Morphogenesis #Mechanical #Actomyosin

📰 "Rosette formations as symmetry-breaking events: theory and experiment"
https://arxiv.org/abs/2505.20543 #Physics.Bio-Ph #Morphogenesis #Q-Bio.Cb #Cell

📰 "Integration of focal adhesion morphogenesis and polarity by DOCK5 promotes YAP/TAZ-driven drug resistance in TNBC"
https://doi.org/doi:10.1039/d4mo00154k
https://pubmed.ncbi.nlm.nih.gov/40353692/
#Morphogenesis #Cytoskeleton #Mechanical #Adhesion

📰 "The geometric nature of homeostatic stress in biological growth"
https://arxiv.org/abs/2412.16021 #Physics.Bio-Ph #Morphogenesis #Cell

📰 "Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling"
https://www.biorxiv.org/content/10.1101/2025.04.25.650632v1?rss=1 #Morphogenesis #Mechanical #Adhesion #Cell

How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @PLOSBiology https://plos.io/4cUw827

📰 "A role for Myosin in triggering and executing amnioserosa cell delaminations during dorsal closure."
https://www.biorxiv.org/content/10.1101/2025.03.21.644291v1?rss=1 #Morphogenesis #Myosin #Cell

📰 "AI-driven control of bioelectric signalling for real-time topological reorganization of cells"
https://arxiv.org/abs/2503.13489 #Physics.Bio-Ph #Morphogenesis #Q-Bio.Qm #Q-Bio.Cb #Eess.Sy #Cs.Sy #Cs.Ai #Cell

📰 "Eph-ephrin-mediated differential persistence as a mechanism for cell sorting"
https://arxiv.org/abs/2503.13714 #Physics.Bio-Ph #Morphogenesis #Cond-Mat.Soft #Cell

📰 "AI-driven control of bioelectric signalling for real-time topological reorganization of cells"
https://arxiv.org/abs/2503.13489 #Physics.Bio-Ph #Morphogenesis #Q-Bio.Qm #Q-Bio.Cb #Eess.Sy #Cs.Sy #Cs.Ai #Cell

📰 "Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila"
https://www.biorxiv.org/content/10.1101/2025.03.15.643376v1?rss=1 #Morphogenesis #Mechanical #Adhesion

📰 "PolyMorph: Extension of PolyHoop for tissue morphogenesis coupled to chemical signaling"
https://arxiv.org/abs/2503.09319 #Physics.Bio-Ph #Cond-Mat.Soft #Morphogenesis #Cell

Sir, ma'am, do you have a minute to talk about #evolution?

In these gloomy days, teaching #evolution is the safe harbour. Tomorrow the lecture is online, because I (and many students) are going to a strike in #Utrecht against budget cuts to higher education 🟥 , but I hope they will still enjoy these absolute classics:

Niklas, Karl J. "Evolutionary walks through a land plant morphospace." Journal of Experimental Botany 50.330 (1999): 39-52.

I still remember being awe-struck by the work of Karl Niklas on plant #biophysics and #morphogenesis when I was a 1st year student at the University of Warsaw. This was truly a portal to a world where everything in nature could be explained and had an underlying principle.

Budd, Graham E. "Morphospace." Current Biology 31.19 (2021): R1181-R1185.

While I am learning my part in French to explain #simulations of #evolution in Brussels for a Science is Wonderful show by @ERC_Research later this week.

📰 "Mechanical fracturing of the extracellular matrix patterns the vertebrate heart"
https://www.biorxiv.org/content/10.1101/2025.03.07.641942v1?rss=1 #Extracellular #Morphogenesis #Mechanical #Cell

📰 "Engineering morphogenesis of cell clusters with differentiable programming"
https://arxiv.org/abs/2407.06295 #Morphogenesis #Mechanical #Q-Bio.Cb #Cs.Lg #Cell

📰 "Morphogenesis of confined biofilms: how mechanical interactions determine cellular patterning and global geometry"
https://doi.org/doi:10.1039/d4sm01180e
https://pubmed.ncbi.nlm.nih.gov/39901805/
#Morphogenesis #Extracellular #Mechanical

Mapping of a gigantic #salamander #genome reveals secrets of #regeneration.

#Pleurodeles #gallipato #morphogenesis #non-coding_DNA

https://phys.org/news/2025-01-gigantic-salamander-genome-reveals-secrets.html

📰 "Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver development"
https://www.biorxiv.org/content/10.1101/2025.01.22.633528v1?rss=1 #Morphogenesis #Mechanical #Cell

📰 "Mechanical signalling through collagen I regulates cholangiocyte specification and tubulogenesis during liver development"
https://biorxiv.org/content/10.1101/2025.01.22.633528v1?rss=1 #Morphogenesis #Mechanical #Cell

This is a useful concept from Andrew Dryhurst in a recent paper in JCR. I’ve been prone to arguing for the same framing by talking about the need to historicise AI, in terms of a broader history of digitalisation then platformisation. I think Dryhurst’s framing here helps me account for how a particular framing of AI emerges both from failing to historicise it, as well as contributes to making it more difficult to do so in the future:

Traditionally, a large amount of philosophical functionalism has pervaded the AI space (Bryson Citation2019; Searle Citation1984), which has served to underpin an instrumentalist understanding of AI technology in much of the social science literature on the topic. Instrumentalism here refers to AI being understood as a tool and solely in terms of what it does. This is of course necessary at a certain level, given the wide-reaching scope of AI-use cases, the diversity of models and training sets, and the opacity that frequently surrounds AI’s societal deployment (O’Neil Citation2017). Nevertheless, instrumental notions of AI are inescapably presentist in their analytical scope, and it is important to consider that different AI are themselves embedded in an enormous variety of material relations and processes. AI are constructed and deployed by agents who are imbued with their own structural and institutional contexts, interests, ideals, and situational logics. A particular company’s AI systems are necessarily intertwined with the dynamics of (inter)national regulations, supply chains, and (national) accumulation regimes, as well as corporate agents’ reflexive and culturally conditioned actions in and through time. That is, AI are open complex systems embedded in other open complex systems.

https://www.tandfonline.com/doi/full/10.1080/14767430.2023.2279950#abstract

I think you can make this point without the CR vocabulary but it is a very important point which is very powerfully made here:

there is a research gap to be filled through tracing AI’s conceptual and material development in relation to the morphogenetically derived systemic imperatives traversing the political economy of the Internet and its history. For example, the ubiquitous deployment of AI models across all aspects of society presupposes questions about attribution concerning the datasets that are fed into different models; the transparency of data collection and processing; and the complex regulatory challenges that widescale AI deployment creates

And this is exactly what I’m interested in addressing, particularly the notion of models as cultural technologies, even if I arrived there through a slightly different route:

Similarly, the recursive and emergent consequences of people’s interactions with powerful AI models across industry and society make the models akin to cultural substrates from which particular worldviews may be inscribed and cultivated. To paraphrase Marshall McLuhan, the model may well be the message (Bratton and Agüera y Arcas Citation2022). All of these connote significant economic and social outcomes, and also exemplify a situation where the rise of powerful AI companies, possessive of their own intellectual property, datasets, and modelling practices, ought clearly to be situated within the accumulation imperatives and systemically persistent dynamics shaping the Internet’s development in capitalism because they are intertwined with and shaped by AI’s regulation and deployment as well.

https://markcarrigan.net/2024/08/01/against-an-instrumentalist-understanding-of-ai-critical-realism-and-conceptualising-artificial-intelligence/

#artificialIntelligence #digital #morphogenesis #MorphogeneticApproach #ontology #philosophyOfTechnology #platformisation #platfromCapitalism

Centuries ago, I published a manuscript on BioRχiv about the love/hate relationship between variability and robustness in embryogenesis.

And now, it's published in Science! I am so proud 🥳

https://www.science.org/doi/10.1126/science.adh1145

We went through three (3!) rounds of revisions. Although we did not change a comma in the abstract, the revisions improved the quality of the work very much (we nearly doubled the sample size and added an entire figure).

#variability #robustness #embryology #morphogenesis #mouse

Because the search function here doesn't work so well, as I've seen others do, here is a list of hashtags # I'm following (some of which I'm also adding to my profile):

#DevBio
#DevBiol
#Development
#Myoverse (as a possible equivalent of #Myotwitter )
#Morphogenesis
#Regeneration #MuscularDystrophy
#FSHD
#Mechanobiology
#CellBiology
#Neurobiology
#NeuroDev
#Imaging
#biorxiv
#preLights
#Microscopy
#axonguidance