#actomyosin — Public Fediverse posts

📰 "Protocol to identify mechanosensitive nuclear proteins using tunable actomyosin contractility and proximity biotinylation in mammalian cells"
https://doi.org/doi:10.1016/j.xpro.2025.104288
https://pubmed.ncbi.nlm.nih.gov/41447521/
#Mechanical #Actomyosin #Cell

📰 "Actomyosin dynamics in detached cells: linking clutch model to cell migration and cytokinesis"
https://doi.org/doi:10.1186/s12860-025-00563-7
https://pubmed.ncbi.nlm.nih.gov/41437214/
#Actomyosin #Dynamics

📰 "Molecular tension tether based on electrochemiluminescence sensor for cellular mechanics measurement"
https://doi.org/doi:10.1016/j.bios.2025.118324
https://pubmed.ncbi.nlm.nih.gov/41435709/
#Actomyosin #Mechanical #Mechanics

📰 "Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis"
https://doi.org/doi:10.1016/j.mbm.2025.100134
https://pubmed.ncbi.nlm.nih.gov/40519214/
#Morphogenesis #Mechanical #Actomyosin

📰 "Reconstitution of actomyosin networks in cell-sized liposomes reveals distinct mechanical roles of cytoskeletal organization in membrane shape remodeling"
https://doi.org/doi:10.1101/2025.05.18.654456
https://pubmed.ncbi.nlm.nih.gov/40475593/
#Actomyosin #Mechanical #Forces #Actin

📰 "Age-associated Tissue Organisation Shifts Retinal Pigment Epithelium Actomyosin Plasticity in Phagocytosis"
https://www.biorxiv.org/content/10.1101/2025.05.22.655517v1?rss=1 #Extracellular #Actomyosin #Mechanical

📰 "Active waves from non-reciprocity and cytoplasmic exchange"
https://arxiv.org/abs/2505.09740 #Physics.Flu-Dyn #Physics.Bio-Ph #Actomyosin #Mechanical #Nlin.Ps

📰 "Microscale velocity-dependent unbinding generates a macroscale performance-efficiency tradeoff in actomyosin systems"
https://doi.org/doi:10.1038/s42003-025-08098-5
https://pubmed.ncbi.nlm.nih.gov/40355470/
#Actomyosin #Mechanical #Myosin

📰 "Brief Pulses of High-Level Fluid Shear Stress Enhance Metastatic Potential and Rapidly Alter the Metabolism of Cancer Cells."
https://www.biorxiv.org/content/10.1101/2025.04.09.647247v1?rss=1 #Actomyosin #Mechanical

📰 "Nonlinear contractile response of actomyosin active gels to control signals"
https://arxiv.org/abs/2502.18672 #Physics.Bio-Ph #Cond-Mat.Soft #Actomyosin #Mechanical

📰 "Deciphering Mechanochemical Influences of Emergent Actomyosin Crosstalk Using QCM-D"
https://doi.org/doi:10.1007/s12195-024-00835-w
https://pubmed.ncbi.nlm.nih.gov/39949486/
#Actomyosin #Mechanical

📰 "Mitochondria mechanosensing: The powerhouse fueling cellular force signaling"
https://doi.org/doi:10.1016/j.cub.2024.12.006
https://pubmed.ncbi.nlm.nih.gov/39837277/
#Mechanosensing #Mechanical #Actomyosin

📰 "Crb3 and NF2: A dynamic duo that controls assembly of the apical junctions and barrier function via Rho/ROCK signaling"
http://biorxiv.org/cgi/content/short/2025.01.15.633166v1?rss=1 #Mechanical #Actomyosin

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

Our article on the #mechanics of "active" entropic biopolymer networks [possibly including #actomyosin, this is debated experimentally] is now published in J Elas.

Compared to enthalpic models, we're able to go right from the #thermodynamics of an unbiased #molecularMotor activity (in the spirit of the model by #JacquesProst for #myosin) at the molecular scale to a network-scale model in a closed form.

And we derive a method for solving quite easily the (usually tough) #viscoelastic #liquid model that we obtain, using #deformationGradientDecomposition.

https://doi.org/10.1007/s10659-024-10102-8
(I share a paywall-free link to my followers below, but it's also on arXiv: https://arxiv.org/abs/2405.07287 and on my webpage https://liphy-annuaire.univ-grenoble-alpes.fr/pages_personnelles/jocelyn_etienne/papers.html#Jallon+Etienne.2025.1)

#cytoskeleton #cell #tissue #morphogenesis #activeMatter #livingMatter

📰 "Density-dependent flow generation in active cytoskeletal fluids"
https://doi.org/doi:10.1038/s41598-024-82864-z
https://pubmed.ncbi.nlm.nih.gov/39732914/
#Cytoskeletal #Actomyosin #Dynamics

📰 "More ATP Does Not Equal More Contractility: Power And Remodelling In Reconstituted Actomyosin"
https://arxiv.org/abs/2108.00764 #Physics.Bio-Ph #Cond-Mat.Soft #Cytoskeletal #Mechanical #Actomyosin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

Our #preprint where we derive an #activeGel #model with entropic elasticity of the #microstructure from the thermodynamic constraints on the dynamics of #myosin molecular motors is now updated!

Hopefully more readable, and with the example of a #cyst like contractile sphere.

#cytoskeleton #rheology #activeMatter #softMatter #actomyosin

#Influenza A virus exploits the motility of membrane cytoskeletal #actomyosin filaments for its genome packaging in the host cell http://biorxiv.org/cgi/content/short/2024.09.11.612468v1?rss=1

locking myosin activity with blebbistatin prevented the active movement of membrane cytoskeletal actin filaments just below the plasma membrane visualised by AFM and abrogated proper aggregation of vRNPs.

#Influenza A virus exploits the motility of membrane cytoskeletal #actomyosin filaments for its genome packaging in the host cell http://biorxiv.org/cgi/content/short/2024.09.11.612468v1?rss=1

locking myosin activity with blebbistatin prevented the active movement of membrane cytoskeletal actin filaments just below the plasma membrane visualised by AFM and abrogated proper aggregation of vRNPs.

~60% of germ cells in #Celegans hermaphrodites are eliminated in meiotic prophase to maintain tissue homeostasis, but how? This study shows that size of meiotic #GermCells is reduced by apical #actomyosin constriction, leading to #apoptosis #PLOSBiology https://plos.io/4g4hpTE

~60% of germ cells in #Celegans hermaphrodites are eliminated in meiotic prophase to maintain tissue homeostasis, but how? This study shows that size of meiotic #GermCells is reduced by apical #actomyosin constriction, leading to #apoptosis #PLOSBiology https://plos.io/4g4hpTE

#Optogenetic manipulation of focal adhesion targeting shows that local #actomyosin traction force development induces focal #adhesion sliding and disassembly

Julien Aureille, Alexander Bershadsky et al

https://www.embopress.org/doi/full/10.1038/s44318-024-00114-4

#Optogenetic manipulation of focal adhesion targeting shows that local #actomyosin traction force development induces focal #adhesion sliding and disassembly

Julien Aureille, Alexander Bershadsky et al

https://www.embopress.org/doi/full/10.1038/s44318-024-00114-4

Evidence for a special role of mitofusin-2 in regulating the #actin #cytoskeleton through #calcium, #RhoA, and #actomyosin contractility. https://elifesciences.org/articles/88828?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Evidence for a special role of mitofusin-2 in regulating the #actin #cytoskeleton through #calcium, #RhoA, and #actomyosin contractility. https://elifesciences.org/articles/88828?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Evidence for a special role of mitofusin-2 in regulating the #actin #cytoskeleton through #calcium, #RhoA, and #actomyosin contractility. https://elifesciences.org/articles/88828?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Replacing external domain of #Ecadherin with DNA binders and giving a kiss of death to another cell to see how strongly they bind!

...lovely ! 😃

#actomyosin #contractility considered too.

Replacing external domain of #Ecadherin with DNA binders and giving a kiss of death to another cell to see how strongly they bind!

...lovely ! 😃

#actomyosin #contractility considered too.

Are you interested in the #cytoskeleton ...?

#actin, #actomyosin, #myosin, #microtubule, #kinesin, #intermediatefilament, #vimentin, #keratin, #desmin, #GFAP, #peripherin, #syncoilin, #internexin, #neurofilament, #synemin, #syncoilin, #lamin

are hashtags used by @Rxiv_cytoskeleton bot.

Unfortunately, if you search / follow one of these hashtags, most of the posts from this bot will be invisible because a recent policy makes them "unlisted", see https://botsin.space/@muffinista/110378654504428500

#ScienceMastodon

1/2

Are you interested in the #cytoskeleton ...?

#actin, #actomyosin, #myosin, #microtubule, #kinesin, #intermediatefilament, #vimentin, #keratin, #desmin, #GFAP, #peripherin, #syncoilin, #internexin, #neurofilament, #synemin, #syncoilin, #lamin

are hashtags used by @Rxiv_cytoskeleton bot.

Unfortunately, if you search / follow one of these hashtags, most of the posts from this bot will be invisible because a recent policy makes them "unlisted", see https://botsin.space/@muffinista/110378654504428500

#ScienceMastodon

1/2

From their abstract:
"Emerging evidence suggests that understanding of #timescales may be important in resolving this issue, but that further work is needed to understand the role of adhesive strengthening across scales."

Same the conclusion as in our theory paper https://doi.org/10.1371/journal.pcbi.1009812 : the interplay of #cadherin #adhesion & cortical #actomyosin timescales triggers emergent phenomena in terms of #tissue mechanics. If one adds #mechanotransduction on top of that then expect awesome effects.

From their abstract:
"Emerging evidence suggests that understanding of #timescales may be important in resolving this issue, but that further work is needed to understand the role of adhesive strengthening across scales."

Same the conclusion as in our theory paper https://doi.org/10.1371/journal.pcbi.1009812 : the interplay of #cadherin #adhesion & cortical #actomyosin timescales triggers emergent phenomena in terms of #tissue mechanics. If one adds #mechanotransduction on top of that then expect awesome effects.

New paper from the Zerial Lab!

My colleagues and I have shown that apical projections across the bile canaliculi are load-bearing structures. These structures contribute to sustaining the anisotropic #growth of the nascent tube under increased intraluminal #pressure during #liver #development. These structures are supported by adherens #junctions and sealed by tight junctions.
I believe only @nunopmartins is here but if I am mistaken please tag any other author.
#CellPolarity #CellBiology #actomyosin #tubulogenesis

https://rupress.org/jcb/article/222/4/e202208002/213840/Hepatocyte-apical-bulkheads-provide-a-mechanical

New paper from the Zerial Lab!

My colleagues and I have shown that apical projections across the bile canaliculi are load-bearing structures. These structures contribute to sustaining the anisotropic #growth of the nascent tube under increased intraluminal #pressure during #liver #development. These structures are supported by adherens #junctions and sealed by tight junctions.
I believe only @nunopmartins is here but if I am mistaken please tag any other author.
#CellPolarity #CellBiology #actomyosin #tubulogenesis

https://rupress.org/jcb/article/222/4/e202208002/213840/Hepatocyte-apical-bulkheads-provide-a-mechanical

📰 "The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics"
by 🔬 Lembo, S., Strauss, L., Cheng, W. C. D., Vermeil, J., Siggel, M., Toro-Nahuelpan, M., Chan, C. J., Kosinski, J., Piel, M., Du Roure, O., Heuvingh, J., Mahamid, J., Diz-Munoz, A.
http://biorxiv.org/content/10.1101/2023.01.31.526409v1?rss=1 #Morphogenesis #Actomyosin #Mechanics #Cell

📰 "The distance between the plasma membrane and the actomyosin cortex acts as a nanogate to control cell surface mechanics"
by 🔬 Lembo, S., Strauss, L., Cheng, W. C. D., Vermeil, J., Siggel, M., Toro-Nahuelpan, M., Chan, C. J., Kosinski, J., Piel, M., Du Roure, O., Heuvingh, J., Mahamid, J., Diz-Munoz, A.
http://biorxiv.org/content/10.1101/2023.01.31.526409v1?rss=1 #Morphogenesis #Actomyosin #Mechanics #Cell

📰 "Geometric control of Myosin-II orientation during axis elongation"
by 🔬 Matthew F Lefebvre, Nikolas H Claussen, Noah P Mitchell, Hannah J Gustafson, Sebastian J Streichan
https://pubmed.ncbi.nlm.nih.gov/36715100/ #Morphogenesis #Actomyosin #Myosin

📰 "Nuclear pore complexes concentrate on Actin/LINC/Lamin nuclear lines in response to mechanical stress in a SUN1 dependent manner"
by 🔬 Mark A Smith, Elizabeth Blankman, Christopher C Jensen, Laura M Hoffman, Katharine S Ullman, Mary C Beckerle
https://pubmed.ncbi.nlm.nih.gov/36619427/ #Actomyosin #Mechanical #Actin

New bot! @Rxiv_cytoskeleton will toot all papers & preprints about the #cytoskeleton.
Namely, any match with "#actin, #actomyosin, #myosin, #microtubule, #kinesin, #intermediatefilament, #vimentin, #keratin, #desmin, #GFAP, #peripherin, #syncoilin, #internexin, #neurofilament, #synemin, #syncoilin, #lamin" in abstracts from #bioRxiv, #arXiv and #PubMed will be posted with #tags to tell you what's in there.
#biology #biophysics #science #ScienceMastodon #feed2toot @bioRxiv_biophys

Buckling tissue to a ...straight line! Not the sort of #buckling we're used to, in #Drosophila mesoderm #actomyosin narrows #tissue in DV and tension builds up along AP until forming a wire that indents embryo... like a cheese wire.
Now in NComms: https://rdcu.be/cPnZT #xp