#microtubule — Public Fediverse posts

📰 "Probing mechanisms of allosteric regulation in AAA+ ATPases for microtubule severing and protein disaggregation"
https://doi.org/doi:10.1063/5.0347970
https://pubmed.ncbi.nlm.nih.gov/42820442/
#Microtubule #Mechanical

📰 "Accurate chromosome segregation is more dependent on kinetochore-bound Stu2 in meiosis than mitosis"
https://doi.org/doi:10.64898/2026.09.06.749677
https://pubmed.ncbi.nlm.nih.gov/42818265/
#Microtubule #Mitosis

📰 "A structural model for the autoinhibition of the γ-TuRC-activating CM1 domain"
https://doi.org/doi:10.1083/jcb.202605160
https://pubmed.ncbi.nlm.nih.gov/42814412/
#CellDivision #Microtubule

📰 "Dynamic centrosomes: functional diversity and remodeling across cell types"
https://doi.org/doi:10.1038/s41401-026-01935-1
https://pubmed.ncbi.nlm.nih.gov/42806000/
#CellDivision #Microtubule #Cell

📰 "Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons"
https://doi.org/doi:10.7554/eLife.110011
https://pubmed.ncbi.nlm.nih.gov/42804373/
#Microtubule #Dynamics

📰 "Microtubule Cytoskeleton Dysfunction in Chronic Pain: Mechanisms of Transport Failure and Emerging Therapeutic Targets"
https://doi.org/doi:10.3390/ijms27188135
https://pubmed.ncbi.nlm.nih.gov/42794564/
#Microtubule #Dynamics

📰 "Arabidopsis TPXL Proteins Mediate a Selective Aurora Kinase-Microtubule Association During Cell Division"
https://doi.org/doi:10.3390/ijms27187980
https://pubmed.ncbi.nlm.nih.gov/42794412/
#CellDivision #Microtubule

New preprint:

Mutating the interprotofilament interface allows microtubules to assemble in GDP

Yean Ming Chew and Rob Cross

#cytoskeleton #microtubule

https://www.biorxiv.org/content/10.64898/2026.07.09.737542v1

New preprint:

Mutating the interprotofilament interface allows microtubules to assemble in GDP

Yean Ming Chew and Rob Cross

#cytoskeleton #microtubule

https://www.biorxiv.org/content/10.64898/2026.07.09.737542v1

📰 "Mammalian metaphase kinetochores are elastic and require condensin for robust structure and function"
https://www.biorxiv.org/content/10.64898/2025.12.23.696255v1?rss=1 #Microtubule #Force

📰 "Residue-Specific Modulation of Aggregation-Associated Interactions bySpermine in Tau, α-Synuclein, and Aβ40"
https://www.biorxiv.org/content/10.64898/2025.12.23.696224v1?rss=1 #Microtubule #Dynamics

📰 "Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling"
https://www.biorxiv.org/content/10.64898/2025.12.20.695343v1?rss=1 #CellDivision #Microtubule #Cell

📰 "Hyperbilirubinemia and phototherapy differentially alter hippocampal transcriptome in the preterm Gunn rat model"
https://doi.org/doi:10.1038/s41390-025-04700-y
https://pubmed.ncbi.nlm.nih.gov/41429952/
#Microtubule #Dynamics

📰 "MARK4 as a novel biomarker of acute myocardial ischemia-induced sudden cardiac death"
https://doi.org/doi:10.1016/j.legalmed.2025.102766
https://pubmed.ncbi.nlm.nih.gov/41421298/
#Microtubule #Dynamics

📰 "Single-molecule microtubule dynamics measurements reveal an intermediate state and clarify the role of nucleotide"
https://doi.org/doi:10.1038/s41467-025-67251-0
https://pubmed.ncbi.nlm.nih.gov/41419733/
#Microtubule #Dynamics

📰 "Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology"
https://www.biorxiv.org/content/10.1101/2025.06.27.662005v1?rss=1 #Microtubule #Mechanical #Cell

📰 "Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology"
https://www.biorxiv.org/content/10.1101/2025.06.27.662005v1?rss=1 #Microtubule #Mechanical #Cell

📰 "Tubulin Acetylation and the Cellular Mechanosensing and Stress Response"
https://doi.org/doi:10.1007/978-3-031-91459-1_5
https://pubmed.ncbi.nlm.nih.gov/40593209/
#Mechanosensing #Microtubule #Mechanical

📰 "Tubulin Acetylation and the Cellular Mechanosensing and Stress Response"
https://doi.org/doi:10.1007/978-3-031-91459-1_5
https://pubmed.ncbi.nlm.nih.gov/40593209/
#Mechanosensing #Microtubule #Mechanical

📰 "The Extremely Low Mechanical Force Generated by Nano-Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons"
https://doi.org/doi:10.1002/smll.202503011
https://pubmed.ncbi.nlm.nih.gov/40500945/
#Microtubule #Mechanical

📰 "The Extremely Low Mechanical Force Generated by Nano-Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons"
https://doi.org/doi:10.1002/smll.202503011
https://pubmed.ncbi.nlm.nih.gov/40500945/
#Microtubule #Mechanical

📰 "Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation"
https://doi.org/doi:10.1016/j.mtbio.2025.101838
https://pubmed.ncbi.nlm.nih.gov/40487178/
#Cytoskeletal #Microtubule #Mechanical

📰 "Nanotube topography inhibits NLRP3 inflammasome activation by reducing microtubule glutamylation"
https://doi.org/doi:10.1016/j.mtbio.2025.101838
https://pubmed.ncbi.nlm.nih.gov/40487178/
#Cytoskeletal #Microtubule #Mechanical

📰 "Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer's disease and related Tau pathologies"
https://doi.org/doi:10.3389/fmed.2025.1519628
https://pubmed.ncbi.nlm.nih.gov/40438379/
#Microtubule #Mechanical

📰 "Mechanical stimulation prevents impairment of axon growth and overcompensates microtubule destabilization in cellular models of Alzheimer's disease and related Tau pathologies"
https://doi.org/doi:10.3389/fmed.2025.1519628
https://pubmed.ncbi.nlm.nih.gov/40438379/
#Microtubule #Mechanical

📰 "On the Potential of Microtubules for Scalable Quantum Computation"
https://arxiv.org/abs/2505.20364 #Physics.Bio-Ph #Microtubule #Quant-Ph #Dynamics

📰 "On the Potential of Microtubules for Scalable Quantum Computation"
https://arxiv.org/abs/2505.20364 #Physics.Bio-Ph #Microtubule #Quant-Ph #Dynamics

📰 "Microtubule polymerization generates microtentacles important in circulating tumor cell invasion"
https://arxiv.org/abs/2505.18301 #Physics.Med-Ph #Physics.Bio-Ph #Microtubule #Adhesion #Force

📰 "Microtubule polymerization generates microtentacles important in circulating tumor cell invasion"
https://arxiv.org/abs/2505.18301 #Physics.Med-Ph #Physics.Bio-Ph #Microtubule #Adhesion #Force

📰 "Liquid-Liquid Phase Separation-Mediated Cellular-Scale Compartmentalization of Hydrogel Covalent Cross-Linking Promotes Microtubule-Based Mechanosensing"
https://doi.org/doi:10.1021/jacs.5c00079
https://pubmed.ncbi.nlm.nih.gov/40252026/
#Mechanosensing #Extracellular #Microtubule #Mechanical

📰 "Liquid-Liquid Phase Separation-Mediated Cellular-Scale Compartmentalization of Hydrogel Covalent Cross-Linking Promotes Microtubule-Based Mechanosensing"
https://doi.org/doi:10.1021/jacs.5c00079
https://pubmed.ncbi.nlm.nih.gov/40252026/
#Mechanosensing #Extracellular #Microtubule #Mechanical

📰 "Tekt3 Safeguards Proper Functions and Morphology of Neuromast Hair Bundles"
https://doi.org/doi:10.3390/ijms26073115
https://pubmed.ncbi.nlm.nih.gov/40243732/
#Microtubule #Mechanical

📰 "Microtubule-driven cell shape changes and actomyosin flow synergize to position the centrosome"
https://doi.org/doi:10.1083/jcb.202405126
https://pubmed.ncbi.nlm.nih.gov/40243666/
#Extracellular #Microtubule #Mechanical

📰 "Tekt3 Safeguards Proper Functions and Morphology of Neuromast Hair Bundles"
https://doi.org/doi:10.3390/ijms26073115
https://pubmed.ncbi.nlm.nih.gov/40243732/
#Microtubule #Mechanical

📰 "Microtubule-driven cell shape changes and actomyosin flow synergize to position the centrosome"
https://doi.org/doi:10.1083/jcb.202405126
https://pubmed.ncbi.nlm.nih.gov/40243666/
#Extracellular #Microtubule #Mechanical

📰 "Rethinking tubulin acetylation: From regulation to cellular adaptation"
https://doi.org/doi:10.1016/j.ceb.2025.102512
https://pubmed.ncbi.nlm.nih.gov/40220734/
#Microtubule #Mechanical

📰 "Rethinking tubulin acetylation: From regulation to cellular adaptation"
https://doi.org/doi:10.1016/j.ceb.2025.102512
https://pubmed.ncbi.nlm.nih.gov/40220734/
#Microtubule #Mechanical

📰 "Feedback controlled microengine powered by motor protein"
https://arxiv.org/abs/2503.07112 #Cond-Mat.Mes-Hall #Physics.Bio-Ph #Microtubule #Force

📰 "Feedback controlled microengine powered by motor protein"
https://arxiv.org/abs/2503.07112 #Cond-Mat.Mes-Hall #Physics.Bio-Ph #Microtubule #Force

📰 "Peptide-mediated display of Tau-derived peptide for construction of microtubule superstructures"
https://doi.org/doi:10.1039/d4cb00290c
https://pubmed.ncbi.nlm.nih.gov/40162136/
#Microtubule #Mechanical #Cell

📰 "Peptide-mediated display of Tau-derived peptide for construction of microtubule superstructures"
https://doi.org/doi:10.1039/d4cb00290c
https://pubmed.ncbi.nlm.nih.gov/40162136/
#Microtubule #Mechanical #Cell

📰 "Feedback controlled microengine powered by motor protein"
https://arxiv.org/abs/2503.07112 #Cond-Mat.Mes-Hall #Physics.Bio-Ph #Microtubule #Force

📰 "Feedback controlled microengine powered by motor protein"
https://arxiv.org/abs/2503.07112 #Cond-Mat.Mes-Hall #Physics.Bio-Ph #Microtubule #Force

📰 "Microtubule Deformation Modulates Intracellular Transport by Kinesin Differently than Dynein"
https://doi.org/doi:10.1109/TNB.2024.3507021
https://pubmed.ncbi.nlm.nih.gov/40030316/
#Microtubule #Mechanical #Cell

📰 "Microtubule Deformation Modulates Intracellular Transport by Kinesin Differently than Dynein"
https://doi.org/doi:10.1109/TNB.2024.3507021
https://pubmed.ncbi.nlm.nih.gov/40030316/
#Microtubule #Mechanical #Cell

📰 "Control of the force-bearing properties of microtubule-associated proteins via stalk/linker regions: insights from the NDC80 complex"
https://www.biorxiv.org/content/10.1101/2025.02.12.637486v1?rss=1 #Microtubule #Mechanical #Force

📰 "Control of the force-bearing properties of microtubule-associated proteins via stalk/linker regions: insights from the NDC80 complex"
https://www.biorxiv.org/content/10.1101/2025.02.12.637486v1?rss=1 #Microtubule #Mechanical #Force

@Rxiv_mechanobio

Interesting review !

"Far from being homogeneous beams, cytoskeletal filaments have complex mechanical properties, which are directly related to the specific structural arrangement of their subunits. They are also versatile, as the filaments’ mechanics and biochemistry are tightly coupled, and their
properties can vary with the cellular context."

#actin #microtubule #vimentin

@Rxiv_mechanobio

Interesting review !

"Far from being homogeneous beams, cytoskeletal filaments have complex mechanical properties, which are directly related to the specific structural arrangement of their subunits. They are also versatile, as the filaments’ mechanics and biochemistry are tightly coupled, and their
properties can vary with the cellular context."

#actin #microtubule #vimentin

@Rxiv_mechanobio

Interesting review !

"Far from being homogeneous beams, cytoskeletal filaments have complex mechanical properties, which are directly related to the specific structural arrangement of their subunits. They are also versatile, as the filaments’ mechanics and biochemistry are tightly coupled, and their
properties can vary with the cellular context."

#actin #microtubule #vimentin

📰 "Liquid-solid coexistence at single fibril resolution during tau condensate ageing"
https://www.biorxiv.org/content/10.1101/2025.02.06.636870v1?rss=1 #Microtubule #Mechanical

📰 "Liquid-solid coexistence at single fibril resolution during tau condensate ageing"
https://www.biorxiv.org/content/10.1101/2025.02.06.636870v1?rss=1 #Microtubule #Mechanical

📰 "Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress"
https://doi.org/doi:10.1167/iovs.66.1.43
https://pubmed.ncbi.nlm.nih.gov/39820277/
#Microtubule #Mechanical #Cell

📰 "Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical Stress"
https://doi.org/doi:10.1167/iovs.66.1.43
https://pubmed.ncbi.nlm.nih.gov/39820277/
#Microtubule #Mechanical #Cell

📰 "Microtubule acetylation is not required for HIV-1 infection or TRIM69-mediated restriction of HIV-1 infection"
https://doi.org/doi:10.1128/jvi.01026-24
https://pubmed.ncbi.nlm.nih.gov/39804091/
#Microtubule #Mechanical

A previous study in #plosbiology found that Wnt receptors are housed in early endosomes and required for dendritic #microtubule nucleation. This Update Article shows that microtubule dynamics in #dendrites can be influenced non-autonomously by surrounding epithelial cells plos.io/3DK0M0J

A previous study in #plosbiology found that Wnt receptors are housed in early endosomes and required for dendritic #microtubule nucleation. This Update Article shows that microtubule dynamics in #dendrites can be influenced non-autonomously by surrounding epithelial cells plos.io/3DK0M0J

Arl2 regulates asymmetric division in fly neural stem cells via control of #microtubule growth. @HongyanWang9 &co show that, in mammalian #cortex, Arl2 binds to Cdk5rap2 to control microtubule growth, so regulating #corticogenesis #PLOSBiology https://plos.io/4dqDo5q

Mutations in #microtubule regulatory protein Katnal2 have been linked to #autism. This study finds that loss of Katnal2 in mice leads to autism-related phenotypes, driven in part by altered #ciliary function in the lateral #ventricles #PLOSBiology https://plos.io/4aezHNy

CFDP1 regulates cell proliferation & higher-order #chromatin structure. This study shows that CFDP1 is essential for structural stability of centromeric #heterochromatin, so influencing #microtubule nucleation during #MitoticSpindle formation #PLOSBiology https://plos.io/3W5eFhc