#cadherin — Public Fediverse posts

📰 "Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle"
https://www.biorxiv.org/content/10.64898/2026.04.21.719880v1?rss=1 #Morphogenesis #Cadherin

📰 "DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue"
https://doi.org/doi:10.1016/j.bpj.2026.01.026
https://pubmed.ncbi.nlm.nih.gov/41548041/
#Morphogenesis #Cadherin #Cell

📰 "E-cadherin negatively regulates hESCs endodermal differentiation under varied substrate stiffnesses"
https://doi.org/doi:10.1007/s00018-025-05776-9
https://pubmed.ncbi.nlm.nih.gov/40549002/
#Mechanical #Adhesion #Cadherin

📰 "Adherens junctions co-opt EGFR-ERK signaling for epithelial mechanotransduction"
https://doi.org/doi:10.1126/scisignal.adx0682
https://pubmed.ncbi.nlm.nih.gov/40359263/
#Mechanotransduction #Mechanical #Cadherin

📰 "E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding"
https://doi.org/doi:10.1126/scisignal.adr7926
https://pubmed.ncbi.nlm.nih.gov/40359261/
#Mechanotransduction #Mechanical #Cadherin

#SensoryGating helps animals to distinguish threatening & non-threatening stimuli. This study reveals a mechanism whereby #cadherin 16 (cdh16)-dependent changes in the corpuscle of Stannius regulate whole-body #calcium homeostasis & sensory gating in #zebrafish @PLOSBiology https://plos.io/4m8XZA2

📰 "E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding"
https://www.biorxiv.org/content/10.1101/2025.03.06.641828v1?rss=1 #Mechanotransduction #Mechanical #Cadherin

📰 "Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature"
https://doi.org/doi:10.1126/sciadv.adu0989
https://pubmed.ncbi.nlm.nih.gov/39951520/
#Cadherin #Afadin #Force

From their abstract:
"Emerging evidence suggests that understanding of #timescales may be important in resolving this issue, but that further work is needed to understand the role of adhesive strengthening across scales."

Same the conclusion as in our theory paper https://doi.org/10.1371/journal.pcbi.1009812 : the interplay of #cadherin #adhesion & cortical #actomyosin timescales triggers emergent phenomena in terms of #tissue mechanics. If one adds #mechanotransduction on top of that then expect awesome effects.