#biorxiv — Public Fediverse posts

New preprint dropped: __Systemic diazepam alters local hippocampal CA1 circuits and differentially affects entorhinal and CA3 inputs__

Peterson et al. (2026) #bioRxiv

https://www.biorxiv.org/content/10.64898/2026.08.18.745488v1

Really cool and amazing results that systemic diazepam obliterates hippocampal #sharpWaveRipples in vivo, particularly during the post-task rest, and disrupts representations during running.

Implies important issues that diazepam's side effects on consolidation really ought to be looked at. (All the diazepam memory tests we could find in the literature are short-term tests, no one seems to have looked at long-term consolidation, but would love citations if people have them.)

PS. To be honest, though, my favorite figure is the proof-of-efficacy in Figure 2 where decreased spiking cross-correlation directly reveals diazepam's effects on inhibition. It's so clean!

#science #neuroscience #hippocampus

Otro pequeño orgullo de nuestro laboratorio del #iibce ya está en @biorxiv_neursci .
Un importante volumen de trabajo sobre las conexinas en la reparación de la médula espinal.
Gran equipo #MadeInUruguay lo hizo posible, gracias a financiación extranjera de #WingsForLife.

@constanzasilvera

#neuroscience #neuromastodon #medulaeespinal #conexinas #neurociencia #biology #biologia #investigacion #ciencia #Uruguay #spinalcordinjury #spinalcord #research #pedeciba @SocNeuroUy #preprint #biorxiv

https://www.biorxiv.org/content/10.64898/2026.01.16.699895v1.full.pdf+html

A new preprint from the lab (together with Marthe Walvoort's group) is now on #bioRxiv : https://www.biorxiv.org/content/10.1101/2023.03.16.532902v1 This manuscript presents nice work by Pushpa Rampratap, who did a great job figuring out how to make 13C-enriched hyaluronic acid #polysaccharide for use in #ssNMR . More forthcoming on the applications, but this paper introduces the protocols for producing the high-molecular weight HA. Enjoy! #glycotime #nmrchat #TeamMassSpec (Feedback welcome!)

In case you’ve ever wondered what we’re doing in the lab, here is a preview -> Comparison of commercial DNA extraction kits for whole metagenome sequencing of human oral, vaginal, and rectal microbiome samples #bioRxiv #microbiome #microbiology #DNAextraction #shotgunsequencing #metagenomics #kitbias

https://www.biorxiv.org/content/10.1101/2023.02.01.526597v1