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#biorxiv — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #biorxiv, aggregated by home.social.

  1. New preprint from the lab!

    How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.

    Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.

    🔗 [doi.org/10.64898/2026.05.25.72]

    #newsmayerlab #Neuroscience #DevBio #Transcription #bioRxiv

  2. New preprint from the lab!

    How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.

    Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.

    🔗 [doi.org/10.64898/2026.05.25.72]

    #newsmayerlab #Neuroscience #DevBio #Transcription #bioRxiv

  3. New preprint from the lab!

    How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.

    Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.

    🔗 [doi.org/10.64898/2026.05.25.72]

    #newsmayerlab #Neuroscience #DevBio #Transcription #bioRxiv

  4. New preprint from the lab!

    How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.

    Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.

    🔗 [doi.org/10.64898/2026.05.25.72]

    #newsmayerlab #Neuroscience #DevBio #Transcription #bioRxiv

  5. New preprint from the lab!

    How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.

    Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.

    🔗 [doi.org/10.64898/2026.05.25.72]

    #newsmayerlab #Neuroscience #DevBio #Transcription #bioRxiv

  6. 📢 We are pleased to announce that authors can now submit manuscripts directly from bioRxiv to CSBJ through the 𝗯𝗶𝗼𝗥𝘅𝗶𝘃-𝘁𝗼-𝗝𝗼𝘂𝗿𝗻𝗮𝗹 (B2J) transfer service.

    🙏We sincerely thank Cold Spring Harbor Laboratory (CSHL) for integrating CSBJ into the B2J service.

    #CSBJ #bioRxiv #AAAS #OpenScience #Preprints #SystemsBiology #StructuralBiology #Biotechnology #ComputationalBiology #Omics #Nanoscience #MedicalInformatics #Biomedicine #AdvancedMaterials #Biomaterials #QuantumBiology #Biophotonics