home.social

#biorxiv — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #biorxiv, aggregated by home.social.

  1. New preprint from the lab!

    How do brain progenitors choose between D1 and D2 medium spiny neurons? We find the *relative levels* of SP9 and DLX TFs tip the balance: SP9 activates D2 genes at promoters, and represses D1 enhancers via DLX/NuRD.

    Proud of the team — combining sparse in vivo CRISPR, lineage barcoding, scRNA-seq, ChIP-seq, CUT&RUN and proteomics for mechanistic depth in in vivo functional genomics.

    🔗 [doi.org/10.64898/2026.05.25.72]

    #newsmayerlab #Neuroscience #DevBio #Transcription #bioRxiv

  2. " Instead, #Hepatoblastoma #tumors contain a large suppressive #myeloid compartment which poses opportunities for targeting. Specifically, therapeutic antibodies
    targeting the #tumor antigen #GPC3 to induce ADCP by #macrophages, in combination with myeloid
    #ImmuneCheckpointBlockade (#CD47/SIRPa, or VISTA) could be a feasible strategy to explore in future studies"

    Krijgsman et al. from Vercoulen lab in the #UMCUtrecht, on #bioRXiv:
    biorxiv.org/content/10.1101/20

    #scRNAseq #spatial #CyTOF #immunology

  3. biorxiv.org/content/10.1101/20 Benchmarking of virus detection methods from WGS data. PPR-Meta seems best in environmental samples, while VirSorter2 is best in the gut. Which is good, because VirSorter2 is what we're using at the moment in the @BorkLab 😅

    #bioRxiv #microbiome #virome