#biorxiv — Public Fediverse posts

New preprint dropped: __Systemic diazepam alters local hippocampal CA1 circuits and differentially affects entorhinal and CA3 inputs__

Peterson et al. (2026) #bioRxiv

https://www.biorxiv.org/content/10.64898/2026.08.18.745488v1

Really cool and amazing results that systemic diazepam obliterates hippocampal #sharpWaveRipples in vivo, particularly during the post-task rest, and disrupts representations during running.

Implies important issues that diazepam's side effects on consolidation really ought to be looked at. (All the diazepam memory tests we could find in the literature are short-term tests, no one seems to have looked at long-term consolidation, but would love citations if people have them.)

PS. To be honest, though, my favorite figure is the proof-of-efficacy in Figure 2 where decreased spiking cross-correlation directly reveals diazepam's effects on inhibition. It's so clean!

#science #neuroscience #hippocampus

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