#cellcycle — Public Fediverse posts

Postdoctoral Fellow
Columbia University

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/

#cancerbiology #cellbiology #cellcycle #ScienceJobs #hiring #research
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/?fsp_sid=13682

Postdoctoral Fellow
Columbia University

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/

#cancerbiology #cellbiology #cellcycle #ScienceJobs #hiring #research
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/?fsp_sid=13682

Postdoctoral Fellow
Columbia University

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/

#cancerbiology #cellbiology #cellcycle #ScienceJobs #hiring #research
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/?fsp_sid=13562

Postdoctoral Fellow
Columbia University

See the full job description on jobRxiv: https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/

#cancerbiology #cellbiology #cellcycle #ScienceJobs #hiring #research
https://jobrxiv.org/job/columbia-university-27778-postdoctoral-fellow-2/?fsp_sid=13562

SpudCell: The first synthetic cell with a complete cell cycle

https://biotic.org/research/spudcell/

#HackerNews #SpudCell #synthetic #biology #cellcycle #research #innovation

SpudCell: The first synthetic cell with a complete cell cycle

https://biotic.org/research/spudcell/

#HackerNews #SpudCell #synthetic #biology #cellcycle #research #innovation

#CellCycle progression is linkied to #HistoneModification dynamics, but how is this regulated in vivo? @classenlab &co show that levels of H3K27ac, H3K27me3 & H3K9me3 are tightly linked to cell cycle dynamics in the #Drosophila wing imaginal disc @PLOSBiology https://plos.io/4bPkPbv

#CellCycle progression is linkied to #HistoneModification dynamics, but how is this regulated in vivo? @classenlab &co show that levels of H3K27ac, H3K27me3 & H3K9me3 are tightly linked to cell cycle dynamics in the #Drosophila wing imaginal disc @PLOSBiology https://plos.io/4bPkPbv

Tribute to Béla Novák (1956–2025) by Alexis Barr, Francis Barr and John Tyson, in J Cell Sci.

#CellBiology #SystemsBiology #CellCycle

https://doi.org/10.1242/jcs.264438

Tribute to Béla Novák (1956–2025) by Alexis Barr, Francis Barr and John Tyson, in J Cell Sci.

#CellBiology #SystemsBiology #CellCycle

https://doi.org/10.1242/jcs.264438

Paracetamol disrupts early embryogenesis by cell cycle inhibition

https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deaf116/8234396

#HackerNews #Paracetamol #Embryogenesis #CellCycle #Inhibition #Research #HealthScience

Paracetamol disrupts early embryogenesis by cell cycle inhibition

https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deaf116/8234396

#HackerNews #Paracetamol #Embryogenesis #CellCycle #Inhibition #Research #HealthScience

Androgen receptor-positive #ProstateCancer cells express hormone-dependent tRNA halves, but what are they for? This study shows that the 5′-tRNALysCUU half promotes #CellCycle progression by destabilizing the mRNA of p21, a negative regulator @PLOSBiology https://plos.io/3SHIilO

Androgen receptor-positive #ProstateCancer cells express hormone-dependent tRNA halves, but what are they for? This study shows that the 5′-tRNALysCUU half promotes #CellCycle progression by destabilizing the mRNA of p21, a negative regulator @PLOSBiology https://plos.io/3SHIilO

What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @PLOSBiology https://plos.io/3SUN4we

What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @PLOSBiology https://plos.io/3SUN4we

Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @PLOSBiology https://plos.io/43TnG0L

Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @PLOSBiology https://plos.io/43TnG0L

ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @PLOSBiology https://plos.io/3EaNFX4

ER-resident IRE1 plays a role in #cancer development via enzymatic activation of XPB1 TFs and regulated #RNAdecay. This study shows that some cancer cells also have an unexpected nonenzymatic dependency on IRE1 to promote #CellCycle progression & tumor growth @PLOSBiology https://plos.io/3EaNFX4

Current methods to study #CellCycle progression in #yeast ignore variations in cell size. The FLCCR reporter system can quantify the duration of cell cycle phase in single cells, allowing independent assessment of cell size & cell cycle progression #plosbiology https://plos.io/4j48NxJ

Current methods to study #CellCycle progression in #yeast ignore variations in cell size. The FLCCR reporter system can quantify the duration of cell cycle phase in single cells, allowing independent assessment of cell size & cell cycle progression #plosbiology https://plos.io/4j48NxJ

From post 5,
Amino acids that are enriched/depleted next to the phospho-site reflect which protein kinase enzymes did the phosphorylation.

Phospho-dawn sees acid-directed sites being phosphorylated (D and E enriched at ZT0),
but by evening it's #CellCycle kinases guided by Proline (P at ZT12-16). 😎

#Shiftwork

Apicomplexan #parasite division: @MGissot &co show that the #phosphatase TgPP1 in #Toxoplasma regulates the #CellCycle & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins #PLOSBiology https://plos.io/3XwMYgj

Apicomplexan #parasite division: @MGissot &co show that the #phosphatase TgPP1 in #Toxoplasma regulates the #CellCycle & amylopectin accumulation by dephosphorylating inner membrane complex & starch-binding domain proteins #PLOSBiology https://plos.io/3XwMYgj

How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c

How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c

Cell cycle genes are re-activated in some #neurons as our brains age. This study uses bioinformatics to characterize the prevalence, nature & fate of these #CellCycle re-entry neurons, within the healthy #aging & diseased human brain. #PLOSBiology https://plos.io/4dbHoXt

Cell cycle genes are re-activated in some #neurons as our brains age. This study uses bioinformatics to characterize the prevalence, nature & fate of these #CellCycle re-entry neurons, within the healthy #aging & diseased human brain. #PLOSBiology https://plos.io/4dbHoXt

When you have “ATM” in your name your destiny is to either work for a bank or become a researcher specialising in #DNAdamage #science #CellCycle

https://pubmed.ncbi.nlm.nih.gov/38625790/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1TkPOxkdaxtnnrl5wnZzn2VRNhPyzrYC_QUuJ0PP1Pdf91LMB7&fc=None&ff=20240416205101&v=2.18.0.post9+e462414

New #ReviewedPreprint investigates the regulatory role of Mecp2 in #quiescence exit, providing “fundamental insights” into the mechanism controlling the #CellCycle.

#Preprint with public reviews by @eLife.

https://sciety.org/articles/activity/10.1101/2023.07.24.550263?utm_source=mastodon&utm_medium=social&utm_campaign=sci_mastodon_2023_190

Chromatin is less mobile during S-phase compared to G1 and G2 phases of the #CellCycle, new study finds.

#ReviewedPreprint with public reviews by @eLife-

https://sciety.org/articles/activity/10.1101/2023.03.07.531331?utm_source=mastodon&utm_medium=social&utm_campaign=sci_mastodon_2023_177

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

How do #cellcycle oscillators generate exactly two #meiotic divisions for production of haploid #gametes?
Wolfgang Zachariae and colleagues show that #Spo13/#MEIKIN and #Cdc5/#Plk1 cooperate to prevent premature APC/C-#Ama1 activation after #meiosis I
https://www.embopress.org/doi/full/10.15252/embj.2023114288

How do #cellcycle oscillators generate exactly two #meiotic divisions for production of haploid #gametes?
Wolfgang Zachariae and colleagues show that #Spo13/#MEIKIN and #Cdc5/#Plk1 cooperate to prevent premature APC/C-#Ama1 activation after #meiosis I
https://www.embopress.org/doi/full/10.15252/embj.2023114288

#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis

https://www.embopress.org/doi/full/10.15252/embj.2023113647

#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis

https://www.embopress.org/doi/full/10.15252/embj.2023113647

cell 🚴‍♂️ cyclists & DNA replicationists take note 👇

super interesting thread by kristina jonas on twitter (X):
https://twitter.com/krijonas/status/1684903480069128192

#microbiology #replication #cellcycle

cell 🚴‍♂️ cyclists & DNA replicationists take note 👇

super interesting thread by kristina jonas on twitter (X):
https://twitter.com/krijonas/status/1684903480069128192

#microbiology #replication #cellcycle

bacterial cell cyclists take note 👇

'The Nordström Question' by William D. Donachie. This will remain one of the most memorable papers I’ve ever read by the end of my career. — Suckjoon Jun @junlab_ucsd

(https://twitter.com/junlab_ucsd/status/1673262090734141440)

https://www.mdpi.com/2075-1729/13/7/1442

#microbiology #cellcycle

bacterial cell cyclists take note 👇

'The Nordström Question' by William D. Donachie. This will remain one of the most memorable papers I’ve ever read by the end of my career. — Suckjoon Jun @junlab_ucsd

(https://twitter.com/junlab_ucsd/status/1673262090734141440)

https://www.mdpi.com/2075-1729/13/7/1442

#microbiology #cellcycle

A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle

https://www.embopress.org/doi/full/10.15252/embj.2022111951

A #transcription-independent mechanism -#RBM10-mediated RNA alternative #splicing coupled to nonsense-mediated #mRNA decay- determines rapid periodic fluctuations of #BRCA1 expression throughout the #cellcycle

https://www.embopress.org/doi/full/10.15252/embj.2022111951

"In this study, we revisit and significantly extend the initiator-titration model, proposed thirty years ago, and explain how bacteria precisely and robustly control replication initiation based on the mechanism of protein copy-number sensing."

#preprint #microbiology #cellcycle

https://www.biorxiv.org/content/10.1101/2023.05.26.542547v1

"In this study, we revisit and significantly extend the initiator-titration model, proposed thirty years ago, and explain how bacteria precisely and robustly control replication initiation based on the mechanism of protein copy-number sensing."

#preprint #microbiology #cellcycle

https://www.biorxiv.org/content/10.1101/2023.05.26.542547v1

Transferred #mitochondria accumulate reactive oxygen species, promoting proliferation. #Cancer #ReactiveOxygenSpecies #CellCycle https://elifesciences.org/articles/85494?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Transferred #mitochondria accumulate reactive oxygen species, promoting proliferation. #Cancer #ReactiveOxygenSpecies #CellCycle https://elifesciences.org/articles/85494?utm_source=mastodon&utm_medium=social&utm_campaign=organic

I have been asked to bring this meeting to the attention of the #CellBiology crowd on #ScienceMastodon so here goes:

The SEB Centenary Conference is happening in Edinburgh in early July. There’s a very nice #CellCycle session!

https://www.sebiology.org/events/seb-centenary-conference-2023.html

Abstract deadline has been extended - contact Jim and James direct if you want to participate (details in the image).

How is #biomass production controlled during cell growth and the cell cycle?

New assay by Clovis Basier & Paul Nurse @thecrick using unperturbed exponentially growing populations shows how #cellcycle and cell size affect global rates of RNA and protein synthesis in #fissionyeast

#RefereedPreprint c/o @ReviewCommons now published in revised form!

https://www.embopress.org/doi/10.15252/embj.2022113333

The molecular basis for recognition of #CENPA #nucleosomes by ‘Mis18 licensing factor component #KNL2:
Tatsuo Fukagawa and coworkers present #cryoEM structure with chicken KNL2 and insight into its dynamic localization regulation during the #cellcycle
https://www.embopress.org/doi/10.15252/embj.2022111965

Cover feature in issue 42/2:

#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com

And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2

cell cyclists & divisionists take note 👇

The cell cycle of Staphylococcus aureus: An updated review

Maria D. Barbuti, Ine S. Myrbråten, Danae Morales Angeles, Morten Kjos

https://doi.org/10.1002/mbo3.1338

#cellcycle #microbiology

“But I’m #newhere / will you show me around”
(Bill Callahan, 2006)

Ok, after looking around a bit, finally time for proper #introduction

I am a #biochemist and former #researcher, still fond of #ubiquitin and #cellcycle stuff!
I work now as full-time #LifeScience #editor for @embojournal, interested in #scicomm #reproducibility #researchintegrity

I may not directly toot about them, but other things I am looking for here are #cycling, #photography, #outdoors, #languages, #history, #music…

#introduction
Hello #ScienceMastodon community!

I am a professor at Rockefeller University in #NYC and dean of the graduate school. Interested in all things #science, but especially #CellBiology, #centrosomes, #cilia, #CellCycle, the #cytoskeleton and #microscopy.

I also want to make science a better place for students and postdocs, and am interested in science education, outreach, publishing and policy. #ScienceEducation

Occasional infrared and film #photography posts to keep it interesting