#cellcycle — Public Fediverse posts

Paracetamol disrupts early embryogenesis by cell cycle inhibition

https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deaf116/8234396

#HackerNews #Paracetamol #Embryogenesis #CellCycle #Inhibition #Research #HealthScience

What is the role of m5C #RNAmodifications during neural development? This study shows that m5C reader protein Ybx1 plays a crucial role in promoting #CellCycle progression of embryonic cortical #ProgenitorCells, essential for proper cortical development @PLOSBiology https://plos.io/3SUN4we

Multiple #myeloma often requires IRE1 to sustain malignant growth, but why? This study shows that IRE1 promotes #CellCycle progression via the transcription factor IRF4, paving the way for new therapeutic strategies @PLOSBiology https://plos.io/43TnG0L

From post 5,
Amino acids that are enriched/depleted next to the phospho-site reflect which protein kinase enzymes did the phosphorylation.

Phospho-dawn sees acid-directed sites being phosphorylated (D and E enriched at ZT0),
but by evening it's #CellCycle kinases guided by Proline (P at ZT12-16). 😎

#Shiftwork

How do cells respond to defects in nuclear reassembly after #mitosis? This study in #Drosophila shows that damaged cells are either removed by #apoptosis or activate a p53-dependent #CellCycle checkpoint to maintain tissue integrity #PLOSBiology https://plos.io/3AA4g4c

Proliferating cells need to maintain a stable size distribution across the generations. This study shows that this is achieved by tightly controlling #CellSize variation throughout the #CellCycle, mainly via regulation of cell growth rate #PLOSBiology https://plos.io/4aMUWHS

How do #cellcycle oscillators generate exactly two #meiotic divisions for production of haploid #gametes?
Wolfgang Zachariae and colleagues show that #Spo13/#MEIKIN and #Cdc5/#Plk1 cooperate to prevent premature APC/C-#Ama1 activation after #meiosis I
https://www.embopress.org/doi/full/10.15252/embj.2023114288

#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis

https://www.embopress.org/doi/full/10.15252/embj.2023113647

Cover feature in issue 42/2:

#Golgi #oxygen sensor controlling #intestinal ‘mucin #glycosylation
by Tal Ilani, Deborah Fass and colleagues with SciStories.com

And:
Gut colonization via #GTPase-less EF-G paralog
#Yeast cells in two minds about #cellcycle start
#MASTL/#PP2A module restraining #PI3K-Akt
Zinc-dependent structural transition in ALS-mutated #SOD1
https://www.embopress.org/toc/14602075/2023/42/2