#phosphorylation — Public Fediverse posts

In a new #JIPB review, Zhang and Liu explore the role of #phosphorylation as a molecular switch that dynamically controls #light signaling, helping #plants adjust their #growth and #development to adapt to changing light conditions.
https://doi.org/10.1111/jipb.13913
@wileyplantsci
#PlantSci

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=89240

PhD Position in Megakaryocyte Biology

University Hospital Würzburg

See the full job description on jobRxiv: https://jobrxiv.org/job/university-hospital-wurzburg-27778-phd-position-in-megakaryocyte-biology/?feed_id=88610

#hematology #hematopoiesis #phosphorylation #platelet_biology #single_cell #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-hospital-wurzburg-27778-phd-position-in-megakaryocyte-biology/?feed_id=88610

PhD Position in Megakaryocyte Biology

University Hospital Würzburg

See the full job description on jobRxiv: https://jobrxiv.org/job/university-hospital-wurzburg-27778-phd-position-in-megakaryocyte-biology/?feed_id=88582

#hematology #hematopoiesis #phosphorylation #platelet_biology #single_cell #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-hospital-wurzburg-27778-phd-position-in-megakaryocyte-biology/?feed_id=88582

Computational Origins of Life Postdoc

Lund University

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-computational-origins-of-life-postdoc/?feed_id=88169

#biophysics #computational_biology #computational_chemistry #origins_of_life #phosphorylation #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-computational-origins-of-life-postdoc/?feed_id=88169

PhD Position in Megakaryocyte Biology

University Hospital Würzburg

See the full job description on jobRxiv: https://jobrxiv.org/job/university-hospital-wurzburg-27778-phd-position-in-megakaryocyte-biology/?feed_id=88141

#hematology #hematopoiesis #phosphorylation #platelet_biology #single_cell #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-hospital-wurzburg-27778-phd-position-in-megakaryocyte-biology/?feed_id=88141

Computational Origins of Life Postdoc

Lund University

See the full job description on jobRxiv: https://jobrxiv.org/job/lund-university-27778-computational-origins-of-life-postdoc/?feed_id=87406

#biophysics #computational_biology #computational_chemistry #origins_of_life #phosphorylation #ScienceJobs #hiring #research
https://jobrxiv.org/job/lund-university-27778-computational-origins-of-life-postdoc/?feed_id=87406

🌐💡 We suggest which protein kinases (like CK1 and CK2) are involved (see bonus post 👇!).
These are key enzymes ensuring everything runs in sync in humans too, making O. tauri an intriguing example of efficient biological timing.
#Kinase #Phosphorylation 5/7

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=86297

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=80205

The molecular shield: How #tea #plants combat #drought through #protein #phosphorylation.

#agriculture #climate_change #CsMPK4a #CsWD40 #flavonoid

https://phys.org/news/2024-08-molecular-shield-tea-combat-drought.html

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79673

Open PhD student position

Hebrew University of Jerusalem

Our lab studies the relationship between metabolism, mitochondrial dysfunction and mitophagy in S. cerevisiae.

See the full job description on jobRxiv: https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064

#autophagy #biochemistry #cell_biology #kinases #mitophagy #phosphorylation #Sc...
https://jobrxiv.org/job/hebrew-university-of-jerusalem-27778-open-phd-student-position/?feed_id=79064

"two Medicago truncatula cortical cell–specific, #membrane-bound #proteins of a CYCLIN-DEPENDENT KINASE-LIKE (CKL) family associate with, and are #phosphorylation substrates of, DMI2 and a subset of the LysM #receptor #kinases. CKL1 and CKL2 are required for AM #symbiosis and control expression of #transcription factors that regulate part of the #lipid provisioning program. Onset of lipid provisioning is coupled with..the REDUCED ARBUSCULAR #MYCORRHIZA 1 (RAM1) #regulon"

https://www.science.org/doi/10.1126/science.ade1124

Regulation of viral biomolecular #condensates:
#Phosphorylation in the intrinsically disordered region #IDR of #adenovirus protein 52K modulates its liquid-like properties and function in viral packaging

Nicholas Grams, Matthew Charman, Matthew Weitzman and colleagues

https://www.embopress.org/doi/full/10.1038/s44318-023-00021-0

"ECSIT binding induces a major conformational change in the FAD-binding loop of ACAD9, releasing the FAD cofactor and converting ACAD9 from a fatty acid β-oxidation (FAO) enzyme to a CI assembly factor. We provide evidence that ECSIT #phosphorylation downregulates its association with ACAD9 and is reduced in #neuronal cells upon exposure to #amyloid-β (Aβ) oligomers."

https://www.nature.com/articles/s41467-023-43865-0

Cas #phosphorylation regulates focal adhesion assembly. https://elifesciences.org/articles/90234?utm_source=mastodon&utm_medium=social&utm_campaign=organic

TOR-mediated Ypt1 #phosphorylation regulates autophagy initiation complex assembly

The Rab #GTPase #Ypt1 serves as a bridge that connects environmental sensing to the formation of the #autophagy initiation complex.

https://www.embopress.org/doi/full/10.15252/embj.2022112814

#Phosphorylation control in #mitosis:
Julie Welburn and colleagues reveal the molecular basis for #cellcycle regulation of #Kif4A and #CENPE motor interaction with #PRC1, needed to organize antiparallel #microtubule bundles and to ensure central spindle integrity, #midbody assembly and #cytokinesis

https://www.embopress.org/doi/full/10.15252/embj.2023113647

Are there functions specific to #CUL4A and #CUL4B-based #ubiquitin E3 #ligases?

Matthias Peter Lab, Anna Stier et al find a CUL4B-specific N-terminal extension undergoing heavy #mitotic #phosphorylation, and promoting recruitment of a specific set of #DCAF substrate receptors involved in #cytoskeleton regulation

https://www.embopress.org/doi/10.15252/embj.2022112847

#Phosphorylation of phase-separated #p62 bodies by #ULK1 activates a #redox-independent stress response
Masaaki Komatsu, Nobuo Noda, Yoshinobu Ichimura and colleagues

https://www.embopress.org/doi/full/10.15252/embj.2022113349

How mature are the identification algorithms for top-down #proteomics? If we use two different algorithms on the same data, do we see the same proteoforms? I was recently lucky enough to invest two whole years in top-down #bioinformatics, courtesy of Julia Chamot-Rooke. Kyowon Jeong invested some serious time to teach me about #deconvolution, too! We feature new data from Mowei Zhou for #phosphorylation proteomics.
https://doi.org/10.1021/acs.jproteome.2c00673

The EGFR #phosphatase RPTPγ is a #redox-regulated suppressor of promigratory signaling
Maitreyi Joshi, Philippe Bastiaens et al show that #RPTPγ is coupled to autocatalytic, ligandless #EGFR #phosphorylation by a ROS-mediated toggle-switch, enabling ultrasensitive EGFR activation at the plasma membrane
https://www.embopress.org/doi/10.15252/embj.2022111806

A new proteomic workflow establishing interdependencies between protein #phosphorylation & complex formation is applied to the signal integrator & Hippo pathway effector YAP1 ➡️ http://bit.ly/3mJ4W0t
Matthias Gstaiger @eth_en
#proteomics #interactome #ProteinProteinInteractions #CellSignaling

How do #nutrient-starved cells preserve a basal supply of dormant #ribosomes?
Michael Hall and colleagues (Biozentrum Basel) identify conserved #TORC1 #phosphorylation and inhibition of ribosome-binding factor #Stm1/#SERBP1 in #yeast and human cells
https://www.embopress.org/doi/10.15252/embj.2022112344

Happy New Year 2023!
Our first issue brings:

#Calreticulin conformation changes in cold response

Mammalian #CDC14 #phosphatase controls #stemness exit in #pluripotent cells

#Exosomal #interleukin release via #IQGAP1-mediated #gasdermin-#ESCRT bridging

#Microglial TNFα and cortical protein #phosphorylation during #sleep

...and more:
https://www.embopress.org/toc/14602075/2023/42/1

#Phytosulfokine #peptide optimizes #plant growth and defense via #glutamine #synthetase GS2 #phosphorylation in #tomato

Shuting Ding et al. Zhejiang University

https://www.embopress.org/doi/10.15252/embj.2022111858